Altered Perceptual Networks in Tuberous Sclerosis Complex Patients with Epilepsy Revealed by Resting Functional Magnetic Resonance Imaging_West China Medical Journal

Authors：

 YANGTian-hua ¹ , YANBo ¹ , LUOCheng ² , RENJie-chuan ¹ , GONGQi-yong ³ , YAODe-zhong ² ,  ZHOUDong ¹

1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. School of Life Science and Technology School of Mathematics, University of Electronic Science and Technology of China, Chengdu, Sichuan 610051, P. R. China;
3. Huaxi MR Research Center, Department of Radiology, West China Hospital, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

ZHOUDong, Email: zhoudong66@yahoo.de

Keywords：

Tuberous sclerosis complex; Epilepsy; Perceptual network; Resting-state network; Functional connectivity MRI

DOI：

10.7507/1002-0179.20140431

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Objective To reveal impairments in the perceptual networks in tuberous sclerosis complex (TSC) with epilepsy by functional connectivity MRI (fcMRI). Methods The fcMRI-based independent component analysis (ICA) was used to measure the resting state functional connectivity in nine TSC patients with epilepsy recruited from June 2010 to June 2012 and perceptual networks including the sensorimotor network (SMN), visual network (VN), and auditory network (AN) were investigated. The correlation between Z values in regions of interest (ROIs) and age of seizure onset or duration of epilepsy were analyzed. Results Compared with the controls, the TSC patients with epilepsy presented decreased functional connectivity in primary visual cortex within the VN networks and there were no increased connectivity. Increased connectivity in left middle temporal gyrus and inferior temporal gyrus was found and decreased connectivity was detected in right inferior frontal gyrus within AN networks. Decreased connectivity was detected at the right inferior frontal gyrus and the increase in connectivity was found in right thalamus within SMN netwoks. No significant correlations were found between Z values in ROIs including the primary visual cortex within the VN, right thalamus and inferior frontal gyrus within SMN, left temporal lobe and right inferior frontal gyrus within AN and the duration of the disease or the age of onset. Conclusion Fhere is altered (both increased and decreased) functional connectivity in the perceptual networks of TSC patients with epilepsy. The decreased functional connectivity may reflect the dysfunction of correlative perceptual networks in TSC patients, and the increased functional connectivity may indicate the compensatory mechanism or reorganization of cortical networks. Our fcMRI study may contribute to the understanding of neuropathophysiological mechanisms underlying perceptual impairments in TSC patients with epilepsy.

Citation： YANGTian-hua, YANBo, LUOCheng, RENJie-chuan, GONGQi-yong, YAODe-zhong, ZHOUDong. Altered Perceptual Networks in Tuberous Sclerosis Complex Patients with Epilepsy Revealed by Resting Functional Magnetic Resonance Imaging. West China Medical Journal, 2014, 29(8): 1402-1406. doi: 10.7507/1002-0179.20140431 Copy

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23.	Matsuyama K, Ohsawa I, Ogawa T. Do children with tuberous sclerosis complex have superior musical skill? A unique tendency of musical responsiveness in children with TSC[J]. Med Sci Monit, 2007, 13(4):Cr156-Cr164.
24.	Brown S, Martinez MJ, Parsons LM. Music and language side by side in the brain:a PET study of the generation of melodies and sentences[J]. Eur J Neurosci, 2006, 23(10):2791-2803.
25.	Grant AC, Henry TR, Fernandez R, et al. Somatosensory processing is impaired in temporal lobe epilepsy[J]. Epilepsia, 2005, 46(4):534-539.
26.	D'argenzio L, Koch G, Bombardieri R, et al. Abnormal parieto-motor connectivity in tuberous sclerosis complex[J]. Epilepsy Res, 2009, 87(1):102-105.
27.	Luat AF, Chugani HT. Molecular and diffusion tensor imaging of epileptic networks[J]. Epilepsia, 2008, 49(Suppl 3):15-22.
28.	Wong M. Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation[J]. Epilepsia, 2008, 49(1):8-21.
29.	Kassiri J, Snyder TJ, Bhargava R, et al. Cortical tubers, cognition, and epilepsy in tuberous sclerosis[J]. Pediatr Neurol, 2011(44):328-332.
30.	Kaczorowska M, Jurkiewicz E, Domańska-Pakieła D, et al. Cerebral tuber count and its impact on mental outcome of patients with tuberous sclerosis complex[J]. Epilepsia, 2011, 52(1):22-27.

1. De Vries P, Humphrey A, Mccartney D, et al. Consensus clinical guidelines for the assessment of cognitive and behavioural problems in tuberous sclerosis[J]. Eur Child Adolesc Psychiatry, 2005, 14(4):183-190.
2. Tierney KM, Mccartney DL, Serfontein JR, et al. Neuropsychological attention skills and related behaviours in adults with tuberous sclerosis complex[J]. Behav Genet, 2011, 41(3):437-444.
3. De Luca M, Beckmann CF, De Stefano N, et al. fMRI resting state networks define distinct modes of long-distance interactions in the human brain[J]. Neuroimage, 2006, 29(4):1359-1367.
4. Damoiseaux JS, Rombouts S, Barkhof F, et al. Consistent resting-state networks across healthy subjects[J]. Proc Natl Acad Sci USA, 2006, 103(37):13848-13853.
5. Chandra PS, Salamon N, Nguyen ST, et al. Infantile spasm-associated microencephaly in tuberous sclerosis complex and cortical dysplasia[J]. Neurology, 2007, 68(6):438-445.
6. Ridler K, Bullmore ET, De Vries PJ, et al. Widespread anatomical abnormalities of grey and white matter structure in tuberous sclerosis[J]. Psychol Med, 2001(31):1437-1446.
7. Ridler K, Suckling J, Higgins NJ, et al. Neuroanatomical correlates of memory deficits in tuberous sclerosis complex[J]. Cereb Cortex, 2007, 17(2):261-271.
8. Krishnan ML, Commowick O, Jeste SS, et al. Diffusion features of white matter in tuberous sclerosis with tractography[J]. Pediatr Neurol, 2010, 42(2):101-106.
9. Tsai P, Sahin M. Mechanisms of neurocognitive dysfunction and therapeutic considerations in tuberous sclerosis complex[J]. Curr Opin Neurol, 2011, 24(2):106-113.
10. Roach ES, DiMario FJ, Kandt RS, et al. Tuberous Sclerosis Consensus Conference:recommendations for diagnostic evaluation. National Tuberous Sclerosis Association[J]. J Child Neurol, 1999, 14(6):401-407.
11. Calhoun VD, Adali T, Pearlson GD, et al. A method for making group inferences from functional MRI data using independent component analysis[J]. Hum Brain Mapp, 2001, 14(3):140-151.
12. Hyvärinen A. Fast and robust fixed-point algorithms for independent component analysis[J]. IEEE Trans Neural Netw, 1999, 10(3):626-634.
13. Jafri MJ, Pearlson GD, Stevens M, et al. A method for functional network connectivity among spatially independent resting-state components in schizophrenia[J]. Neuroimage, 2008, 39(4):1666-1681.
14. Genovese CR, Lazar NA, Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate[J]. Neuroimage, 2002, 15(4):870-878.
15. Zhang ZQ, Lu GM, Zhong Y, et al. Impaired perceptual networks in temporal lobe epilepsy revealed by resting fMRI[J]. J Neurol, 2009, 256(10):1705-1713.
16. Van Dijk KR, Hedden T, Venkataraman A, et al. Intrinsic functional connectivity as a tool for human connectomics:theory, properties, and optimization[J]. J Neurophysiol, 2010, 103(1):297-321.
17. Luo C, Li Q, Lai Y, et al. Altered functional connectivity in default mode network in absence epilepsy:a resting-state fMRI study[J]. Hum Brain Mapp, 2011, 32(3):438-449.
18. Vlooswijk MC, Jansen JF, Majoie HJ, et al. Functional connectivity and language impairment in cryptogenic localization-related epilepsy[J]. Neurology, 2010, 75(5):395-402.
19. Nie D, Di Nardo A, Han JM, et al. Tsc2-Rheb signaling regulates EphA-mediated axon guidance[J]. Nat Neurosci, 2010, 13(2):163-172.
20. Seri S, Cerquiglini A, Pisani F, et al. Autism in tuberous sclerosis:evoked potential evidence for a deficit in auditory sensory processing[J]. Clin Neurophysiol, 1999, 110(10):1825-1830.
21. Wilson SM, Molnar-Szakacs I, Iacoboni M. Beyond superior temporal cortex:intersubject correlations in narrative speech comprehension[J]. Cereb Cortex, 2008, 18(1):230-242.
22. Doeller CF, Opitz B, Mecklinger A, et al. Prefrontal cortex involvement in preattentive auditory deviance detection:neuroimaging and electrophysiological evidence[J]. Neuroimage, 2003, 20(2):1270-1282.
23. Matsuyama K, Ohsawa I, Ogawa T. Do children with tuberous sclerosis complex have superior musical skill? A unique tendency of musical responsiveness in children with TSC[J]. Med Sci Monit, 2007, 13(4):Cr156-Cr164.
24. Brown S, Martinez MJ, Parsons LM. Music and language side by side in the brain:a PET study of the generation of melodies and sentences[J]. Eur J Neurosci, 2006, 23(10):2791-2803.
25. Grant AC, Henry TR, Fernandez R, et al. Somatosensory processing is impaired in temporal lobe epilepsy[J]. Epilepsia, 2005, 46(4):534-539.
26. D'argenzio L, Koch G, Bombardieri R, et al. Abnormal parieto-motor connectivity in tuberous sclerosis complex[J]. Epilepsy Res, 2009, 87(1):102-105.
27. Luat AF, Chugani HT. Molecular and diffusion tensor imaging of epileptic networks[J]. Epilepsia, 2008, 49(Suppl 3):15-22.
28. Wong M. Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation[J]. Epilepsia, 2008, 49(1):8-21.
29. Kassiri J, Snyder TJ, Bhargava R, et al. Cortical tubers, cognition, and epilepsy in tuberous sclerosis[J]. Pediatr Neurol, 2011(44):328-332.
30. Kaczorowska M, Jurkiewicz E, Domańska-Pakieła D, et al. Cerebral tuber count and its impact on mental outcome of patients with tuberous sclerosis complex[J]. Epilepsia, 2011, 52(1):22-27.

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