发作性运动诱发性运动障碍临床分析_West China Medical Journal

Authors：

 涂良丹

四川大学华西医院神经内科（成都，610041）;

Corresponding author：

Keywords：

发作性运动诱发性运动障碍; 临床特征; 鉴别诊断; 治疗

DOI：

10.7507/1002-0179.20140433

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目的提高对发作性运动诱发性运动障碍（PKD）疾病的认识。方法对2011年1月－2013年12月收治的11例患者的临床资料进行回顾分析,总结PKD的临床特征和治疗方法。结果 11例患者经卡马西平、托吡酯等药物治疗，病情均得以控制。9例患者经半年至3年随访，5例能坚持每日正规按时服药，症状无发作或偶有发作且轻微；3例患者间断服药，症状时有发作，发作后服药最初剂量同样能控制症状；1例24岁患者服用近1年后未继续服药，症状未再发作或偶有发作先兆，但能自行控制症状。结论 PKD为一种少见的神经系统发作性疾病，应提高对该疾病的认识，注意同其他发作性疾病的鉴别，选择合适的抗癫痫药物治疗，一般预后良好。

Citation： 涂良丹. 发作性运动诱发性运动障碍临床分析. West China Medical Journal, 2014, 29(8): 1410-1412. doi: 10.7507/1002-0179.20140433 Copy

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11.	吕玉丹, 崔俐, 孟红梅, 等. 12例发作性运动诱发性肌张力障碍的临床、脑电图特点及文献复习[J]. 中风与神经疾病杂志, 2011, 28(10):920-922.
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14.	Mir P, Huang YZ, Gilio F, et al. Abnormal cortical and spinal inhibition in paroxysmal kinesigenic dyskinesia[J]. Brain, 2005, 128(pt2):291-299.
15.	Bhatia KP. Paroxysmal dyskinesias[J]. Mov Disord, 2011, 26(3):1157-1165.
16.	周铨, 黄志民, 章成国, 等. 发作性运动障碍临床特征及误诊分析[J]. 广东医学, 2012, 33(12):1776-1779.
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1. Bruno MK, Hallett M, Gwinn Hardy K, et al. Clinical evaluation of idiopathic paroxysmal kinesigenic dyskinesia:new diagnostic criteria[J]. Neurology, 2004, 63(12):2280-2287.
2. Demirkiran M, Jankovic J. Paroxysmal dyskinesias:clinical featues and classfication[J]. Ann Neuro, 1995, 38(4):571-579.
3. Tomita Ha, Nagamitsu S, Wakui K, et al. Paroxysmal kinesigenic choreoathetosis locus maps to chromosome16p11.2-q12.1[J]. Am J Hum Genet, 1999, 65(6):1688-1697.
4. Bennett LB, Roach ES, Bowcock AM. A locus for paroxysmal kinesigenic dyskinesia maps to human chromsome16[J]. Neurology, 2000, 54(1):125-130.
5. Valente EM, Spacey SD, Wali GM, et al. A second paroxysmal kinesigenic dyskinesia locus (EKD2) mapping on 16q13-q22.1 indicates a family of genes which give rise to paroxysmal disorders on human chromsome16[J]. Brain, 2000, 123(Pt10):2040-2045.
6. Spacey SD, Valente EM, Wali GM, et al. Genetic and clinical heterogeneity in paroxysmal kinesigenic dyskinesia:evidence for a third EKD gene[J]. Mov Disord, 2002, 17(4):717-725.
7. 丁静, 逢锦晶, 李银柱, 等. 发作性运动诱发性运动障碍九例临床特点分析[J]. 中华医学杂志, 2013, 93(37):3000-3001.
8. 粟艳芳, 陈国洪, 杨志晓. 发作性运动诱发性运动障碍研究进展[J]. 中华实用儿科临床杂志, 2013, 28(18):1427-1429.
9. Ohmori I, Ohtsuka Y, Yoshinaga H, et al. The relationship between paroxysmal kinesigenic choreoathetosis and epilepsy[J]. Neuropediatrics, 2002, 35(1):15-20.
10. 黄元桂. 发作性运动诱发性运动障碍患者的脑电图改变[J]. 临床神经电生理学杂志, 2004, 13(1):5-7.
11. 吕玉丹, 崔俐, 孟红梅, 等. 12例发作性运动诱发性肌张力障碍的临床、脑电图特点及文献复习[J]. 中风与神经疾病杂志, 2011, 28(10):920-922.
12. Joo EY, Hong SB, Tae WS, et al. Perfusion abnormality of the caudate nucleus in patients with paroxysmal kinesigenic choreoathetosis[J]. Eur J Nucl Med Mol Imaging, 2005, 32(10):1205-1209.
13. Zhou B, Chen Q, Gong Q, et al. The thalamic ultrastructural abnormalities in paroxysmal kinesigenic choreoathetosis:a diffusion tensor imaging study[J]. J Neurol, 2010, 257(3):405-409.
14. Mir P, Huang YZ, Gilio F, et al. Abnormal cortical and spinal inhibition in paroxysmal kinesigenic dyskinesia[J]. Brain, 2005, 128(pt2):291-299.
15. Bhatia KP. Paroxysmal dyskinesias[J]. Mov Disord, 2011, 26(3):1157-1165.
16. 周铨, 黄志民, 章成国, 等. 发作性运动障碍临床特征及误诊分析[J]. 广东医学, 2012, 33(12):1776-1779.
17. 黄颖, 张青山, 姜可. 发作性运动诱发性肌张力障碍的临床特点及治疗[J]. 中国临床实用医学, 2010, 4(10):177-178.

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