Clinical Value of Different Biochemical Markers in Diagnosing Fetal Sepsis in Premature Neonates_West China Medical Journal

Authors：

 SHIWei ,  CHENChang-hui

Department of Pediatrics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

CHENChang-hui, Email: changfhuichen@163.com

Keywords：

Biochemical markers; Procalcitonin; C-reactive protein; Interleukin-6; Premature neonates; Fetal sepsis

DOI：

10.7507/1002-0179.20140451

Video：

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Objective To examine and compare the value of procalcitonin (PCT), C-reactive protein (CRP) and interleukin (IL)-6 in diagnosing fetal sepsis in premature neonates. Methods Preterm neonates with premature rupture of membrane between January 2010 and September 2012 were screened, and the serum levels of PCT, CRP and IL-6 were detected in the first day of life. All preterm neonates were divided into two groups according to the development of sepsis (45 cases with sepsis and 39 cases without sepsis). Results The levels of PCT, CRP and IL-6 in premature neonates with sepsis were all significantly higher than those without sepsis. The cut-off value of PCT in diagnosis of sepsis was 2.14 μg/L, with a sensitivity and specificity of 76% and 85% respectively; the cut-off value of CRP in diagnosis of sepsis was 7.90 mg/L, with a sensitivity and specificity of 67% and 61% respectively. For IL-6, the cut-off value in diagnosis of sepsis was 13.80 ng/L, and its sensitivity and specificity were high to 90% and 94%, respectively. Conclusion IL-6 is the most reliable biochemical marker for the detection of early-onset sepsis in preterm neonates with premature rupture of membrane.

Citation： SHIWei, CHENChang-hui. Clinical Value of Different Biochemical Markers in Diagnosing Fetal Sepsis in Premature Neonates. West China Medical Journal, 2014, 29(8): 1469-1471. doi: 10.7507/1002-0179.20140451 Copy

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15.	戴标. IL-6、CRP和CD64在新生儿感染性疾病诊断中的价值[J]. 江苏大学学报·医学版, 2012, 22(5):434-436.
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1. 姜毅. 新生儿败血症诊疗进展[J]. 中国新生儿科杂志, 2010, 25(2):69-72.
2. 冯琪. 新生儿脓毒症诊断与治疗[J]. 中国实用儿科杂志, 2011, 26(12):902-906.
3. 张谦慎. 北美新生儿早发败血症的评估和抗生素治疗[J]. 中国新生儿科杂志, 2012, 27(4):284-286.
4. Ng PC, Lam HS. Biomarkers for late-onset neonatal sepsis:cytokines and beyond[J]. Clin Perinatol, 2010, 37(3):599-610.
5. Bender L, Thaarup J, Varming K, et al. Early and late markers for the detection of early-onset neonatal sepsis[J]. Dan Med Bull, 2008, 55(4):219-223.
6. 郝玲, 任常军, 王炳辉, 等. CD64、降钙素原在新生儿败血症诊断中的价值[J]. 临床儿科杂志, 2011, 29(3):216-218.
7. 欧阳颖, 梁立阳, 苏浩彬, 等. 新生儿败血症病原学分析[J]. 中国新生儿科杂志, 2007, 22(5):302-303.
8. 吴华, 卿文衡, 杨良勇. 血培养联合降钙素原与超敏C反应蛋白在新生儿败血症早期诊断中的应用[J]. 检验医学与临床, 2010, 7(21):2328-2329.
9. 魏东, 黄绍敏. 新生儿败血症单个核细胞产生肿瘤坏死因子α的能力及意义[J]. 实用儿科临床杂志, 1998, 13(4):191-192.
10. 王今达, 雪琳. 细菌、内毒素、炎性介质并治——治疗重症脓毒病的新对策[J]. 中国危重病急救医学, 1998, 10(6):5-7.
11. 齐文清. 白细胞介素6、白细胞介素8在新生儿败血症诊断中的价值[J]. 中国社区医师·医学专业, 2012, 14(14):124.
12. Lam HS, Ng PC. Biochemical markers of neonatal sepsis[J]. Pathology, 2008, 40(2):141-148.
13. 饶丽娟, 周秋莲. 孕妇血清和羊水中IL-8、MMP-9检测在诊断胎膜早破并绒毛膜羊膜炎中的价值[J]. 医学临床研究, 2009, 26(4):637-639.
14. 金胜鑫, 石海矾, 李伟. 血清降钙素原与超敏C反应蛋白及白介素6在新生儿早期感染中的诊断价值[J]. 中华医院感染学杂志, 2013, 23(7):1600-1601.
15. 戴标. IL-6、CRP和CD64在新生儿感染性疾病诊断中的价值[J]. 江苏大学学报·医学版, 2012, 22(5):434-436.
16. Muller B, White JC, Nylen ES, et al. Ubiquitous expression of the calcitonin-I gene in multiple tissues in response to sepsis[J]. J Clin Endocrinol Metab, 2001, 86(1):396-404.
17. 李贵霞, 马莉, 张丽霞. 新生儿败血症降钙素原和C反应蛋白检测及临床意义[J]. 检验医学, 2005, 20(3):250-252.

West China Medical Journal

Clinical Value of Different Biochemical Markers in Diagnosing Fetal Sepsis in Premature Neonates

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