A Meta-analysis on Prostat Combined with Antibiotic for Chronic Prostatitis_West China Medical Journal

Authors：

 YANFeng-hua ,  YANXing-ke , HETian-you , YAOXu-hong

School of Acupuncture-moxibustion and Massotherapy, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, P. R. China;

Corresponding author：

YANXing-ke, Email: yanxingke@126.com

Keywords：

Chronic prostatitis; Prostat; Antibiotic; Randomized controlled trial; Meta-analysis

DOI：

10.7507/1002-0179.20140463

Video：

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Objective To evaluate the efficacy and safety of prostat in combination with antibiotic on the treatment of chronic proatatitis. Methods We searched the literatures which were randomized controlled trials (RCT) on the treatment of combination of prostat and antibiotic for chronic prostatitis published between January 2003 and August 2013 in the Databases including CNKI, Wanfang database, VIP, CBM, PubMed, according to the demand of Cochrane Colloboration, combining computer retrieval with manual retrieval. The quality of literature was assessed by using Jadad scale and extract data from literature. Meta-analyses were performed by using the RevMan 5.1 Software. Results A total of 12 clinical RCT, involving 3 947 patients were identified. One study was double-blind and three studies were single-blind. Only one study had a Jadad scale score of 3, belonging to high quality document; the rest had a score of 2 or 1, and all were low quality documents. The results of the Meta-analysis showed that compared with the control groups, the treatment of combination of prostat with gatifloxacin on chronic prostatitis had a significant difference in total effective rate[OR=3.98, 95%CI (2.67, 5.94), P<0.000 01], NIH-CPSI score[WMD=-6.45, 95%CI(-7.55, -5.34), P<0.000 01]; the treatment of combination of prostat with Levofloxacin on chronic prostatitis had a significant difference in total effective rate[OR=1.71, 95%CI (1.43, 2.05), P<0.000 01], NIH-CPSI score[WMD=-2.85, 95%CI(-3.39, -2.31), P<0.000 01]. Conclusion The treatment of combination of prostat with antibiotic was superior to the treatment of prostat or antibiotics on chronic prostatitis. It is an effective therapeutic schedule. But the safety of the treatment of combination of prostat and antibiotic on chronic prostatitis needs further evaluation.

Citation： YANFeng-hua, YANXing-ke, HETian-you, YAOXu-hong. A Meta-analysis on Prostat Combined with Antibiotic for Chronic Prostatitis. West China Medical Journal, 2014, 29(8): 1512-1517. doi: 10.7507/1002-0179.20140463 Copy

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3.	邵强, 张玉海. 舍尼通治疗慢性非细菌性前列腺炎和前列腺痛的临床研究(附40例报告)[J]. 现代泌尿外科杂志, 1999, 64(2):94-96.
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13.	刘随. 米诺环素、舍尼通联合治疗慢性盆腔疼痛综合征疗效观察[J]. 中国麻风皮肤病杂志, 2005, 21(5):402.
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15.	区烈良, 宋平, 易东生, 等. 舍尼通联合希舒美治疗慢性前列腺炎103例的疗效观察[J]. 广东医学院学报, 2007, 25(2):171-172.
16.	张芬芝, 宁群宜. 加替沙星联合普适泰治疗慢性前列腺炎的疗效观察[J]. 亚太传统医药, 2012, 8(4):140-141.
17.	王俊岭, 邵强, 刘光华. 普适泰联合加替沙星治疗慢性前列腺炎患者的临床疗效[J]. 医学临床研究, 2012, 29(12):2404-2405.
18.	黄谊. 加替沙星联合普适泰治疗慢性前列腺炎138例疗效观察[J]. 中外医疗, 2011, 30(34):131.
19.	孙振祥, 王继忠, 徐真. 舍尼通联合左氧氟沙星治疗Ⅲ型前列腺炎临床观察[J]. 中国性科学, 2011, 20(1):7-8, 15.

1. 许明, 张永康. 抗菌药对慢性非细菌性前列腺炎的治疗作用[J]. 临床泌尿外科杂志, 2000, 15(5):195-196.
2. Loschen G, Ebeling L. Inhibition of the arachidonate metabolism by an extract from rye pollen[J]. Arzneimittelforschung, 1991, 41(2):162-167.
3. 邵强, 张玉海. 舍尼通治疗慢性非细菌性前列腺炎和前列腺痛的临床研究(附40例报告)[J]. 现代泌尿外科杂志, 1999, 64(2):94-96.
4. Buck AC, Rees RWM, Ebeling L. Treatment of chronic prostatitis andprostatodynia with pollen extract[J]. Br J Urol, 1989, 64(5):496-499.
5. 严兴科, 崔海福, 陈程, 等. 针灸治疗慢性前列腺炎随机对照临床研究文献的Meta分析[J]. 时珍国医国药, 2012, 23(10):2592-2595.
6. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials:is blinding necessary?[J]. Control Clin Trials, 1996, 17(1):1-12.
7. Moher D, Pham B, Jones A, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?[J]. Lancet, 1998, 352(9128):609-613.
8. 叶章群, 蓝儒竹, 王少刚, 等. 舍尼通^®和抗生素联合用药治疗慢性非细菌性前列腺炎临床研究[J]. 中华男科学杂志, 2006, 12(9):807-810.
9. 杨伟忠, 袁铮豪, 曹志彬, 等. 舍尼通联合左氧氟沙星治疗慢性非细菌性前列腺炎临床研究[J]. 临床医学, 2010, 30(11):66-67.
10. 顾本宏, 徐瑞云, 吴满香, 等. 舍尼通联合左氧氟沙星治疗慢性非细菌性前列腺炎临床研究[J]. 南通医学院学报, 2009, 29(1):38-39, 41.
11. 舒增平, 徐生涛, 欧海军. 舍尼通联合抗生素治疗慢性非细菌性前列腺炎的临床研究[J]. 西南军医, 2011, 13(6):1035-1037.
12. 韦强, 罗艳红, 于沛涛. 依替米星联合舍尼通治疗前列腺炎临床疗效[J]. 中国男科学杂志, 2010, 24(7):58-59.
13. 刘随. 米诺环素、舍尼通联合治疗慢性盆腔疼痛综合征疗效观察[J]. 中国麻风皮肤病杂志, 2005, 21(5):402.
14. 黄文林. 加替沙星联合普适泰治疗慢性前列腺炎130例疗效观察[J]. 山西医药杂志, 2011, 40(3):283-284.
15. 区烈良, 宋平, 易东生, 等. 舍尼通联合希舒美治疗慢性前列腺炎103例的疗效观察[J]. 广东医学院学报, 2007, 25(2):171-172.
16. 张芬芝, 宁群宜. 加替沙星联合普适泰治疗慢性前列腺炎的疗效观察[J]. 亚太传统医药, 2012, 8(4):140-141.
17. 王俊岭, 邵强, 刘光华. 普适泰联合加替沙星治疗慢性前列腺炎患者的临床疗效[J]. 医学临床研究, 2012, 29(12):2404-2405.
18. 黄谊. 加替沙星联合普适泰治疗慢性前列腺炎138例疗效观察[J]. 中外医疗, 2011, 30(34):131.
19. 孙振祥, 王继忠, 徐真. 舍尼通联合左氧氟沙星治疗Ⅲ型前列腺炎临床观察[J]. 中国性科学, 2011, 20(1):7-8, 15.

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