全身麻醉下超快速脱毒的研究进展_West China Medical Journal

Authors：

 欧梦婵 ,  李羽

四川大学华西医院麻醉科（成都，610041）;

Corresponding author：

李羽, Email: biaojieli@tom.com

Keywords：

阿片类药物; 成瘾; 全身麻醉; 超快速阿片类脱毒; 脱毒

DOI：

10.7507/1002-0179.20140485

Video：

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Abstract Full text Figures/Tables Video References Cited by

全身麻醉（全麻）下超快速阿片类脱毒是一种新的脱毒方法，即在全麻患者无意识时运用大剂量的阿片类药物拮抗剂激发戒断症状的发生，使患者安全地渡过脱毒期。与传统的利用美沙酮等脱毒方法相比，它具有近期脱毒成功率高、时间短、患者痛苦少等特点。现就全麻下超快速脱毒的研究进展作一综述。

Citation： 欧梦婵, 李羽. 全身麻醉下超快速脱毒的研究进展. West China Medical Journal, 2014, 29(8): 1586-1588. doi: 10.7507/1002-0179.20140485 Copy

1.	Cami J, Farre M. Drug addiction[J]. N Engl J Med, 2003, 349(10):975-986.
2.	吴宁, 李锦. 药物成瘾的生物学本质[J]. 中国药物滥用防治杂志, 2013, 19(1):1-6, 19.
3.	Hyman SE, Malenka RC, Nestler EJ. Neural mechanisms of addiction:the role of reward-related learning and memory[J]. Annu Rev Neurosci, 2006(29):565-598.
4.	Mcclung CA, Nestler EJ. Regulation of gene expression and cocaine reward by CREB and DeltaFosB[J]. Nat Neurosci, 2003, 6(11):1208-1215.
5.	Zachariou V, Bolanos CA, Selley DE, et al. An essential role for DeltaFosB in the nucleus accumbens in morphine action[J]. Nat Neurosci, 2006, 9(2):205-211.
6.	Kalivas PW, O'brien C. Drug addiction as a pathology of staged neuroplasticity[J]. Neuropsychopharmacology, 2008, 33(1):166-180.
7.	徐启明, 郭曲练, 姚尚龙, 等. 临床麻醉学[M]. 2版. 北京:人民卫生出版社, 2005:415-418.
8.	Bryson EO, Elizabeth AM, Frost. Perioperative addiction:clinical management of the addicted patient[M]. New York:Springer, 2012:10-50.
9.	Raisch DW, Fye CL, Boardman KD, et al. Opioid dependence treatment, including buprenorphine/naloxone[J]. Ann Pharmacother, 2002, 36(2):312-321.
10.	Singh J, Basu D. Ultra-rapid opioid detoxification:current status and controversies[J]. J Postgrad Med, 2004, 50(3):227-232.
11.	Demaria PA, Rodgers C, Braccia G. Propofol for sedation during rapid opiate detoxification[J]. Am J Psychiatry, 1997, 154(2):290-291.
12.	Cucchia AT, Monnat M, Spagnoli J, et al. Ultra-rapid opiate detoxification using deep sedation with oral midazolam:short and long-term results[J]. Drug Alcohol Depend, 1998, 52(3):243-250.
13.	Gutiérrez REP. Clinical case of rapid opiate detoxification under anesthesia[J]. Anestesia Pediatrica e Neonatale, 2011, 9:1-9.
14.	罗俊, 刘进, 刘斌. 全麻下纳曲酮快速阿片类脱毒1例分析[J]. 中国误诊学杂志, 2007, 7(18):4429-4430.
15.	Hensel M, Kox WJ. Safety, efficacy, and long-term results of a modified version of rapid opiate detoxification under general anaesthesia:a prospective study in methadone, heroin, codeine and morphine addicts[J]. Acta Anaesthesiol Scand, 2000, 44(3):326-333.
16.	Nasr D, Omran H, Hakim SM, et al. Ultra-rapid opiate detoxification using dexmedetomidine under general anesthesia[J]. J Opioid Manag, 2011, 7(5):337-344.
17.	Roozen HG, De Kan R, Van Den Brink W, et al. Dangers involved in rapid opioid detoxification while using opioid antagonists:dehydration and renal failure[J]. Addiction, 2002, 97(8):1071-1073.
18.	Kaye AD, Gevirtz C, Bosscher HA, et al. Ultrarapid opiate detoxification:a review[J]. Can J Anaesth, 2003, 50(7):663-671.
19.	Safari F, Mottaghi K, Malek S, et al. Effect of ultra-rapid opiate detoxification on withdrawal syndrome[J]. J Addict Dis, 2010, 29(4):449-454.
20.	Nasseri K, Ahsan B, Farhadifar F, et al. Shortening anesthesia duration does not affect severity of withdrawal syndrome in patients undergoing ultra rapid opioid detoxification[J]. Acta Med Iran, 2010, 48(1):27-32.
21.	Streel E, Verbanck P. Ultra-rapid opiate detoxification:from clinical applications to basic science[J]. Addict Biol, 2003, 8(2):141-146.

1. Cami J, Farre M. Drug addiction[J]. N Engl J Med, 2003, 349(10):975-986.
2. 吴宁, 李锦. 药物成瘾的生物学本质[J]. 中国药物滥用防治杂志, 2013, 19(1):1-6, 19.
3. Hyman SE, Malenka RC, Nestler EJ. Neural mechanisms of addiction:the role of reward-related learning and memory[J]. Annu Rev Neurosci, 2006(29):565-598.
4. Mcclung CA, Nestler EJ. Regulation of gene expression and cocaine reward by CREB and DeltaFosB[J]. Nat Neurosci, 2003, 6(11):1208-1215.
5. Zachariou V, Bolanos CA, Selley DE, et al. An essential role for DeltaFosB in the nucleus accumbens in morphine action[J]. Nat Neurosci, 2006, 9(2):205-211.
6. Kalivas PW, O'brien C. Drug addiction as a pathology of staged neuroplasticity[J]. Neuropsychopharmacology, 2008, 33(1):166-180.
7. 徐启明, 郭曲练, 姚尚龙, 等. 临床麻醉学[M]. 2版. 北京:人民卫生出版社, 2005:415-418.
8. Bryson EO, Elizabeth AM, Frost. Perioperative addiction:clinical management of the addicted patient[M]. New York:Springer, 2012:10-50.
9. Raisch DW, Fye CL, Boardman KD, et al. Opioid dependence treatment, including buprenorphine/naloxone[J]. Ann Pharmacother, 2002, 36(2):312-321.
10. Singh J, Basu D. Ultra-rapid opioid detoxification:current status and controversies[J]. J Postgrad Med, 2004, 50(3):227-232.
11. Demaria PA, Rodgers C, Braccia G. Propofol for sedation during rapid opiate detoxification[J]. Am J Psychiatry, 1997, 154(2):290-291.
12. Cucchia AT, Monnat M, Spagnoli J, et al. Ultra-rapid opiate detoxification using deep sedation with oral midazolam:short and long-term results[J]. Drug Alcohol Depend, 1998, 52(3):243-250.
13. Gutiérrez REP. Clinical case of rapid opiate detoxification under anesthesia[J]. Anestesia Pediatrica e Neonatale, 2011, 9:1-9.
14. 罗俊, 刘进, 刘斌. 全麻下纳曲酮快速阿片类脱毒1例分析[J]. 中国误诊学杂志, 2007, 7(18):4429-4430.
15. Hensel M, Kox WJ. Safety, efficacy, and long-term results of a modified version of rapid opiate detoxification under general anaesthesia:a prospective study in methadone, heroin, codeine and morphine addicts[J]. Acta Anaesthesiol Scand, 2000, 44(3):326-333.
16. Nasr D, Omran H, Hakim SM, et al. Ultra-rapid opiate detoxification using dexmedetomidine under general anesthesia[J]. J Opioid Manag, 2011, 7(5):337-344.
17. Roozen HG, De Kan R, Van Den Brink W, et al. Dangers involved in rapid opioid detoxification while using opioid antagonists:dehydration and renal failure[J]. Addiction, 2002, 97(8):1071-1073.
18. Kaye AD, Gevirtz C, Bosscher HA, et al. Ultrarapid opiate detoxification:a review[J]. Can J Anaesth, 2003, 50(7):663-671.
19. Safari F, Mottaghi K, Malek S, et al. Effect of ultra-rapid opiate detoxification on withdrawal syndrome[J]. J Addict Dis, 2010, 29(4):449-454.
20. Nasseri K, Ahsan B, Farhadifar F, et al. Shortening anesthesia duration does not affect severity of withdrawal syndrome in patients undergoing ultra rapid opioid detoxification[J]. Acta Med Iran, 2010, 48(1):27-32.
21. Streel E, Verbanck P. Ultra-rapid opiate detoxification:from clinical applications to basic science[J]. Addict Biol, 2003, 8(2):141-146.

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