多发性骨软骨瘤病例分析_West China Medical Journal

Authors：

 刘东 ,  叶永杰 , 银毅 , 陈刚

遂宁市中心医院骨科（四川遂宁，629000）;

Corresponding author：

叶永杰, Email: ye001@aliyun.com

Keywords：

多发性骨软骨瘤; 病因; 诊断; 治疗; 恶变

DOI：

10.7507/1002-0179.20140632

Video：

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目的对多发性骨软骨瘤进行病例分析，以提高对该病的认识。方法回顾分析2008年1月－2013年4月收治的14例多发性骨软骨瘤患者的临床资料。结果男9例，女5例；年龄6～45岁，中位年龄17岁；4例有家族史。5例全身多发，1例双上肢多发，1例累及双侧膝关节，7例累及单侧膝关节。合并畸形包括2例前臂尺桡关节脱位，1例下肢短缩。合并疾病包括1例肋骨软骨瘤伴胸腔积血，1例肝功能异常及1例额部毛细血管瘤。所有患者行局部肿瘤切除术，手术史：1例7次，1例4次，2例2次，10例1次；每次手术切除部位：2例3个，5例2个，7例1个。1例患者术后（在外院行局部病灶切除术）20年复发再次行局部肿瘤切除术。1例术后发生右腓深神经运动支损伤。术后1例失访，余随访时间6～68个月，中位时间38个月。随访期内无恶变患者。结论多发性骨软骨瘤可能是累及全身组织的一组临床综合征，诊断容易，畸形比例小、程度轻，局部肿瘤切除术效果确切，恶变几率小。

Citation： 刘东, 叶永杰, 银毅, 陈刚. 多发性骨软骨瘤病例分析. West China Medical Journal, 2014, 29(11): 2102-2104. doi: 10.7507/1002-0179.20140632 Copy

1.	Garner OB, Yamaguchi Y, Esko JD, et al. Small changes in lymphocyte development and activation in mice through tissue specificalteration of heparan sulphate[J]. Immunology, 2008, 125(3):420-429.
2.	Chen S, Wassenhove-Mccarthy DJ, Yamaguchi Y, et al. Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria[J]. Kidney Int, 2008, 74(3):289-299.
3.	Iwao K, Inatani M, Mastsumoto Y, et al. Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling[J]. J Clin Invest, 2009, 119(7):1997-2008.
4.	Iwao K, Inatani M, Ogata-Iwao M, et al. Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis[J]. Exp Eye Res, 2010, 90(1):81-88.
5.	Kucharzewska P, Welch JE, Birgersson JA. Establishment of heparan sulphate deficient primary endothelial cells from EXT-1(flox/flox) mouse lungs and sprouting aortas[J]. In Vitro Cell Dev Biol Anim, 2010, 46(7):577-584.
6.	Bishop JR, Schuksz M, Esko JD. Heparan sulphate proteoglycans fine-tune mammalian physiology[J]. Nature, 2007, 446(7139):1030-1037.
7.	李剑雄, 周瑞方. 多发性骨软骨瘤1例[J]. 长江大学学报·自然科学版医学卷, 2010, 7(3):198-199.
8.	Roach JW, Klatt JW, Faulkner ND. Involvement of the spine in patients with multiple hereditary exostoses[J]. J Bone Joint Surg Am, 2009, 91A(8):1942-1948.
9.	曹轶伦, 刘傥, 黎志宏, 等. 骨痂延长术治疗尺骨远端遗传性多发性骨软骨瘤致前臂畸形的疗效分析[J]. 中国矫形外科杂志, 2013, 21(11):1145-1148.
10.	郭伟韬, 曾荣, 孙欣, 等. 桡尺骨截骨治疗遗传性多发性骨软骨瘤病所致严重前臂畸形的疗效评估[J]. 第四军医大学学报, 2009, 30(21):2424-2425.
11.	刘振江, 张立军, 马瑞雪, 等. 髂骨植骨尺骨延长治疗多发性骨软骨瘤前臂畸形的疗效评价[J]. 中国矫形外科杂志, 2005, 13(13):990-992.
12.	Bovée JV. Multiple osteochondromas[J]. Orphanet J Rare Dis, 2008, 3:3.
13.	Jones KB. Glycobiology and the growth plate:current concepts in multiple hereditary exostoses[J]. J Pediatr Orthop, 2011, 31(5):577-586.
14.	郭世炳, 冯卫. 遗传性多发性骨软骨瘤[J]. 中国医师进修杂志, 2007, 30(4):72-74.
15.	王永胜, 李军, 陈梓锋. 遗传性多发性骨软骨瘤并膝外翻矫形术后并发腓总神经损伤一例[J]. 中国骨与关节损伤杂志, 2013, 28(2):121.

1. Garner OB, Yamaguchi Y, Esko JD, et al. Small changes in lymphocyte development and activation in mice through tissue specificalteration of heparan sulphate[J]. Immunology, 2008, 125(3):420-429.
2. Chen S, Wassenhove-Mccarthy DJ, Yamaguchi Y, et al. Loss of heparan sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria[J]. Kidney Int, 2008, 74(3):289-299.
3. Iwao K, Inatani M, Mastsumoto Y, et al. Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling[J]. J Clin Invest, 2009, 119(7):1997-2008.
4. Iwao K, Inatani M, Ogata-Iwao M, et al. Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis[J]. Exp Eye Res, 2010, 90(1):81-88.
5. Kucharzewska P, Welch JE, Birgersson JA. Establishment of heparan sulphate deficient primary endothelial cells from EXT-1(flox/flox) mouse lungs and sprouting aortas[J]. In Vitro Cell Dev Biol Anim, 2010, 46(7):577-584.
6. Bishop JR, Schuksz M, Esko JD. Heparan sulphate proteoglycans fine-tune mammalian physiology[J]. Nature, 2007, 446(7139):1030-1037.
7. 李剑雄, 周瑞方. 多发性骨软骨瘤1例[J]. 长江大学学报·自然科学版医学卷, 2010, 7(3):198-199.
8. Roach JW, Klatt JW, Faulkner ND. Involvement of the spine in patients with multiple hereditary exostoses[J]. J Bone Joint Surg Am, 2009, 91A(8):1942-1948.
9. 曹轶伦, 刘傥, 黎志宏, 等. 骨痂延长术治疗尺骨远端遗传性多发性骨软骨瘤致前臂畸形的疗效分析[J]. 中国矫形外科杂志, 2013, 21(11):1145-1148.
10. 郭伟韬, 曾荣, 孙欣, 等. 桡尺骨截骨治疗遗传性多发性骨软骨瘤病所致严重前臂畸形的疗效评估[J]. 第四军医大学学报, 2009, 30(21):2424-2425.
11. 刘振江, 张立军, 马瑞雪, 等. 髂骨植骨尺骨延长治疗多发性骨软骨瘤前臂畸形的疗效评价[J]. 中国矫形外科杂志, 2005, 13(13):990-992.
12. Bovée JV. Multiple osteochondromas[J]. Orphanet J Rare Dis, 2008, 3:3.
13. Jones KB. Glycobiology and the growth plate:current concepts in multiple hereditary exostoses[J]. J Pediatr Orthop, 2011, 31(5):577-586.
14. 郭世炳, 冯卫. 遗传性多发性骨软骨瘤[J]. 中国医师进修杂志, 2007, 30(4):72-74.
15. 王永胜, 李军, 陈梓锋. 遗传性多发性骨软骨瘤并膝外翻矫形术后并发腓总神经损伤一例[J]. 中国骨与关节损伤杂志, 2013, 28(2):121.

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