磁共振氢波谱技术在肿瘤临床诊疗研究中的进展_West China Medical Journal

Authors：

 张晗媚 ¹ , 甘奇 ² , 宋彬 ¹ ,  邬颖华 ³

1. ;
2. ;
3. ;

Corresponding author：

邬颖华, Email: wuyinghua_1111@163.com

Keywords：

功能磁共振技术; 波谱成像; 磁共振氢波谱技术; 肿瘤诊断; 肿瘤疗效评价

DOI：

10.7507/1002-0179.20140722

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磁共振波谱（MRS）成像技术作为一种无创的功能影像学方法，广泛应用于临床多领域的研究，包括当今研究热点临床肿瘤诊断和疗效评价。现以MRS技术中最常用的氢质子波谱（1H-MRS）为对象，由成像原理、检测意义入手，就1H-MRS技术在肿瘤诊疗研究中的新进展作一综述，以客观评估该技术在临床肿瘤诊断和疗效评价中的应用。

Citation： 张晗媚, 甘奇, 宋彬, 邬颖华. 磁共振氢波谱技术在肿瘤临床诊疗研究中的进展. West China Medical Journal, 2014, 29(12): 2387-2390. doi: 10.7507/1002-0179.20140722 Copy

1.	曹开明, 郝楠馨, 常时新. 1H-MRS在肾脏肿瘤的应用[J]. 同济大学学报·医学版, 2006, 27(增刊1):69-71.
2.	Zira AN, Theocharis SE, Mitropoulos D, et al. (1)H NMR metabonomic analysis in renal cell carcinoma:a possible diagnostic tool[J]. J Proteome Res, 2010, 9(8):4038-4044.
3.	Schwerk A, Alves FD, Pouwels PJ, et al. Metabolic alterations associated with schizophrenia:a critical evaluation of proton magnetic resonance spectroscopy studies[J]. J Neurochem, 2014, 128(1):1-87.
4.	Murphy G, Haider M, Ghai S, et al. The expanding role of MRI in prostate cancer[J]. Am J Roentgenol, 2013, 201(6):1229-1238.
5.	Geethanath S, Baek HM, Ganji SK, et al. Compressive sensing could accelerate 1H Mr metabolic imaging in the clinic[J]. Radiology, 2012, 262(3):985-994.
6.	Falk MJ, Li D, Gai X, et al. AGC1 deficiency causes infantile epilepsy, abnormal myelination, and reduced N-Acetylaspartate[J/OL]. JIMD Rep. (2014-02-11)[2014-07-01]. http://link.springer.com/chapter/10.1007%2F8904_2013_287.
7.	Kim DY, Kim KB, Kim OD, et al. Localized in vivo proton spectroscopy of renal cell carcinoma in human kidney[J]. J Korean Med Sci, 1998, 13(1):49-53.
8.	Kraguljac NV, Reid M, White D, et al. Neurometabolites in schizophrenia and bipolar disorder:a systematic review and meta-analysis[J]. Psychiatry Res, 2012, 203(2/3):111-125.
9.	包尚联, 孙启玉, 谢宜学. 磁共振谱成像及其在肿瘤诊疗中的应用[J]. 中国医疗器械信息, 2005, 11(2):6-8.
10.	Sarkar BK, Chakraborty C, Sharma AR, et al. Novel biomarker for prostate cancer diagnosis by MRS[J]. Front Biosci (Landmark Ed), 2014, 19(19):1186-1201.
11.	白玉贞, 韩晓东, 牛广明. 1H-MRS诊断脑胶质瘤的临床应用进展[J]. 内蒙古医学院学报, 2009, 31(1):70-75.
12.	Chawalparit O, Sangruchi T, Witthiwej T, et al. Diagnostic performance of advanced MRI in differentiating high-grade from low-grade gliomas in a setting of routine service[J]. Med Assoc Thai, 2013, 96(10):1365-1373.
13.	潘初, 朱文珍, 黄博, 等. 脑胶质瘤病的MRI及MRS研究[J]. 放射学实践, 2004, 19(9):631-634.
14.	Bendszus M, Warmuth-Metz M, Klein R, et al. Mr spectroscopy in gliomatosis cerebri[J]. Am J Neuroradiol, 2000, 21(2):375-380.
15.	De Carvalho Neto A, Gasparetto EL, Bruck I. Subependymal giant cell astrocytoma with high choline/creatine ratio on proton Mr spectroscopy[J]. Arq Neuropsiquiatr, 2006, 64(3B):877-880.
16.	Majós C, Alonso J, Aguilera C, et al. Adult primitive neuroectodermal tumor:proton Mr spectroscopic findings with possible application for differential diagnosis[J]. Radiology, 2002, 225(2):556-565.
17.	陈鹏, 赵卫东, 张红宇, 等. 肝细胞癌患者1.5T氢质子磁共振波谱分析[J]. 中国癌症杂志, 2010, 20(1):55-58.
18.	Kuo YT, Li CW, Chen CY, et al. In vivo proton magnetic resonance spectroscopy of large focal hepatic lesions and metabolite change of hepatocellular carcinoma before and after transcatheter arterial chemoembolization using 3.0-T Mr scanner[J]. J Magn Reson Imaging, 2004, 19(5):598-604.
19.	颜荣华, 肖恩华, 梁斌. 1.5 T磁共振兔VX2肝癌活体二维多体素1H-MRS应用初探[J]. 临床放射学杂志, 2005, 24(12):1097-1102.
20.	Lassel EA, Rao R, Schwenke C, et al. Diffusion-weighted imaging of focal renal lesions:a meta-analysis[J]. Eur Radiol, 2014, 24(1):241-249.
21.	Corcoran AT, Russo P, Lowrance WT, et al. A review of contemporary data on surgically resected renal Masses-Benign or malignant?[J]. Urology, 2013, 81(4):707-713.
22.	Taouli B, Thakur RK, Mannelli L, et al. Renal lesions:characterization with diffusion-weighted imaging versus contrast-enhanced Mr imaging[J]. Radiology, 2009, 251(2):398-407.
23.	Chung MS, Choi HJ, Kim MH, et al. Comparison of T2-Weighted MRI with and without fat suppression for differentiating renal angiomyolipomas without visible fat from other renal tumors[J]. Am J Roentgenol, 2014, 202(4):765-771.
24.	蒋涛, 韩希年, 肖湘生. 磁共振质子波谱分析在肾脏肿瘤中的应用[J]. 实用放射学杂志, 2006, 22(10):1273-1276.
25.	Katz-Brull R, Rofsky NM, Morrin MM, et al. Decreases in free cholesterol and fatty acid unsaturation in renal cell carcinoma demonstrated by breath-hold magnetic resonance spectroscopy[J]. Am J Physiol Renal Physiol, 2005, 288(4):F637-F641.
26.	Righi V, Mucci A, Schenetti L, et al. Ex vivo HR-MAS magnetic resonance spectroscopy of normal and malignant human renal tissues[J]. Anticancer Res, 2007, 27(5A):3195-3204.
27.	Gao H, Dong B, Jia J, et al. Application of ex vivo (1)H NMR metabonomics to the characterization and possible detection of renal cell carcinoma metastases[J]. J Cancer Res Clin Oncol, 2012, 138(5):753-761.
28.	Reeves GK, Beral V, Bull D, et al. Estimating relative survival among people registered with cancer in England and Wales[J]. Br J Cancer, 1999, 79(1):18-22.
29.	孙颖浩. 我国前列腺癌的现状研究[J]. 中华泌尿外科杂志, 2004, 25(2):77-80.
30.	黄松涛, 卜丽红, 王景林, 等. 磁共振波谱对前列腺癌的诊断价值[J]. 哈尔滨医科大学学报, 2010, 44(2):171-173, 176.
31.	Sarici H, Telli O, Yigitbasi O, et al. Predictors of gleason score upgrading in patients with prostate biopsy gleason score ≤ 6[J]. Can Urol Assoc J, 2014, 8(5/6):E342-E346.
32.	王霄英, 周良平, 李飞宇, 等. 前列腺癌的MR波谱特征与Gleason评分的关系[J]. 中华放射学杂志, 2006, 40(11):1181-1184.
33.	Isobe T, Matsumura A, Anno I, et al. Changes in 1H-MRS in glioma patients before and after irradiation:the significance of quantitative analysis of choline-containing compounds[J]. No Shinkei Geka, 2003, 31(2):167-172.
34.	Weybright P, Sundgren PC, Maly P, et al. Differentiation between brain tumor recurrence and radiation injury using Mr spectroscopy[J]. AJR Am J Roentgenol, 2005, 185(6):1471-1476.
35.	Wu B, Peng WJ, Wang PJ, et al. In vivo 1H magnetic resonance spectroscopy in evaluation of hepatocellular carcinoma and its early response to transcatheter arterial chemoembolization[J]. Chin Med Sci J, 2006, 21(4):258-264.
36.	罗银灯, 钟维佳, 赵建农, 等. 磁共振氢质波谱成像评估高强度聚焦超声治疗原发性肝癌疗效的可行性及其价值[J]. 中华肝脏病杂志, 2011, 19(2):102-105.
37.	卞读军, 肖恩华. 质子磁共振波谱成像技术及其在肝癌的临床应用[J]. 中华临床医师杂志·电子版, 2011, 5(23):7012-7015.

1. 曹开明, 郝楠馨, 常时新. 1H-MRS在肾脏肿瘤的应用[J]. 同济大学学报·医学版, 2006, 27(增刊1):69-71.
2. Zira AN, Theocharis SE, Mitropoulos D, et al. (1)H NMR metabonomic analysis in renal cell carcinoma:a possible diagnostic tool[J]. J Proteome Res, 2010, 9(8):4038-4044.
3. Schwerk A, Alves FD, Pouwels PJ, et al. Metabolic alterations associated with schizophrenia:a critical evaluation of proton magnetic resonance spectroscopy studies[J]. J Neurochem, 2014, 128(1):1-87.
4. Murphy G, Haider M, Ghai S, et al. The expanding role of MRI in prostate cancer[J]. Am J Roentgenol, 2013, 201(6):1229-1238.
5. Geethanath S, Baek HM, Ganji SK, et al. Compressive sensing could accelerate 1H Mr metabolic imaging in the clinic[J]. Radiology, 2012, 262(3):985-994.
6. Falk MJ, Li D, Gai X, et al. AGC1 deficiency causes infantile epilepsy, abnormal myelination, and reduced N-Acetylaspartate[J/OL]. JIMD Rep. (2014-02-11)[2014-07-01]. http://link.springer.com/chapter/10.1007%2F8904_2013_287.
7. Kim DY, Kim KB, Kim OD, et al. Localized in vivo proton spectroscopy of renal cell carcinoma in human kidney[J]. J Korean Med Sci, 1998, 13(1):49-53.
8. Kraguljac NV, Reid M, White D, et al. Neurometabolites in schizophrenia and bipolar disorder:a systematic review and meta-analysis[J]. Psychiatry Res, 2012, 203(2/3):111-125.
9. 包尚联, 孙启玉, 谢宜学. 磁共振谱成像及其在肿瘤诊疗中的应用[J]. 中国医疗器械信息, 2005, 11(2):6-8.
10. Sarkar BK, Chakraborty C, Sharma AR, et al. Novel biomarker for prostate cancer diagnosis by MRS[J]. Front Biosci (Landmark Ed), 2014, 19(19):1186-1201.
11. 白玉贞, 韩晓东, 牛广明. 1H-MRS诊断脑胶质瘤的临床应用进展[J]. 内蒙古医学院学报, 2009, 31(1):70-75.
12. Chawalparit O, Sangruchi T, Witthiwej T, et al. Diagnostic performance of advanced MRI in differentiating high-grade from low-grade gliomas in a setting of routine service[J]. Med Assoc Thai, 2013, 96(10):1365-1373.
13. 潘初, 朱文珍, 黄博, 等. 脑胶质瘤病的MRI及MRS研究[J]. 放射学实践, 2004, 19(9):631-634.
14. Bendszus M, Warmuth-Metz M, Klein R, et al. Mr spectroscopy in gliomatosis cerebri[J]. Am J Neuroradiol, 2000, 21(2):375-380.
15. De Carvalho Neto A, Gasparetto EL, Bruck I. Subependymal giant cell astrocytoma with high choline/creatine ratio on proton Mr spectroscopy[J]. Arq Neuropsiquiatr, 2006, 64(3B):877-880.
16. Majós C, Alonso J, Aguilera C, et al. Adult primitive neuroectodermal tumor:proton Mr spectroscopic findings with possible application for differential diagnosis[J]. Radiology, 2002, 225(2):556-565.
17. 陈鹏, 赵卫东, 张红宇, 等. 肝细胞癌患者1.5T氢质子磁共振波谱分析[J]. 中国癌症杂志, 2010, 20(1):55-58.
18. Kuo YT, Li CW, Chen CY, et al. In vivo proton magnetic resonance spectroscopy of large focal hepatic lesions and metabolite change of hepatocellular carcinoma before and after transcatheter arterial chemoembolization using 3.0-T Mr scanner[J]. J Magn Reson Imaging, 2004, 19(5):598-604.
19. 颜荣华, 肖恩华, 梁斌. 1.5 T磁共振兔VX2肝癌活体二维多体素1H-MRS应用初探[J]. 临床放射学杂志, 2005, 24(12):1097-1102.
20. Lassel EA, Rao R, Schwenke C, et al. Diffusion-weighted imaging of focal renal lesions:a meta-analysis[J]. Eur Radiol, 2014, 24(1):241-249.
21. Corcoran AT, Russo P, Lowrance WT, et al. A review of contemporary data on surgically resected renal Masses-Benign or malignant?[J]. Urology, 2013, 81(4):707-713.
22. Taouli B, Thakur RK, Mannelli L, et al. Renal lesions:characterization with diffusion-weighted imaging versus contrast-enhanced Mr imaging[J]. Radiology, 2009, 251(2):398-407.
23. Chung MS, Choi HJ, Kim MH, et al. Comparison of T2-Weighted MRI with and without fat suppression for differentiating renal angiomyolipomas without visible fat from other renal tumors[J]. Am J Roentgenol, 2014, 202(4):765-771.
24. 蒋涛, 韩希年, 肖湘生. 磁共振质子波谱分析在肾脏肿瘤中的应用[J]. 实用放射学杂志, 2006, 22(10):1273-1276.
25. Katz-Brull R, Rofsky NM, Morrin MM, et al. Decreases in free cholesterol and fatty acid unsaturation in renal cell carcinoma demonstrated by breath-hold magnetic resonance spectroscopy[J]. Am J Physiol Renal Physiol, 2005, 288(4):F637-F641.
26. Righi V, Mucci A, Schenetti L, et al. Ex vivo HR-MAS magnetic resonance spectroscopy of normal and malignant human renal tissues[J]. Anticancer Res, 2007, 27(5A):3195-3204.
27. Gao H, Dong B, Jia J, et al. Application of ex vivo (1)H NMR metabonomics to the characterization and possible detection of renal cell carcinoma metastases[J]. J Cancer Res Clin Oncol, 2012, 138(5):753-761.
28. Reeves GK, Beral V, Bull D, et al. Estimating relative survival among people registered with cancer in England and Wales[J]. Br J Cancer, 1999, 79(1):18-22.
29. 孙颖浩. 我国前列腺癌的现状研究[J]. 中华泌尿外科杂志, 2004, 25(2):77-80.
30. 黄松涛, 卜丽红, 王景林, 等. 磁共振波谱对前列腺癌的诊断价值[J]. 哈尔滨医科大学学报, 2010, 44(2):171-173, 176.
31. Sarici H, Telli O, Yigitbasi O, et al. Predictors of gleason score upgrading in patients with prostate biopsy gleason score ≤ 6[J]. Can Urol Assoc J, 2014, 8(5/6):E342-E346.
32. 王霄英, 周良平, 李飞宇, 等. 前列腺癌的MR波谱特征与Gleason评分的关系[J]. 中华放射学杂志, 2006, 40(11):1181-1184.
33. Isobe T, Matsumura A, Anno I, et al. Changes in 1H-MRS in glioma patients before and after irradiation:the significance of quantitative analysis of choline-containing compounds[J]. No Shinkei Geka, 2003, 31(2):167-172.
34. Weybright P, Sundgren PC, Maly P, et al. Differentiation between brain tumor recurrence and radiation injury using Mr spectroscopy[J]. AJR Am J Roentgenol, 2005, 185(6):1471-1476.
35. Wu B, Peng WJ, Wang PJ, et al. In vivo 1H magnetic resonance spectroscopy in evaluation of hepatocellular carcinoma and its early response to transcatheter arterial chemoembolization[J]. Chin Med Sci J, 2006, 21(4):258-264.
36. 罗银灯, 钟维佳, 赵建农, 等. 磁共振氢质波谱成像评估高强度聚焦超声治疗原发性肝癌疗效的可行性及其价值[J]. 中华肝脏病杂志, 2011, 19(2):102-105.
37. 卞读军, 肖恩华. 质子磁共振波谱成像技术及其在肝癌的临床应用[J]. 中华临床医师杂志·电子版, 2011, 5(23):7012-7015.

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磁共振氢波谱技术在肿瘤临床诊疗研究中的进展

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