Correlation between T/C Polymorphism in 190 Locus ofβ<sub>3</sub>-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis_West China Medical Journal

Authors：

 YOUHang ^1,2 , ZHANGBen-long ^1,2 , SUNYun-peng ³ ,  SHIXiao-ke ^1,2

1. Evidence-based Medicine Center, Chouzhou Hospital of Yiwu City, Yiwu, Zhejiang 322000, P. R. China;
2. Surgical Center, Chouzhou Hospital of Yiwu City, Yiwu, Zhejiang 322000, P. R. China;
3. Department of Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P. R. China;

Corresponding author：

SHIXiao-ke, Email: sxk158258@163.com

Keywords：

β₃-adrenergic receptor gene; Polymorphism; Type-2 Diabetes Mellitus; Chinese population; Systematic review

DOI：

10.7507/1002-0179.20150003

Video：

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Objective To systematically evaluate the correlation between type-2 diabetes mellitus (T2DM) and T/C polymorphism in 190 locus ofβ3-adrenergic receptor (β₃-AR) gene in Chinese population. Methods The following databases such as CNKI, VIP, CBM, PubMed, EMbase, the Cochrane Library (Issue 8, 2012) and WanFang Data were searched to collect case-control studies on the correlation between T2DM and T/C polymorphism in 190 locus of β₃-AR gene. The retrieval time was from October 1980 to October 2013. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data and assessed the quality. Then the meta-analysis was conducted by using RevMan 5.0 and Stata 12.0 software, and the publication bias was analyzed by means of Egger's linear regression. Results A total of 11 studies involving 1 602 T2DM patients and 1 773 healthy volunteers were included. The results of meta-analyses showed that, for Chinese population, TC genotype in case group was more than that in control group[OR=1.19, 95%CI (1.01, 1.40), P=0.04]. CC+TC genotype in case group was more than that in control group[OR=1.23, 95%CI (1.05, 1.45), P=0.01]. Allele C in case group was more than that in control group[OR=1.24, 95%CI (1.08, 1.43), P=0.003]. Conclusions The allele C in 190 locus of β₃-AR gene in Chinese population is significantly associated with T2DM. For the quantity and quality limitation of the included studies, this conclusion has to be further proved by more studies.

Citation： YOUHang, ZHANGBen-long, SUNYun-peng, SHIXiao-ke. Correlation between T/C Polymorphism in 190 Locus ofβ₃-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis. West China Medical Journal, 2015, 30(1): 12-11. doi: 10.7507/1002-0179.20150003 Copy

1.	Walston J, Silver K, Hilfiker H, et al. Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor[J]. J Clin Endocrinol Metab, 2000, 85(11):4019-4022.
2.	Masuo K, Katsuya T, Fu Y, et al. Beta2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals[J]. Am J Hypertens, 2005, 18(7):1009-1014.
3.	Little J, Higgins JP, Ioannidis JP, et al. Strengthening the reporting of genetic association studies (STREGA):an extension of the STROBE statement[J]. Eur J Epidemiol, 2009, 24(1):37-55.
4.	王静, 莫传伟, 陈群, 等.应用Stata软件的Meta分析完成医学科研定量评价[J].中华中医药学刊, 2008, 26(5):947-949.
5.	包爱民, 肖尚喜, 王长江, 等. 2型糖尿病与正常人群中β3肾上腺素能受体基因Trp64Arg多态性表型特征[J].中国糖尿病杂志, 2000, 8(1):13-16.
6.	孙黎明, Iizuka Y, Ishibashi S, 等.中国人与日本人β3肾上腺素能受体基因Trp64Arg突变的比较[J].中华医学杂志, 2000, 80(2):107-110.
7.	陈玉, 周玲, 徐耀初, 等.β3-肾上腺素能受体基因与2型糖尿病关系的研究[J].中国公共卫生, 2001, 17(7):586-588.
8.	李耀明, 梁剑宁. 2型糖尿病与β3肾上腺素能受体基因Trp64Arg多态性的相关性探讨[J].广州医学院学报, 2004, 32(2):60-62.
9.	孙玉茹, 杨泽, 纪立农.β3肾上腺素能受体基因Trp64Arg变异与2型糖尿病的关联研究[J].中华糖尿病杂志, 2004, 12(1):43-44.
10.	修玲玲, 翁建平, 隋昳, 等.解偶联蛋白2基因和β3-肾上腺素能受体基因联合变异与2型糖尿病及肥胖症的关系[J].中华医学杂志, 2004, 84(5):375-379.
11.	惠宗光, 周学伟, 王晓玲, 等. 2型糖尿病人群胰岛素抵抗和β₃-AR基因的相关性[J].潍坊医学院学报, 2005, 27(3):173-175.
12.	李利, 孙黎明, 王军, 等.β3肾上腺素能受体基因Trp64Arg突变与胰岛素抵抗相关[J].中国医师杂志, 2006, 8(5):636-638.
13.	姜秀云, 侯新国, 侯为开, 等.肾上腺素能β3受体基因多态性与肥胖和胰岛素抵抗的相关性[J].中国糖尿病杂志, 2007, 15(9):526-527.
14.	李慧华, 杨敏, 余敏, 等. β₃-AR Trp64Arg遗传多态性对T2DM患者罗格列酮疗效的影响[J].中国药理学通报, 2009, 25(3):317-321.
15.	孟晓嵘, 骆杰伟, 郑姜钦, 等. 2型糖尿病痰湿证的β3肾上腺素能受体基因Trp64Arg多态性分析[J].福建中医药, 2011, 42(5):7-8, 13.
16.	Zaagsma J, Nahorski SR. Is the adipocyte beta-adrenoceptor a prototype for the recently cloned atypical "beta 3-adrenoceptor"?[J]. Trends Pharmacol Sci, 1990, 11(1):3-7.
17.	Walston J, Silver K, Bogardus C, et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene[J]. N Engl J Med, 1995, 333(6):343-347.
18.	Sakane N, Yoshida T, Umekawa T, et al. Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients[J]. Diabetes Care, 1997, 20(12):1887-1890.
19.	王瑶, 萧建中, 李光伟.原发性高血压人群胰岛素抵抗与β3-肾上腺素能受体基因多态性的关联[J].中华内分泌代谢杂志, 2001, 17(3):148-150.
20.	Umekawa T, Yoshida T, Sakane N, et al. Anti-obesity and anti-diabetic effects of CL316, 243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats:induction of uncoupling protein and activation of glucose transporter 4 in white fat[J]. Eur J Endocrinol, 1997, 136(4):429-437.
21.	单志桂, 杨新玲, 姚亚妮.如何运用系统评价结果进行临床实践[J].中国循证医学杂志, 2012, 12(3):357-359.

1. Walston J, Silver K, Hilfiker H, et al. Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor[J]. J Clin Endocrinol Metab, 2000, 85(11):4019-4022.
2. Masuo K, Katsuya T, Fu Y, et al. Beta2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals[J]. Am J Hypertens, 2005, 18(7):1009-1014.
3. Little J, Higgins JP, Ioannidis JP, et al. Strengthening the reporting of genetic association studies (STREGA):an extension of the STROBE statement[J]. Eur J Epidemiol, 2009, 24(1):37-55.
4. 王静, 莫传伟, 陈群, 等.应用Stata软件的Meta分析完成医学科研定量评价[J].中华中医药学刊, 2008, 26(5):947-949.
5. 包爱民, 肖尚喜, 王长江, 等. 2型糖尿病与正常人群中β3肾上腺素能受体基因Trp64Arg多态性表型特征[J].中国糖尿病杂志, 2000, 8(1):13-16.
6. 孙黎明, Iizuka Y, Ishibashi S, 等.中国人与日本人β3肾上腺素能受体基因Trp64Arg突变的比较[J].中华医学杂志, 2000, 80(2):107-110.
7. 陈玉, 周玲, 徐耀初, 等.β3-肾上腺素能受体基因与2型糖尿病关系的研究[J].中国公共卫生, 2001, 17(7):586-588.
8. 李耀明, 梁剑宁. 2型糖尿病与β3肾上腺素能受体基因Trp64Arg多态性的相关性探讨[J].广州医学院学报, 2004, 32(2):60-62.
9. 孙玉茹, 杨泽, 纪立农.β3肾上腺素能受体基因Trp64Arg变异与2型糖尿病的关联研究[J].中华糖尿病杂志, 2004, 12(1):43-44.
10. 修玲玲, 翁建平, 隋昳, 等.解偶联蛋白2基因和β3-肾上腺素能受体基因联合变异与2型糖尿病及肥胖症的关系[J].中华医学杂志, 2004, 84(5):375-379.
11. 惠宗光, 周学伟, 王晓玲, 等. 2型糖尿病人群胰岛素抵抗和β₃-AR基因的相关性[J].潍坊医学院学报, 2005, 27(3):173-175.
12. 李利, 孙黎明, 王军, 等.β3肾上腺素能受体基因Trp64Arg突变与胰岛素抵抗相关[J].中国医师杂志, 2006, 8(5):636-638.
13. 姜秀云, 侯新国, 侯为开, 等.肾上腺素能β3受体基因多态性与肥胖和胰岛素抵抗的相关性[J].中国糖尿病杂志, 2007, 15(9):526-527.
14. 李慧华, 杨敏, 余敏, 等. β₃-AR Trp64Arg遗传多态性对T2DM患者罗格列酮疗效的影响[J].中国药理学通报, 2009, 25(3):317-321.
15. 孟晓嵘, 骆杰伟, 郑姜钦, 等. 2型糖尿病痰湿证的β3肾上腺素能受体基因Trp64Arg多态性分析[J].福建中医药, 2011, 42(5):7-8, 13.
16. Zaagsma J, Nahorski SR. Is the adipocyte beta-adrenoceptor a prototype for the recently cloned atypical "beta 3-adrenoceptor"?[J]. Trends Pharmacol Sci, 1990, 11(1):3-7.
17. Walston J, Silver K, Bogardus C, et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene[J]. N Engl J Med, 1995, 333(6):343-347.
18. Sakane N, Yoshida T, Umekawa T, et al. Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients[J]. Diabetes Care, 1997, 20(12):1887-1890.
19. 王瑶, 萧建中, 李光伟.原发性高血压人群胰岛素抵抗与β3-肾上腺素能受体基因多态性的关联[J].中华内分泌代谢杂志, 2001, 17(3):148-150.
20. Umekawa T, Yoshida T, Sakane N, et al. Anti-obesity and anti-diabetic effects of CL316, 243, a highly specific beta 3-adrenoceptor agonist, in Otsuka Long-Evans Tokushima Fatty rats:induction of uncoupling protein and activation of glucose transporter 4 in white fat[J]. Eur J Endocrinol, 1997, 136(4):429-437.
21. 单志桂, 杨新玲, 姚亚妮.如何运用系统评价结果进行临床实践[J].中国循证医学杂志, 2012, 12(3):357-359.

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West China Medical Journal

Correlation between T/C Polymorphism in 190 Locus ofβ₃-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis

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West China Medical Journal

Correlation between T/C Polymorphism in 190 Locus ofβ3-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis

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Correlation between T/C Polymorphism in 190 Locus ofβ₃-adrenergic Receptor Gene and Type-2 Diabetes Mellitus in Chinese Population: A Meta-analysis