Efficacy of Dezocine for Atrial Fibrillation Radiofrequency Catheter Ablation_West China Medical Journal

Authors：

 LIFang-zhou ¹ , WEIXiao-qiong ² , ZHENGMing-xia ³ , ZENGYi ³ ,  CUIKai-jun ³

1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. State Key Laboratory of Biotherapy, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
1. Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

CUIKai-jun, Email: cuikaijun@hotmail.com

Keywords：

Dezocine; Atrial fibrillation; Radiofrequency catheter ablation; Efficacy

DOI：

10.7507/1002-0179.20150021

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Objective To observe the efficacy of dezocine used for atrial fibrillation radiofrequency catheter ablation. Methods Forty-five patients who would undergo radiofrequency catheter ablation of atrial fibrillation were randomly chosen to be our study subjects between April and July 2013. According to the randomized and double-blind principle, they were divided into group D (dezocine group) and group M (morphine group). During routine visits prior to surgery, we recorded the patients' vital signs, pain score and degree of comfort. Before the ablation procedure, 5 mg dezocine or 5 mg morphine was administered intravenously for patients in both the two groups. During the procedure, blood pressure, heart rate, oxygen saturation, electrocardiogram, pain scores, and comfort score of the patients were monitored. Furthermore, 2-3 mg dezocine or morphine were administered intravenously if additional analgesia was needed. The time of the procedure was recorded. The patients were followed up and evaluated 2, 6 h and 24 hours after the procedure. Results The procedure time, pain rating index, and visual analogue scores were significantly different between the two groups (P < 0.05). Adverse reaction during or after the procedure was not significantly different (P > 0.05). Conclusions The analgesic effect of dezocine is better than morphine for atrial fibrillation radiofrequency catheter ablation. The incidence of adverse reactions such as nausea and vomiting is still high. Dezocine for analgesia in atrial fibrillation ablation can be used as an ideal alternative instead of general anesthesia.

Citation： LIFang-zhou, WEIXiao-qiong, ZHENGMing-xia, ZENGYi, CUIKai-jun. Efficacy of Dezocine for Atrial Fibrillation Radiofrequency Catheter Ablation. West China Medical Journal, 2015, 30(1): 77-79. doi: 10.7507/1002-0179.20150021 Copy

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1. Gharagozlou P, Hashemi E, DeLorey TM, et al. Pharmacological profiles of opioid ligands at kappa opioid receptors[J]. BMC Pharmacol, 2006, 25(6):3.
2. Zhu Y, Jing G, Yuan W. Preoperative administration of intramuscular dezocine reduces postoperative pain for laparoscopic cholecystectomy[J]. J Biomed Res, 2011, 25(5):356-361.
3. Sun ZT, Yang CY, Cui Z, et al. Effect of intravenous dezocine on fentanyl-induced cough during general anesthesia induction:a double-blinded, prospective, randomized, controlled trial[J]. J Anesth, 2011, 25(6):860-863.
4. Calkins H, Reynolds MR, Spector P, et al. Treatment of atrial fibrillation with antiarrhythmic drugs or radiofrequency ablation two systematic literature reviews and Meta-analyses[J]. Circ Arrhythm Electrophysiol, 2009, 2(4):U49-U349.
5. Bonanno C, Paccanaro M, La Vecchia L, et al. Efficacy and safety of catheter ablation versus antiarrhythmic drugs for atrial fibrillation:a meta-analysis of randomized trials[J]. J Cardiovasc Med (Hagerstown), 2010, 11(6):408-418.
6. Nair GM, Nery PB, Diwakaramenon SA, et al. A systematic review of randomized trials comparing radiofrequency ablation with antiarrhythmic medications in patients with atrial fibrillation[J]. J Cardiovasc Electrophysiol, 2009, 20(2):138-144.
7. Parkash R, Tang AS, Sapp JL, et al. Approach to the catheter ablation technique of paroxysmal and persistent atrial fibrillation:a Meta-analysis of the randomized controlled trials[J]. J Cardiovasc Electrophysiol, 2011, 22(7):729-738.
8. Piccini JP, Lopes RD, Kong MH, et al. Pulmonary vein isolation for the maintenance of sinus rhythm in patients with atrial fibrillation:a meta-analysis of randomized, controlled trials[J]. Circ Arrhythm Electrophysiol, 2009, 2(6):626-633.
9. Jais P, Cauchemez B, Macle L, et al. Catheter ablation versus antiarrhythmic drugs for atrial fibrillation the a4 study[J]. Circulation, 2008, 118(24):2498-2505.
10. Camm AJ, Lip GY, De Caterina R, et al. An update of the 2010 ESC Guidelines for the management of atrial fibrillation[J]. Eur Heart J, 2012, 33(21):2719-2747.
11. 岳修勤.地佐辛与芬太尼应用于术后静脉镇痛的临床效果比较[J].中国疼痛医学杂志, 2010, 16(4):255-256.
12. 殷霞丽, 李勇.地佐辛与曲马多术后镇痛效果及安全性的Meta分析[J].药学与临床研究, 2013, 21(2):190-193.

West China Medical Journal

Efficacy of Dezocine for Atrial Fibrillation Radiofrequency Catheter Ablation

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