The Relationship between the Aldehyde Dehydrogenase 2 Gene Polymorphism and Carotid Intima-media Thickness in the Han Population of Sichuan, China_West China Medical Journal

Authors：

 MAXiao-xiang ^1,2 , CHENXiao-ping ² , CHENGYou-fu ¹ , HEXia ³ , SHUAIPing ¹ , YANGYan-hua ¹ , XIAOXian ¹ ,  LIUYu-ping ¹

1. Center of Health Physical Examination and Health Management, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;
2. Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
3. Pharmacogenomics Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

LIUYu-ping, Email: 651231899@qq.com

Keywords：

Aldehyde dehydrogenase 2; Gene polymorphism; Carotid intima-media thickness

DOI：

10.7507/1002-0179.20150119

Video：

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Objective To investigate the relationship between the aldehyde dehydrogenase 2 gene (ALDH2) polymorphism and carotid intima-media thickness (IMT). Methods From April 2013 to February 2014, 310 cases of carotid IMT thickening (IMT thickening group) from the physical examination center were included in the study and 280 cases of normal carotid IMT were regarded as controls. DNA was extracted from peripheral blood. ALDH2 gene polymorphism was detected by DNA microarray method. Results Genotype distributions had no deviation from Hardy-Weinberg equilibrium in both groups. Compared with controls, the frequency of AA/AG genotypes (67.4%, 41.1%; P<0.01) and the frequency of A allele (37.9%, 22.3%; P<0.001) of ALDH2 gene were apparently increased in the subjects of IMT thickening group. There was a significant difference in the frequency distribution of genotype and allele in ALDH2 between the two groups. The logistic analysis showed that the ALDH2 gene polymorphism was associated with the increased carotid IMT [OR=2.381, 95%CI (1.356, 4.213), P=0.004]. Conclusion The ALDH2 gene polymorphism is correlated with the increased carotid IMT in the Han population of China Sichuan. The ALDH2 gene polymorphism may play an important role in genetic susceptibility of increased carotid IMT.

Citation： MAXiao-xiang, CHENXiao-ping, CHENGYou-fu, HEXia, SHUAIPing, YANGYan-hua, XIAOXian, LIUYu-ping. The Relationship between the Aldehyde Dehydrogenase 2 Gene Polymorphism and Carotid Intima-media Thickness in the Han Population of Sichuan, China. West China Medical Journal, 2015, 30(3): 401-406. doi: 10.7507/1002-0179.20150119 Copy

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15.	艾智华, 金小岚, 游志清, 等. PPAR-γ_2基因Pro12Ala多态性与2型糖尿病患者动脉粥样硬化的关系[J]. 实用医院临床杂志,2011, 8(3): 22-24.
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18.	万琪, 王飞, 陈亚丽, 等. 乙醛脱氢酶1与肿瘤干细胞相关性研究[J]. 华西医学, 2011, 26(3): 476-478.
19.	Li TK, Yin SJ, Crabb DW, et al. Genetic and environment infl uence on alcohol metabolism in human[J]. Alcohol Clin Exp Res, 2001, 25(1): 136-144.
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21.	Zhang M, Shah AM. Role of reactive oxygen species in myocardial remodeling[J]. Curr Heart Fail Rep, 2007, 4(1): 26-30.
22.	Narita M. Effects of aldehydrogenase genotypes on carotid atherosclerosis[J]. Utrasound Med Bio, 2003, 29(9): 1415-1419.

1. 赵鹏飞, 张怡, 季晓云, 等. 高血压病人eNOS基因Glu298Asp多态性与颈动脉内中膜厚度的关联性[J]. 青岛大学医学院学报, 2014,50(1): 26-28, 30.
2. 张强, 邓峰美, 唐斌. 颈动脉内膜-中层厚度与高血压相关性的研究进展[J]. 医学综述, 2011, 17(11): 1611-1613.
3. 毛跟年, 李鑫, 瞿建波. 乙醛脱氢酶及其医疗领域研究进展[J]. 天然产物研究与开发, 2011, 23(1): 193-197.
4. 钱士匀, 邬强. 对氧磷酶生物学特性及临床研究进展[J]. 国际检验医学杂志, 2007, 28(4): 361-362, 365.
5. 杨宁, 田军, 董彦, 等. 高血压患者血清脂联素与颈动脉内膜中层厚度及血压相关因素的研究[J]. 新乡医学院学报, 2013, 30(1): 62-65.
6. 尚蓉, 殷军. 彩色多普勒超声在糖尿病颈动脉硬化中的应用[J]. 第三军医大学报, 2010, 32(11): 1232-1234.
7. 杨秀云, 陶剑虹, 蔡力. 过氧化物酶体增殖物激活受体与动脉粥样硬化研究进展[J]. 实用医院临床杂志, 2008, 5(3): 99-102.
8. Yu MA, Sánchez-Lozada LG, Johnson RJ, et al. Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction[J]. J Hypertens, 2010, 28(6): 1234-1242.
9. 刘海红, 李海珍. 动脉粥样硬化的研究进展[J].中国医药导报,2010, 7(19): 9-10.
10. 刘坤梅, 丁小君, 刘修燕, 等. 阿托伐他汀钙对颈动脉粥样硬化患者血管内皮的保护作用[J]. 华西医学, 2013, 28(1): 33-35.
11. 金修才, 赵宝珍. 颈动脉内中膜厚度的测量及其与心血管危险因素的关系[J]. 中国医学影像学杂志, 2006, 14(1): 55-57.
12. Shenkin SD, Bastin ME, Macgillivray TJ, et al. Carotid intima-media thickness and cerebrovascular disease in community-dwelling older people without stroke[J]. Stroke, 2010, 41(9): 2083-2086.
13. Nasri H, Baradaran A. Association of serum lipoprotein-a with ultrasonographically determined early atherosclerotic changes in the carotid and femoral arteries in kidney transplanted patients[J]. Transplant Proc, 2004, 36(9): 2683-2686.
14. 贾晓利, 曹晓红, 陈树. 老老年患者颈动脉中层厚度的相关危险因素分析[J]. 华西医学, 2010, 25(1): 16-19.
15. 艾智华, 金小岚, 游志清, 等. PPAR-γ_2基因Pro12Ala多态性与2型糖尿病患者动脉粥样硬化的关系[J]. 实用医院临床杂志,2011, 8(3): 22-24.
16. Za KA, Tsivoulis G, Barlas G, et al. Time rate of blood pressure variation is associated with increased common carotid artery intimamedia thickness[J]. Hypertension, 2005, 45(4): 505-512.
17. Seitz HK, Matsuzaki S, Yokoyama A, et al. Alcohol and cancer[J]. Alcohol Clin Res, 2001, 25(5 Suppl SBRA): 137S-143S.
18. 万琪, 王飞, 陈亚丽, 等. 乙醛脱氢酶1与肿瘤干细胞相关性研究[J]. 华西医学, 2011, 26(3): 476-478.
19. Li TK, Yin SJ, Crabb DW, et al. Genetic and environment infl uence on alcohol metabolism in human[J]. Alcohol Clin Exp Res, 2001, 25(1): 136-144.
20. Hood JD, Cheresh D. Role of integrins in cell invasion and migration[J]. Nat Rev Cancer, 2002, 2(2): 91-100.
21. Zhang M, Shah AM. Role of reactive oxygen species in myocardial remodeling[J]. Curr Heart Fail Rep, 2007, 4(1): 26-30.
22. Narita M. Effects of aldehydrogenase genotypes on carotid atherosclerosis[J]. Utrasound Med Bio, 2003, 29(9): 1415-1419.

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The Relationship between the Aldehyde Dehydrogenase 2 Gene Polymorphism and Carotid Intima-media Thickness in the Han Population of Sichuan, China

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