Modified Ultrafiltration Used for Cardiopulmonary Bypass in Children_West China Medical Journal

Authors：

 YANShi-wei , FUChang-jiang , WANGJi-hong , ZHANGJun-biao

Department of Cardiovascular Anesthesiology, the Third People's Hospital of Xingtai, Xingtai, Hebei 054000, P. R. China;

Corresponding author：

Keywords：

Modified ultrafiltration; Congenital heart disease; Infants; Inflammatory factors

DOI：

10.7507/1002-0179.20150132

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Objective To summarize the clinical usage of modified ultrafiltration in pediatric cardiopulmonary bypass. Methods We selected 40 infants with congenital heart defects as our study subjects between January 2010 and February 2012. They were randomly divided into two groups. One group used modified ultrafiltration, while the other did not, during the operation with cardiopulmonary bypass. The different perioperative changes of pulmonary pressure and the tumor necrosis factor (TNF) and interleukin-8 (IL-8) concentration in plasma were observed in both the two groups. Results No complication relative to modified ultrafiltration was found. After the operations began, TNF and IL-8 concentration in the two groups rose fast; at the end of operations and 2 hours after operation, the pulmonary pressure and TNF and IL-8 concentration in the two groups decreased, and the decrease in the modified ultrafiltration group was faster. Conclusion The use of modified ultrafiltration during operations with cardiopulmonary bypass can reduce residual water within the body in a short period and decrease the concentration of inflammatory factors, which is helpful for postoperative recovery of the cardiac and lung functions.

Citation： YANShi-wei, FUChang-jiang, WANGJi-hong, ZHANGJun-biao. Modified Ultrafiltration Used for Cardiopulmonary Bypass in Children. West China Medical Journal, 2015, 30(3): 464-467. doi: 10.7507/1002-0179.20150132 Copy

1.	Naik SK, Knight A, Elliott MJ. A successful modification of ultrafiltration for cardiopulmonary bypass in children[J]. Perfusion, 1991, 6(5):41-50.
2.	Magilligan DJ, Kam CA, Johnson DC, et al. Hematocrit and blood volume control during cardiopulmonary bypass with the use of hemofiltration[J]. Circulation, 1987, 60(7):478-480.
3.	Tallman RD, Dumond M, Brown D. Inflammatory mediator removal by zero-balance ultrafiltration during cardiopulmonary bypass[J]. Perfusion, 2002, 17(2):111-115.
4.	赵举, 龙村, 冯正义, 等. 库血预充液零平衡超滤对婴幼儿体外循环中炎性反应的影响[J]. 中国胸心血管外科临床杂志, 2005, 12(6):396-398.
5.	Naik Sk, Knight A, Elliott MJ. A prospective randomized study of a modified technique of ultrafiltration during pediatric open-heart surgery[J]. Circulation, 1991, 84(5 Suppl):Ⅲ422-Ⅲ431.
6.	Kirklin JK, Weshaby S, Blackstine EH, et al. Complement and the damageing effect of cardiopulmonary bypass[J]. Thorac Cardiovasc, 1983, 86(3):845-847.
7.	王为民, 刘玉贞, 崔传玉. 改良超滤在婴幼儿先心病体外循环中的应用[J]. 江苏医药, 2003, 29(2):144-145.
8.	吴铁军, 汤服民, 张跃东, 等. 改良超滤对心脏瓣膜置换术患者肺功能的影响[J]. 中国医师杂志, 2009, 11(10):1382-1383.
9.	张鲁英, 张广福, 姜冠华, 等. 改良超滤技术在体外循环中的应用[J]. 中国体外循环杂志, 2004, 2(1):14-15.
10.	王伟, 朱德明, 黄惠民, 等. 10公斤以下先天性心脏病患儿围术期减少用血[J]. 中国胸心血管外科临床杂志, 1999, 6(4):220-222.
11.	Elliott MJ. Ultrafitration and nodified ultrafiltration in pediatric open-heart poerations[J]. Ann Thorac Surg, 1993, 56(11):1518-1522.
12.	Cheung N, Wong MP, Yuen ST, et al. Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon[J]. Hum Pathol, 1998, 29(9):910-914.
13.	Shimpo H, Shimamoto A, Sawamura Y, et al. Ultrafiltration of the priming blood before cardiopulmonary bypass attenuates inflammatory response and improves postoperative clinical course in pediatricpatients[J]. Shock, 2001, 16(Suppl 1):51-54.
14.	赵琦峰, 施霖, 赵曙光, 等. 新法改良超滤在小儿体外循环术中的应用[J]. 临床小儿外科杂志, 2002, 1(4):264-267, 276.
15.	段大为, 杨景学. 婴幼儿体外循环的特殊性[J]. 中华胸心血管外科杂志, 2001, 17(3):185-187.
16.	陈京南, 黄胜, 马乐龙. 改良超滤法在婴幼儿体外循环中的应用[J]. 中国体外循环杂志, 2004, 2(4):240-241.
17.	朱德明, 王伟, 丁文祥, 等. 平衡超滤法对小儿体外循环中炎症因子影响[J]. 临床儿科杂志, 2003, 21(9):561-562.
18.	Konmai H, Adatia IT, Elliot MJ, et al. Incereased plasma levels of endothelin-1 after cardiopulmonary bypass in patient with pulmonary hypertension and congenital heart disease[J]. J Thorac Cardiovase Surg, 1993, 106(3):473-478.

1. Naik SK, Knight A, Elliott MJ. A successful modification of ultrafiltration for cardiopulmonary bypass in children[J]. Perfusion, 1991, 6(5):41-50.
2. Magilligan DJ, Kam CA, Johnson DC, et al. Hematocrit and blood volume control during cardiopulmonary bypass with the use of hemofiltration[J]. Circulation, 1987, 60(7):478-480.
3. Tallman RD, Dumond M, Brown D. Inflammatory mediator removal by zero-balance ultrafiltration during cardiopulmonary bypass[J]. Perfusion, 2002, 17(2):111-115.
4. 赵举, 龙村, 冯正义, 等. 库血预充液零平衡超滤对婴幼儿体外循环中炎性反应的影响[J]. 中国胸心血管外科临床杂志, 2005, 12(6):396-398.
5. Naik Sk, Knight A, Elliott MJ. A prospective randomized study of a modified technique of ultrafiltration during pediatric open-heart surgery[J]. Circulation, 1991, 84(5 Suppl):Ⅲ422-Ⅲ431.
6. Kirklin JK, Weshaby S, Blackstine EH, et al. Complement and the damageing effect of cardiopulmonary bypass[J]. Thorac Cardiovasc, 1983, 86(3):845-847.
7. 王为民, 刘玉贞, 崔传玉. 改良超滤在婴幼儿先心病体外循环中的应用[J]. 江苏医药, 2003, 29(2):144-145.
8. 吴铁军, 汤服民, 张跃东, 等. 改良超滤对心脏瓣膜置换术患者肺功能的影响[J]. 中国医师杂志, 2009, 11(10):1382-1383.
9. 张鲁英, 张广福, 姜冠华, 等. 改良超滤技术在体外循环中的应用[J]. 中国体外循环杂志, 2004, 2(1):14-15.
10. 王伟, 朱德明, 黄惠民, 等. 10公斤以下先天性心脏病患儿围术期减少用血[J]. 中国胸心血管外科临床杂志, 1999, 6(4):220-222.
11. Elliott MJ. Ultrafitration and nodified ultrafiltration in pediatric open-heart poerations[J]. Ann Thorac Surg, 1993, 56(11):1518-1522.
12. Cheung N, Wong MP, Yuen ST, et al. Tissue-specific expression pattern of vascular endothelial growth factor isoforms in the malignant transformation of lung and colon[J]. Hum Pathol, 1998, 29(9):910-914.
13. Shimpo H, Shimamoto A, Sawamura Y, et al. Ultrafiltration of the priming blood before cardiopulmonary bypass attenuates inflammatory response and improves postoperative clinical course in pediatricpatients[J]. Shock, 2001, 16(Suppl 1):51-54.
14. 赵琦峰, 施霖, 赵曙光, 等. 新法改良超滤在小儿体外循环术中的应用[J]. 临床小儿外科杂志, 2002, 1(4):264-267, 276.
15. 段大为, 杨景学. 婴幼儿体外循环的特殊性[J]. 中华胸心血管外科杂志, 2001, 17(3):185-187.
16. 陈京南, 黄胜, 马乐龙. 改良超滤法在婴幼儿体外循环中的应用[J]. 中国体外循环杂志, 2004, 2(4):240-241.
17. 朱德明, 王伟, 丁文祥, 等. 平衡超滤法对小儿体外循环中炎症因子影响[J]. 临床儿科杂志, 2003, 21(9):561-562.
18. Konmai H, Adatia IT, Elliot MJ, et al. Incereased plasma levels of endothelin-1 after cardiopulmonary bypass in patient with pulmonary hypertension and congenital heart disease[J]. J Thorac Cardiovase Surg, 1993, 106(3):473-478.

West China Medical Journal

Modified Ultrafiltration Used for Cardiopulmonary Bypass in Children

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