来曲唑微刺激促排卵方案在卵巢反应低下患者的临床应用探讨_West China Medical Journal

Authors：

 林洪波 ,  钱卫平 , 李蓉 , 张秋菊 , 黄品秀

北京大学深圳医院生殖医学科（广东深圳 518036）;

Corresponding author：

钱卫平, Email: qianweipingsz@126.com

Keywords：

微刺激方案; 常规超促排卵方案; 卵巢低反应

DOI：

10.7507/1002-0179.20150142

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的探讨来曲唑微刺激方案在卵巢低反应患者的临床应用价值。方法选取2009年9月－2011年12月期间就诊的第1周期采用常规超促排卵方案，即常规长方案超促排卵行体外受精/卵胞浆内单精子注射助孕的卵巢低反应且助孕失败的74例患者，第2周期采用微刺激方案，即采用来曲唑微刺激促排卵方案治疗，进行前后自身对照研究。比较前后2次促排卵方案中促性腺激素释放激素（Gn）用量、使用Gn的时间以及注射人绒毛膜促性腺激素（HCG）日的雌激素水平、获卵数、受精率、优质胚胎率和周期取消率。结果第1周期常规超促排卵方案的Gn用量及使用Gn的时间均高于第2周期微刺激方案，差异有统计学意义（P＜0.05）。但两个周期在HCG日的雌激素水平、获卵数、受精率、优质胚胎数和周期取消率，差异无统计学意义（P＞0.05）。结论对于卵巢低反应患者采用微刺激方案较经济，且治疗周期短，并且可连续重复进行，有利于提高累计妊娠率。

Citation： 林洪波, 钱卫平, 李蓉, 张秋菊, 黄品秀. 来曲唑微刺激促排卵方案在卵巢反应低下患者的临床应用探讨. West China Medical Journal, 2015, 30(3): 502-504. doi: 10.7507/1002-0179.20150142 Copy

1.	Galey-Fontaine J, Cédrin-Durnerin I, Chabi R, et al. Age and ovarian reserve are distinct predictive factors of cycle outcome in low responders[J]. Reprod Biomed Online, 2005, 10(1):94-99.
2.	Mohsen IA, El Din RE. Minimal stimulation protocol using letrozole versus microdose flare up GnRH agonist protocol in women with poor ovarian response undergoing ICSI[J]. Gynecol Endocrinol, 2013, 29(2):105-108.
3.	Lamazou F, Fuchs F, Grynberg M, et al. Cancellation of IVF-ET cycles:poor prognosis, poor responder, or variability of the response to controlled ovarian hyperstimualtion? An analysis of 142 cancellations[J]. J Gynecol Obstet Biol Reprod (Paris), 2012, 41(1):41-47.
4.	La Marca A, Sighinolfi G, Radi D, et al. Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART)[J]. Hum Reprod Update, 2010, 16(2):113-130.
5.	田莉, 吴丹, 沈浣. 长、短效GnRH激动剂在控制性超排卵长方案中应用效果比较[J]. 中国妇产科临床杂志, 2009, 10(6):413-415, 453.
6.	郭慧, 罗克丽, 龚斐, 等. 三种不同促排卵方案在卵巢低反应患者中的应用[J]. 医学临床研究, 2011, 28(5):873-875.
7.	匡延平. 微刺激促排卵方案的临床研究[J]. 生殖医学杂志, 2010, 19(4):356-359.
8.	Polinder S, Heijnen EM, Macklon NS, et al. Cost-effectiveness of a mild compared with a standard strategy for IVF:a randomized comparison using cumulative term live birth as the primary endpoint[J]. Hum Reprod, 2008, 23(2):316-323.
9.	Revelli A, Casano S, Salvagno F, et al. Milder is better? Advantages and disadvantages of "mild" ovarian stimulation for human in vitro fertilization[J]. Reprod Biol Endocrinol, 2011, 9:25.

1. Galey-Fontaine J, Cédrin-Durnerin I, Chabi R, et al. Age and ovarian reserve are distinct predictive factors of cycle outcome in low responders[J]. Reprod Biomed Online, 2005, 10(1):94-99.
2. Mohsen IA, El Din RE. Minimal stimulation protocol using letrozole versus microdose flare up GnRH agonist protocol in women with poor ovarian response undergoing ICSI[J]. Gynecol Endocrinol, 2013, 29(2):105-108.
3. Lamazou F, Fuchs F, Grynberg M, et al. Cancellation of IVF-ET cycles:poor prognosis, poor responder, or variability of the response to controlled ovarian hyperstimualtion? An analysis of 142 cancellations[J]. J Gynecol Obstet Biol Reprod (Paris), 2012, 41(1):41-47.
4. La Marca A, Sighinolfi G, Radi D, et al. Anti-Mullerian hormone (AMH) as a predictive marker in assisted reproductive technology (ART)[J]. Hum Reprod Update, 2010, 16(2):113-130.
5. 田莉, 吴丹, 沈浣. 长、短效GnRH激动剂在控制性超排卵长方案中应用效果比较[J]. 中国妇产科临床杂志, 2009, 10(6):413-415, 453.
6. 郭慧, 罗克丽, 龚斐, 等. 三种不同促排卵方案在卵巢低反应患者中的应用[J]. 医学临床研究, 2011, 28(5):873-875.
7. 匡延平. 微刺激促排卵方案的临床研究[J]. 生殖医学杂志, 2010, 19(4):356-359.
8. Polinder S, Heijnen EM, Macklon NS, et al. Cost-effectiveness of a mild compared with a standard strategy for IVF:a randomized comparison using cumulative term live birth as the primary endpoint[J]. Hum Reprod, 2008, 23(2):316-323.
9. Revelli A, Casano S, Salvagno F, et al. Milder is better? Advantages and disadvantages of "mild" ovarian stimulation for human in vitro fertilization[J]. Reprod Biol Endocrinol, 2011, 9:25.

Previous Article
单J管内引流在胆总管一期缝合术中的应用
Next Article
改良弯接头连接喉罩全身麻醉在小儿纤维支气管镜检查中的应用

West China Medical Journal

来曲唑微刺激促排卵方案在卵巢反应低下患者的临床应用探讨

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content