围生期脑卒中的研究进展及诊治现状_West China Medical Journal

Authors：

 牛佳慧 ,  陈娟

四川大学华西第二医院儿科（成都 610041）;

Corresponding author：

陈娟, Email: chenjuan2000@163.com

Keywords：

脑卒中; 围生期; 新生儿; 危险因素; 亚低温; 干细胞

DOI：

10.7507/1002-0179.20150165

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

围生期脑卒中是一种严重的神经系统疾病，近年来引起了临床医生的高度重视。由于该病缺乏特异性症状和体征，常漏诊和延误治疗，部分患者遗留严重的神经系统后遗症，影响患儿的生活质量。因此有必要提高对该病的认识，熟悉其病因和诊疗手段。现就围生期脑卒中的病因、相关危险因素及治疗的最新研究进展作一综述。

Citation： 牛佳慧, 陈娟. 围生期脑卒中的研究进展及诊治现状. West China Medical Journal, 2015, 30(3): 573-576. doi: 10.7507/1002-0179.20150165 Copy

1.	Raju TN, Nelson KB, Ferriero D, et al. Ischemic perinatal stroke:summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke[J]. Pediatrics, 2007, 120(3):609-616.
2.	Lynch JK. Epidemiology and classification of perinatal stroke[J]. Semin Fetal Neonatal Med, 2009, 14(5):245-249.
3.	Lee J, Croen LA, Backstrand KH, et al. Maternal and infant characteristics associated with perinatal arterial stroke in the infant[J]. JAMA, 2005, 293(6):723-729.
4.	曹云. 新生儿惊厥[J]. 中国小儿急救医学, 2009, 16(3):306-308.
5.	Cheong JL, Cowan FM. Neonatal arterial ischaemic stroke:obstetric issues[J]. Semin Fetal Neonatal Med, 2009, 14(5):267-271.
6.	Renaud C, Bonneau C, Presles E, et al. Lipoprotein (a), birth weight and neonatal stroke[J]. Neonatology, 2010, 98(3):225-228.
7.	Krause M, Sonntag B, Klamroth R, et al. Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage:results of a multicentre case-control study[J]. Thromb Haemost, 2005, 93(5):867-871.
8.	李丽华, 张莉, 母得志. 新生儿脑卒中与产前因素[J]. 实用儿科临床杂志, 2006, 21(14):949-950.
9.	Nelson KB, Lynch JK. Stroke in newborn infants[J]. Lancet Neurol, 2004, 3(3):150-158.
10.	李丽华, 张莉, 屈艺, 等. 新生儿脑卒中与产时及产后发病因素[J]. 中国儿童保健杂志, 2007, 15(1):65-66.
11.	母得志. 围生期缺血性脑卒中临床研究面临的问题[J]. 中华妇幼临床医学杂志:电子版, 2013, 9(1):1-4.
12.	Redline, Raymond W. Correlation of placental pathology with perinatal brain injury[J]. Surg Pathol, 2013, 6(1):153-180.
13.	黄春玲, 周丛乐, 汤泽中, 等. 新生儿脑梗死的危险因素[J]. 中华围产医学杂志, 2012, 15(6):337-344.
14.	黄春玲, 周丛乐, 汤泽中. 新生儿脑梗死病因研究进展[J]. 中华围产医学杂志, 2011, 14(1):55-60.
15.	Gawish GE. Molecular characterization of factor V leiden G1691A and prothrombin G20210A mutations in saudi newborns with stroke[J]. Biochem Genet, 2011, 49(9/10):601-610.
16.	Mallick AA, O'callaghan FJ. The epidemiology of childhood stroke[J]. Eur J Paediatr Neurol, 2010, 14(3):197-205.
17.	Du LN, Bayir H, Lai YC, et al. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway[J]. J Biol Chem, 2004, 279(37):38563-38570.
18.	Maingay-De GF, Lequin MH, Roofthooft DW, et al. Extensive cerebral infarctio in the newborn due to incontinentia pigmenti[J]. Eur J Paediatr Neurol, 2008, 12(4):284-289.
19.	李志华, 陈超. 新生儿脑梗死58例分析[J]. 中华儿科杂志, 2013, 51(1):16-20.
20.	母得志. 新生儿脑卒中的诊断和治疗[J]. 临床儿科杂志, 2010, 28(3):207-211.
21.	Badve CA, Khanna PC, Ishak GE. Neonatal ischemic brain injury:what every radiologist needs to know[J]. Pediatr Radiol, 2012, 42(5):606-619.
22.	Kuker W, Mohrle S, Mader I, et al. MRI for the management of neonatal cerebral infarctions:importance of timing[J]. Childs NervSyst, 2004, 20(10):742-748.
23.	富建华, 毛健, 薛辛东, 等. 磁共振弥散加权成像在新生儿脑梗死早期诊断中的意义及其变化规律[J]. 中华儿科杂志, 2007, 45(5):360-364.
24.	Jordan LC, Rafay MF, Smith SE, et al. Antithrombotic treatment in neonatal cerebral sinovenous thrombosis:results of the international pediatric stroke study[J]. J Pediatrics, 2010, 156(5):U43-U704.
25.	Lebas A, Chabrier S, Fluss J, et al. EPNS/SFNP guideline on the anticoagulant treatment of cerebral sinovenous thrombosis in children and neonates[J]. Eur J Paediatr Neurol, 2012, 16(3):219-228.
26.	Roach ES, Golomb MR, Adams R, et al. Management of stroke in infants and children:a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young[J]. Stroke, 2008, 39(9):2644-2691.
27.	Amlie-Lefond C, Deveber G, Chan AK, et al. Use of alteplase in childhood arterial ischaemic stroke:a multicentre, observational, cohort study[J]. Lancet Neurol, 2009, 8(6):530-536.
28.	Wasay M, Dai AI, Ansari M, et al. Cerebral venous sinus thrombosis in children:a multicenter cohort from the United States[J]. J Child Neurol, 2008, 23(1):26-31.
29.	Jenkins DD, Lee T, Chiuzan C, et al. Altered circulating leukocytes and their chemokines in a clinical trial of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy[J]. Pediatr Crit Care Med, 2013, 14(8):786-795.
30.	Klehmet J, Harms H, Richter M, et al. Stroke-induced immunodepression and post-stroke infections:lessons from the preventive antibacterial therapy in stroke trial[J]. Neuroscience, 2009, 158(3):1184-1193.
31.	Velthoven CT, Sheldon RA, Kavelaars A, et al. Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke[J]. Stroke, 2013, 44(5):1426-1432.
32.	廖文斌. 人脐带间充质干细胞移植治疗脑血管疾病的实验研究[D]. 北京:中国协和医科大学, 2009.
33.	Doycheva D, Shih G, Chen H, et al. Granulocyte-colony stimulating factor in combination with stem cell factor confers greater neuroprotection after hypoxic-ischemic brain damage in the neonatal rats than a olitary treatment[J]. Transl Stroke Res, 2013, 4(2):171-178.
34.	Solaroglu I, Tsubokawa T, Cahill J, et al. Anti-apoptotic effect of granulocyte-colony stimulating factor after focal cerebral ischemia in the rat[J]. Neuroscience, 2006, 143(4):965-974.
35.	Kaneko Y, Tajiri N, Su TP, et al. Combination treatment of hypothermia and mesenchymal stromal cells amplifies neuroprotection in primary rat neurons exposed to hypoxic-ischemic-like injury in vitro:role of the opioid system[J]. PLoS One, 2012, 7(10):e47583.
36.	Tsai SY, Lee CT, Hayashi T, et al. Delta opioid peptide DADLE and naltrexone cause cell cycle arrest and differentiation in a CNS neural progenitor cell line[J]. Synapse, 2010, 64(4):267-273.

1. Raju TN, Nelson KB, Ferriero D, et al. Ischemic perinatal stroke:summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke[J]. Pediatrics, 2007, 120(3):609-616.
2. Lynch JK. Epidemiology and classification of perinatal stroke[J]. Semin Fetal Neonatal Med, 2009, 14(5):245-249.
3. Lee J, Croen LA, Backstrand KH, et al. Maternal and infant characteristics associated with perinatal arterial stroke in the infant[J]. JAMA, 2005, 293(6):723-729.
4. 曹云. 新生儿惊厥[J]. 中国小儿急救医学, 2009, 16(3):306-308.
5. Cheong JL, Cowan FM. Neonatal arterial ischaemic stroke:obstetric issues[J]. Semin Fetal Neonatal Med, 2009, 14(5):267-271.
6. Renaud C, Bonneau C, Presles E, et al. Lipoprotein (a), birth weight and neonatal stroke[J]. Neonatology, 2010, 98(3):225-228.
7. Krause M, Sonntag B, Klamroth R, et al. Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage:results of a multicentre case-control study[J]. Thromb Haemost, 2005, 93(5):867-871.
8. 李丽华, 张莉, 母得志. 新生儿脑卒中与产前因素[J]. 实用儿科临床杂志, 2006, 21(14):949-950.
9. Nelson KB, Lynch JK. Stroke in newborn infants[J]. Lancet Neurol, 2004, 3(3):150-158.
10. 李丽华, 张莉, 屈艺, 等. 新生儿脑卒中与产时及产后发病因素[J]. 中国儿童保健杂志, 2007, 15(1):65-66.
11. 母得志. 围生期缺血性脑卒中临床研究面临的问题[J]. 中华妇幼临床医学杂志:电子版, 2013, 9(1):1-4.
12. Redline, Raymond W. Correlation of placental pathology with perinatal brain injury[J]. Surg Pathol, 2013, 6(1):153-180.
13. 黄春玲, 周丛乐, 汤泽中, 等. 新生儿脑梗死的危险因素[J]. 中华围产医学杂志, 2012, 15(6):337-344.
14. 黄春玲, 周丛乐, 汤泽中. 新生儿脑梗死病因研究进展[J]. 中华围产医学杂志, 2011, 14(1):55-60.
15. Gawish GE. Molecular characterization of factor V leiden G1691A and prothrombin G20210A mutations in saudi newborns with stroke[J]. Biochem Genet, 2011, 49(9/10):601-610.
16. Mallick AA, O'callaghan FJ. The epidemiology of childhood stroke[J]. Eur J Paediatr Neurol, 2010, 14(3):197-205.
17. Du LN, Bayir H, Lai YC, et al. Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway[J]. J Biol Chem, 2004, 279(37):38563-38570.
18. Maingay-De GF, Lequin MH, Roofthooft DW, et al. Extensive cerebral infarctio in the newborn due to incontinentia pigmenti[J]. Eur J Paediatr Neurol, 2008, 12(4):284-289.
19. 李志华, 陈超. 新生儿脑梗死58例分析[J]. 中华儿科杂志, 2013, 51(1):16-20.
20. 母得志. 新生儿脑卒中的诊断和治疗[J]. 临床儿科杂志, 2010, 28(3):207-211.
21. Badve CA, Khanna PC, Ishak GE. Neonatal ischemic brain injury:what every radiologist needs to know[J]. Pediatr Radiol, 2012, 42(5):606-619.
22. Kuker W, Mohrle S, Mader I, et al. MRI for the management of neonatal cerebral infarctions:importance of timing[J]. Childs NervSyst, 2004, 20(10):742-748.
23. 富建华, 毛健, 薛辛东, 等. 磁共振弥散加权成像在新生儿脑梗死早期诊断中的意义及其变化规律[J]. 中华儿科杂志, 2007, 45(5):360-364.
24. Jordan LC, Rafay MF, Smith SE, et al. Antithrombotic treatment in neonatal cerebral sinovenous thrombosis:results of the international pediatric stroke study[J]. J Pediatrics, 2010, 156(5):U43-U704.
25. Lebas A, Chabrier S, Fluss J, et al. EPNS/SFNP guideline on the anticoagulant treatment of cerebral sinovenous thrombosis in children and neonates[J]. Eur J Paediatr Neurol, 2012, 16(3):219-228.
26. Roach ES, Golomb MR, Adams R, et al. Management of stroke in infants and children:a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young[J]. Stroke, 2008, 39(9):2644-2691.
27. Amlie-Lefond C, Deveber G, Chan AK, et al. Use of alteplase in childhood arterial ischaemic stroke:a multicentre, observational, cohort study[J]. Lancet Neurol, 2009, 8(6):530-536.
28. Wasay M, Dai AI, Ansari M, et al. Cerebral venous sinus thrombosis in children:a multicenter cohort from the United States[J]. J Child Neurol, 2008, 23(1):26-31.
29. Jenkins DD, Lee T, Chiuzan C, et al. Altered circulating leukocytes and their chemokines in a clinical trial of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy[J]. Pediatr Crit Care Med, 2013, 14(8):786-795.
30. Klehmet J, Harms H, Richter M, et al. Stroke-induced immunodepression and post-stroke infections:lessons from the preventive antibacterial therapy in stroke trial[J]. Neuroscience, 2009, 158(3):1184-1193.
31. Velthoven CT, Sheldon RA, Kavelaars A, et al. Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke[J]. Stroke, 2013, 44(5):1426-1432.
32. 廖文斌. 人脐带间充质干细胞移植治疗脑血管疾病的实验研究[D]. 北京:中国协和医科大学, 2009.
33. Doycheva D, Shih G, Chen H, et al. Granulocyte-colony stimulating factor in combination with stem cell factor confers greater neuroprotection after hypoxic-ischemic brain damage in the neonatal rats than a olitary treatment[J]. Transl Stroke Res, 2013, 4(2):171-178.
34. Solaroglu I, Tsubokawa T, Cahill J, et al. Anti-apoptotic effect of granulocyte-colony stimulating factor after focal cerebral ischemia in the rat[J]. Neuroscience, 2006, 143(4):965-974.
35. Kaneko Y, Tajiri N, Su TP, et al. Combination treatment of hypothermia and mesenchymal stromal cells amplifies neuroprotection in primary rat neurons exposed to hypoxic-ischemic-like injury in vitro:role of the opioid system[J]. PLoS One, 2012, 7(10):e47583.
36. Tsai SY, Lee CT, Hayashi T, et al. Delta opioid peptide DADLE and naltrexone cause cell cycle arrest and differentiation in a CNS neural progenitor cell line[J]. Synapse, 2010, 64(4):267-273.

Previous Article
病毒相关性弥漫大B细胞淋巴瘤的临床及免疫学特点
Next Article
性别及性腺激素对睡眠影响的临床研究进展

West China Medical Journal

围生期脑卒中的研究进展及诊治现状

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content