Clinical Application of Dexmedetomidine Combined with Dezocine for Patient-controlled Intravenous Analgesia in Patients after Abdominal Tumor Radical Surgery_West China Medical Journal

Authors：

 WANGXin-yuan ,  GANJian-hui , HUWan-ning , GAOHui-jun , LIUHao-ran

Department of Anesthesiology, the Affiliated Tangshan People's Hospital of Hebei Union University, Tangshan, Hebei 063000, P. R. China;

Corresponding author：

GANJian-hui, Email: gjh71@163.com

Keywords：

Dexmedetomidine; Dezocine; Sufentanil; Patient-controlled intravenous analgesia

DOI：

10.7507/1002-0179.20150192

Video：

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Objective To evaluate the efficacy and safety of dexmedetomidine combined with dezocine for patient-controlled intravenous analgesia (PCIA) in patients after radical operation for abdominal tumor. Methods Between September 2012 and May 2013, 60 patients (aged 40-60, American Sociaty of Anesthesiologists physical statusⅠ-Ⅱ) undergoing abdominal tumor surgery and asking for PCIA pumps voluntarily were randomly divided into two groups (group D and group DF) with 30 in each group. Patients in group D were given sufentanil 0.25 μg/kg+ dezocine 0.4 mg/kg, which were added into 100 mL 0.9% normal saline, while in group DF, the patients received dexmedetomidine 1.5 μg/kg+ sufentanil 0.15 μg/kg+ dezocine 0.4 mg/kg, which were added into 100 mL 0.9% normal saline. The changes of mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), the visual analog scale (VAS), Ramsay sedation scale, Bruggrmann analgesia scale (BCS), the efficacy of postoperative analgesia and adverse effects were observed and recorded at the preoperative time (T₀), and 2 (T₁), 4 (T₂), 8 (T₃), 24 (T₄) and 48 hours (T₅) postoperatively. Results Hemodynamics in group DF was more stable than that in group D (P<0.05). There were no statically significant differences in terms of VAS and BCS between the two groups at each time point (P>0.05). The Ramsay sedation scale of group DF was better than group D, and the difference was statistically significant (P<0.05). The efficient number of pressing within 48 hours in the two groups was not significantly different (P>0.05). The incidence of nausea, vomiting and drowsiness in group D was more than that of group DF (P<0.05). Conclusion Dexmedetomidine combined with dezocine can provide effective postoperative analgesia with less adverse effects for patients after radical surgery of abdominal tumor, which provides higher satisfaction to the abdominal surgery patients.

Citation： WANGXin-yuan, GANJian-hui, HUWan-ning, GAOHui-jun, LIUHao-ran. Clinical Application of Dexmedetomidine Combined with Dezocine for Patient-controlled Intravenous Analgesia in Patients after Abdominal Tumor Radical Surgery. West China Medical Journal, 2015, 30(4): 669-672. doi: 10.7507/1002-0179.20150192 Copy

1.	方永珍, 丘小青. 静脉与硬膜外泵注芬太尼患者自控镇痛的临床应用[J]. 海南医学院学报, 2009, 15(9):1154-1156, 1159.
2.	Tan JA, Ho KM. Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients:a meta-analysis[J]. Intensive Care Med, 2010, 36(6):926-939.
3.	郭小花, 佘守章, 宋兴荣, 等. 地佐辛用于经腹全子宫切除术后自控静脉镇痛的量效关系[J]. 广东医学, 2012, 33(20):3092-3094.
4.	王纯辉, 沈启英, 李珺, 等. 地佐辛联合舒芬太尼用于术后静脉镇痛的效果观察[J]. 安徽医科大学学报, 2012, 47(8):1003-1004.
5.	Wang ZY, Wang CQ, Yang JJ, et al. Which has the least immunity depression during postoperative analgesia:morphine, tramadol, or tramadol with lornoxicam?[J]. Clin Chim Acta, 2006, 369(1):40-45.
6.	叶铁虎, 李大魁. 麻醉药理学基础与临床[M]. 北京:人民卫生出版社, 2011:210-211.
7.	韩雪萍, 黄运里, 孙振涛, 等. 地佐辛和芬太尼用于甲状腺术后镇痛对患者呼吸的影响[J]. 临床麻醉学杂志, 2011, 27(10):993-994.
8.	中华医学会麻醉学分会. 成人术后镇痛处理专家共识[J]. 临床麻醉学杂志, 2010, 26(3):190-196.
9.	成毅, 于瑞文. 地佐辛复合芬太尼在术后静脉镇痛中的临床观察[J]. 中国医药, 2011, 6(5):587-588.
10.	岳修勤. 地佐辛与芬太尼应用于术后静脉镇痛的临床效果比较[J]. 中国疼痛医学杂志, 2010, 16(4):255.
11.	Afonso J, Reis F. Dexmedetomidine:current role in anesthesia and intensive care[J]. Rev Bras Anestesiol, 2012, 62(1):118-133.
12.	马思杰, 张清. 右美托咪啶对术后阿片类需求的影响研究[J]. 现代中西医结合杂志, 2012, 21(29):3256-3258.
13.	Carollo DS, Nossaman BD, Ramadhyani U. Dexmedetomidine:a review of clinical applications[J]. Curr Opin Anaesthesiol, 2008, 21(4):457-461.
14.	Yildiz M, Tavlan A, Tuncer S, et al. Effect of dexmedetomidine on haemodynamic responses to laryngoscopy and intubation:perioperative haemodynamics and anaesthetic requirements[J]. Drugs R D, 2006, 7(1):43-52.
15.	Lin TF, Yeh YC, Lin FS, et al. Effect of combining dexmedetomidinc and morphine for intravenous patient-controlled analgesia[J]. Br J Anaesth, 2009, 102(1):117-122.
16.	甘建辉, 史金麟, 胡万宁, 等. 右美托咪定在乳腺癌前哨淋巴结活检术中的临床应用[J]. 中国药房, 2013, 24(10):921-922.
17.	李志鹏, 柳垂亮. 右美托咪定的临床应用进展[J]. 实用医学杂志, 2013, 29(19):3254-3256.
18.	Ingersoll-Weng E, Manecke GR, Thistlethwaite PA. Dexmedetomine and cardiac arrest[J]. Anesthesiology, 2004, 100(3):738-739.

1. 方永珍, 丘小青. 静脉与硬膜外泵注芬太尼患者自控镇痛的临床应用[J]. 海南医学院学报, 2009, 15(9):1154-1156, 1159.
2. Tan JA, Ho KM. Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients:a meta-analysis[J]. Intensive Care Med, 2010, 36(6):926-939.
3. 郭小花, 佘守章, 宋兴荣, 等. 地佐辛用于经腹全子宫切除术后自控静脉镇痛的量效关系[J]. 广东医学, 2012, 33(20):3092-3094.
4. 王纯辉, 沈启英, 李珺, 等. 地佐辛联合舒芬太尼用于术后静脉镇痛的效果观察[J]. 安徽医科大学学报, 2012, 47(8):1003-1004.
5. Wang ZY, Wang CQ, Yang JJ, et al. Which has the least immunity depression during postoperative analgesia:morphine, tramadol, or tramadol with lornoxicam?[J]. Clin Chim Acta, 2006, 369(1):40-45.
6. 叶铁虎, 李大魁. 麻醉药理学基础与临床[M]. 北京:人民卫生出版社, 2011:210-211.
7. 韩雪萍, 黄运里, 孙振涛, 等. 地佐辛和芬太尼用于甲状腺术后镇痛对患者呼吸的影响[J]. 临床麻醉学杂志, 2011, 27(10):993-994.
8. 中华医学会麻醉学分会. 成人术后镇痛处理专家共识[J]. 临床麻醉学杂志, 2010, 26(3):190-196.
9. 成毅, 于瑞文. 地佐辛复合芬太尼在术后静脉镇痛中的临床观察[J]. 中国医药, 2011, 6(5):587-588.
10. 岳修勤. 地佐辛与芬太尼应用于术后静脉镇痛的临床效果比较[J]. 中国疼痛医学杂志, 2010, 16(4):255.
11. Afonso J, Reis F. Dexmedetomidine:current role in anesthesia and intensive care[J]. Rev Bras Anestesiol, 2012, 62(1):118-133.
12. 马思杰, 张清. 右美托咪啶对术后阿片类需求的影响研究[J]. 现代中西医结合杂志, 2012, 21(29):3256-3258.
13. Carollo DS, Nossaman BD, Ramadhyani U. Dexmedetomidine:a review of clinical applications[J]. Curr Opin Anaesthesiol, 2008, 21(4):457-461.
14. Yildiz M, Tavlan A, Tuncer S, et al. Effect of dexmedetomidine on haemodynamic responses to laryngoscopy and intubation:perioperative haemodynamics and anaesthetic requirements[J]. Drugs R D, 2006, 7(1):43-52.
15. Lin TF, Yeh YC, Lin FS, et al. Effect of combining dexmedetomidinc and morphine for intravenous patient-controlled analgesia[J]. Br J Anaesth, 2009, 102(1):117-122.
16. 甘建辉, 史金麟, 胡万宁, 等. 右美托咪定在乳腺癌前哨淋巴结活检术中的临床应用[J]. 中国药房, 2013, 24(10):921-922.
17. 李志鹏, 柳垂亮. 右美托咪定的临床应用进展[J]. 实用医学杂志, 2013, 29(19):3254-3256.
18. Ingersoll-Weng E, Manecke GR, Thistlethwaite PA. Dexmedetomine and cardiac arrest[J]. Anesthesiology, 2004, 100(3):738-739.

West China Medical Journal

Clinical Application of Dexmedetomidine Combined with Dezocine for Patient-controlled Intravenous Analgesia in Patients after Abdominal Tumor Radical Surgery

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