Correlation of Anti-Oxidized Low Density Lipoprotein Antibody with Human Cytomegalovirus Antibody in Healthy Women_West China Medical Journal

Authors：

 JIANGLi-quan , LIUFeng-ling , GAOJing-hong ,  YINJi-dong

Department of Gynecology and Obstetrics, the People's Hospital of Santai County, Santai, Sichuan 621100, P. R. China;

Corresponding author：

YINJi-dong, Email: 1376536803@qq.com

Keywords：

Oxidized low density lipoprotein; Human cytomegalovirus; Dislipidemia

DOI：

10.7507/1002-0179.20150202

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To detect the relationship between human cytomegalovirus (HCMV) antibody and anti-oxidized low density lipoprotein (anti-ox-LDL). Methods Sixty blood samples from healthy women who underwent physical examination between April 2008 and October 2012 in our hospital was collected. Anti-ox-LDL antibody was detected by enzyme-linked immunosorbent assay. All samples were divided into high-titer group and low-titer group according to the level of ox-LDL antibody. HCMV- immunoglobulin (Ig)G and -IgM were then assayed by specific kit. Results In ox-LDL high-titer group, the level of anti-HCMV antibody was also dramatically higher than ox-LDL low-titer group (P<0.001). Conclusion There is a significant relationship between expression of ox-LDL and HCMV infection.

Citation： JIANGLi-quan, LIUFeng-ling, GAOJing-hong, YINJi-dong. Correlation of Anti-Oxidized Low Density Lipoprotein Antibody with Human Cytomegalovirus Antibody in Healthy Women. West China Medical Journal, 2015, 30(4): 708-711. doi: 10.7507/1002-0179.20150202 Copy

1.	Wang W, Yu P, Zhang P, et al. The infection of human primary cells and cell lines by human cytomegalovirus:new tropism and new reservoirs for HCMV[J]. Virus Res, 2008, 131(2):160-169.
2.	Tuthill M, Chen F, Paston S, et al. The prevention and treatment of cytomegalovirus infection in haematopoietic stem cell transplantation[J]. Cancer Immunol Immunother, 2009, 58(9):1481-1488.
3.	Sayers MH, Anderson KC, Goodnough LT, et al. Reducing the risk for transfusion-transmitted cytomegalovirus infection[J]. Ann Intern Med, 1992, 116(1):55-62.
4.	陈玉成, 梁玉佳, 刘瑞, 等. 氧化低密度脂蛋白对血管内皮细胞骨架的损伤及其机制[J]. 心血管康复医学杂志, 2004, 13(4):320-321, 348.
5.	Nieto FJ, Adam E, Sorlie P, et al. Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis[J]. Circulation, 1996, 94(5):922-927.
6.	Hendrix MG, Dormans PH, Kitslaar P, et al. The presence of cytomegalovirus nucleic acids in arterial walls of atherosclerotic and nonatherosclerotic patients[J]. Am J Pathol, 1989, 134(5):1151-1157.
7.	王瑞金, 王得新, 王佳伟, 等. 巨细胞病毒感染对内皮细胞凝集素样氧化型低密度脂蛋白受体-1MRNA表达的影响[J]. 北京医学, 2006, 28(3):139-141.
8.	Wentworth BB, Aleander ER. Sero epidemiology of infections due to members of the herpes virus group[J]. Am J Epidemiology, 1971, 94(6):496-507.
9.	Gandhi MK, Khanna R. Human cytomegalovirus:clinical aspects, immune regulation, and emerging treatments[J]. Lancet Infect Dis, 2004, 4(12):725-738.
10.	Michaelis M, Doerr HW, Cinatl J. The story of human cytomegalovirus and cancer:increasing evidence and open questions[J]. Neoplasia, 2009, 11(1):1-9.
11.	Vanarsdall AL, Ryckman BJ, Chase MC, et al. Human cytomegalovirus glycoproteins gB and gH/gL mediate epithelial cell-cell fusion when expressed either in cis or in trans[J]. J Virol, 2008, 82(23):11837-11850.
12.	Feire AL, Koss H, Compton T. Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain[J]. Proc Natl Acad Sci USA, 2004, 101(43):15470-15475.
13.	Landry ML, Ferguson D, Cohen S, et al. Effect of delayed specimen processing on cytomegalovirus antigenemia test results[J]. J Clin Microbiol, 1995, 33(1):257-259.
14.	Rubin RH. The indirect effects of cytomegalovirus infection on the outcome of organ transplantation[J]. JAMA, 1989, 261(24):3607-3609.
15.	Varani S, Frascaroli G, Landini MP. Human cytomegalovirus targets different subsets of antigen-presenting cells with pathological consequences for host immunity:implications for immunosuppression, chronic inflammation and autoimmunity[J]. Rev Med Virol, 2009, 19(3):131-145.
16.	Michaelis M, Doerr HW, Cinatl J. Oncomodulation by human cytomegalovirus:evidence becomes stronger[J]. Med Microbiol Immunol, 2009, 198(2):79-81.
17.	Söderberg-Nauclér C. HCMV microinfections in inflammatory diseases and cancer[J]. J Clin Virol, 2008, 41(3):218-223.
18.	Diao YT, Li H, Li HQ, et al. Association of serum levels of lipid and its novel constituents with the different stages of esophageal carcinoma[J]. Lipids Health Dis, 2009, 8(2):48-54.
19.	Vielma SA, Mironova M, Ku JR, et al. Oxidized LDL further enhances expression of adhesion molecules in Chlamydophila pneumoniae-infected endothelial cells[J]. J Lipid Res, 2004, 45(5):873-880.

1. Wang W, Yu P, Zhang P, et al. The infection of human primary cells and cell lines by human cytomegalovirus:new tropism and new reservoirs for HCMV[J]. Virus Res, 2008, 131(2):160-169.
2. Tuthill M, Chen F, Paston S, et al. The prevention and treatment of cytomegalovirus infection in haematopoietic stem cell transplantation[J]. Cancer Immunol Immunother, 2009, 58(9):1481-1488.
3. Sayers MH, Anderson KC, Goodnough LT, et al. Reducing the risk for transfusion-transmitted cytomegalovirus infection[J]. Ann Intern Med, 1992, 116(1):55-62.
4. 陈玉成, 梁玉佳, 刘瑞, 等. 氧化低密度脂蛋白对血管内皮细胞骨架的损伤及其机制[J]. 心血管康复医学杂志, 2004, 13(4):320-321, 348.
5. Nieto FJ, Adam E, Sorlie P, et al. Cohort study of cytomegalovirus infection as a risk factor for carotid intimal-medial thickening, a measure of subclinical atherosclerosis[J]. Circulation, 1996, 94(5):922-927.
6. Hendrix MG, Dormans PH, Kitslaar P, et al. The presence of cytomegalovirus nucleic acids in arterial walls of atherosclerotic and nonatherosclerotic patients[J]. Am J Pathol, 1989, 134(5):1151-1157.
7. 王瑞金, 王得新, 王佳伟, 等. 巨细胞病毒感染对内皮细胞凝集素样氧化型低密度脂蛋白受体-1MRNA表达的影响[J]. 北京医学, 2006, 28(3):139-141.
8. Wentworth BB, Aleander ER. Sero epidemiology of infections due to members of the herpes virus group[J]. Am J Epidemiology, 1971, 94(6):496-507.
9. Gandhi MK, Khanna R. Human cytomegalovirus:clinical aspects, immune regulation, and emerging treatments[J]. Lancet Infect Dis, 2004, 4(12):725-738.
10. Michaelis M, Doerr HW, Cinatl J. The story of human cytomegalovirus and cancer:increasing evidence and open questions[J]. Neoplasia, 2009, 11(1):1-9.
11. Vanarsdall AL, Ryckman BJ, Chase MC, et al. Human cytomegalovirus glycoproteins gB and gH/gL mediate epithelial cell-cell fusion when expressed either in cis or in trans[J]. J Virol, 2008, 82(23):11837-11850.
12. Feire AL, Koss H, Compton T. Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain[J]. Proc Natl Acad Sci USA, 2004, 101(43):15470-15475.
13. Landry ML, Ferguson D, Cohen S, et al. Effect of delayed specimen processing on cytomegalovirus antigenemia test results[J]. J Clin Microbiol, 1995, 33(1):257-259.
14. Rubin RH. The indirect effects of cytomegalovirus infection on the outcome of organ transplantation[J]. JAMA, 1989, 261(24):3607-3609.
15. Varani S, Frascaroli G, Landini MP. Human cytomegalovirus targets different subsets of antigen-presenting cells with pathological consequences for host immunity:implications for immunosuppression, chronic inflammation and autoimmunity[J]. Rev Med Virol, 2009, 19(3):131-145.
16. Michaelis M, Doerr HW, Cinatl J. Oncomodulation by human cytomegalovirus:evidence becomes stronger[J]. Med Microbiol Immunol, 2009, 198(2):79-81.
17. Söderberg-Nauclér C. HCMV microinfections in inflammatory diseases and cancer[J]. J Clin Virol, 2008, 41(3):218-223.
18. Diao YT, Li H, Li HQ, et al. Association of serum levels of lipid and its novel constituents with the different stages of esophageal carcinoma[J]. Lipids Health Dis, 2009, 8(2):48-54.
19. Vielma SA, Mironova M, Ku JR, et al. Oxidized LDL further enhances expression of adhesion molecules in Chlamydophila pneumoniae-infected endothelial cells[J]. J Lipid Res, 2004, 45(5):873-880.

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Correlation of Anti-Oxidized Low Density Lipoprotein Antibody with Human Cytomegalovirus Antibody in Healthy Women

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