<trans-title xml:lang="en"/>_West China Medical Journal

Authors：

袁满 ^1,2 ,  王丽春 ^1,2

1. ;
2. ;

Corresponding author：

王丽春, Email: mindywang0218@163.com

Keywords：

吲哚氰绿; 清除试验; 肝病; 应用进展

DOI：

10.7507/1002-0179.201503134

Video：

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目前评价肝脏功能的检测方法较多，吲哚氰绿清除试验作为动态评价肝脏功能的检测手段之一，能够全面地反映肝脏相关情况，为患者的诊治及预后评估提供一定依据。本文就吲哚氰绿清除试验在肝硬化、肝衰竭、肝切除术以及肝移植领域的应用进展进行了综述。

Citation： 袁满, 王丽春. . West China Medical Journal, 2017, 32(3): 471-474. doi: 10.7507/1002-0179.201503134 Copy

1.	Mobley CM, Zarrinpar A. Portable device for the analysis of liver function: a boon to liver surgery and critical care. Expert Rev Med Devices, 2016, 13(1): 1-4.
2.	Vos JJ, Wietasch J, Absalom AR,et al. Green light for liver function monitoring using indocyanine green? An overview of current clinical applications. Anaesthesia, 2014, 69(12): 1364-1376.
3.	De Graaf W, Haeusler S, Heger M,et al. Transporters involved in the hepatic uptake of Tc-99m-mebrofenin and indocyanine green. J Hepatol, 2011, 54(4): 738-745.
4.	Stockmann M, Malinowski M, Lock JF,et al. Factors influencing the indocyanine green (ICG) test: additional impact of acute cholestasis. Hepatogastroenterology, 2009, 56(91/92): 734-738.
5.	Kim GY, Bae KS, Noh GJ,et al. Estimation of indocyanine green elimination rate constant k and retention rate at 15 min using patient age, weight, bilirubin, and albumin. J Hepatobiliary Pancreat Surg, 2009, 16(4): 521-528.
6.	Nanashima A, Abo T, Tobinaga S,et al. Prediction of indocyanine green retention rate at 15 minutes by correlated liver function parameters before hepatectomy. J Surg Res, 2011, 169(2): e119-e125.
7.	D'onofrio M, De Robertis R, Ruzzenente AA,et al. Time-to-peak values can estimate hepatic functional reserve in patients undergoing surgical resection: a comparison between perfusion CT and indocyanine green retention test. J Comput Assist Tomogr, 2014, 38(5): 733-741.
8.	Inal MT, Memis D, Sezer YA,et al. Effects of intra-abdominal pressure on liver function assessed with the LiMON in critically ill patients. Can J Surg, 2011, 54(3): 161-166.
9.	Janssen MW, Druckrey-Fiskaaen KT, Omidi L,et al. Indocyanine green R15 ratio depends directly on liver perfusion flow rate. J Hepatobiliary Pancreat Sci, 2010, 17(2): 180-185.
10.	胡滨, 臧娴, 陈娟娟, 等. 肝储备功能检测中吲哚菁绿不良反应的预防及处理. 按摩与康复医学: 中旬刊, 2012, 3(11): 82-83.
11.	Levesque E, Martin E, Dudau D,et al. Current use and perspective of indocyanine green clearance in liver diseases. Anaesth Crit Care Pain Med, 2016, 35(1): 49-57.
12.	De Chantemele EB, Gauquelin-Koch G, Duvareille M,et al. Blood volume measurement: The comparison of pulse dye densitometry and Dill and Costill's methods. Life Sci, 2006, 78(14): 1564-1569.
13.	Reekers M, Simon MJ, Boer F,et al. Pulse dye densitometry and indocyanine green plasma disappearance in ASA physical status I-II patients. Anesth Analg, 2010, 110(2): 466-472.
14.	Akita H, Sasaki Y, Yamada T,et al. Real-time intraoperative assessment of residual liver functional reserve using pulse dye densitometry. World J Surg, 2008, 32(12): 2668-2674.
15.	刘光达, 金晟来, 李飞, 等. 基于光电脉搏色素浓度谱分析的肝储备功能检测方法. 光电子·激光, 2012, 23(6): 1216-1220.
16.	程钧. 吲哚菁绿清除试验在终末期肝病评估中的应用现状和进展. 西部医学, 2015, 27(9): 1433-1436.
17.	李红梅, 魏雪, 管晓娟, 等. DDG-3300K肝储备功能分析仪检测方法与临床应用. 西北国防医学杂志, 2013, 34(2): 178-179.
18.	王雪丽, 徐敏芬, 陈红, 等. 吲哚菁绿在肝储备功能检测中致不良反应的护理体会. 海峡药学, 2011, 23(5): 262-263.
19.	Gupta S, Chawla Y, Kaur J,et al. Indocyanine green clearance test (using spectrophotometry) and its correlation with model for end stage liver disease (MELD) score in Indian patients with cirrhosis of liver. Trop Gastroenterol, 2012, 33(2): 129-134.
20.	黄文琪, 许金超, 闵峰, 等. 吲哚菁绿清除试验对肝硬化患者肝脏储备功能的评估价值. 实用肝脏病杂志, 2015, 18(5): 468-471.
21.	Merle U, Sieg O, Stremmel W,et al. Eisenbach C.sensitivity and specificity of plasma disappearance rate of indocyanine green as a prognostic indicator in acute liver failure. BMC Gastroenterol, 2009, 9(1): 91.
22.	Feng HL, Li Q, Wang L,et al. Indocyanine green clearance test combined with MELD score in predicting the short-term prognosis of patients with acute liver failure. Hepatobiliary & Pancreatic Dis Int, 2014, 13(3): 271-275.
23.	胡守廉, 胡爱荣, 蒋素文, 等. 脉冲式色素浓度分析法吲哚菁绿清除试验在肝衰竭患者预后判断中的价值. 中国预防医学杂志, 2012, 13(6): 443-446.
24.	Harada N, Shirabe K, Maeda T,et al. Surgical resection for hepatocellular carcinoma with concomitant esophageal varices. World J Surg, 2015, 39(10): 2510-2518.
25.	Hwang S, Ha TY, Song GW,et al. Quantified risk assessment for major hepatectomy via the indocyanine green clearance rate and liver volumetry combined with standard liver volume. J Gastrointest Surg, 2015, 19(7): 1305-1314.
26.	Mizuguchi T, Kawamoto M, Meguro M,et al. Prognosis and predictors of surgical complications in hepatocellular carcinoma patients with or without cirrhosis after hepatectomy. World J Surg, 2013, 37(6): 1379-1387.
27.	Greco E, Nanji S, Bromberg IL,et al. Predictors of peri-opertative morbidity and liver dysfunction after hepatic resection in patients with chronic liver disease. HPB (Oxford), 2011, 13(8): 559-565.
28.	中华人民共和国卫生部. 原发性肝癌诊疗规范(2011年版). 临床肝胆病杂志, 2011, 27(11): 1141-1159.
29.	Ren ZH, Xu Y, Zhu SH. Indocyanine green retention test avoiding liver failure after hepatectomy for hepatolithiasis. Hepatogastroenterology, 2012, 59(115): 782-784.
30.	Thomas MN, Weninger E, Angele M,et al. Intraoperative simulation of remnant liver function during anatomic liver resection with indocyanine green clearance (LiMON) measurements. HPB (Oxford), 2015, 17(6): 471-476.
31.	Ho CM, Dhawan A, Hughes RD,et al. Use of indocyanine green for functional assessment of human hepatocytes for transplantation. Asian J Surg, 2012, 35(1): 9-15.
32.	Zipprich A, Kuss O, Rogowski S,et al. Incorporating indocyanin green clearance into the Model for End Stage Liver Disease (MELD-ICG) improves prognostic accuracy in intermediate to advanced cirrhosis. Gut, 2010, 59(7): 963-968.
33.	Ecochard M, Boillot O, Guillaud O,et al. Could metabolic liver function tests predict mortality on waiting list for liver transplantation? A study on 560 patients. Clin Transplant, 2011, 25(5): 755-765.
34.	Vos JJ, Scheeren TW, Lukes DJ,et al. Intraoperative ICG plasma disappearance rate helps to predict absence of early postoperative complications after orthotopic liver transplantation. J Clin Monit Comput, 2013, 27(5): 591-598.
35.	Caesar J, Shaldon S, Chiandussi L,et al. The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function. Clin Sci. 1961, 21(21): 43-57.

1. Mobley CM, Zarrinpar A. Portable device for the analysis of liver function: a boon to liver surgery and critical care. Expert Rev Med Devices, 2016, 13(1): 1-4.
2. Vos JJ, Wietasch J, Absalom AR,et al. Green light for liver function monitoring using indocyanine green? An overview of current clinical applications. Anaesthesia, 2014, 69(12): 1364-1376.
3. De Graaf W, Haeusler S, Heger M,et al. Transporters involved in the hepatic uptake of Tc-99m-mebrofenin and indocyanine green. J Hepatol, 2011, 54(4): 738-745.
4. Stockmann M, Malinowski M, Lock JF,et al. Factors influencing the indocyanine green (ICG) test: additional impact of acute cholestasis. Hepatogastroenterology, 2009, 56(91/92): 734-738.
5. Kim GY, Bae KS, Noh GJ,et al. Estimation of indocyanine green elimination rate constant k and retention rate at 15 min using patient age, weight, bilirubin, and albumin. J Hepatobiliary Pancreat Surg, 2009, 16(4): 521-528.
6. Nanashima A, Abo T, Tobinaga S,et al. Prediction of indocyanine green retention rate at 15 minutes by correlated liver function parameters before hepatectomy. J Surg Res, 2011, 169(2): e119-e125.
7. D'onofrio M, De Robertis R, Ruzzenente AA,et al. Time-to-peak values can estimate hepatic functional reserve in patients undergoing surgical resection: a comparison between perfusion CT and indocyanine green retention test. J Comput Assist Tomogr, 2014, 38(5): 733-741.
8. Inal MT, Memis D, Sezer YA,et al. Effects of intra-abdominal pressure on liver function assessed with the LiMON in critically ill patients. Can J Surg, 2011, 54(3): 161-166.
9. Janssen MW, Druckrey-Fiskaaen KT, Omidi L,et al. Indocyanine green R15 ratio depends directly on liver perfusion flow rate. J Hepatobiliary Pancreat Sci, 2010, 17(2): 180-185.
10. 胡滨, 臧娴, 陈娟娟, 等. 肝储备功能检测中吲哚菁绿不良反应的预防及处理. 按摩与康复医学: 中旬刊, 2012, 3(11): 82-83.
11. Levesque E, Martin E, Dudau D,et al. Current use and perspective of indocyanine green clearance in liver diseases. Anaesth Crit Care Pain Med, 2016, 35(1): 49-57.
12. De Chantemele EB, Gauquelin-Koch G, Duvareille M,et al. Blood volume measurement: The comparison of pulse dye densitometry and Dill and Costill's methods. Life Sci, 2006, 78(14): 1564-1569.
13. Reekers M, Simon MJ, Boer F,et al. Pulse dye densitometry and indocyanine green plasma disappearance in ASA physical status I-II patients. Anesth Analg, 2010, 110(2): 466-472.
14. Akita H, Sasaki Y, Yamada T,et al. Real-time intraoperative assessment of residual liver functional reserve using pulse dye densitometry. World J Surg, 2008, 32(12): 2668-2674.
15. 刘光达, 金晟来, 李飞, 等. 基于光电脉搏色素浓度谱分析的肝储备功能检测方法. 光电子·激光, 2012, 23(6): 1216-1220.
16. 程钧. 吲哚菁绿清除试验在终末期肝病评估中的应用现状和进展. 西部医学, 2015, 27(9): 1433-1436.
17. 李红梅, 魏雪, 管晓娟, 等. DDG-3300K肝储备功能分析仪检测方法与临床应用. 西北国防医学杂志, 2013, 34(2): 178-179.
18. 王雪丽, 徐敏芬, 陈红, 等. 吲哚菁绿在肝储备功能检测中致不良反应的护理体会. 海峡药学, 2011, 23(5): 262-263.
19. Gupta S, Chawla Y, Kaur J,et al. Indocyanine green clearance test (using spectrophotometry) and its correlation with model for end stage liver disease (MELD) score in Indian patients with cirrhosis of liver. Trop Gastroenterol, 2012, 33(2): 129-134.
20. 黄文琪, 许金超, 闵峰, 等. 吲哚菁绿清除试验对肝硬化患者肝脏储备功能的评估价值. 实用肝脏病杂志, 2015, 18(5): 468-471.
21. Merle U, Sieg O, Stremmel W,et al. Eisenbach C.sensitivity and specificity of plasma disappearance rate of indocyanine green as a prognostic indicator in acute liver failure. BMC Gastroenterol, 2009, 9(1): 91.
22. Feng HL, Li Q, Wang L,et al. Indocyanine green clearance test combined with MELD score in predicting the short-term prognosis of patients with acute liver failure. Hepatobiliary & Pancreatic Dis Int, 2014, 13(3): 271-275.
23. 胡守廉, 胡爱荣, 蒋素文, 等. 脉冲式色素浓度分析法吲哚菁绿清除试验在肝衰竭患者预后判断中的价值. 中国预防医学杂志, 2012, 13(6): 443-446.
24. Harada N, Shirabe K, Maeda T,et al. Surgical resection for hepatocellular carcinoma with concomitant esophageal varices. World J Surg, 2015, 39(10): 2510-2518.
25. Hwang S, Ha TY, Song GW,et al. Quantified risk assessment for major hepatectomy via the indocyanine green clearance rate and liver volumetry combined with standard liver volume. J Gastrointest Surg, 2015, 19(7): 1305-1314.
26. Mizuguchi T, Kawamoto M, Meguro M,et al. Prognosis and predictors of surgical complications in hepatocellular carcinoma patients with or without cirrhosis after hepatectomy. World J Surg, 2013, 37(6): 1379-1387.
27. Greco E, Nanji S, Bromberg IL,et al. Predictors of peri-opertative morbidity and liver dysfunction after hepatic resection in patients with chronic liver disease. HPB (Oxford), 2011, 13(8): 559-565.
28. 中华人民共和国卫生部. 原发性肝癌诊疗规范(2011年版). 临床肝胆病杂志, 2011, 27(11): 1141-1159.
29. Ren ZH, Xu Y, Zhu SH. Indocyanine green retention test avoiding liver failure after hepatectomy for hepatolithiasis. Hepatogastroenterology, 2012, 59(115): 782-784.
30. Thomas MN, Weninger E, Angele M,et al. Intraoperative simulation of remnant liver function during anatomic liver resection with indocyanine green clearance (LiMON) measurements. HPB (Oxford), 2015, 17(6): 471-476.
31. Ho CM, Dhawan A, Hughes RD,et al. Use of indocyanine green for functional assessment of human hepatocytes for transplantation. Asian J Surg, 2012, 35(1): 9-15.
32. Zipprich A, Kuss O, Rogowski S,et al. Incorporating indocyanin green clearance into the Model for End Stage Liver Disease (MELD-ICG) improves prognostic accuracy in intermediate to advanced cirrhosis. Gut, 2010, 59(7): 963-968.
33. Ecochard M, Boillot O, Guillaud O,et al. Could metabolic liver function tests predict mortality on waiting list for liver transplantation? A study on 560 patients. Clin Transplant, 2011, 25(5): 755-765.
34. Vos JJ, Scheeren TW, Lukes DJ,et al. Intraoperative ICG plasma disappearance rate helps to predict absence of early postoperative complications after orthotopic liver transplantation. J Clin Monit Comput, 2013, 27(5): 591-598.
35. Caesar J, Shaldon S, Chiandussi L,et al. The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function. Clin Sci. 1961, 21(21): 43-57.

West China Medical Journal

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