Clinical Analysis of Cranial Venous Sinus Thrombosis_West China Medical Journal

Authors：

 TANGYu-feng , ZHANGShan-shan , ZHANGYun , DUHong-cai , LIZhao-kun , ZHANGXian-wen ,  DUANJin-feng

Department of Neurologic Medicine, Mianyang Central Hospital, Mianyang, Sichuan 621000, P. R. China;

Corresponding author：

DUANJin-feng, Email: duancs63@163.com

Keywords：

Cranial venous sinus thrombosis; Symptoms; Anticoagulation; rombolysis; Imaging

DOI：

10.7507/1002-0179.20150532

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective ?To explore the clinical and imaging features of cranial venous sinus thrombosis (CVST). Methods The clinical data of 20 patients with CVST treated between January 2008 and December 2012 were retrospectively analyzed, including the clinical manifestations, neuroimaging characters and treatment outcomes. Results Among the 20 patients, there were 10 infected cases; D-dimer was detected positively in only 2 cases; cerebrospinal fluid pressure increased in 13 patients; and red blood cell population of cerebrospinal fluid increased in 12 patients. The common clinical symptoms included headache in 16 cases, eye symptoms in 12 cases, and vomiting in 10 cases. CT showed the direct signs of CVST in 3 cases, and MRI showed the direct signs of CVST in 6 cases. The common disease regions were in left transverse sinus and sigmoid sinus in 5 cases, superior sagittal sinus in 5 cases, and multiple venous sinus in 5 cases. Eighteen patients only received anticoagulation, and 2 received anticoagulation and local thrombolytic treatment. Fourteen cases recovered fully, 6 had dysfunctions. Conclusion The clinical manifestations of CVST are nonspecific. This disorder predominantly affects childbearing women. Infection is a common cause of CVST. The occlusive venous sinus can be confirmed by enhanced magnetic resonance venography or digital subtraction angiography. Anticoagulation and local thrombolytic therapy are both proved to be safe and effective in the treatment of CVST. The early diagnosis rate of CVST remains to be improved.

Citation： TANGYu-feng, ZHANGShan-shan, ZHANGYun, DUHong-cai, LIZhao-kun, ZHANGXian-wen, DUANJin-feng. Clinical Analysis of Cranial Venous Sinus Thrombosis. West China Medical Journal, 2015, 30(10): 1849-1852. doi: 10.7507/1002-0179.20150532 Copy

1.	Saposnik G, Barinagarrementeria F, Brown RD, et al. Diagnosis and management of cerebral venous thrombosis:a statement for healthcare professionals from the American Heart Association/American Stroke Association[J]. Stroke, 2011, 42(4):1158-1192.
2.	Borhani Haghighi A, Edgell RC, Cruz-Flores S, et al. Mortality of cerebral venous-sinus thrombosis in a large National sample[J]. Stroke, 2012, 43(1):262-264.
3.	Wasay M, Kojan S, Dai AI, et al. Headache in cerebral venous thrombosis:incidence, pattern and location in 200 consecutive patients[J]. J Headache Pain, 2010, 11(2):137-139.
4.	顾晓苏, 徐得恩, 周永. 颅内静脉窦血栓形成的临床与影像学特点[J]. 临床神经病学杂志, 2012, 25(2):111-114.
5.	朱德生, 张悦, 管阳太. 脑静脉窦血栓形成的临床与影像学特点[J]. 临床神经病学杂志, 2013, 26(4):268-271.
6.	唐宇凤, 段劲峰, 吴孝苹, 等. 颅内静脉窦血栓形成导致中枢性视野缺损的临床特点(附3例报告)[J]. 临床神经病学杂志, 2013, 26(2):142-143.
7.	魏妍平, 吴立文, 卢强, 等. 自发性低颅压并发静脉血栓形成和出血性梗死一例临床分析[J]. 脑与神经疾病杂志, 2009, 17(4): 312-314.
8.	李佳, 邓晖, 吴小坤, 等. 低颅压综合征伴发颅内静脉窦血栓形成1例报告及文献复习[J]. 中风与神经疾病杂志, 2012, 29(12): 1131-1132.
9.	Chiewvit P, Piyapittayanan S, Poungvarin N. Cerebral venous thrombosis:diagnosis dilemma[J]. Neurol Int, 2011, 3(3):e13.
10.	范一木, 李旭东, 王世波, 等. 颅内静脉窦血栓形成的临床研究[J]. 中国现代神经疾病杂志, 2013, 13(3):226-231.
11.	吴昊, 付国惠. 颅内静脉窦血栓形成的临床与影像学特点分析[J]. 中国实用神经疾病杂志, 2013, 16(17):43-44.
12.	Bushnell C, Saposnik G. Evaluation and management of cerebral venous thrombosis[J]. Continuum (Minneap Minn), 2014, 20(2): 335-351.
13.	黄海华, 秦超, 梁志坚. 颅内静脉窦血栓形成的临床特点及影像学分析[J]. 脑与神经疾病杂志, 2015, 23(1):53-56.
14.	李志方, 孙彬彬, 薛伟宁, 等. 颅内静脉窦血栓形成9例临床与影像学分析[J]. 疑难病杂志, 2015, 14(2):121-124.
15.	康晓雨, 黄理金, 文军, 等. 颅内静脉窦血栓形成合并颅内血肿的治疗方式的系统评价[J]. 中华神经医学杂志, 2015, 14(6):586-590.

1. Saposnik G, Barinagarrementeria F, Brown RD, et al. Diagnosis and management of cerebral venous thrombosis:a statement for healthcare professionals from the American Heart Association/American Stroke Association[J]. Stroke, 2011, 42(4):1158-1192.
2. Borhani Haghighi A, Edgell RC, Cruz-Flores S, et al. Mortality of cerebral venous-sinus thrombosis in a large National sample[J]. Stroke, 2012, 43(1):262-264.
3. Wasay M, Kojan S, Dai AI, et al. Headache in cerebral venous thrombosis:incidence, pattern and location in 200 consecutive patients[J]. J Headache Pain, 2010, 11(2):137-139.
4. 顾晓苏, 徐得恩, 周永. 颅内静脉窦血栓形成的临床与影像学特点[J]. 临床神经病学杂志, 2012, 25(2):111-114.
5. 朱德生, 张悦, 管阳太. 脑静脉窦血栓形成的临床与影像学特点[J]. 临床神经病学杂志, 2013, 26(4):268-271.
6. 唐宇凤, 段劲峰, 吴孝苹, 等. 颅内静脉窦血栓形成导致中枢性视野缺损的临床特点(附3例报告)[J]. 临床神经病学杂志, 2013, 26(2):142-143.
7. 魏妍平, 吴立文, 卢强, 等. 自发性低颅压并发静脉血栓形成和出血性梗死一例临床分析[J]. 脑与神经疾病杂志, 2009, 17(4): 312-314.
8. 李佳, 邓晖, 吴小坤, 等. 低颅压综合征伴发颅内静脉窦血栓形成1例报告及文献复习[J]. 中风与神经疾病杂志, 2012, 29(12): 1131-1132.
9. Chiewvit P, Piyapittayanan S, Poungvarin N. Cerebral venous thrombosis:diagnosis dilemma[J]. Neurol Int, 2011, 3(3):e13.
10. 范一木, 李旭东, 王世波, 等. 颅内静脉窦血栓形成的临床研究[J]. 中国现代神经疾病杂志, 2013, 13(3):226-231.
11. 吴昊, 付国惠. 颅内静脉窦血栓形成的临床与影像学特点分析[J]. 中国实用神经疾病杂志, 2013, 16(17):43-44.
12. Bushnell C, Saposnik G. Evaluation and management of cerebral venous thrombosis[J]. Continuum (Minneap Minn), 2014, 20(2): 335-351.
13. 黄海华, 秦超, 梁志坚. 颅内静脉窦血栓形成的临床特点及影像学分析[J]. 脑与神经疾病杂志, 2015, 23(1):53-56.
14. 李志方, 孙彬彬, 薛伟宁, 等. 颅内静脉窦血栓形成9例临床与影像学分析[J]. 疑难病杂志, 2015, 14(2):121-124.
15. 康晓雨, 黄理金, 文军, 等. 颅内静脉窦血栓形成合并颅内血肿的治疗方式的系统评价[J]. 中华神经医学杂志, 2015, 14(6):586-590.

West China Medical Journal

Clinical Analysis of Cranial Venous Sinus Thrombosis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content