Study of Glucose and Insulin Secretion Function in People with Normal Glucose Tolerance with Different Educational Background_West China Medical Journal

Authors：

 WANGWen , XUXun-mei

Department of Endocrinology and Metabolism, the Third People's Hospital of Mianyang, Mianyang, Sichuan 621000, P. R. China;

Corresponding author：

Keywords：

Educational levels; Normal glucose tolerance; Plasma glucose; Insulin secretion function

DOI：

10.7507/1002-0179.20150573

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Objective To explore the levels of serum glucose and insulin secretion function in people with different educational background of normal glucose tolerance and to investigate its relationship with educational levels. Methods We had telephone connections with normal fast glucose people who did health examination from January 2007 to January 2011, then the 75 g oral glucose tolerance test was performed and the level of insulin were measured. A total of 340 people with normal glucose tolerance who completed our examination and answered a questionnaire on lifestyle were included in our study. They were divided into three groups according to their educational levels. The levels of plasma glucose and insulin were measured in 92 high educational level participants, 68 middle educational level participants and 70 low educational level participants. We calculated homevstasis model assessment (HOMA)-S, HOMA-IR, and HOMA-β and compared differences between the three groups. Results With the decline of educational levels, fasting plasma glucose, body mass index (BMI), fasting insulin, postprandial insulin, HOMA-β, and HOMA-IR gradually increased, while HOMA-S gradually decreased. The level of BMI, fasting insulin and HOMA-IR in high educational level group were significantly lower than those in low educational level group. The level of BMI, HOMA-IR in middle educational level group were significantly lower than those in low educational level group (P<0.05). Correlation analysis indicated that level of fasting plasma glucose was related to age, BMI, and educational levels. Conclusion With the decline of educational levels, BMI and HOMA-IR increase, and HOMA-S decreases, which indicates that they already have differences in glucose metabolism and insulin secretion function in people with normal glucose tolerance, presaging that in the future the proportion of development of diabetes in the low educational level may increase.

Citation： WANGWen, XUXun-mei. Study of Glucose and Insulin Secretion Function in People with Normal Glucose Tolerance with Different Educational Background. West China Medical Journal, 2015, 30(11): 2005-2008. doi: 10.7507/1002-0179.20150573 Copy

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1. 中华医学会糖尿病分会. 中国2型糖尿病防治指南[M]. 北京:北京大学医学出版社, 2010.
2. WHO. Diagnosis and classification of diabetes mellitus and its complications[R]. Geneva:World Health Organization, 1999.
3. Borrell LN, Dallo FJ, White K. Education and diabetes in a racially and ethnically diverse population[J]. Am J Public Health, 2006, 96(9):1637-1642.
4. Shang X, Li J, Tao Q, et al. Educational level, obesity and incidence of diabetes among Chinese adult men and women aged 18-59 years old:an 11-year follow-up study[J]. PLoS One, 2013, 8(6):e66479.
5. Sacerdote C, Ricceri F, Rolandsson O, et al. Lower educational level is a predictor of incident type 2 diabetes in European countries:the EPIC-InterAct stud[J]. Int J Epidemiol, 2012, 41(6):1162-1173.
6. Tang M, Chen Y, Krewski D. Gender-related differences in the association between socioeconomic status and self-reported diabetes[J]. Int J Epidemiol, 2003, 32(3):381-385.
7. Lee TC, Glynn RJ, Peña JM, et al. Socioeconomic status and incident type 2 diabetes mellitus:data from the Women's Health Study[J]. PLoS One, 2011, 6(12):e27670.
8. Agardh EE, Ahlbom A, Andersson T, et al. Socio-economic position at three points in life in association with type 2 diabetes and impaired glucose tolerance in middle-aged Swedish men and women[J]. Int J Epidemiol, 2007, 36(1):84-92.
9. Leonetti DL, Fujimoto WY, Wahl PW. Early-life background and the development of non-insulin-dependent diabetes mellitus[J]. Am J Phys Anthropol, 1989, 79(3):345-355.
10. Krishnan S, Cozier YC, Rosenberg L, et al. Socioeconomic status and incidence of type 2 diabetes:results from the Black Women's Health Study[J]. Am J Epidemiol, 2010, 171(5):564-570.
11. 袁明霞, 袁申元, 傅汉菁, 等. 北京市社区2型糖尿病患者糖化血红蛋白水平控制现状及其影响因素[J]. 中国糖尿病杂志, 2010, 18(10):752-756.
12. 肖杰. 文化程度对糖尿病控制状况的影响研究[J]. 中华全科医学, 2010, 8(2):220-221.
13. Saydah S, Lochner K. Socioeconomic status and risk of diabetes-related mortality in the U.S[J]. Public Health Rep, 2010, 125(3):377-388.
14. Chaturvedi N, Stephenson JM, Fuller JH. The relationship between socioeconomic status and diabetes control and complications in the EURODIAB IDDM Complications Study[J]. Diabetes Care, 1996, 19(5):423-430.
15. Jeremy JW, Shona JL, Helen MC, et al. Effect of socioeconomic status on mortality among people with type 2 diabetes[J]. Diabetes Care, 2011, 34(5):1127-1132.

West China Medical Journal

Study of Glucose and Insulin Secretion Function in People with Normal Glucose Tolerance with Different Educational Background

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