Clinical analysis on the influencing factors of cognitive impairment in 65 alcohol dependent patients_West China Medical Journal

Authors：

 CAO Bingrong , CHEN Juan , HE Ying , YANG Zi , XIA Ying

Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

CAO Bingrong, Email: roth13579@163.com

Keywords：

Alcohol dependence; Cognitive function; Montreal Cognitive Assessment

DOI：

10.7507/1002-0179.201507149

Video：

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Objective To explore the characteristics of cognitive impairment in patients with alcohol dependence, and analyze the related influencing factors. Methods The Montreal Cognitive Assessment Scale (MoCA) was used to evaluate the cognitive function of 65 alcohol dependent patients hospitalized between January 1st and December 31st, 2014. The features of cognitive impairment and related influencing factors were analyzed. Results The differences of MoCA attention and delayed recall between different drinking year groups had statistical significance (P<0.05). The correlations of drinking year with MoCA attention (r=–0.250,P=0.044), and with delayed recall (r=–0.326,P=0.008) were both negative. MoCA scores, naming, attention and delayed recall were different statistically among different age groups (P<0.05). The correlations of ages with MoCA scores (r=–0.429,P<0.001), naming (r=–0.261,P=0.035), attention (r=–0.391,P=0.001) and delayed recall (r=–0.461,P<0.001) were all negative. MoCA scores, the visuoconstructional skills, language, abstraction and delayed recall were significantly different among different education level groups (P<0.05). The correlations of education level with MoCA scores (r_s=0.650,P<0.001), the visuoconstructional skills (r_s=0.540,P<0.001), language (r_s=0.486,P<0.001), abstraction (r=0.602,P<0.001) and delayed recall (r_s=0.593,P<0.001) were all positive. Ages had an effect on MoCA scores by multiple linear regression analysis (P<0.01). Conclusions For alcohol dependent patients with cognitive impairment, cognitive function is correlated with drinking year, age and education level. The cognitive function is much serious in patients with older age and longer drinking years. This kind of patients should be focused on and intervened early.

Citation： CAO Bingrong, CHEN Juan, HE Ying, YANG Zi, XIA Ying. Clinical analysis on the influencing factors of cognitive impairment in 65 alcohol dependent patients. West China Medical Journal, 2017, 32(5): 731-735. doi: 10.7507/1002-0179.201507149 Copy

1.	李艳祥, 王学义. 酒依赖对认知功能的影响. 中国药物依赖性杂志, 2009, 18(5): 380-383.
2.	Gupta S, Warner J. Alcohol-related dementia: a 21st-century silent epidemic? Br J Psychiatry, 2008, 193(5): 351-353.
3.	黄燕萍. 慢性酒依赖者认知功能的对照研究. 中国行为医学科学, 2005, 14(4): 332-333.
4.	闫社因, 葛金钊, 牛艳, 等. 酒精所致精神障碍患者的 P300、智能损害及相关因素研究. 临床精神医学杂志, 2012, 22(1): 21-23.
5.	张惠光, 张天琦, 商玉洁, 等. 蒙特利尔认知评估量表在评估慢性酒精中毒致认知损害的应用与相关临床因素分析. 中风与神经疾病杂志, 2012, 29(3): 229-231.
6.	孙云闯, 秦斌. MoCA 和 MMSE 在轻度认知障碍中的应用比较. 中国神经免疫学和神经病学杂志, 2010, 17(2): 138-140.
7.	Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc, 2005, 53(4): 695-699.
8.	王伟男, 李喜泼, 丛晓山. 保定市酒精滥用和酒精依赖的流行病学调查. 上海精神医学, 2008, 20(4): 209-212.
9.	黄敬, 栗克清, 刘德芳, 等. 河北省酒精滥用和依赖性障碍流行病学调查. 中国药物滥用防治杂志, 2008, 14(1): 33-34, 58.
10.	华俊杰, 胡峻梅, Coid JW等. 成都市 18-34 岁男性青年酒精滥用影响因素分析. 中国公共卫生, 2014, 30(5): 556-559.
11.	刘刚, 谢世平, 范俭雄, 等. 结构磁共振和¹H-磁共振波谱对酒精性认知损害的研究. 国际精神病学杂志, 2007, 34(4): 228-230.
12.	李艳祥, 王学义, 姚绍敏, 等. 酒依赖者戒饮期认知功能及其相关因素研究. 中国药物依赖性杂志, 2010, 19(2): 100-104.
13.	郭佳翔. 蒙特利尔认知评估量表中文版的初步应用. 北京协和医学院: 中国医学科学院, 2011.
14.	张立秀, 刘雪琴. 蒙特利尔认知评估量表中文版的信效度研究. 护理研究, 2007, 21(31): 2906-2907.

1. 李艳祥, 王学义. 酒依赖对认知功能的影响. 中国药物依赖性杂志, 2009, 18(5): 380-383.
2. Gupta S, Warner J. Alcohol-related dementia: a 21st-century silent epidemic? Br J Psychiatry, 2008, 193(5): 351-353.
3. 黄燕萍. 慢性酒依赖者认知功能的对照研究. 中国行为医学科学, 2005, 14(4): 332-333.
4. 闫社因, 葛金钊, 牛艳, 等. 酒精所致精神障碍患者的 P300、智能损害及相关因素研究. 临床精神医学杂志, 2012, 22(1): 21-23.
5. 张惠光, 张天琦, 商玉洁, 等. 蒙特利尔认知评估量表在评估慢性酒精中毒致认知损害的应用与相关临床因素分析. 中风与神经疾病杂志, 2012, 29(3): 229-231.
6. 孙云闯, 秦斌. MoCA 和 MMSE 在轻度认知障碍中的应用比较. 中国神经免疫学和神经病学杂志, 2010, 17(2): 138-140.
7. Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc, 2005, 53(4): 695-699.
8. 王伟男, 李喜泼, 丛晓山. 保定市酒精滥用和酒精依赖的流行病学调查. 上海精神医学, 2008, 20(4): 209-212.
9. 黄敬, 栗克清, 刘德芳, 等. 河北省酒精滥用和依赖性障碍流行病学调查. 中国药物滥用防治杂志, 2008, 14(1): 33-34, 58.
10. 华俊杰, 胡峻梅, Coid JW等. 成都市 18-34 岁男性青年酒精滥用影响因素分析. 中国公共卫生, 2014, 30(5): 556-559.
11. 刘刚, 谢世平, 范俭雄, 等. 结构磁共振和¹H-磁共振波谱对酒精性认知损害的研究. 国际精神病学杂志, 2007, 34(4): 228-230.
12. 李艳祥, 王学义, 姚绍敏, 等. 酒依赖者戒饮期认知功能及其相关因素研究. 中国药物依赖性杂志, 2010, 19(2): 100-104.
13. 郭佳翔. 蒙特利尔认知评估量表中文版的初步应用. 北京协和医学院: 中国医学科学院, 2011.
14. 张立秀, 刘雪琴. 蒙特利尔认知评估量表中文版的信效度研究. 护理研究, 2007, 21(31): 2906-2907.

West China Medical Journal

Clinical analysis on the influencing factors of cognitive impairment in 65 alcohol dependent patients

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