Analysis of the Correlation between Insulin Resistance and Plasma Homocysteine Level in Patients with Cerebral Infarction_West China Medical Journal

Authors：

 GuChengwu , GuoWeipeng , JiangShijie , YuMing , LiLinlin , FangDengfu

Department of Neurology, Suining Central Hospital, Suining, Sichuan 629000, P. R. China;

Corresponding author：

Keywords：

Brain infarction; Homocysteine; Insulin resistance; Risk factors

DOI：

10.7507/1002-0179.20160002

Video：

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Objective To analyze insulin resistance in patients with cerebral infarction and its correlation with plasma homocysteine level. Methods A total of 100 cerebral infarction patients diagnosed between July 2013 and August 2014 and 100 healthy physical examination subjects were included in our research. The plasma homocysteine level was detected; the levels of fasting plasma glucose and fasting insulin were detected at the same time. Results Plasma homocysteine level (34.95±14.55) μmol/L in patients with cerebral infarction was significantly higher than that of the control group (8.84±2.27) μmol/L (P<0.05). Insulin resistance index (6.24±3.15) in patients with cerebral infarction was significantly higher than that of the control group (2.19±0.63) (P<0.05). The plasma homocysteine level in the infarction group with insulin resistance was significantly higher than that in the infarction group without insulin resistance (P<0.05). The plasma homocysteine level in the infarction group without insulin resistance was significantly higher than that of the patients with insulin resistance in the control group (P<0.05). In the cerebral infarction group, insulin resistance index was positively correlated with plasma homocysteine level (r=0.600, P<0.01). Conclusion Insulin resistance and plasma homocysteine level play important roles in clinical cerebral infarction. Improving insulin resistance and decreasing plasma homocysteine level may be effective ways to reduce the incidence of cerebral infarction.

Citation： GuChengwu, GuoWeipeng, JiangShijie, YuMing, LiLinlin, FangDengfu. Analysis of the Correlation between Insulin Resistance and Plasma Homocysteine Level in Patients with Cerebral Infarction. West China Medical Journal, 2016, 31(1): 7-9. doi: 10.7507/1002-0179.20160002 Copy

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14.	常向云, 尹颖, 孙侃, 等. 不同糖耐量人群血浆前列腺素E2水平及与胰岛素抵抗的关系[J]. 中国糖尿病杂志, 2011, 19(3):213-215.
15.	Li Y, Jiang C, Xu G, et al. Homocysteine upregulates resistin production from adipocytes in vivo and in vivo[J]. Diabetes, 2008, 57(4):817-827.
16.	王蕴慧, 吴惠华, 丁红, 等. 妊娠期胰岛素抵抗及胰岛β细胞功能与体重指数、血脂水平、C反应蛋白的关系探讨[J]. 中华临床医师杂志:电子版, 2011, 5(16):4736-4740.

1. 李广灿, 张玉玲, 张敏, 等. 全国第三次死因回顾抽样调查资料分析Ⅰ:湖北省居民主要病伤死亡原因[J]. 肿瘤防治研究, 2008, 35(增刊1):31-33.
2. 中华医学会神经病学分会脑血管病学组缺血性脑卒中二级预防指南撰写组. 中国缺血性脑卒中和短暂性脑缺血发作二级预防指南2010[J]. 中国医学前沿杂志:电子版, 2011, 3(3):84-93.
3. 顾成武, 郭伟鹏, 蒋世杰, 等. 脑梗死患者血浆同型半胱氨酸水平与颅内动脉粥样硬化的相关性[J]. 华西医学, 2014, 29(2):207-209.
4. 邓美珍, 潘英. 脑梗死患者胰岛素抵抗与脑血流动力学的相关性分析[J]. 中华临床医师杂志:电子版, 2014, 8(19):3462-3465.
5. 沈燕, 黎红华, 徐志鹏, 等. 脑梗死患者胰岛素抵抗与血管内皮功能损伤机制研究[J]. 中风与神经疾病杂志, 2012, 29(9):816-818.
6. 贾伟平. 中国人群胰岛素抵抗的状况[J]. 国外医学:内分泌学分册, 2002, 22(4):264.
7. 许予明, 谭颂, 刘鸣, 等. 脑血管疾病诊断与治疗临床指南[J]. 内科急危重症杂志, 2005, 11(5):243-245.
8. 顾炳权, 王多宁. 血浆同型半胱氨酸水平及临床诊断意义[J]. 中国血液流变学杂志, 2004, 14(4):630-634, 638.
9. 张丽云, 贾颐, 刘建军, 等. 急性脑梗死患者血浆同型半脘氨酸水平及其与改良急性卒中治疗低分子肝素试验病因分型的关系[J]. 华西医学, 2014, 29(2):202-205.
10. 李钢, 张玉平. 胰岛素抵抗与脑梗死关系的临床研究[J]. 华中医学杂志, 2003, 27(5):265-266.
11. 潘英, 魏佳娜, 侯清华, 等. 2型糖尿病伴胰岛素抵抗与脑梗死的关系探讨[J]. 中西医结合心脑血管病杂志, 2014, 12(3):314-316.
12. Caccamo G, Bonura F, Bonura F, et al. Insulin resistance and acute coronary syndrome[J]. Atherosclerosis, 2010, 211(2):672-675.
13. Ustundag S, Arikan E, Sen S, et al. The relationship between the levels of plasma total homocysteine and insulin resistance in uncomplicated mild-to-moderate primary hypertension[J]. J Hum Hypertens, 2006, 20(5):379-381.
14. 常向云, 尹颖, 孙侃, 等. 不同糖耐量人群血浆前列腺素E2水平及与胰岛素抵抗的关系[J]. 中国糖尿病杂志, 2011, 19(3):213-215.
15. Li Y, Jiang C, Xu G, et al. Homocysteine upregulates resistin production from adipocytes in vivo and in vivo[J]. Diabetes, 2008, 57(4):817-827.
16. 王蕴慧, 吴惠华, 丁红, 等. 妊娠期胰岛素抵抗及胰岛β细胞功能与体重指数、血脂水平、C反应蛋白的关系探讨[J]. 中华临床医师杂志:电子版, 2011, 5(16):4736-4740.

West China Medical Journal

Analysis of the Correlation between Insulin Resistance and Plasma Homocysteine Level in Patients with Cerebral Infarction

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