• 1. Department of Nephrology and Endocrinology, Jiangjin District Central Hospital of Chongqing City, Chongqing 402260, P. R. China;
  • 2. Department of Endocrinology, the First Hospital Affiliated to Chongqing Medical University, Chongqing 400016, P. R. China;
RenWei, Email: weiren67@aliyun.com
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Objective To research on the clinical efficacy of gonadotropin releasing hormone (GnRH) pump in the treatment of hypogonadotropic hypogonadism (HH) by using micropulse pump subcutaneous pump Gonadorelin to treat patients with HH. Methods Through the report of one case of GnRH pump treatment patient and related literature review, we studied the effect of GnRH pump therapy and the traditional treatment on HH patients' sex hormone level, secondary sexual characteristics, spermatogenesis and pregnancy rate. Results Through treatment, GnRH pump effectively improved the patient's sex hormone level, secondary sexual characteristics development and sperm production ability, and eventually the patient attained the goal of fertility. The patient had a change in his voice tone; Beard and armpit hair grew out; The patient had a good mood with sexual drive; luteotropic hormone, follicle-stimulating hormone and testosterone became normal. The patient's sperm density was 20×109/L, and the average sperm motility was higher than 30%. Conclusion Pulse pump GnRH conforms to the physiological rhythm of GnRH secretion with a good clinical efficacy and tolerance. So we recommend GnRH pump as the preferential choice for treatment of hypogonadotropic hypogonadism.

Citation: MiaoHongyun, RenWei, DengHuacong, WangZhihong, LongJian, LiBin. Gonadotropin Releasing Hormone Pump in the Treatment of Hypogonadotropic Hypogonadism: A Report of One Case and the Literature Review. West China Medical Journal, 2016, 31(1): 21-24. doi: 10.7507/1002-0179.20160006 Copy

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