Study on the Seasonal Distribution of Multidrug-resistant Organism in Neurosurgical Intensive Care Unit_West China Medical Journal

Authors：

 LüYu , XiangQian , WeiDaoqiong , WuJiayu , ZhouZhonghua , LiuHua ,  WangHui

Nosocomial Infection Management Office, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

WangHui, Email: 1139181198@qq.com

Keywords：

Neurosurgical intensive care unit; Multidrug-resistant organism; Surveillance; Seasonal

DOI：

10.7507/1002-0179.201600111

Video：

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Objective To analyze epidemic characteristics of multidrug-resistant organism (MDRO) in Neurosurgical Intensive Care Unit (NSICU), and to analyze the status of infection and colonization, in order to provide reference for constituting intervention measures. Methods Patients who stayed in NSICU during January 2014 to April 2015 were actively monitored for the MDRO situation. Results A total of 218 MDRO pathogens were isolated from 159 patients, and 42 cases were healthcare-associated infections (HAI) among 159 patients. The Acinetobacter baumannii was the most common one in the isolated acinetobacter. Colonization rate was positively correlated with the incidence of HAI. From January to December, there was a significantly increase in the colonization rate, but not in the incidence of HAI. Conclusion The main MDRO situation is colonization in NSICU. The obvious seasonal variation makes the HAI risk at different levels. So it is necessary that full-time and part-time HAI control staff be on alert, issue timely risk warning, and strengthen risk management. The Acinetobacter baumannii has become the number one target for HAI prevention and control in NSICU, so their apparent seasonal distribution is worthy of more attention, and strict implementation of HAI prevention and control measures should be carried out.

Citation： LüYu, XiangQian, WeiDaoqiong, WuJiayu, ZhouZhonghua, LiuHua, WangHui. Study on the Seasonal Distribution of Multidrug-resistant Organism in Neurosurgical Intensive Care Unit. West China Medical Journal, 2016, 31(3): 403-408. doi: 10.7507/1002-0179.201600111 Copy

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1. 文细毛, 任南, 吴安华, 等. 全国医院感染监控网细菌耐药情况及变化趋势[J]. 中国感染控制杂志, 2009, 8(6):389-396, 408.
2. 刘华, 罗蓓蓓. ICU医院感染多重耐药菌类型、耐药性及感染相关因素研究[J]. 实用医院临床杂志, 2009, 6(3):140-142.
3. 李文郎, 唐恒锋, 王文杰, 等. 神经外科ICU与普通神经外科医院感染病原菌及耐药性对比研究[J]. 中国医药导刊, 2011, 13(11):1957-1958, 1939.
4. 李倩, 武元星, 唐明忠, 等. 神经外科重症监护病房细菌流行及耐药性的20年监测[J]. 临床神经外科杂, 2016, 13(1):49-59.
5. 朱爱萍, 朱彦, 王新民, 等. 多重耐药菌感染监测与预防控制措施[J]. 医药论坛杂志, 2010, 31(20):175-176.
6. 王宏沛, 孟灵, 王鸿玮, 等. 多重耐药菌监测与易感因素的临床研究[J]. 兰州大学学报:医学版, 2005, 31(2):55-56.
7. 孙晓, 张平, 华卫红, 等. 多重耐药菌医院感染相关因素与控制[J]. 现代医药卫生, 2009, 25(16):2535-2536.
8. 中华人民共和国卫生部. WS/T 312-2009医院感染监测规范[S]. 2009.
9. 中华人民共和国卫生部. 关于印发医院感染诊断标准(试行) 的通知[EB/OL]. (2001-11-07)[2014-01-01]. http://www.nhfpc.gov.cn/yzygj/s3593/200804/e19e4448378643a09913ccf2a055c79d.shtml.
10. 中华人民共和国卫生和计划生育委员会. 医院感染管理质量控制指标(2015年版)[EB/OL]. (2015-04-10)[2015-05-01]. http://www.nhfpc.gov.cn/ewebeditor/uploadfile/2015/04/20150415094217171.pdf.
11. Richet H. Seasonality in gram-negative and healthcare-associated infections[J]. Clin Microbiol Infect, 2012, 18(10):934-940.
12. Chazan B, Colodner R, Edelstein H, et al. Seasonal variation in Escherichia coli bloodstream infections in northern Israel[J]. Clin Microbiol Infect, 2011, 17(6):851-854.
13. Ramos GP, Rocha JL, Tuon FF. Seasonal humidity may influence Pseudomonas aeruginosa hospital-acquired infection rates[J]. Int J Infect Dis, 2013, 17(9):e757-e761.
14. 王枢群, 张邦燮. 医院感染学[M]. 重庆:科学技术文献出版社重庆分社, 1990:50-83.
15. Perencevich EN, Mcgregor JC, Shardell M, et al. Summer peaks in the incidences of Gram-negative bacterial infection among hospitalized patients[J]. Infect Control Hosp Epidemiol, 2008, 29(12):1124-1131.
16. McDonald LC, Banerjee SN, Jarvis WR. Seasonal variation of Acinetobacter infections:1987-1996. Nosocomial infections surveillance system[J]. Clin Infect Dis, 1999, 29(5):1133-1137.
17. 蒋国钦. ICU病人鲍曼不动杆菌定植的流行病学特征及危险因素探讨[D]. 苏州:苏州大学, 2011.
18. Fournier PE, Richet H. The epidemiology and control of Acinetobacter baumannii in health care facilities[J]. Clin Infect Dis, 2006, 42(5):692-699.
19. Climo MW, Yokoe DS, Warren DK, et al. Effect of daily chlorhexidine bathing on hospital-acquired infection[J]. N Engl J Med, 2013, 368(6):533-542.
20. Dixon JM, Carver RL. Daily chlorohexidine gluconate bathing with impregnated cloths results in statistically significant reduction in central line-associated bloodstream infections[J]. Am J Infect Control, 2010, 38(10):817-821.

West China Medical Journal

Study on the Seasonal Distribution of Multidrug-resistant Organism in Neurosurgical Intensive Care Unit

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