Comparison between the Effect of Bromfenac Sodium and Fluorometholone after Sub-bowmans Keratomileusis_West China Medical Journal

Authors：

 JiangJun , TangJing , MaKe , LuoChang , WuDongfang ,  DengYingping

Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

DengYingping, Email: dyp558@163.com

Keywords：

Sub-bowmans keratomileusis; Non-steroidal anti-inflammatory drugs; Bromfenac sodium; Fluorometholone

DOI：

10.7507/1002-0179.201600135

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Objective To compare the effect of bromfenac sodium hydrate ophthalmic solution and fluorometholone following sub-bowmans keratomileusis (SBK) from the aspects of subjective visual perception, ophthalmic signs and intraocular pressure. Methods Fifty myopic patients (94 eyes) who underwent SBK from April to May 2013 were divided into two groups according to the different postoperative drug treatment. Patients in group A were treated with bromfenac sodium hydrate (51 eyes), and patients in group B were treated with fluorometholone (43 eyes). To compare the effects of two kinds of drugs after SBK, results of the routine examination were recorded including uncorrected visual acuity (UCVA), refractive status, visual symptoms and signs, intraocular pressure (IOP) and Haze under Corneal Epithelium (HAZE) on pre-operational and postoperative day 1, 7, and 30. Results On the 30th day, IOP in group A and group B were (9.88±2.34) mm Hg (1 mm Hg=0.133 kPa) and (11.00±2.27) mm Hg, respectively, and the difference between the two groups was statistically significant (P<0.05), but there were no statistically significant differences at other time points. There was no statistically significant difference in UCVA, refractive status, visual symptoms and signs, and corneal epithelial staining between the two groups (on day 1, 7, and 30). Conclusion Bromfenac sodium and fluorometholone have the same effect in the control of postoperative visual acuity and ophthalmic inflammation. Bromfenac sodium has greater advantages in IOP control. Therefore, bromfenac sodium can substitute fluorometholone in resisting inflammation after SBK.

Citation： JiangJun, TangJing, MaKe, LuoChang, WuDongfang, DengYingping. Comparison between the Effect of Bromfenac Sodium and Fluorometholone after Sub-bowmans Keratomileusis. West China Medical Journal, 2016, 31(3): 511-515. doi: 10.7507/1002-0179.201600135 Copy

1.	Badalà F, Fioretto M, Macrì A. Effect of topical 0.1% indomethacin solution versus 0.1% fluorometholon acetate on ocular surface and pain control following laser subepithelial keratomileusis (LASEK)[J]. Cornea, 2004, 23(6):550-553.
2.	Fantes FE, Hanna KD, Waring GO, et al. Wound healing after exicmer laser keratiomileusis (photorefractive Keratectomy) in monkeys[J]. Arch Ophthalmol, 1990, 108(5):665-675.
3.	Kim SJ, Flach AJ, Jampol LM. Nonsteroidal anti-inflammatory drugs in ophthalmology[J]. Surv Ophthalmol, 2010, 55(2):108-133.
4.	Donnenfeld ED, Donnenfeld A. Global experience with xibrom (bromfenac ophthalmic solution) 0.09%:the first twice-daily ophthalmic nonsteroidal anti-inflammatory drug[J]. Int Ophthalmol Clin, 2006, 46(4):21-40.
5.	Group Eye Disease Study Research Age-related. Risk factors associated with age-related nuclear and cortical cataract:a case-control study in the Age-Related Eye Disease Study, AREDS Report No. 5[J]. Ophthalmology, 2001, 108(8):1400-1408.
6.	Abelson MB, Butrus SI, Weston JH. Aspirin therapy in vernal conjunctivitis[J]. Am J Ophthalmol, 1983, 95(4):502-505.
7.	Abelson MB, Schaefer K. Conjunctivitis of allergic origin:immunologic mechanisms and current approaches to therapy[J]. Surv Ophthalmol, 1993, 38(Suppl):115-132.
8.	Wang XJ, Wong SH, Givergis R, et al. Evaluation of analgesic efficacy of bromfenac sodium ophthalmic solution 0.09% versus ketorolac tromethamine ophthalmic solution 0.5% following LASEK or Epi-LASIK[J]. Clin Ophthalmol, 2011, 5(4):1451-1457.
9.	Guex-Crosier Y. Non-steroidal anti-inflammatory drugs and ocular inflammation[J]. Klin Monbl Augenheilkd, 2001, 218(5):305-308.
10.	Bakalyan GA, Deshmukh HM, Patterson H, et al. Concentrations of radioactivity in ocular tissues after a single topical dose of ¹⁴C-bromfenac ophthalmic solution[C]//Proceedings of the American Society of Cataract & Refractive Surgery (ASCRS) Meeting. San Francisco, CA:American Society of Cataract & Refractive Surgery, 2006:227.
11.	Mcnamara TR, Baklayan GA, Deshmukh HM, et al. Concentrations of radioactivity in ocular tissues after a single topical dose of ¹⁴C-bromfenac ophthalmic solution[C]//Proceedings of the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. Ft. Lauderdale:Association for Research in Vision and Ophthalmology, 2006:5086.
12.	Ogawa T, Miyake K, Mcnamara TR, et al. Pharmacokinetic profile of topically applied bromfenac sodium ophthalmic solution 0.1% in subijects undergoing cataract surgery[C]//Proceedings of the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. Ft. Lauderdale:Association for Research in Vision and Ophthalmology, 2006:687.
13.	Masuda K, Fukado Y, Shimizu H, et al. Effect of bromfenac sodium ophthalmic solution on inflammation following intraocular lens implantation[J]. Ganka Rinsho Iho (Jpn Rev Clin Ophthalmol), 1997, 91(2):745-750.
14.	Kawaguchi T, Kida T, Nemoto S, et al. Effect of bromfenac sodium ophthalmic solution on ocular inflammation and corneal epithelial barrier function following cataract surgery[J]. Folia Ophthalmol Jpn, 2003, 54(5):276-279.
15.	Takamatsu F, Shiroyama N, Saito Y, et al. Efficacy and adverse effects of bromfenac ophthalmic solution following cataract surgery[J]. Rinsho Ganka (Jpn J Clin Ophthalmol), 2003, 11(8):57.
16.	Ohara K, Ohkuba A, Miyamoto T, et al. Effect of bromfenac sodium on postoperative inflammation[J]. Jpn J Catarac Refract Surg, 2004, 18(5):1-21.
17.	Stewart RH, Walters TR, Cooke DL, et al. Integrated results from two phase Ⅲ studies of topical xibromt 0.1%, an investigational NSAID for post-cataract surgery inflammation[C]//Proceedings of the 108th Annual American Academy of Ophthalmology Meeting. New Orleans, LA:American Academy of Ophthalmology, 2004:22-24.
18.	Donnenfeld ED, Holland EJ, Stewart RH, et al. Topical xibrom 0.1%, an investigational NSAID for post-cataract surgery inflammation, markedly decreases inflammation[C]//Proceedings of the American Society of Cataract & Refractive Surgery (ASCRS) Meeting. Washington, DC:American Society of Cataract & Refractive Surgery, 2005:650-653.
19.	Donnenfeld ED, Holland EJ, Stewart RH, et al. Topical xibromt 0.09% significantly and rapidly decreased post-cataract surgery inflammation and reduced ocular pain[J]. Invest Ophthalmol Vis Sci, 2005, 25(3):46.
20.	Miyake-Kashima M, Takano Y, Tanaka M, et al. Comparison of 0.1% bromfenac sodium and 0.1% pemirolast potassium for the treatment of allergic conjunctivitis[J]. Jpn J Ophthalmol, 2004, 48(6):587-590.
21.	Usui M, Masuda K. Effect of bromfenac sodium (AHR-10282B) eye drops on anterior uveitis[J]. Ganka Rinsho Iho (J Rev Clin Ophthalmol), 1997, 91(4):39-44.
22.	Elman MJ, Raden RZ, Sloan MD, et al. A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema[J]. Ophthalmology, 2008, 115(9):1449.
23.	The DAMAD Study Group. Effect of aspirin alone, aspirin plus dipyridamole in early diabetic retinopathy. A multicenter randomized controlled clinical trial[J]. Diabetes, 1989, 38(4):491-498.
24.	Benson SE, Ratclliffe S, Van Raders P, et al. A randomized comparison of parecoxib/valdecoxib and placebo for the prevention of cystoid macular edema after scleral buckling surgery[J]. Retina, 2009, 29(3):387-394.
25.	Bhagat N, Grigorian RA, Tutela A, et al. Diabetic macular edema:pathogenesis and treatment[J]. Surv Ophthalmol, 2009, 54(1):1-32.
26.	Bielory L, Friedlaender MH. Allergic conjunctivitis[J]. Immunol Allergy Clin North Am, 2008, 28(1):43-58.
27.	Brooks CD, Karl KJ. Hay fever treatment with combined antihistamine and cyclooxygenase-inhibiting drugs[J]. J Allergy Clin Immunol, 1988, 81(6):1110-1117.
28.	Brooks CD, Nelson AL, Metzler C. Effect of flurbiprofen, a cyclooxygenase inhibiting drug, on induced allergic rhinitis[J]. J Allergy Clin Immunol, 1984, 73(5 Pt 1):584-589.
29.	许艳, 张丰菊. 非甾体类抗炎药在角膜屈光手术后的应用[J]. 大连医科大学学报, 2012, 34(2):189-193.

1. Badalà F, Fioretto M, Macrì A. Effect of topical 0.1% indomethacin solution versus 0.1% fluorometholon acetate on ocular surface and pain control following laser subepithelial keratomileusis (LASEK)[J]. Cornea, 2004, 23(6):550-553.
2. Fantes FE, Hanna KD, Waring GO, et al. Wound healing after exicmer laser keratiomileusis (photorefractive Keratectomy) in monkeys[J]. Arch Ophthalmol, 1990, 108(5):665-675.
3. Kim SJ, Flach AJ, Jampol LM. Nonsteroidal anti-inflammatory drugs in ophthalmology[J]. Surv Ophthalmol, 2010, 55(2):108-133.
4. Donnenfeld ED, Donnenfeld A. Global experience with xibrom (bromfenac ophthalmic solution) 0.09%:the first twice-daily ophthalmic nonsteroidal anti-inflammatory drug[J]. Int Ophthalmol Clin, 2006, 46(4):21-40.
5. Group Eye Disease Study Research Age-related. Risk factors associated with age-related nuclear and cortical cataract:a case-control study in the Age-Related Eye Disease Study, AREDS Report No. 5[J]. Ophthalmology, 2001, 108(8):1400-1408.
6. Abelson MB, Butrus SI, Weston JH. Aspirin therapy in vernal conjunctivitis[J]. Am J Ophthalmol, 1983, 95(4):502-505.
7. Abelson MB, Schaefer K. Conjunctivitis of allergic origin:immunologic mechanisms and current approaches to therapy[J]. Surv Ophthalmol, 1993, 38(Suppl):115-132.
8. Wang XJ, Wong SH, Givergis R, et al. Evaluation of analgesic efficacy of bromfenac sodium ophthalmic solution 0.09% versus ketorolac tromethamine ophthalmic solution 0.5% following LASEK or Epi-LASIK[J]. Clin Ophthalmol, 2011, 5(4):1451-1457.
9. Guex-Crosier Y. Non-steroidal anti-inflammatory drugs and ocular inflammation[J]. Klin Monbl Augenheilkd, 2001, 218(5):305-308.
10. Bakalyan GA, Deshmukh HM, Patterson H, et al. Concentrations of radioactivity in ocular tissues after a single topical dose of ¹⁴C-bromfenac ophthalmic solution[C]//Proceedings of the American Society of Cataract & Refractive Surgery (ASCRS) Meeting. San Francisco, CA:American Society of Cataract & Refractive Surgery, 2006:227.
11. Mcnamara TR, Baklayan GA, Deshmukh HM, et al. Concentrations of radioactivity in ocular tissues after a single topical dose of ¹⁴C-bromfenac ophthalmic solution[C]//Proceedings of the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. Ft. Lauderdale:Association for Research in Vision and Ophthalmology, 2006:5086.
12. Ogawa T, Miyake K, Mcnamara TR, et al. Pharmacokinetic profile of topically applied bromfenac sodium ophthalmic solution 0.1% in subijects undergoing cataract surgery[C]//Proceedings of the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. Ft. Lauderdale:Association for Research in Vision and Ophthalmology, 2006:687.
13. Masuda K, Fukado Y, Shimizu H, et al. Effect of bromfenac sodium ophthalmic solution on inflammation following intraocular lens implantation[J]. Ganka Rinsho Iho (Jpn Rev Clin Ophthalmol), 1997, 91(2):745-750.
14. Kawaguchi T, Kida T, Nemoto S, et al. Effect of bromfenac sodium ophthalmic solution on ocular inflammation and corneal epithelial barrier function following cataract surgery[J]. Folia Ophthalmol Jpn, 2003, 54(5):276-279.
15. Takamatsu F, Shiroyama N, Saito Y, et al. Efficacy and adverse effects of bromfenac ophthalmic solution following cataract surgery[J]. Rinsho Ganka (Jpn J Clin Ophthalmol), 2003, 11(8):57.
16. Ohara K, Ohkuba A, Miyamoto T, et al. Effect of bromfenac sodium on postoperative inflammation[J]. Jpn J Catarac Refract Surg, 2004, 18(5):1-21.
17. Stewart RH, Walters TR, Cooke DL, et al. Integrated results from two phase Ⅲ studies of topical xibromt 0.1%, an investigational NSAID for post-cataract surgery inflammation[C]//Proceedings of the 108th Annual American Academy of Ophthalmology Meeting. New Orleans, LA:American Academy of Ophthalmology, 2004:22-24.
18. Donnenfeld ED, Holland EJ, Stewart RH, et al. Topical xibrom 0.1%, an investigational NSAID for post-cataract surgery inflammation, markedly decreases inflammation[C]//Proceedings of the American Society of Cataract & Refractive Surgery (ASCRS) Meeting. Washington, DC:American Society of Cataract & Refractive Surgery, 2005:650-653.
19. Donnenfeld ED, Holland EJ, Stewart RH, et al. Topical xibromt 0.09% significantly and rapidly decreased post-cataract surgery inflammation and reduced ocular pain[J]. Invest Ophthalmol Vis Sci, 2005, 25(3):46.
20. Miyake-Kashima M, Takano Y, Tanaka M, et al. Comparison of 0.1% bromfenac sodium and 0.1% pemirolast potassium for the treatment of allergic conjunctivitis[J]. Jpn J Ophthalmol, 2004, 48(6):587-590.
21. Usui M, Masuda K. Effect of bromfenac sodium (AHR-10282B) eye drops on anterior uveitis[J]. Ganka Rinsho Iho (J Rev Clin Ophthalmol), 1997, 91(4):39-44.
22. Elman MJ, Raden RZ, Sloan MD, et al. A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema[J]. Ophthalmology, 2008, 115(9):1449.
23. The DAMAD Study Group. Effect of aspirin alone, aspirin plus dipyridamole in early diabetic retinopathy. A multicenter randomized controlled clinical trial[J]. Diabetes, 1989, 38(4):491-498.
24. Benson SE, Ratclliffe S, Van Raders P, et al. A randomized comparison of parecoxib/valdecoxib and placebo for the prevention of cystoid macular edema after scleral buckling surgery[J]. Retina, 2009, 29(3):387-394.
25. Bhagat N, Grigorian RA, Tutela A, et al. Diabetic macular edema:pathogenesis and treatment[J]. Surv Ophthalmol, 2009, 54(1):1-32.
26. Bielory L, Friedlaender MH. Allergic conjunctivitis[J]. Immunol Allergy Clin North Am, 2008, 28(1):43-58.
27. Brooks CD, Karl KJ. Hay fever treatment with combined antihistamine and cyclooxygenase-inhibiting drugs[J]. J Allergy Clin Immunol, 1988, 81(6):1110-1117.
28. Brooks CD, Nelson AL, Metzler C. Effect of flurbiprofen, a cyclooxygenase inhibiting drug, on induced allergic rhinitis[J]. J Allergy Clin Immunol, 1984, 73(5 Pt 1):584-589.
29. 许艳, 张丰菊. 非甾体类抗炎药在角膜屈光手术后的应用[J]. 大连医科大学学报, 2012, 34(2):189-193.

West China Medical Journal

Comparison between the Effect of Bromfenac Sodium and Fluorometholone after Sub-bowmans Keratomileusis

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