不适宜的左心室质量_West China Medical Journal

Authors：

 衡越 ¹ , 黄宝涛 ² ,  陈茂 ²

1. ;
2. ;

Corresponding author：

衡越, Email: 21837869@qq.com; 陈茂, Email: hmaochen@vip.sina.com

Keywords：

不适宜的左心室质量; 左心室肥厚; 心力衰竭

DOI：

10.7507/1002-0179.201600156

Video：

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Abstract Full text Figures/Tables Video References Cited by

心血管疾病是严重危害人类健康的疾病之一，冠状动脉粥样硬化性心脏病、高血压、心肌肥厚、心力衰竭等疾病的发病率呈逐年上升趋势，临床上，正确地对心血管疾病进行风险分层具有重大意义。相较于正常左心室质量的人群而言，并非所有的左心室肥厚均会增加患者心血管不良事件（心肌梗死、卒中、室性心律失常、心力衰竭、心源性死亡等）的发生率。不适宜的左心室质量（iLVM），是指某一个体的左心室质量超过个人血流动力学负荷所能代偿部分的一种状态。iLVM不仅与左心室构型异常及心脏收缩及舒张功能障碍密切相关，而且预示了较高的心血管疾病风险。评估iLVM能够提高对患者潜在心血管疾病的识别能力并及时提示医生采取干预措施，有利于减缓及逆转左心室肥厚的发展，一定程度上减少不良心血管事件的发生，对于降低患者的心血管疾病的发病率和病死率，改善长期预后具有重要的临床意义。现就iLVM的研究进展进行综述。

Citation： 衡越, 黄宝涛, 陈茂. 不适宜的左心室质量. West China Medical Journal, 2016, 31(3): 586-588. doi: 10.7507/1002-0179.201600156 Copy

1.	Bang CN, Gerdts E, Aurigemma GP, et al. Four-group classification of left ventricular hypertrophy based on ventricular concentricity and dilatation identifies a low-risk subset of eccentric hypertrophy in hypertensive patients[J]. Circ Cardiovasc Imaging, 2014, 7(3) :422-429.
2.	Huang BT, Peng Y, Liu W, et al. Inappropriate left ventricular mass and poor outcomes in patients with angina pectoris and normal ejection fraction[J]. Coron Artery Dis, 2015, 26(2) :163-169.
3.	Masugata H, Senda S, Inukai M, et al. Differences in left ventricular diastolic dysfunction between eccentric and concentric left ventricular hypertrophy in hypertensive patients with preserved systolic function[J]. J Int Med Res, 2011, 39(3) :772-779.
4.	Palmieri V, de Simone G, Roman MJ, et al. Ambulatory blood pressure and metabolic abnormalities in hypertensive subjects with inappropriately high left ventricular mass[J]. Hypertension, 1999, 34(5) :1032-1040.
5.	Libhaber CD, Norton GR, Maseko MJ, et al. Relationship between inappropriate left ventricular hypertrophy and ejection fraction Independent of absolute or indexed mass in a community sample of black African ancestry[J]. J Hypertens, 2013, 31(1) :169-176.
6.	Galderisi M, de Simone G, Cicala S, et al. Coronary flow reserve in hypertensive patients with appropriate or inappropriate left ventricular mass[J]. J Hypertens, 2003, 21(11) :2183-2188.
7.	Muiesan ML, de Simone G, Ganau A, et al. Inappropriate left ventricular mass:reliability and limitations of echocardiographic measurement for risk stratification and follow-up in single patients[J]. J Hypertens, 2006, 24(11) :2293-2298.
8.	Mureddu GF, Pasanisi F, Palmieri V, et al. Appropriate or inappropriate left ventricular mass in the presence or absence of prognostically adverse left ventricular hypertrophy[J]. J Hypertens, 2001, 19(6) :1113-1119.
9.	de Simone G, Devereux RB, Kimball TR, et al. Interaction between body size and cardiac workload:influence on left ventricular mass during body growth and adulthood[J]. Hypertension, 1998, 31(5) :1077-1082.
10.	de Simone G, Verdecchia P, Pede S, et al. Prognosis of inappropriate left ventricular mass in hypertension:the MAVI Study[J]. Hypertension, 2002, 40(4) :470-476.
11.	Palmieri V, Wachtell K, Gerdts E, et al. Left ventricular function and hemodynamic features of inappropriate left ventricular hypertrophy in patients with systemic hypertension:the LIFE study[J]. Am Heart J, 2001, 141(5) :784-791.
12.	Woodiwiss AJ, Libhaber CD, Libhaber E, et al. Relationship between on-treatment decreases in inappropriate versus absolute or indexed left ventricular mass and increases in ejection fraction in hypertension[J]. Hypertension, 2012, 60(3) :810-817.
13.	Celentano A, Palmieri V, Esposito ND, et al. Inappropriate left ventricular mass in normotensive and hypertensive patients[J]. Am J Cardiol, 2001, 87(3) :361-363, A10.
14.	de Simone G, Kitzman DW, Palmieri V, et al. Association of inappropriate left ventricular mass with systolic and diastolic dysfunction:the HyperGEN study[J]. Am J Hypertens, 2004, 17(9) :828-833.
15.	Hung CS, Ho YL, Chang YY, et al. Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism[J]. Sci World J 2013, 2013:294594.
16.	Celentano A, Pietropaolo I, Palmieri V, et al. Inappropriate left ventricular mass and angiotensin converting enzyme gene polymorphism[J]. J Hum Hypertens, 2001, 15(11) :811-813.
17.	Gregori M, Tocci G, Befani A, et al. Synergic effect of high renin and aldosterone levels on inappropriate left ventricular mass and systolic function:a tissue Doppler study[J]. Int J Cardiol, 2013, 168(5) :4934-4936.
18.	Paneni F, Gregori M, Marra A, et al. Preclinical effects of healthy obesity on inappropriate left ventricular mass and systolic function[J]. Int J Cardiol, 2013, 167(6) :3047-3049.
19.	Ratto E, Leoncini G, Viazzi F, et al. Inappropriate left ventricular mass is associated with microalbuminuria independently of left ventricular hypertrophy in primary hypertension[J]. J Hypertens, 2008, 26(2) :345-350.
20.	Su HM, Lin TH, Hsu PC, et al. Association of chronic kidney disease and peripheral artery disease with inappropriate left ventricular mass[J]. PLoS One, 2012, 7(10) :e48422.
21.	Mureddu GF, Cioffi G, Stefenelli C, et al. Compensatory or inappropriate left ventricular mass in different models of left ventricular pressure overload:comparison between patients with aortic stenosis and arterial hypertension[J]. J Hypertens, 2009, 27(3) :642-649.
22.	López B, Castellano JM, González A, et al. Association of increased plasma cardiotrophin-1 with inappropriate left ventricular mass in essential hypertension[J]. Hypertension, 2007, 50(5) :977-983.
23.	Muiesan ML, Salvetti M, Paini A, et al. Inappropriate left ventricular mass in patients with primary aldosteronism[J]. Hypertension, 2008, 52(3) :529-534.
24.	Olsen MH, Wachtell K, de Simone G, et al. Is inappropriate left ventricular mass related to neurohormonal factors and/or arterial changes in hypertension? A LIFE substudy[J]. J Hum Hypertens, 2004, 18(6) :437-443.
25.	Muiesan ML, Salvetti M, Paini A, et al. Inappropriate left ventricular mass changes during treatment adversely affects cardiovascular prognosis in hypertensive patients[J]. Hypertension, 2007, 49(5) :1077-1083.

1. Bang CN, Gerdts E, Aurigemma GP, et al. Four-group classification of left ventricular hypertrophy based on ventricular concentricity and dilatation identifies a low-risk subset of eccentric hypertrophy in hypertensive patients[J]. Circ Cardiovasc Imaging, 2014, 7(3) :422-429.
2. Huang BT, Peng Y, Liu W, et al. Inappropriate left ventricular mass and poor outcomes in patients with angina pectoris and normal ejection fraction[J]. Coron Artery Dis, 2015, 26(2) :163-169.
3. Masugata H, Senda S, Inukai M, et al. Differences in left ventricular diastolic dysfunction between eccentric and concentric left ventricular hypertrophy in hypertensive patients with preserved systolic function[J]. J Int Med Res, 2011, 39(3) :772-779.
4. Palmieri V, de Simone G, Roman MJ, et al. Ambulatory blood pressure and metabolic abnormalities in hypertensive subjects with inappropriately high left ventricular mass[J]. Hypertension, 1999, 34(5) :1032-1040.
5. Libhaber CD, Norton GR, Maseko MJ, et al. Relationship between inappropriate left ventricular hypertrophy and ejection fraction Independent of absolute or indexed mass in a community sample of black African ancestry[J]. J Hypertens, 2013, 31(1) :169-176.
6. Galderisi M, de Simone G, Cicala S, et al. Coronary flow reserve in hypertensive patients with appropriate or inappropriate left ventricular mass[J]. J Hypertens, 2003, 21(11) :2183-2188.
7. Muiesan ML, de Simone G, Ganau A, et al. Inappropriate left ventricular mass:reliability and limitations of echocardiographic measurement for risk stratification and follow-up in single patients[J]. J Hypertens, 2006, 24(11) :2293-2298.
8. Mureddu GF, Pasanisi F, Palmieri V, et al. Appropriate or inappropriate left ventricular mass in the presence or absence of prognostically adverse left ventricular hypertrophy[J]. J Hypertens, 2001, 19(6) :1113-1119.
9. de Simone G, Devereux RB, Kimball TR, et al. Interaction between body size and cardiac workload:influence on left ventricular mass during body growth and adulthood[J]. Hypertension, 1998, 31(5) :1077-1082.
10. de Simone G, Verdecchia P, Pede S, et al. Prognosis of inappropriate left ventricular mass in hypertension:the MAVI Study[J]. Hypertension, 2002, 40(4) :470-476.
11. Palmieri V, Wachtell K, Gerdts E, et al. Left ventricular function and hemodynamic features of inappropriate left ventricular hypertrophy in patients with systemic hypertension:the LIFE study[J]. Am Heart J, 2001, 141(5) :784-791.
12. Woodiwiss AJ, Libhaber CD, Libhaber E, et al. Relationship between on-treatment decreases in inappropriate versus absolute or indexed left ventricular mass and increases in ejection fraction in hypertension[J]. Hypertension, 2012, 60(3) :810-817.
13. Celentano A, Palmieri V, Esposito ND, et al. Inappropriate left ventricular mass in normotensive and hypertensive patients[J]. Am J Cardiol, 2001, 87(3) :361-363, A10.
14. de Simone G, Kitzman DW, Palmieri V, et al. Association of inappropriate left ventricular mass with systolic and diastolic dysfunction:the HyperGEN study[J]. Am J Hypertens, 2004, 17(9) :828-833.
15. Hung CS, Ho YL, Chang YY, et al. Twenty-four-hour urinary aldosterone predicts inappropriate left ventricular mass index in patients with primary aldosteronism[J]. Sci World J 2013, 2013:294594.
16. Celentano A, Pietropaolo I, Palmieri V, et al. Inappropriate left ventricular mass and angiotensin converting enzyme gene polymorphism[J]. J Hum Hypertens, 2001, 15(11) :811-813.
17. Gregori M, Tocci G, Befani A, et al. Synergic effect of high renin and aldosterone levels on inappropriate left ventricular mass and systolic function:a tissue Doppler study[J]. Int J Cardiol, 2013, 168(5) :4934-4936.
18. Paneni F, Gregori M, Marra A, et al. Preclinical effects of healthy obesity on inappropriate left ventricular mass and systolic function[J]. Int J Cardiol, 2013, 167(6) :3047-3049.
19. Ratto E, Leoncini G, Viazzi F, et al. Inappropriate left ventricular mass is associated with microalbuminuria independently of left ventricular hypertrophy in primary hypertension[J]. J Hypertens, 2008, 26(2) :345-350.
20. Su HM, Lin TH, Hsu PC, et al. Association of chronic kidney disease and peripheral artery disease with inappropriate left ventricular mass[J]. PLoS One, 2012, 7(10) :e48422.
21. Mureddu GF, Cioffi G, Stefenelli C, et al. Compensatory or inappropriate left ventricular mass in different models of left ventricular pressure overload:comparison between patients with aortic stenosis and arterial hypertension[J]. J Hypertens, 2009, 27(3) :642-649.
22. López B, Castellano JM, González A, et al. Association of increased plasma cardiotrophin-1 with inappropriate left ventricular mass in essential hypertension[J]. Hypertension, 2007, 50(5) :977-983.
23. Muiesan ML, Salvetti M, Paini A, et al. Inappropriate left ventricular mass in patients with primary aldosteronism[J]. Hypertension, 2008, 52(3) :529-534.
24. Olsen MH, Wachtell K, de Simone G, et al. Is inappropriate left ventricular mass related to neurohormonal factors and/or arterial changes in hypertension? A LIFE substudy[J]. J Hum Hypertens, 2004, 18(6) :437-443.
25. Muiesan ML, Salvetti M, Paini A, et al. Inappropriate left ventricular mass changes during treatment adversely affects cardiovascular prognosis in hypertensive patients[J]. Hypertension, 2007, 49(5) :1077-1083.

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