Clinical Efficacy of Glucosamine Hydrochloride Tablets in Treating Knee Cartilage Injury Caused by Rheumatoid Arthritis_West China Medical Journal

Authors：

 XianPing ,  XiangYuanbing , HuangChaoli , GuLi

Department of Rheumatology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610081, P. R. China;

Corresponding author：

XiangYuanbing, Email: 527455958@qq.com

Keywords：

Rheumatoid arthritis; Knee cartilage injury; Glucosamine hydrochloride

DOI：

10.7507/1002-0179.201600227

Video：

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Objective To investigate the clinical efficacy of glucosamine hydrochloride tablets in treating knee cartilage injury resulting from rheumatoid arthritis. Methods We selected 200 knee cartilage injury patients with rheumatoid arthritis treated in our hospital from January 2011 to January 2015 as the research subjects. They were divided into control group (n=98) and observation group (n=102) according to the time of admission. The control group was treated with conventional disease modifying anti-rheumatic drugs (DMARDs), while the observation group was treated with glucosamine hydrochloride tablets on the basis of DMARDs. The treatment effect was evaluated and compared between the two groups of patients 18, 36 and 54 weeks after the treatment. Results Fifty-four weeks later, knee pain score of the observation group was better than that of the control group, and the difference was statistically significant (P ＜ 0.05) . The observation group had a lower Noyes evaluation level than the control group, and the difference was statistically significant (P ＜ 0.05) . Adverse reaction in the observation group was 3.92% and it was 3.06% in the control group, and the difference between the two groups was not statistically significant (P ＞ 0.05) . Conclusion Glucosamine hydrochloride tablets combined with conventional anti-rheumatic treatment is effective for knee cartilage injury caused by rheumatoid arthritis, which can promote cartilage repair, and it is worthy of clinical application.

Citation： XianPing, XiangYuanbing, HuangChaoli, GuLi. Clinical Efficacy of Glucosamine Hydrochloride Tablets in Treating Knee Cartilage Injury Caused by Rheumatoid Arthritis. West China Medical Journal, 2016, 31(5): 831-834. doi: 10.7507/1002-0179.201600227 Copy

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5.	崔延安, 刘钊, 刘红霞, 等. 骨髓间充质干细胞移植膝类风湿关节炎兔: 关节滑膜体积和软骨厚度的MRI评价[J] . 中国组织工程研究与临床康复, 2011, 15(6) : 1024-1029.
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7.	付昌马, 钱春生, 章有才, 等. 微骨折术联合玻璃酸钠注射修复膝关节软骨损伤[J]. 中国实用医刊, 2013, 40(3) : 34-37.
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9.	王植, 孟祥虹, 锁咏梅, 等. 膝关节类风湿关节炎与骨关节炎MRI 对比研究[J]. 国际医学放射学杂志, 2013, 36(5) : 409-413.
10.	韩贵和, 顾军, 魏威. 盐酸氨基葡萄糖治疗膝骨关节炎的临床研究[J]. 中国骨肿瘤骨病, 2010, 9(3) : 245-247.
11.	Nishioka H, Hirose J, Nakamura E, et al. Detecting ICRS grade 1 cartilage lesions in anterior cruciate ligament injury using T1ρ and T2 mapping[J]. Eur J Radiol, 2013, 82(9) : 1499-1505.
12.	康锦, 汤守营, 张绪斌, 等. 膝关节内骨折软骨下骨与软骨粉碎性损伤结构修复及疗效分析[J]. 医学综述, 2010, 16(17) : 2719-2720.
13.	Huebner KD, Shrive NG, Frank CB. New surgical model of posttraumatic osteoarthritis: isolated intra-articular bone injury in the rabbit[J]. J Orthop Res, 2013, 31(6) : 914-920.

1. Arøen A, Løken S, Heir S, et al. Articular cartilage lesions in 993 consecutive knee arthroscopies[J]. Am J Sports Med, 2004, 32(1) : 211-215.
2. 中华医学会风湿病学分会. 类风湿性关节炎诊断及治疗指南[J]. 中华风湿病学杂志, 2012, 16(2) : 4-8.
3. 丁明, 徐虎, 王迎春, 等. 前交叉韧带断裂并发膝关节软骨损伤的影响因素[J]. 中华创伤杂志, 2015, 31(6) : 512-516.
4. Noyes FR, Stabler CL. A system for grading articular cartilage lesions at arthroscopy[J]. Am J Sports Med, 1989, 17(4) : 505-513.
5. 崔延安, 刘钊, 刘红霞, 等. 骨髓间充质干细胞移植膝类风湿关节炎兔: 关节滑膜体积和软骨厚度的MRI评价[J] . 中国组织工程研究与临床康复, 2011, 15(6) : 1024-1029.
6. 易守红, 郭林, 陈光兴, 等. 2479例膝关节镜手术患者关节软骨损伤的流行病学分布特征[J]. 第三军医大学学报, 2011, 33(9) : 957-960.
7. 付昌马, 钱春生, 章有才, 等. 微骨折术联合玻璃酸钠注射修复膝关节软骨损伤[J]. 中国实用医刊, 2013, 40(3) : 34-37.
8. 周钟珩, 崔延安, 刘钊, 等. 骨髓间充质干细胞治疗兔膝RA模型软骨损伤的MRI评价[J]. 中国临床医学影像杂志, 2011, 22(7) : 479-482.
9. 王植, 孟祥虹, 锁咏梅, 等. 膝关节类风湿关节炎与骨关节炎MRI 对比研究[J]. 国际医学放射学杂志, 2013, 36(5) : 409-413.
10. 韩贵和, 顾军, 魏威. 盐酸氨基葡萄糖治疗膝骨关节炎的临床研究[J]. 中国骨肿瘤骨病, 2010, 9(3) : 245-247.
11. Nishioka H, Hirose J, Nakamura E, et al. Detecting ICRS grade 1 cartilage lesions in anterior cruciate ligament injury using T1ρ and T2 mapping[J]. Eur J Radiol, 2013, 82(9) : 1499-1505.
12. 康锦, 汤守营, 张绪斌, 等. 膝关节内骨折软骨下骨与软骨粉碎性损伤结构修复及疗效分析[J]. 医学综述, 2010, 16(17) : 2719-2720.
13. Huebner KD, Shrive NG, Frank CB. New surgical model of posttraumatic osteoarthritis: isolated intra-articular bone injury in the rabbit[J]. J Orthop Res, 2013, 31(6) : 914-920.

West China Medical Journal

Clinical Efficacy of Glucosamine Hydrochloride Tablets in Treating Knee Cartilage Injury Caused by Rheumatoid Arthritis

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