Analysis of Allergens of Melanosis in 56 Cases_West China Medical Journal

Authors：

 HuaXia ^1,2 , ZhouHui ¹ ,  ZhangYizhi ¹

1. Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Dermatology, Chengdu Second People’s Hospital, Chengdu, Sichuan 610017, P. R. China;

Corresponding author：

ZhangYizhi, Email: yizhi5202@sina.com

Keywords：

Melanosis; Metal; Clinical analysis

DOI：

10.7507/1002-0179.201600239

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the contact allergens of melanosis. Methods Fifty-six patients confirmed with melanosis between June 2010 and October 2013 received patch test and BICOM test, and the results were analyzed statistically and clinical data of the included patients were retrospectively analyzed. Results Of the 56 patients, 50 patch tests and 40 BICOM tests were positive. The top three chemical allergic resources in patch test of these patients were nickel sulfate (33.9%), aluminum (21.4%), and potassium dichromate (16.1%). The positive rates of male patients with aluminum, rubber compounds and cobalt chloride were significantly higher than those of females. The positive rate of female patients with nickel sulfate was significantly higher than that of males. The differences were all significant (P＜0.05) . Conclusion Nickel sulfate, aluminum and potassium dichromate may be the main allergens of melanosis.

Citation： HuaXia, ZhouHui, ZhangYizhi. Analysis of Allergens of Melanosis in 56 Cases. West China Medical Journal, 2016, 31(5): 880-884. doi: 10.7507/1002-0179.201600239 Copy

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1. 王文岭, 杨蓉娅. 28例皮肤黑变病例临床、病理和诊断研究[J]. 实用皮肤病学杂志, 2011, 4(1) : 9-11.
2. 赵辨. 中国临床皮肤病学[M]. 南京: 江苏科学技术出版社, 2010: 243-1250.
3. 陈新, 王洋, 王慧娟, 等. 还原型谷胱甘肽联合多烯磷脂酰胆碱治疗职业性黑变病疗效[J]. 中国职业医学, 2013, 40(3) : 216-217.
4. Imokawa G, Ishida K. Inhibitors of intracellular signaling pathways that lead to stimulated epidermal pigmentation: perspective of antipigmenting agents[J]. Int J Mol Sci, 2014, 15(5) : 8293-8315.
5. 胡瑚, 刘秀红. 黑变病临床分析[J]. 云南医药, 2013, 34(6) : 511.
6. 杨国亮, 王侠生. 现代皮肤病学[M]. 上海: 上海医科大学出版社, 1998: 449．.
7. Seghers AC, Lee JS, Tan CS, et al. atopic dirty neck or acquired atopic hyperpigmentation? An epidemiological and clinical study from the National Skin Centre in Singapore[J]. Dermatology, 2014 , 229(3) : 174.
8. 孙玉德. １例黑变病愈后复发的病因分析[J]. 齐齐哈尔医学院学报, 2012, 33(6) : 838.
9. 宋月星, 高焕学, 邹先彪. 职业性黑变病一例[J]. 实用皮肤病学杂志, 2014, 7(1) : 63-64.
10. 王朋, 权哲, 黄简抒. 苯并呋喃酮致职业性接触性皮炎20例临床分析[J]. 工业卫生与职业病杂志, 2012, 38(2) : 118-119.
11. 聂灵聪, 吴咏兰. 中毒性黑变病11例临床分析[J]. 内蒙古医学杂志, 2002, 34(5) : 458.
12. 陈捷, 韦建华, 覃卫平, 等. 20例职业性黑变病临床观察[J]. 中国职业医学, 2010, 37(5) : 398-400.
13. 兰雅璐, 王璐, 李巍. 面部皮炎患者123例斑贴试验分析[J]. 中国美容医学, 2013, 22(7) : 743-746.
14. Hallab NJ, Caicedo M, Epstein R. Invitro reactivity to implant metals demonstrates a person-dependent association with both T-Cell and B-Cell activation[J]. J Biomed Mater Res, 2010, 92(2) : 667-682．.
15. 胡燕, 夏汝山, 陆雪芬, 等. 颜面再发性皮炎665例接触性变应原分析[J]. 中国皮肤性病学杂志, 2013, 27(5) : 472-474.
16. Hostynek J. Sensitization to nickel etiology, epidemiology, immune reactions, prevention, and therapy[J]. Rev Environ Health, 2006, 21(4) : 253-280.
17. Wang L, Xu AE. Four views of Riehl’s melanosis: clinical appearance, dermoscopy, confocal microscopy and histopathology[J]. J Eur Acad Dermatol Venereol, 2014 , 28(9) : 1199-1206.
18. 李波, 谭军, 钟茜, 等. 调Q1064nm激光治疗面部皮肤黑变病临床观察[J]. 中国美容医学, 2014, 23(7) : 551-553.

West China Medical Journal

Analysis of Allergens of Melanosis in 56 Cases

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