1. |
Breitfeld D, Ohl L, Kremmer E, et al. Follicular B helper T cells Express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production[J]. J Exp Med, 2000, 192(11) : 1545-1552.
|
2. |
Allen CD, Okada T, Cyster JG. Germinal-center organization and cellular dynamics[J]. Immunity, 2007, 27(2) :190-202.
|
3. |
Linterman MA, Liston A, Vinuesa CG. T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells[J]. Immunol Rev, 2012, 247(1) :143-159.
|
4. |
Murphy KM, Reiner SL. The lineage decisions of helper T cells[J]. Nat Rev Immunol, 2002, 2(12) :933-944.
|
5. |
King C, Tangye SG, Mackay CR. T follicular helper (TFH) cells in normal and dysregulated immune responses[J]. Annu Rev Immunol, 2008, 26:741-766.
|
6. |
Kim CH, Rott LS, Clark-Lewis I, et al. Subspecialization of CXCR5+ T cells:B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells[J]. J Exp Med, 2001, 193(12) :1373-1381.
|
7. |
Akiba H, Takeda K, Kojima Y, et al. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo[J]. J Immunol, 2005, 175(4) :2340-2348.
|
8. |
Dong C, Juedes AE, Temann UA, et al. ICOS co-stimulatory receptor is essential for T-cell activation and function[J]. Nature, 2001, 409(6816) :97-101.
|
9. |
Bauquet AT, Jin H, Paterson AM, et al. Costimulatory molecule ICOS plays a critical role in the development of TH-17 and follicular T-helper cells by regulating c-Maf expression and IL-21 production[J]. Nat Immunol, 2009, 10(2) :167.
|
10. |
Haymaker C, Wu R, Bernatchez C, et al. PD-1 and BTLA and CD8+ T-cell "exhaustion" in cancer:"Exercising" an alternative viewpoint[J]. Oncoimmunology, 2012, 1(5) :735-738.
|
11. |
Riella LV, Paterson AM, Sharpe AH, et al. Role of the PD-1 pathway in the immune response[J]. Am J Transplant, 2012, 12(10) :2575-2587.
|
12. |
Renshaw BR, Fanslow WC, Armitage RJ, et al. Humoral immune responses in CD40 ligand-deficient mice[J]. J Exp Med, 1994, 180(5) :1889-1900.
|
13. |
Kawabe T, Naka T, Yoshida K, et al. The immune responses in CD40-deficient mice:impaired immunoglobulin class switching and germinal center formation[J]. Immunity, 1994, 1(3) :167-178.
|
14. |
Bryant VL, Ma CS, Avery DT, et al. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells:predominant role of IL-21 produced by CXCR5+ T follicular helper cells[J]. J Immunol, 2007, 179(12) :8180-8190.
|
15. |
Liu Y, Zhu T, Cai G, et al. Elevated circulating CD4+ ICOS+ Foxp3+ T cells contribute to overproduction of IL-10 and are correlated with disease severity in patients with systemic lupus erythematosus[J]. Lupus, 2011, 20(6) :620-627.
|
16. |
Ettinger R, Sims GP, Fairhurst AM, et al. IL-21 induces differentiation of human naive and memory B cells into antibodysecreting plasma cells[J]. J Immunol, 2005, 175(12) :7867-7879.
|
17. |
Kuchen S, Robbins R, Sims GP, et al. Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration[J]. J Immunol, 2007, 179(9) :5886-5896.
|
18. |
Suto A, Kashiwakuma D, Kagami S, et al. Development and characterization of IL-21-producing CD4+ T cells[J]. J Exp Med, 2008, 205(6) :1369-1379.
|
19. |
Eto D, Lao C, Ditoro D, et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation[J]. PLoS One, 2011, 6(3) : e17739.
|
20. |
Kusam S, Toney LM, Sato H, et al. Inhibition of Th2 differentiation and GATA-3 expression by BCL-6[J]. J Immunol, 2003, 170(5) : 2435-2441.
|
21. |
Dent AL, Shaffer AL, Yu X, et al. Control of inflammation, cytokine expression, and germinal center formation by BCL-6[J]. Science, 1997, 276(5312) :589-592.
|
22. |
Ozaki K, Spolski R, Ettinger R, et al. Regulation of B cell differentiation and plasma cell Generation by IL-21, a novel inducer of Blimp-1 and Bcl-6[J]. J Immunol, 2004, 173(9) :5361-5371.
|
23. |
Luther SA, Bidgol A, Hargreaves DC, et al. Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis[J]. J Immunol, 2002, 169(1) :424-433.
|
24. |
Haynes NM, Allen CD, Lesley R, et al. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation[J]. J Immunol, 2007, 179(8) :5099-5108.
|
25. |
Allen CD, Ansel KM, Low C, et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5[J]. Nat Immunol, 2004, 5(9) :943-952.
|
26. |
Xu H, Li X, Liu D, et al. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility[J]. Nature, 2013, 496(7446) :523-527.
|
27. |
Nurieva RI, Chung Y, Martinez GJ, et al. Bcl6 mediates the development of T follicular helper cells[J]. Science, 2009, 325(5943) : 1001-1005.
|
28. |
Johnston RJ, Choi YS, Diamond JA, et al. STAT5 is a potent negative regulator of TFH cell differentiation[J]. J Exp Med, 2012, 209(2) : 243-250.
|
29. |
Choi YS, Yang JA, Crotty S. Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells[J]. Curr Opin Immunol, 2013, 25(3) :366-372.
|
30. |
Kitano M, Moriyama S, Ando Y, et al. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity[J]. Immunity, 2011, 34(6) :961-972.
|
31. |
Yu D, Rao S, Tsai LM, et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment[J]. Immunity, 2009, 31(3) :457-468.
|
32. |
Cobb BS, Nesterova TB, Thompson E, et al. T cell lineage choice and differentiation in the absence of the RNase Ⅲ enzyme Dicer[J]. J Exp Med, 2005, 201(9) :1367-1373.
|
33. |
Kang SG, Liu WH, Lu P, et al. MicroRNAs of the miR-17~92 family are critical regulators of T(FH) differentiation[J]. Nat Immunol, 2013, 14(8) :849-857.
|
34. |
Baumjohann D, Kageyama R, Clingan JM, et al. The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression[J]. Nat Immunol, 2013, 14(8) : 840-848.
|
35. |
Takahashi H, Kanno T, Nakayamada SA, et al. TGF-beta and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells[J]. Nat Immunol, 2012, 13(6) :587.
|
36. |
Luzina IG, Atamas SP, Storrer CE, et al. Spontaneous formation of germinal centers in autoimmune mice[J]. J Leukoc Biol, 2001, 70(4) : 578-584.
|
37. |
Simpson N, Gatenby PA, Wilson A, et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus[J]. Arthritis Rheum, 2010, 62(1) :234-244.
|
38. |
Vinuesa CG, Cook MC, Angelucci C, et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity[J]. Nature, 2005, 435(741) :452-458.
|
39. |
Zhang X, Lindwall E, Gauthier C, et al. Circulating CXCR5+ CD4+ helper T cells in systemic lupus erythematosus patients share phenotypic properties with germinal center follicular helper T cells and promote antibody production[J]. Lupus, 2015, 24(9) :909-917.
|
40. |
Dolff S, Abdulahad WH, Westra J, et al. Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus[J]. Arthritis Res Ther, 2011, 13(5) :R157.
|
41. |
赵洁, 曾莉, 陈元, 等. 系统性红斑狼疮患儿外周血滤泡辅助性T细胞相关细胞因子及受体表达水平研究[J]. 重庆医学, 2014, 43(21) :2689-2690, 2694.
|
42. |
Wang JL, Hao PP, Chen YG. Angiotensin Ⅱ type 1 receptor gene A1166C polymorphism and essential hypertension in Chinese: a meta-analysis[J]. J Renin Angiotensin Aldosterone Syst, 2010, 11(2) :127-135.
|
43. |
Timaru-Kast R, Wyschkon S, Luh C, et al. Delayed inhibition of angiotensin Ⅱ receptor type 1 reduces secondary brain damage and improves functional recovery after experimental brain trauma[J]. Crit Care Med, 2012, 40(3) :935-944.
|
44. |
Wong CK, Wong PT, Tam LS, et al. Elevated production of B cell chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity[J]. J Clin Immunol, 2010, 30(1) :45-52.
|
45. |
董大群, 王忠永, 李海英, 等. 系统性红斑狼疮患者外周血滤泡辅助性T细胞水平的检测[J]. 中国皮肤性病学杂志, 2014, 28(10) : 1007-1011.
|
46. |
Le Coz C, Joublin A, Pasquali JL, et al. Circulating TFH subset distribution is strongly affected in lupus patients with an active disease[J]. PLoS One, 2013, 8(9) :e75319.
|
47. |
Kim HJ, Verbinnen B, Tang XL, et al. Inhibition of follicular T-helper cells by CD8(+) regulatory T cells is essential for self tolerance[J]. Nature, 2010, 467(7313) :328-U107.
|
48. |
Yang X, Yang J, Chu Y, et al. T follicular helper cells and regulatory B cells dynamics in systemic lupus erythematosus[J]. PLoS One, 2014, 9(2) :e88441.
|
49. |
Linterman MA, Rigby RJ, Wong RK, et al. Follicular helper T cells are required for systemic autoimmunity[J]. J Exp Med, 2009, 206(3) : 561-576.
|
50. |
Sinn DI, Lee ST, Chu K, et al. Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage[J]. Neurosci Lett, 2007, 411(3) :238-242.
|
51. |
Feng X, Wang D, Chen J, et al. Inhibition of aberrant circulating Tfh cell proportions by corticosteroids in patients with systemic lupus erythematosus[J]. PLoS One, 2012, 7(12) :e51982.
|
52. |
Terrier B, Costedoat-Chalumeau N, Garrido M, et al. Interleukin 21 correlates with T cell and B cell subset alterations in systemic lupus erythematosus[J]. J Rheumatol, 2012, 39(9) :1819-1828.
|