Clinical Study on the Therapeutic Effect of Glucosamine Hydrochloride in the Treatment of Chronic Lumbago and Backache_West China Medical Journal

Authors：

 ZhaoMian , DengHong , HeGuanlin , LiYang

Department of Orthopedics, the Third People's Hospital of Yibin City, Yibin, Sichuan 644000, P. R. China;

Corresponding author：

Keywords：

Glucosamine hydrochloride; Chronic lumbago and backache; Short-form McGill pain questionnaire

DOI：

10.7507/1002-0179.201600318

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Objective To investigate the therapeutic effect of glucosamine hydrochloride on chronic lumbago and backache. Methods We selected 328 outpatients with chronic lumbago and backache diagnosed between May 2014 and May 2015, and randomly (with single blind method) divided them into study group (n=172) and control group (n=156). Patients in the control group were treated with ibuprofen and placebo, while those in the study group were treated with ibuprofen and glucosamine hydrochloride. The short-form McGill pain questionnaire (SF-MPQ) was used for investigation at three time points (before the treatment, one month and two months after the treatment). Results The score of SF-MPQ in the study group was 64.34±23.35 before the treatment, 44.04±13.22 one month after the treatment, and 19.87±8.11 two months after the treatment. While in the control group, the results at those three time points were 65.19±24.12, 47.04±11.36, and 54.44±21.39, respectively. There was no obvious difference between the two groups one month after the treatment (P>0.05). The pain was alleviated in both of the two groups one month after the treatment, while the therapeutic effect in the study group was significantly better than that in the control group two months after the treatment (P<0.05). Archenteric complications were found in 3 patients (1.74%) in the study group and 2 (1.28%) in the control group without a significant difference (P>0.05). Conclusion Glucosamine hydrochloride may effectively alleviate the lumbago and backache without any obvious adverse reactions.

Citation： ZhaoMian, DengHong, HeGuanlin, LiYang. Clinical Study on the Therapeutic Effect of Glucosamine Hydrochloride in the Treatment of Chronic Lumbago and Backache. West China Medical Journal, 2016, 31(7): 1167-1169. doi: 10.7507/1002-0179.201600318 Copy

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11.	Wilkens P, Scheel IB, Grundnes O, et al. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis:a randomized controlled trial[J]. JAMA, 2010, 304(1):45-52.
12.	柳万国, 唐成林, 孙莉, 等. 腰椎关节突关节骨性关节炎的CT分级及其临床意义[J]. 中国脊柱脊髓杂志, 2011, 21(12):981-986.
13.	Wilkens P, Scheel IB, Grundnes O, et al. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis:a randomized controlled trial[J]. JAMA, 2010, 304(1):45-52.
14.	卢锋, 郭红卫. 盐酸氨基葡萄糖对骨关节炎作用机制的初步探讨[J]. 卫生研究, 2003, 32(6):594-597.

1. Kelsey JL, White AA 3rd. Epidemiology and impact of low-back pain[J]. Spine (Phila Pa 1976), 1980, 5(2):133-142.
2. Snook SH. Self-care guidelines for the management of nonspecific low back pain[J]. J Occup Rehabil, 2004, 14(4):243-253.
3. Frank J, Sinclair S, Hogg-Johnson S, et al. Preventing disability form workrelated low-back pain. New evidence give new hope-if we can just get all the players onside[J]. CMAJ, 1998, 158(12):1625-1631.
4. Hestbaek L, Leboeuf-Yde C, Manniche C. Low back pain:what is the long-term course? A review of studies of general patient populations[J]. Eur Spine J, 2003, 12(2):149-165.
5. 罗跃嘉. 简化McGill疼痛分表的临床应用评价[J]. 中国康复, 1992, 7(2):160-164.
6. 于洪炜. 腰背痛[J]. 社区医学杂志, 2007, 12(5):21-23.
7. 胡元明, 李春生. 慢性腰背痛X线分析(附120例报告)[J]. 影像诊断与介入放射学, 1996, 5(6):372-375.
8. 詹志刚. 慢性腰背痛病变的相关CT影像分析[J]. 影像诊断与介入放射学, 2006, 15(2):78-81.
9. 吕红玲, 易红赤, 毛晓雯. 腰背痛X线检查的表现特点[J]. 实用医技杂志, 2015, 22(7):733-735.
10. 麦甘树. 腰椎间盘退变腰椎小关节退行性骨关节炎和年龄的相关性分析[J]. 河北医学, 2011, 17(6):796-799.
11. Wilkens P, Scheel IB, Grundnes O, et al. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis:a randomized controlled trial[J]. JAMA, 2010, 304(1):45-52.
12. 柳万国, 唐成林, 孙莉, 等. 腰椎关节突关节骨性关节炎的CT分级及其临床意义[J]. 中国脊柱脊髓杂志, 2011, 21(12):981-986.
13. Wilkens P, Scheel IB, Grundnes O, et al. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis:a randomized controlled trial[J]. JAMA, 2010, 304(1):45-52.
14. 卢锋, 郭红卫. 盐酸氨基葡萄糖对骨关节炎作用机制的初步探讨[J]. 卫生研究, 2003, 32(6):594-597.

West China Medical Journal

Clinical Study on the Therapeutic Effect of Glucosamine Hydrochloride in the Treatment of Chronic Lumbago and Backache

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