Evaluation of Therapeutic Effect of Glucosamine Hydrochloride Combined with Tenghuangjiangu Tablets on Knee Osteoarthritis_West China Medical Journal

Authors：

 ZhongChao , YeHua , TuYujian

Department of Traditional Chinese Medicine Orthopedics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

Keywords：

Osteoarthritis,knee; Glucosamine hydrochloride; Tenghuangjiangu tablets

DOI：

10.7507/1002-0179.201600322

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the therapeutic effect of glucosamine hydrochloride combined with Tenghuangjiangu tablets on knee osteoarthritis. Methods From August 2012 to February 2014, 180 patients with knee osteoarthritis were randomly divided into three groups with 60 in each. Patients in group A were treated with glucosamine hydrochloride; patients in group B were treated with Tenghuangjiangu tablets; and patients in group C were treated with the combination of glucosamine hydrochloride and Tenghuangjiangu tablets. After the 12-week treatment, clinical efficacy and safety of the treatment were observed and compared with those before the treatment. Results The twenty-meter walking pain, Western Ontario and McMaster University Osteoarthritis Index (WOMAC), and the joint tenderness in the three groups 12 weeks after the treatment and 4 weeks after withdrawal improved obviously compared with those before the treatment (P<0.05), and the difference between the results of 12 weeks after treatment and 4 weeks after withdrawal was not significant (P>0.05). The improvement in group C was better than both group A and B with significant differences (P<0.05), while the difference between group A and B was not significant (P>0.05). There was no obvious abnormal routine blood and urine test result or damage of liver and lung functions during the treatment in all the three groups. Twelve weeks after treatment, six patients with abdominal ache were found in group A with an incidence of 10.0%; 5 abdominal ache and 2 diarrhea were in group B with a rate of 12.5%; and 4 abdominal ache and 3 diarrhea were in group C with a rate of 12.5%. All the patients completed the treatment. No significant difference in the incidence of adverse reactions was found among the three groups (P>0.05). Conclusion The therapeutic effect of combined glucosamine hydrochloride and Tenghuangjiangu tablets is obvious on knee osteoarthritis with low incidence of adverse reactions.

Citation： ZhongChao, YeHua, TuYujian. Evaluation of Therapeutic Effect of Glucosamine Hydrochloride Combined with Tenghuangjiangu Tablets on Knee Osteoarthritis. West China Medical Journal, 2016, 31(7): 1181-1184. doi: 10.7507/1002-0179.201600322 Copy

1.	中华医学会风湿病学分会. 骨关节炎诊断及诊治指南[J]. 中华风湿病学杂志, 2010, 14(6):416-419.
2.	Loeser RC. Osteoarthritis:a disease of the joint as an organ[J]. Arthritis Rheum, 2012, 64(6):1697-1707.
3.	Arnold EL, Arnold WJ. Use of glucosamine and chondroitin sulfate in the management of osteoarthritis[J]. J Am Acad Orthop Surg, 2001, 9(5):352-353.
4.	Zhao HY, Huang YZ, Zhang J, et al. Clinical observation of compound recipe Rhizoma Corydalis Decumbentis for the treatment of knee osteoarthritis[J]. Strait Pharm J, 2011, 23(6):101-103.
5.	中华医学会骨科分会. 骨关节炎诊治指南(2007年版)[J]. 中华骨科杂志, 2007, 27(10):793-796.
6.	郑莜萸. 中药新药临床研究指导原则[M]. 北京:中国医药科技出版社, 2005:349-353.
7.	国家中医药管理局. 中医病证诊断疗效标准[M]. 南京:南京大学出版社, 1994:30-31.
8.	Lawrence JS. Rheumatism in population[M]. London:William Heinemann Med Book LTD, 1997:153.
9.	蒋协远, 王大伟. 骨科临床疗效评价标准[M]. 北京:人民卫生出版社, 2005:275-277.
10.	Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). Ⅰ. Conceptual framework and item selection[J]. Med Care, 1992, 30(6):473-483.
11.	van den Berg WB. Osteoarthritis year 2010 in review:pathomechanisms[J]. Osteoarthritis Cartilage, 2011, 19(4):338-341.
12.	Mahendira D, Towheed TE. Systematic review of non-surgical therapies for osteoarthritis of the hand:an update[J]. Osteoarthritis Cartilage, 2009, 17(10):1263-1268.
13.	Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression:a meta-analysis[J]. Rheumatol Int, 2010, 30(3):357-363.
14.	Nakamura H, Shibakawa A, Tanaka M, et al. Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis[J]. Clin Exp Rheumatol, 2004, 22(3):293-299.
15.	李方, 庞学丰. 三痹汤治疗类风湿性关节炎30例[J]. 陕西中医, 2008, 29(8):996-997.
16.	张波, 卢敏, 唐盾. 藤黄健骨片治疗椎动脉型颈椎病临床疗效观察[J]. 中国现代药物应用, 2010, 4(16):171-172.
17.	张波, 卢敏, 唐盾. 藤黄健骨片、玻璃酸钠联用与单用玻璃酸钠治疗骨性关节炎疗效比较[J]. 中国当代医药, 2010, 17(17):67-68.
18.	周洪保, 张曦, 吕正祥. 膝关节骨性关节炎治疗进展[J]. 中医药导报, 2012, 18(2):87-89.

1. 中华医学会风湿病学分会. 骨关节炎诊断及诊治指南[J]. 中华风湿病学杂志, 2010, 14(6):416-419.
2. Loeser RC. Osteoarthritis:a disease of the joint as an organ[J]. Arthritis Rheum, 2012, 64(6):1697-1707.
3. Arnold EL, Arnold WJ. Use of glucosamine and chondroitin sulfate in the management of osteoarthritis[J]. J Am Acad Orthop Surg, 2001, 9(5):352-353.
4. Zhao HY, Huang YZ, Zhang J, et al. Clinical observation of compound recipe Rhizoma Corydalis Decumbentis for the treatment of knee osteoarthritis[J]. Strait Pharm J, 2011, 23(6):101-103.
5. 中华医学会骨科分会. 骨关节炎诊治指南(2007年版)[J]. 中华骨科杂志, 2007, 27(10):793-796.
6. 郑莜萸. 中药新药临床研究指导原则[M]. 北京:中国医药科技出版社, 2005:349-353.
7. 国家中医药管理局. 中医病证诊断疗效标准[M]. 南京:南京大学出版社, 1994:30-31.
8. Lawrence JS. Rheumatism in population[M]. London:William Heinemann Med Book LTD, 1997:153.
9. 蒋协远, 王大伟. 骨科临床疗效评价标准[M]. 北京:人民卫生出版社, 2005:275-277.
10. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). Ⅰ. Conceptual framework and item selection[J]. Med Care, 1992, 30(6):473-483.
11. van den Berg WB. Osteoarthritis year 2010 in review:pathomechanisms[J]. Osteoarthritis Cartilage, 2011, 19(4):338-341.
12. Mahendira D, Towheed TE. Systematic review of non-surgical therapies for osteoarthritis of the hand:an update[J]. Osteoarthritis Cartilage, 2009, 17(10):1263-1268.
13. Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression:a meta-analysis[J]. Rheumatol Int, 2010, 30(3):357-363.
14. Nakamura H, Shibakawa A, Tanaka M, et al. Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis[J]. Clin Exp Rheumatol, 2004, 22(3):293-299.
15. 李方, 庞学丰. 三痹汤治疗类风湿性关节炎30例[J]. 陕西中医, 2008, 29(8):996-997.
16. 张波, 卢敏, 唐盾. 藤黄健骨片治疗椎动脉型颈椎病临床疗效观察[J]. 中国现代药物应用, 2010, 4(16):171-172.
17. 张波, 卢敏, 唐盾. 藤黄健骨片、玻璃酸钠联用与单用玻璃酸钠治疗骨性关节炎疗效比较[J]. 中国当代医药, 2010, 17(17):67-68.
18. 周洪保, 张曦, 吕正祥. 膝关节骨性关节炎治疗进展[J]. 中医药导报, 2012, 18(2):87-89.

West China Medical Journal

Evaluation of Therapeutic Effect of Glucosamine Hydrochloride Combined with Tenghuangjiangu Tablets on Knee Osteoarthritis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content