Clinical Study on the Treatment of Early Patellofemoral Osteoarthritis by the Combination of Glucosamine Hydrochloride with Exercise Therapy and Traditional Chinese Medicine Hot Compress_West China Medical Journal

Authors：

 ZhangYun ¹ , ZengYu ² , LuoYong ¹

1. Department of Traditional Chinese Medicine Orthopedics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;
2. Department of Hyperbaric Oxygen, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

Keywords：

Early patellofemoral osteoarthritis; Glucosamine hydrochloride; Exercise therapy; Traditional Chinese medicine hot compress

DOI：

10.7507/1002-0179.201600323

Video：

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Objective To study the clinical effect of the combination of glucosamine hydrochloride with exercise therapy and traditional Chinese medicine hot compress in the treatment of early patellofemoral osteoarthritis. Methods A total of 126 patients with early patellofemoral osteoarthritis treated between June 2013 and April 2015 were divided into group A (n=43), B (n=42) and C (n=41) with the method of random number table. Oral administration of glucosamine hydrochloride tablets, exercise therapy of knee joints and traditional Chinese medicine hot compress were applied for the 43 patients in group A. Oral administration of glucosamine hydrochloride tablets and exercise therapy of knee joints were applied for the 42 patients in group B. Exercise therapy of knee joints and traditional Chinese medicine hot compress were applied for the 41 patients in group C. Chen's Scoring was applied before the treatment and 2, 4, 12 and 24 weeks after the treatment. Results The differences of Chen's scores at the time points after treatment and those before treatment of the same group had statistical significance (P<0.05). The differences of Chen's scores at the time points after treatment in group A and those in group B and C had statistical significance (P<0.05). There were no obvious adverse effects due to administration of glucosamine hydrochloride tablets in group A and B. Five patients in group A and 4 patients in group C suffered from the symptoms of local erythema, light cutaneous pruritus and other contact dermatitis after traditional Chinese medicine hot compress. Those symptoms disappeared automatically several hours later without any special treatment. Conclusion The treatment of early patellofemoral osteoarthritis by the combination of glucosamine hydrochloride tablets with exercise therapy and traditional Chinese medicine hot compress can rapidly relieve joint pain, and maintain efficacy for a long time.

Citation： ZhangYun, ZengYu, LuoYong. Clinical Study on the Treatment of Early Patellofemoral Osteoarthritis by the Combination of Glucosamine Hydrochloride with Exercise Therapy and Traditional Chinese Medicine Hot Compress. West China Medical Journal, 2016, 31(7): 1185-1188. doi: 10.7507/1002-0179.201600323 Copy

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13.	陈世菊, 刘源, 石桂秀. 氨基葡萄糖治疗亚洲人群骨关节炎的Meta分析[J]. 华西医学, 2015, 30(9):1627-1632.
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18.	陆志夫, 吴清琳, 刘永利. 蠲痹汤加减结合中药熏洗治疗髌股关节早期骨关节炎57例疗效观察[J]. 中医药导报, 2014, 20(8):68-70.
19.	叶启彬, 吴志宏, 王以朋, 等. 髌股关节早期骨关节炎的病因、诊断和治疗探索[J]. 中国医学科学院学报, 2001, 23(2):181-183.
20.	黄建, 杨丽薇. 电针配合盐酸氨基葡萄糖治疗膝骨关节炎的临床研究[J]. 华西医学, 2014, 29(1):30-33.
21.	邱贵兴, 翁习生, 张克, 等. 盐酸、硫酸氨基葡萄糖治疗骨关节炎的平行对照临床研究[J]. 中华医学杂志, 2005, 85(43):3067-3070.
22.	文琼芳, 黄烽. 氨基葡萄糖治疗骨关节炎的争议探讨[J]. 中国药物应用与监测, 2015, 12(4):246-250.

1. Hong E, Kraft MC. Evaluating anterior knee pain[J]. Med Clin North Am, 2014, 98(4):697-717, xi.
2. Chan VO, Moran DE, Mwangi I, et al. Prevalence and clinical significance of chondromalacia isolated to the anterior margin of the lateral femoral condyle as a component of patellofemoral disease:observations at Mr imaging[J]. Skeletal Radiol, 2013, 42(8):1127-1133.
3. Rathleff MS, Rasmussen S, Olesen JL. Unsatisfactory long-term prognosis of conservative treatment of patellofemoral pain syndrome[J]. Ugeskr Laeger, 2012, 174(15):1008-1013.
4. 蒲云青. 中药离子导入联合玻璃酸钠关节腔注射治疗髌股关节早期骨关节炎43例总结[J]. 湖南中医杂志, 2015, 31(4):78-79.
5. 国家中医药管理局. 中医病症诊断疗效标准[M]. 南京:南京大学出版社, 1994:198.
6. 陈大宇, 曹亚飞, 麦庆春, 等. 中药热奄包治疗膝骨关节炎的临床观察[J]. 中医正骨, 2011, 23(6):6-8, 12.
7. 李光辉, 高宏鹰. 髌股关节早期骨关节炎的研究进展[J]. 中国当代医药, 2015, 22(26):22-25.
8. Macmull S, Jaiswal PK, Bentley G, et al. The role of autologous chondrocyte implantation in the treatment of symptomatic chondromalacia patellae[J]. Int Orthop, 2012, 36(7):1371-1377.
9. 李图力·古尔. 氨基葡萄糖治疗髌股关节早期骨关节炎的疗效分析[J]. 海峡药学, 2013, 25(12):164-165.
10. 徐佑军. 硫酸氨基葡萄糖胶囊治疗膝骨关节炎的疗效观察[J]. 中国当代医药, 2010, 17(18):47, 50.
11. 李江, 杨阳, 吕颖. 中西医结合治疗髌股关节早期骨关节炎86 例[J]. 河南中医, 2013, 33(7):1129-1130.
12. Chen S, Huang Y, Chen W, et al. Protective effects of the Tougu Xiaotong capsule on morphology and osteoprotegerin/nuclear factor-kappaB ligand expression in rabbits with knee osteoarthritis[J]. Mol Med Rep, 2016, 13(1):419-425.
13. 陈世菊, 刘源, 石桂秀. 氨基葡萄糖治疗亚洲人群骨关节炎的Meta分析[J]. 华西医学, 2015, 30(9):1627-1632.
14. 陈洁, 兰由玉, 刘伟, 等. 盐酸氨基葡萄糖与双醋瑞因治疗骨关节炎的临床对照研究[J]. 华西医学, 2014, 29(6):1111-1114.
15. 刘学妮, 林惠钗. 股四头肌训练对温针灸治疗膝关节退行性骨关节病远期疗效的影响[J]. 中国实用医药, 2015, 10(23):273-274.
16. 练伟东. 独活寄生汤联合股四头肌训练治疗膝关节骨性关节炎30例临床观察[J]. 河北中医, 2015, 37(4):553-555.
17. 韦汉容. 中药塌渍、TDP、超短波结合股四头肌训练治疗膝骨关节炎22例[J]. 江西中医药, 2015, 46(2):34-36.
18. 陆志夫, 吴清琳, 刘永利. 蠲痹汤加减结合中药熏洗治疗髌股关节早期骨关节炎57例疗效观察[J]. 中医药导报, 2014, 20(8):68-70.
19. 叶启彬, 吴志宏, 王以朋, 等. 髌股关节早期骨关节炎的病因、诊断和治疗探索[J]. 中国医学科学院学报, 2001, 23(2):181-183.
20. 黄建, 杨丽薇. 电针配合盐酸氨基葡萄糖治疗膝骨关节炎的临床研究[J]. 华西医学, 2014, 29(1):30-33.
21. 邱贵兴, 翁习生, 张克, 等. 盐酸、硫酸氨基葡萄糖治疗骨关节炎的平行对照临床研究[J]. 中华医学杂志, 2005, 85(43):3067-3070.
22. 文琼芳, 黄烽. 氨基葡萄糖治疗骨关节炎的争议探讨[J]. 中国药物应用与监测, 2015, 12(4):246-250.

West China Medical Journal

Clinical Study on the Treatment of Early Patellofemoral Osteoarthritis by the Combination of Glucosamine Hydrochloride with Exercise Therapy and Traditional Chinese Medicine Hot Compress

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