Value of Joint Fluid and Blood-related Indicators in the Diagnosis of Gouty Arthritis and Rheumatoid Arthritis_West China Medical Journal

Authors：

 ZhangJing , ZouMing , ChiJimin , ZhangFeng , ZhangHongmei

Clinical Laboratory, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

Keywords：

Gouty arthritis; Rheumatoid arthritis; Joint fluid index; Blood index

DOI：

10.7507/1002-0179.201600375

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Objective To discuss the changes of joint fluid and blood-related indexes in patients with gouty arthritis and rheumatoid arthritis, and to analyze the clinical significance of these changes. Methods Seventy-five patients with gouty arthritis and 68 with rheumatoid arthritis treated between January and December 2014 were included in our study. Their joint fluid-related indicators including white blood cell count (WBC), total protein (TP), albumin (ALB), glucose (GLU), and uric acid (UA), and their blood indicators including immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin A (IgA), C3 and C4, rheumatoid factor (RF), anti-streptolysin O (ASO), and c-reactive protein (CRP) were detected. Results For joint fluid-related indicators, TP and ALB levels were not significantly different between the two groups (P > 0.05), while WBC, GLU, UA, RF and ASO between the two groups were significantly different (P < 0.05); For blood indexes, C4 was not significantly different between the two groups (P > 0.05), but IgG, IgM, IgA, CRP, C3, UA, RF and ASO were significantly different between the two groups (P < 0.05). The detection rate of ASO from the joint fluid was significantly higher than that detected from the blood in both the two groups (P < 0.05), while UA level was not significantly different between the joint fluid and the blood (P > 0.05). In patients with rheumatoid arthritis, RF detection rate was not significantly different between the joint fluid and the blood (P > 0.05), but it was significantly different for patients with gouty arthritis (P < 0.05). The positive rate of ASO in the blood and joint fluid of patients with gouty arthritis was respectively 38.7% and 44.0%, and it was 75.0% and 73.5% for patients with rheumatoid arthritis. UA positive rate in the blood and joint fluid of patients with gouty arthritis was 92.0% and 80.0% respectively, while it was 38.2% and 32.4% for patients with rheumatoid arthritis. RF positive rate was 33.3% and 40.0% in the blood and joint fluid of patients with gouty arthritis, while the rate was 86.8% and 91.2% for patients with rheumatoid arthritis. Conclusion The joint fluid and blood indicators are in change in patients with gouty arthritis and rheumatoid arthritis, which has a certain clinical value in disease diagnosis and curative effect observation.

Citation： ZhangJing, ZouMing, ChiJimin, ZhangFeng, ZhangHongmei. Value of Joint Fluid and Blood-related Indicators in the Diagnosis of Gouty Arthritis and Rheumatoid Arthritis. West China Medical Journal, 2016, 31(8): 1376-1379. doi: 10.7507/1002-0179.201600375 Copy

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11.	刘伯让, 杨结, 薛彩霞, 等. 436例关节液检查白细胞分类结果分析及临床意义[J].检验医学, 2011, 26(1):43-45.
12.	徐勇, 傅松维, 徐友红.风湿三项指标和免疫球蛋白检测对RA患者诊断中的应用[J].放射免疫学杂志, 2011, 24(1):84-85.
13.	Johnson JS, Freemont AJ. A 10 year retrospective comparison of the diagnostic usefulness of synovial fluid and synovial biopsy examination[J]. J Clin Pathol, 2001, 54:605-607.
14.	叶应妩, 杨春生.临床检验学[M].天津:天津科学技术出版社, 1998:433.
15.	熊丽. 70例痛风性关节炎临床表现分析[J].医学信息, 2010(5):1097-1098.

1. 久卖多杰, 贡保措.痛风性关节炎误诊3例分析[J].中国民族医药杂志, 2011(6):19-20.
2. 张巧峥.临床风湿病学[M].上海:上海科技出版杜, 1997:92-93.
3. 蒋明, 朱直平, 林孝义.风湿病学[M].北京:科技出版杜, 1995:844-845.
4. Scott D L, Wolfe F, Huizinga TW. Rheumatoid arthritis[J]. Lancet, 2010, 876(9746):1094.
5. 黄媛霞, 段永壮, 李康, 等.膝关节OA患者血清和关节液中IL-1、MMP-3、TIMP-1的水平变化及意义[J].山东医药, 2010, 50(30):59-60.
6. 池继敏, 张峰, 张静.不同类型关节炎患者血液及关节液中尿酸、抗链球菌溶血素O和类风湿因子含量比较[J].中华临床医师杂志:电子版, 2013, 7(21):9557-9559.
7. 潘云堂, 周连昕, 王惠生.关节液检查及其临床意义[J].上海医学, 1984, 7:218-220.
8. 李林林, 宋先锋, 孙秀丽, 等.关节腔液检查内容概述[J].社区医学杂志, 2009, 7:27-28.
9. 吴晓岩, 终忠山, 李秀伟.关节液ASO和RF检测的临床意义[J].哈尔滨医药, 2001, 21:6.
10. 于淑燕.关节液和血液中ASO、RF、补体C3检测的对比[J].中国煤炭工业医学杂志, 2007, 10:297.
11. 刘伯让, 杨结, 薛彩霞, 等. 436例关节液检查白细胞分类结果分析及临床意义[J].检验医学, 2011, 26(1):43-45.
12. 徐勇, 傅松维, 徐友红.风湿三项指标和免疫球蛋白检测对RA患者诊断中的应用[J].放射免疫学杂志, 2011, 24(1):84-85.
13. Johnson JS, Freemont AJ. A 10 year retrospective comparison of the diagnostic usefulness of synovial fluid and synovial biopsy examination[J]. J Clin Pathol, 2001, 54:605-607.
14. 叶应妩, 杨春生.临床检验学[M].天津:天津科学技术出版社, 1998:433.
15. 熊丽. 70例痛风性关节炎临床表现分析[J].医学信息, 2010(5):1097-1098.

West China Medical Journal

Value of Joint Fluid and Blood-related Indicators in the Diagnosis of Gouty Arthritis and Rheumatoid Arthritis

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