Association between Mannose-binding Lectin 2 Codon 52 A/D Gene Polymorphism and Tuberculosis Risk: a Meta-analysis_West China Medical Journal

Authors：

 QinHua ¹ , LiWancheng ² , YangLi ¹ , LiXiaoyan ¹ ,  HeJie ²

1. Department of Endocrinology; the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China;
2. Department of Respiratory Medicine; the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China;

Corresponding author：

HeJie, Email: 157110097@qq.com

Keywords：

Tuberculosis; Polymorphism; Mannose-binding lectin 2; Meta-analysis

DOI：

10.7507/1002-0179.201600456

Video：

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Objective To investigate the relationship between the mannose-binding lectin 2 (MBL2) codon 52 A/D gene polymorphism and tuberculosis risk by meta-analysis. Methods The Embase, PubMed, China National Knowledg Infrastructure, Wanfang databases were searched to identify domestic and foreign case-control studies involving the association between MBL2 codon 52 A/D gene polymorphism and tuberculosis risk from establishment of these database till May 20, 2015. Two reviewers collected data according to the inclusion and exclusion criteria, and extracted data and assessed quality of the literature. Meta analysis was performed by RevMan 5.2 software and Stata 10.0 software. Results In total, 1 282 cases and 1 483 controls from nine case-control studies were included in this meta-analysis. According to the test of heterogeneity, there was statistical heterogeneity among these studies (P < 0.1). Thus, we conducted the analysis by the random effect model on the basis of heterogeneity test. The results indicated that MBL2 codon 52 A/D gene polymorphism might not be associated with risk of tuberculosis [DD+AD versus AA: OR=1.46, 95% CI (0.87, 2.43), P=0.15] in total analysis by random effect model. However, when stratifying separately according to ethnicity, a significant association between MBL2 codon 52 A/D gene polymorphism and tuberculosis risk was found in Asians [OR=1.96, 95% CI (1.27, 3.03), P=0.003 for DD+AD versus AA], but not among Caucasians [OR=1.36, 95% CI (0.52, 3.56), P=0.53 for DD+AD versus AA]. Conclusion s The present meta-analysis indicates that the polymorphism of MBL2 codon 52 A/D may be a risk factor for TB in Asians. But the MBL2 codon 52 A/D gene polymorphism may not contribute to the risk of tuberculosis in Caucasians.

Citation： QinHua, LiWancheng, YangLi, LiXiaoyan, HeJie. Association between Mannose-binding Lectin 2 Codon 52 A/D Gene Polymorphism and Tuberculosis Risk: a Meta-analysis. West China Medical Journal, 2016, 31(10): 1657-1662. doi: 10.7507/1002-0179.201600456 Copy

1.	Scollard DM, Dacso MM, Abad-Venida ML. Tuberculosis and leprosy: classical granulomatous diseases in the Twenty-First century[J]. Dermatol Clin, 2015, 33(3): 541-562.
2.	Vallinoto AC, Graça ES, Araújo MS, et al. IFNG+874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of tuberculosis[J]. Hum Immunol, 2010, 71(7): 692-696.
3.	Corbett EL, Watt CJ, Walker N, et al. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic[J]. Arch Intern Med, 2003, 163(9): 1009-1021.
4.	苏勇, 李莹, 孙桂香. HLA-DRB1基因多态性与中国人群肺结核关联性的Meta分析[J].中国全科医学, 2014(10): 1167-1171.
5.	Araújo MS, Graça ES, Azevedo VN, et al. No evidence of association between MBL2A/O polymorphisms and Mycobacterium tuberculosis infection in populations from the Brazilian Amazon region[J]. Hum Immunol, 2013, 74(1): 82-84.
6.	Nedovic B, Posteraro B, Leoncini E, et al. Mannose-binding lectin codon 54 gene polymorphism and vulvovaginal candidiasis: a systematic review and meta-analysis[J]. Biomed Res Int, 2014, 2014: 738298.
7.	Zhao Y, Lin W, Li Z, et al. High expression of Mannose-Binding lectin and the risk of vascular complications of diabetes: evidence from a Meta-analysis[J]. Diabetes Technol Ther, 2015, 17(7): 490-497.
8.	Heitzeneder S, Seidel M, Förster-Waldl E, et al. Mannan-binding lectin deficiency-good news, bad news, doesn't matter?[J]. Clin Immunol, 2012, 143(1): 22-38.
9.	Little J, Higgins JP, Ioannidis JP, et al. Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement[J]. Eur J Epidemiol, 2009, 24(1): 37-55.
10.	Alagarasu K, Selvaraj P, Swaminathan S, et al. Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India[J]. Tuberculosis (Edinb), 2007, 87(6): 535-543.
11.	Capparelli R, Iannaccone M, Palumbo D, et al. Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis[J]. J Infect Dis, 2009, 199(5): 666-672.
12.	da Cruz HL, da Silva RC, Segat L, et al. MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population[J]. Infect Genet Evol, 2013, 19: 323-329.
13.	de Wit E, van der Merwe L, van Helden PD, et al. Gene-gene interaction between tuberculosis candidate genes in a South African population[J]. Mamm Genome, 2011, 22(1/2): 100-110.
14.	Ocejo-Vinyals JG, Lavín-Alconero L, Sánchez-Velasco P, et al. Mannose-binding lectin promoter polymorphisms and gene variants in pulmonary tuberculosis patients from cantabria (northern Spain)[J]. Pulm Med, 2012, 2012: 469128.
15.	Selvaraj P, Jawahar MS, Rajeswari DN, et al. Role of mannose binding lectin gene variants on its protein levels and macrophage phagocytosis with live Mycobacterium tuberculosis in pulmonary tuberculosis[J]. FEMS Immunol Med Microbiol, 2006, 46(3): 433-437.
16.	Selvaraj P, Narayanan PR, Reetha AM. Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India[J]. Tuber Lung Dis, 1999, 79(4): 221-227.
17.	冯福民, 郝金奇, 陈怡, 等.河北唐山汉族人群VDR和MBP基因交互作用与肺结核发病的相关性[J].重庆医学, 2010, 39(12): 1527-1529, 1532.
18.	Søborg C, Madsen HO, Andersen AB, et al. Mannose-binding lectin polymorphisms in clinical tuberculosis[J]. J Infect Dis, 2003, 188(5): 777-782.
19.	赵珩博, 朱圭娜, 陈丹丹, 等. MBL基因rs1800450与宁夏人群肺结核易感性研究[J].宁夏医科大学学报, 2014, 36(8): 889-893.
20.	van de Geijn FE, de Man YA, Wuhrer M, et al. Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis[J]. Arthritis Res Ther, 2011, 13(1): 2-7.

1. Scollard DM, Dacso MM, Abad-Venida ML. Tuberculosis and leprosy: classical granulomatous diseases in the Twenty-First century[J]. Dermatol Clin, 2015, 33(3): 541-562.
2. Vallinoto AC, Graça ES, Araújo MS, et al. IFNG+874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of tuberculosis[J]. Hum Immunol, 2010, 71(7): 692-696.
3. Corbett EL, Watt CJ, Walker N, et al. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic[J]. Arch Intern Med, 2003, 163(9): 1009-1021.
4. 苏勇, 李莹, 孙桂香. HLA-DRB1基因多态性与中国人群肺结核关联性的Meta分析[J].中国全科医学, 2014(10): 1167-1171.
5. Araújo MS, Graça ES, Azevedo VN, et al. No evidence of association between MBL2A/O polymorphisms and Mycobacterium tuberculosis infection in populations from the Brazilian Amazon region[J]. Hum Immunol, 2013, 74(1): 82-84.
6. Nedovic B, Posteraro B, Leoncini E, et al. Mannose-binding lectin codon 54 gene polymorphism and vulvovaginal candidiasis: a systematic review and meta-analysis[J]. Biomed Res Int, 2014, 2014: 738298.
7. Zhao Y, Lin W, Li Z, et al. High expression of Mannose-Binding lectin and the risk of vascular complications of diabetes: evidence from a Meta-analysis[J]. Diabetes Technol Ther, 2015, 17(7): 490-497.
8. Heitzeneder S, Seidel M, Förster-Waldl E, et al. Mannan-binding lectin deficiency-good news, bad news, doesn't matter?[J]. Clin Immunol, 2012, 143(1): 22-38.
9. Little J, Higgins JP, Ioannidis JP, et al. Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement[J]. Eur J Epidemiol, 2009, 24(1): 37-55.
10. Alagarasu K, Selvaraj P, Swaminathan S, et al. Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India[J]. Tuberculosis (Edinb), 2007, 87(6): 535-543.
11. Capparelli R, Iannaccone M, Palumbo D, et al. Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis[J]. J Infect Dis, 2009, 199(5): 666-672.
12. da Cruz HL, da Silva RC, Segat L, et al. MBL2 gene polymorphisms and susceptibility to tuberculosis in a northeastern Brazilian population[J]. Infect Genet Evol, 2013, 19: 323-329.
13. de Wit E, van der Merwe L, van Helden PD, et al. Gene-gene interaction between tuberculosis candidate genes in a South African population[J]. Mamm Genome, 2011, 22(1/2): 100-110.
14. Ocejo-Vinyals JG, Lavín-Alconero L, Sánchez-Velasco P, et al. Mannose-binding lectin promoter polymorphisms and gene variants in pulmonary tuberculosis patients from cantabria (northern Spain)[J]. Pulm Med, 2012, 2012: 469128.
15. Selvaraj P, Jawahar MS, Rajeswari DN, et al. Role of mannose binding lectin gene variants on its protein levels and macrophage phagocytosis with live Mycobacterium tuberculosis in pulmonary tuberculosis[J]. FEMS Immunol Med Microbiol, 2006, 46(3): 433-437.
16. Selvaraj P, Narayanan PR, Reetha AM. Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India[J]. Tuber Lung Dis, 1999, 79(4): 221-227.
17. 冯福民, 郝金奇, 陈怡, 等.河北唐山汉族人群VDR和MBP基因交互作用与肺结核发病的相关性[J].重庆医学, 2010, 39(12): 1527-1529, 1532.
18. Søborg C, Madsen HO, Andersen AB, et al. Mannose-binding lectin polymorphisms in clinical tuberculosis[J]. J Infect Dis, 2003, 188(5): 777-782.
19. 赵珩博, 朱圭娜, 陈丹丹, 等. MBL基因rs1800450与宁夏人群肺结核易感性研究[J].宁夏医科大学学报, 2014, 36(8): 889-893.
20. van de Geijn FE, de Man YA, Wuhrer M, et al. Mannose-binding lectin does not explain the course and outcome of pregnancy in rheumatoid arthritis[J]. Arthritis Res Ther, 2011, 13(1): 2-7.

West China Medical Journal

Association between Mannose-binding Lectin 2 Codon 52 A/D Gene Polymorphism and Tuberculosis Risk: a Meta-analysis

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