物理因子对神经干细胞分化影响的研究进展_West China Medical Journal

Authors：

 孟琳 ,  屈云

四川大学华西医院康复医学科四川省康复医学重点实验室（成都 610041）;

Corresponding author：

屈云, Email: quyben@163.com

Keywords：

物理因子; 神经干细胞; 分化

DOI：

10.7507/1002-0179.201600489

Video：

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神经干细胞（NSC）是一类具有分化成为神经元、星形胶质细胞和少突胶质细胞潜能的细胞，其具有广泛的应用价值，尤其对神经损伤康复有重要意义，但NSC定向分化为神经元受多重因素调控。近年来诱导NSC定向分化已经成为科学研究的热点问题。但其中关于药物制剂、激素等化学因子诱导NSC体外定向分化的研究较为多见。而目前相关研究已表明某些物理因子可以干预NSC的调控，现从物理因子对神经干细胞分化影响的研究进展作一综述。

Citation： 孟琳, 屈云. 物理因子对神经干细胞分化影响的研究进展. West China Medical Journal, 2016, 31(10): 1778-1781. doi: 10.7507/1002-0179.201600489 Copy

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2.	Obayashi S, Tabunoki H, Kim SU, et al. Gene expression profiling of human neural progenitor cells following the serum induce dastrocyte differentiation[J]. Cell Mol Neurobiol, 2009, 29(3): 423-438.
3.	高俊玮, 罗湘颖, 伍军, 等.神经干细胞移植促进脑出血大鼠神经功能恢复的实验研究[J].卒中与神经疾病, 2006, 13(4): 208-211.
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5.	李怡, 赵仑, 邢萱, 等．20 Hz磁场对中脑神经千细胞分化的影响[J].航天医学与医学工程, 2002, 15(5): 374-376．.
6.	Piacentini R, Ripoli C, Mezzogori D, et al. Extremely low-frequency electromagnetic fields promote in vitro neurogenesis via upregulation of Ca(v)1-channel activity[J]. J Cell Physiol, 2008, 215(1): 129-139.
7.	Takeuehi N, Chuma T, Matsuo Y, et al. Repetitive transcranial magnetic stimulation of eontralesional primary motor cortex improves hand function after stroke[J]. Stroke, 2005, 36(12): 2681-2686.
8.	Martin PI, Naeser MA, Theoret H, et al. Transcranial magnetic stimulation as a complementary treatment of aphasia[J]. Semin Speech Lang, 2004, 25(2): 181-191．.
9.	Machado AG, Baker KB, Schuster D, et al．Chronic electrical stimulation of the contralesionaI latera1 cerebellar nucleus enhances recovery of motor function after cerebral ischemia in rats[J]. Brain Res, 2009(1280): 107-116.
10.	尹清, 刘宏亮, 汪琴, 等. rTMS促进大鼠局灶性脑缺血海马内源性神经干细胞分化的研究[J].中华神经外科疾病研究杂志, 2010, 9(1): 49-53.
11.	Abbasnia K, Ghanbari A, Abedian M, et al. The effects of repetitive transcranial magnetic stimulation on proliferation and differentiation of neural stem cells[J]. Anat Cell Biol, 2015, 48(2): 104-113.
12.	Tao J, Xue XH, Chen LD, et al. Electroacupuncture improves neurological deficits and enhances proliferation and differentiation of endogenous nerve stem cells in rats with focal cerebral ischemia[J]. Neurol Res, 2010, 32(2): 198-204.
13.	芮君, 裴海涛.电针刺激对脑缺血大鼠神经干细胞分化的影响[J].青岛大学医学院学报, 2011, 47(4): 327-329.
14.	Kim YR, Kim HN, Jang JY, et al. Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia[J]. Int J Mol Med, 2013, 32: 1303-1310.
15.	周利, 张晓艳, 张红星, 等.头针诱导神经干细胞的增殖分化[J].卒中与神经疾病, 2011, 18(3): 138-141.
16.	张礼萍, 邹丽萍, 白丽敏.视黄酸受体β在针灸提高脑损伤幼鼠运动功能中的作用[J].中国康复医学杂志, 2009, 24(9): 821-823.
17.	Zhou F, Guo J, Cheng J, et al. Electroacupuncture and brain protection against cerebral ischemia: specific effects of acupoints[J]. Evid Based Complement Alternat Med, 2013(2013): 804397.
18.	Yang JT, Chang CN, Lee TH, et al. Hyperbaric oxygen treatment decreases postischemic neurotrophin-3 mRNA down-regulation in the rat hippocampus [J]. Neuroreport, 2001, 12(16): 3589-3592.
19.	余海, 田润兰, 潘小雯, 等.高压氧治疗在神经修复与再生过程中的作用及分子学机制[J].现代康复, 2001, 5(3): 48-49.
20.	Yin X, Meng F, Wang Y, et al. Effect of hyperbaric oxygen on neurological recovery of neonatal rats following hypoxic-ischemic brain damage and its underlying mechanism[J]. Int J Clin Exp Pathol, 2013, 6(1): 66-75.
21.	彭争荣, 王素娥, 肖平田.高压氧对脑源性神经干细胞分化的影响[J].中国组织工程研究与临床康复, 2007, 11(3): 427-430.
22.	谌崇峰, 杨于嘉, 王庆红, 等.高压氧影响离体神经干细胞分化的量效及时效关系[J].中国当代儿科杂志, 2010, 12(5): 368-372.
23.	刘萍, 涂彧.电离辐射对神经干细胞分化的影响[J].辐射研究与辐射工艺学报, 2010, 28(2): 124-127.
24.	Wang L, Chopp M, Zhang RL, et al. The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke[J]. Neuroscience, 2009, 158(4): 1356-1363．.
25.	吴学潮, 张永杰.神经干细胞定向诱导分化的研究进展[J].解剖学研究, 2012, 34(5): 373-377.
26.	Ma J, Cui B, Ding X, et al. Over-expression of cyclin D1 promotes NSCs proliferation and induces the differentiation into astrocytes Via Jak-STAT3 pathways[J]. Neurochem Res, 2015, 40(8): 1681-1690.
27.	Kelly CM, Zietlow R, Dunnett S, et al. The effects of various concentrations of FGF-2 on the proliferation and neuronal yield of murine embryonic neural precursor cells in vitro[J]. Cell Transplant, 2003, 12(3): 215-223．.
28.	Amoureux MC, Cunningham BA, Edelman GM, et al. N-CAM binding inhibits the proliferation of hippocampal progenitor cells and promotes their differentiation to a neural phenotype[J]. Neurosci, 2000, 20(10): 3631-3640.
29.	Takahashi J, Palmer TD, Gage FH. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures[J]. Neurobiol, 1999, 38(1): 65-81.
30.	李文晶, 王岩, 姜英虹, 等.未成熟钠通道调控大鼠胚胎神经干细胞分化[J].中国生物化学与分子生物学报, 2015, 31(1): 80-87.

1. Clarke DL, Johansson CB, Wilbertz J, et al. Generalized potential of adult neural stem cells[J]. Science, 2000, 288(5471): 1660-1663.
2. Obayashi S, Tabunoki H, Kim SU, et al. Gene expression profiling of human neural progenitor cells following the serum induce dastrocyte differentiation[J]. Cell Mol Neurobiol, 2009, 29(3): 423-438.
3. 高俊玮, 罗湘颖, 伍军, 等.神经干细胞移植促进脑出血大鼠神经功能恢复的实验研究[J].卒中与神经疾病, 2006, 13(4): 208-211.
4. Jeong SW, Chu K, Jung KH, et al. Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage [J], Stroke, 2003, 34(9): 2258-2263.
5. 李怡, 赵仑, 邢萱, 等．20 Hz磁场对中脑神经千细胞分化的影响[J].航天医学与医学工程, 2002, 15(5): 374-376．.
6. Piacentini R, Ripoli C, Mezzogori D, et al. Extremely low-frequency electromagnetic fields promote in vitro neurogenesis via upregulation of Ca(v)1-channel activity[J]. J Cell Physiol, 2008, 215(1): 129-139.
7. Takeuehi N, Chuma T, Matsuo Y, et al. Repetitive transcranial magnetic stimulation of eontralesional primary motor cortex improves hand function after stroke[J]. Stroke, 2005, 36(12): 2681-2686.
8. Martin PI, Naeser MA, Theoret H, et al. Transcranial magnetic stimulation as a complementary treatment of aphasia[J]. Semin Speech Lang, 2004, 25(2): 181-191．.
9. Machado AG, Baker KB, Schuster D, et al．Chronic electrical stimulation of the contralesionaI latera1 cerebellar nucleus enhances recovery of motor function after cerebral ischemia in rats[J]. Brain Res, 2009(1280): 107-116.
10. 尹清, 刘宏亮, 汪琴, 等. rTMS促进大鼠局灶性脑缺血海马内源性神经干细胞分化的研究[J].中华神经外科疾病研究杂志, 2010, 9(1): 49-53.
11. Abbasnia K, Ghanbari A, Abedian M, et al. The effects of repetitive transcranial magnetic stimulation on proliferation and differentiation of neural stem cells[J]. Anat Cell Biol, 2015, 48(2): 104-113.
12. Tao J, Xue XH, Chen LD, et al. Electroacupuncture improves neurological deficits and enhances proliferation and differentiation of endogenous nerve stem cells in rats with focal cerebral ischemia[J]. Neurol Res, 2010, 32(2): 198-204.
13. 芮君, 裴海涛.电针刺激对脑缺血大鼠神经干细胞分化的影响[J].青岛大学医学院学报, 2011, 47(4): 327-329.
14. Kim YR, Kim HN, Jang JY, et al. Effects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemia[J]. Int J Mol Med, 2013, 32: 1303-1310.
15. 周利, 张晓艳, 张红星, 等.头针诱导神经干细胞的增殖分化[J].卒中与神经疾病, 2011, 18(3): 138-141.
16. 张礼萍, 邹丽萍, 白丽敏.视黄酸受体β在针灸提高脑损伤幼鼠运动功能中的作用[J].中国康复医学杂志, 2009, 24(9): 821-823.
17. Zhou F, Guo J, Cheng J, et al. Electroacupuncture and brain protection against cerebral ischemia: specific effects of acupoints[J]. Evid Based Complement Alternat Med, 2013(2013): 804397.
18. Yang JT, Chang CN, Lee TH, et al. Hyperbaric oxygen treatment decreases postischemic neurotrophin-3 mRNA down-regulation in the rat hippocampus [J]. Neuroreport, 2001, 12(16): 3589-3592.
19. 余海, 田润兰, 潘小雯, 等.高压氧治疗在神经修复与再生过程中的作用及分子学机制[J].现代康复, 2001, 5(3): 48-49.
20. Yin X, Meng F, Wang Y, et al. Effect of hyperbaric oxygen on neurological recovery of neonatal rats following hypoxic-ischemic brain damage and its underlying mechanism[J]. Int J Clin Exp Pathol, 2013, 6(1): 66-75.
21. 彭争荣, 王素娥, 肖平田.高压氧对脑源性神经干细胞分化的影响[J].中国组织工程研究与临床康复, 2007, 11(3): 427-430.
22. 谌崇峰, 杨于嘉, 王庆红, 等.高压氧影响离体神经干细胞分化的量效及时效关系[J].中国当代儿科杂志, 2010, 12(5): 368-372.
23. 刘萍, 涂彧.电离辐射对神经干细胞分化的影响[J].辐射研究与辐射工艺学报, 2010, 28(2): 124-127.
24. Wang L, Chopp M, Zhang RL, et al. The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke[J]. Neuroscience, 2009, 158(4): 1356-1363．.
25. 吴学潮, 张永杰.神经干细胞定向诱导分化的研究进展[J].解剖学研究, 2012, 34(5): 373-377.
26. Ma J, Cui B, Ding X, et al. Over-expression of cyclin D1 promotes NSCs proliferation and induces the differentiation into astrocytes Via Jak-STAT3 pathways[J]. Neurochem Res, 2015, 40(8): 1681-1690.
27. Kelly CM, Zietlow R, Dunnett S, et al. The effects of various concentrations of FGF-2 on the proliferation and neuronal yield of murine embryonic neural precursor cells in vitro[J]. Cell Transplant, 2003, 12(3): 215-223．.
28. Amoureux MC, Cunningham BA, Edelman GM, et al. N-CAM binding inhibits the proliferation of hippocampal progenitor cells and promotes their differentiation to a neural phenotype[J]. Neurosci, 2000, 20(10): 3631-3640.
29. Takahashi J, Palmer TD, Gage FH. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures[J]. Neurobiol, 1999, 38(1): 65-81.
30. 李文晶, 王岩, 姜英虹, 等.未成熟钠通道调控大鼠胚胎神经干细胞分化[J].中国生物化学与分子生物学报, 2015, 31(1): 80-87.

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物理因子对神经干细胞分化影响的研究进展

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