Clinical Analysis on Neonatal Respiratory Failure_West China Medical Journal

Authors：

 ZhangDeshuang ^1,2 , WangHua ¹ ,  ChenJuan ¹

1. Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Neonatology, the Affiliated Hospital of Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;

Corresponding author：

ChenJuan, Email: chenjuan2000@163.com

Keywords：

Neonate; Respiratory failure; Mechanical ventilation

DOI：

10.7507/1002-0179.20160071

Video：

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Objective To explore the incidence, treatment and prognosis of neonatal respiratory failure (NRF). Methods The clinical data of 421 neonates with NRF treated between January 2011 and December 2013 were retrospectively analyzed. Results The incidence and the mortality of NRF was 4.8% and 14.5%, respectively. The main primary disease of NRF was neonatal respiratory distress syndrome (36.1%) and aspiration pneumonia (29.0%). Mechanical ventilation was the main treatment for NRF (77.2%). Premature (χ²=12.216, P<0.001), low birth weight (χ²=8.932, P=0.003) and the neonatal asphyxia (χ²=6.199, P=0.013) were closely related to the prognosis of NRF, which were the risk factors of the death of NRF. Conclusion NRF is a disease with high incidence and high mortality; make effective prevention and treatment measures are important to improve the success rate of therapy for NRF.

Citation： ZhangDeshuang, WangHua, ChenJuan. Clinical Analysis on Neonatal Respiratory Failure. West China Medical Journal, 2016, 31(2): 262-265. doi: 10.7507/1002-0179.20160071 Copy

1.	Horbar JD, Badger GJ, Carpenter JH, et al. Trends in mortality and morbidity for very low birth weight infants, 1991-1999[J]. Pediatrics, 2002, 110(1 Pt 1):143-151.
2.	Markestad T, Kaaresen PI, Rønnestad A, et al. Early death, morbidity, and need of treatment among extremely premature infants[J]. Pediatrics, 2005, 115(5):1289-1298.
3.	Qian L, Liu C, Zhuang W, et al. Neonatal respiratory failure:a 12-month clinical epidemiologic study from 2004 to 2005 in China[J]. Pediatrics, 2008, 121(5):e1115-e1124.
4.	Angus DC, Linde-Zwirble WT, Clermont G, et al. Epidemiology of neonatal respiratory failure in the United States:projections from California and New York[J]. Am J Respir Crit Care Med, 2001, 164(7):1154-1160.
5.	Clark RH. The epidemiology of respiratory failure in neonates born at an estimated gestational age of 34 weeks or more[J]. J Perinatol, 2005, 25(4):251-257.
6.	赖娟, 杜立中, 熊国强, 等. 1 108例新生儿呼吸衰竭的临床流行病学特征[J]. 中国当代儿科杂志, 2016, 18(1):10-14.
7.	Wang H, Gao X, Liu C, et al. Morbidity and mortality of neonatal respiratory failure in China:surfactant treatment in very immature infants[J]. Pediatrics, 2012, 129(3):e731-e740.
8.	程锐, 韩树萍, 周晓玉, 等. 南京两新生儿重症监护室新生儿呼吸衰竭临床流行病学调查[J]. 南京医科大学学报:自然科学版, 2009, 29(12):1750-1752.
9.	朱天闻, 张永红, 陈妍, 等. 晚期早产儿与足月新生儿呼吸衰竭发生及预后的影响因素[J]. 上海交通大学学报:医学版, 2013, 33(7):920-925.
10.	刘敬, 王晓风, 王华伟, 等. 足月新生儿呼吸窘迫综合征的诊断和治疗研究[J]. 中华全科医师杂志, 2013, 12(12):993-995.
11.	潘兆军, 丁素芳, 高子波, 等. 2010年江苏淮安基于出生人口新生儿呼吸衰竭流行病学调查[J]. 中国当代儿科杂志, 2014, 16(11):1138-1142.
12.	王海娟, 杨梅. 外源性肺表面活性物质治疗足月剖宫产儿呼吸窘迫综合征[J]. 中国新生儿科杂志, 2007, 22(5):304-305.
13.	Pawar M, Mehta Y, Khurana P, et al. Ventilator-associated pneumonia:Incidence, risk factors, outcome, and microbiology[J]. J Cardiothorac Vasc Anesth, 2003, 17(1):22-28.
14.	Josephson SA, Moheet AM, Gropper MA, et al. Ventilator-associated pneumonia in a neurologic intensive care unit does not Lead to increased mortality[J]. Neurocrit Care, 2010, 12(2):155-158.
15.	Deng C, Li X, Zou Y, et al. Risk factors and pathogen profile of ventilator-associated pneumonia in a neonatal intensive care unit in China[J]. Pediatr Int, 2011, 53(3):332-337.
16.	Roberts CL, Badgery-Parker T, Algert CS, et al. Trends in use of neonatal CPAP:a population-based study[J]. BMC Pediatr, 2011, 11:89.
17.	林新祝, 赖基栋, 兰朝阳, 等. 猪肺表面活性物质气管内灌洗治疗重症新生儿胎粪吸入综合征的临床研究[J]. 中国当代儿科杂志, 2014, 16(7):709-713.
18.	林新祝, 赖基栋, 吕梅, 等. 高频振荡通气联合肺表面活性物质治疗新生儿肺出血的疗效观察[J]. 中国当代儿科杂志, 2015, 17(4):345-349.
19.	刘金凤, 王军. 肺表面活性物质在新生儿重症肺炎治疗中的应用价值[J]. 东南大学学报:医学版, 2015, 34(6):958-961.
20.	Rüegger C, Hegglin M, Adams M, et al. Population based trends in mortality, morbidity and treatment for very preterm- and very low birth weight infants over 12 years[J]. BMC Pediatr, 2012, 12:17.
21.	Liu J, Yang N, Liu Y. High-risk factors of respiratory distress syndrome in term neonates:a retrospective case-control study[J]. Balkan Med J, 2014, 31(1):64-68.
22.	石树中, 虞人杰, 黄醒华, 等. 新生儿窒息复苏[M]. 上海:上海科技教育出版社, 2005:7.

1. Horbar JD, Badger GJ, Carpenter JH, et al. Trends in mortality and morbidity for very low birth weight infants, 1991-1999[J]. Pediatrics, 2002, 110(1 Pt 1):143-151.
2. Markestad T, Kaaresen PI, Rønnestad A, et al. Early death, morbidity, and need of treatment among extremely premature infants[J]. Pediatrics, 2005, 115(5):1289-1298.
3. Qian L, Liu C, Zhuang W, et al. Neonatal respiratory failure:a 12-month clinical epidemiologic study from 2004 to 2005 in China[J]. Pediatrics, 2008, 121(5):e1115-e1124.
4. Angus DC, Linde-Zwirble WT, Clermont G, et al. Epidemiology of neonatal respiratory failure in the United States:projections from California and New York[J]. Am J Respir Crit Care Med, 2001, 164(7):1154-1160.
5. Clark RH. The epidemiology of respiratory failure in neonates born at an estimated gestational age of 34 weeks or more[J]. J Perinatol, 2005, 25(4):251-257.
6. 赖娟, 杜立中, 熊国强, 等. 1 108例新生儿呼吸衰竭的临床流行病学特征[J]. 中国当代儿科杂志, 2016, 18(1):10-14.
7. Wang H, Gao X, Liu C, et al. Morbidity and mortality of neonatal respiratory failure in China:surfactant treatment in very immature infants[J]. Pediatrics, 2012, 129(3):e731-e740.
8. 程锐, 韩树萍, 周晓玉, 等. 南京两新生儿重症监护室新生儿呼吸衰竭临床流行病学调查[J]. 南京医科大学学报:自然科学版, 2009, 29(12):1750-1752.
9. 朱天闻, 张永红, 陈妍, 等. 晚期早产儿与足月新生儿呼吸衰竭发生及预后的影响因素[J]. 上海交通大学学报:医学版, 2013, 33(7):920-925.
10. 刘敬, 王晓风, 王华伟, 等. 足月新生儿呼吸窘迫综合征的诊断和治疗研究[J]. 中华全科医师杂志, 2013, 12(12):993-995.
11. 潘兆军, 丁素芳, 高子波, 等. 2010年江苏淮安基于出生人口新生儿呼吸衰竭流行病学调查[J]. 中国当代儿科杂志, 2014, 16(11):1138-1142.
12. 王海娟, 杨梅. 外源性肺表面活性物质治疗足月剖宫产儿呼吸窘迫综合征[J]. 中国新生儿科杂志, 2007, 22(5):304-305.
13. Pawar M, Mehta Y, Khurana P, et al. Ventilator-associated pneumonia:Incidence, risk factors, outcome, and microbiology[J]. J Cardiothorac Vasc Anesth, 2003, 17(1):22-28.
14. Josephson SA, Moheet AM, Gropper MA, et al. Ventilator-associated pneumonia in a neurologic intensive care unit does not Lead to increased mortality[J]. Neurocrit Care, 2010, 12(2):155-158.
15. Deng C, Li X, Zou Y, et al. Risk factors and pathogen profile of ventilator-associated pneumonia in a neonatal intensive care unit in China[J]. Pediatr Int, 2011, 53(3):332-337.
16. Roberts CL, Badgery-Parker T, Algert CS, et al. Trends in use of neonatal CPAP:a population-based study[J]. BMC Pediatr, 2011, 11:89.
17. 林新祝, 赖基栋, 兰朝阳, 等. 猪肺表面活性物质气管内灌洗治疗重症新生儿胎粪吸入综合征的临床研究[J]. 中国当代儿科杂志, 2014, 16(7):709-713.
18. 林新祝, 赖基栋, 吕梅, 等. 高频振荡通气联合肺表面活性物质治疗新生儿肺出血的疗效观察[J]. 中国当代儿科杂志, 2015, 17(4):345-349.
19. 刘金凤, 王军. 肺表面活性物质在新生儿重症肺炎治疗中的应用价值[J]. 东南大学学报:医学版, 2015, 34(6):958-961.
20. Rüegger C, Hegglin M, Adams M, et al. Population based trends in mortality, morbidity and treatment for very preterm- and very low birth weight infants over 12 years[J]. BMC Pediatr, 2012, 12:17.
21. Liu J, Yang N, Liu Y. High-risk factors of respiratory distress syndrome in term neonates:a retrospective case-control study[J]. Balkan Med J, 2014, 31(1):64-68.
22. 石树中, 虞人杰, 黄醒华, 等. 新生儿窒息复苏[M]. 上海:上海科技教育出版社, 2005:7.

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