Clinical characteristics of 41 cases of primary salivary glandtype lung cancer_West China Medical Journal

Authors：

YANG Liqing ^1,2 ,  YANG Xiaodong ¹ , ZHANG Yi ¹ , HU Qiufang ^1,3 , WANG Yan ¹ , CHEN Xuping ¹ , ZHOU Zhenxing ¹

1. Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Respiratory Medicine, the East Rigon of the People’s Hospital of Sichuan, Chengdu, Sichuan 610100, P. R. China;
3. Department of Nursing, Leshan Vocational and Technical College, Leshan, Sichuan 614000, P. R. China;

Corresponding author：

YANG Xiaodong, Email: yang-xiaodong@163.com

Keywords：

Primary salivary glandtype lung cancer; Clinical features; Rare low-grade malignancy

DOI：

10.7507/1002-0179.201604032

Video：

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Objective To enhance the understanding of the primary salivary glandtype lung cancer (PSGLC) and improve the diagnostic rate of the disease. Methods The clinical data of 41 patients with PSGLC pathologically confirmed in West China Hospital between October 2009 and October 2015 were analyzed in terms of clinical features, therapy and prognosis. Results All the 41 patients (21 males and 20 females) accounted for 0.22% (41/18 738) of the primary malignant lung tumor diagnosed in the same period. The patients aged from 16 to 72 with the median age of 43.6. The disease course was 1 month to 6 years, and 12 had smoking history. There were 23 cases of adenoid cystic carcinoma, 15 of mucoepidermoid carcinoma and 3 of acinic cell carcinoma. The symptoms, chest-computed tomography and fiberbronchoscopy examination had no specificity. There were 34 patients who had undergone surgery, in whom 3 had fiberbronchoscopy, 4 had oral traditional Chinese medicine treatment, 5 had chemotherapy and radiotherapy at the same time, 9 received chemotherapy only, and 4 recived radiotherapy only. Follow-up period lasted for 2-65 months, with the median time of 38 months. Two patients had recrudescence, 6 patients had distant metastasis and 1 patient died. Conclusions PSGLC have no specific clinical features; its diagnosis basically rely on pathological examination. After comprehensive treatment mainly on surgery, the prognosis of the disease is better than other malignant lung cancers.

Citation： YANG Liqing, YANG Xiaodong, ZHANG Yi, HU Qiufang, WANG Yan, CHEN Xuping, ZHOU Zhenxing. Clinical characteristics of 41 cases of primary salivary glandtype lung cancer. West China Medical Journal, 2017, 32(6): 857-861. doi: 10.7507/1002-0179.201604032 Copy

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5.	吴坚, 赵绍宏, 郭爱桃, 等. 原发涎腺型肺癌的 CT 诊断. 中华肿瘤杂志, 2011, 33(4): 313-316.
6.	Elnayal A, Moran CA, Fox PS, et al. Primary salivary gland-type lung cancer:imagingand clinical. AJR Am J Roentgenol, 2013, 201(1): W57-W63.
7.	陈昊, 王红霞, 闫蓉, 等. 3 种恶性涎腺上皮性肿瘤 EGFR 和 HER-2 表达的差异及意义. 广东医学, 2013, 34(21): 3255-3258.
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11.	Chopra A, Shim C, Sharma N, et al. Primary salivary type lung tumor: Mucoepidermoid carcinoma. Respir Med Case Rep, 2013, 9(4): 18-20.
12.	Chin CH, Huang CC, Lin MC, et al. Prognostic factors of tracheobronchial mucoepidermoid carcinoma--15 years experience. Respirology, 2008, 13(2): 275-280.
13.	Rivera MP. Lung cancer in women:differences in epidemiology,biology,histology,and treatment outcomes.Semin Respir Crit Care Med, 1994, 34(6): 51-52.
14.	Teo YK. Bronchial mucoepidermoid carcinoma: an unusual cause of complex cystic lung mass in a young man. J Bronchology Interv Pulmonol, 2010, 17(1): 73-75.
15.	Monaco SE, Khalbuss WE, Ustinova E, et al. The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: a report of 16 patients. Diagn Cytopathol, 2012, 40(12): 1062-1070.
16.	Brassesco MS, Valera ET, Lira RC, et al. Mucoepidermoid carcinoma of the lung arising at the primary site of a bronchogenic cyst: clinical, cytogenetic, and molecular findings. Pediatr Blood Cancer, 2011, 56(2): 311-313.

1. 杨朝晖, 王建军, 何燕, 等. 青年人肺原发性涎腺型肿瘤的临床病理特征及预后. 临床与实验病理学杂志, 2015, 31(3): 264-267.
2. 郑智, 潘铁成, 赵金平, 等. 涎腺型肺癌的诊断及治疗. 中国肿瘤临床, 2005, 32(12): 694-696.
3. 陆鸣, 柳玮华. 原发性肺涎腺肿瘤临床病理特点. 心肺血管病杂志, 2011, 30(5): 420-423.
4. Triantafillidou K, Dimitrakopoulos J, Iordanidis F, et al. Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature. Oral Dis, 2006, 12(4): 364-370.
5. 吴坚, 赵绍宏, 郭爱桃, 等. 原发涎腺型肺癌的 CT 诊断. 中华肿瘤杂志, 2011, 33(4): 313-316.
6. Elnayal A, Moran CA, Fox PS, et al. Primary salivary gland-type lung cancer:imagingand clinical. AJR Am J Roentgenol, 2013, 201(1): W57-W63.
7. 陈昊, 王红霞, 闫蓉, 等. 3 种恶性涎腺上皮性肿瘤 EGFR 和 HER-2 表达的差异及意义. 广东医学, 2013, 34(21): 3255-3258.
8. Molina R, Aubry M, Christine L, et al. Primary salivary glang-type lung cancer-spectrum of clinical presentation histopathologic and factors. Cancer, 2007, 15(11): 2253-2259.
9. Kanematsu T, Yohena T, Uehara T, et al. Treatment outcome of resected and nonresected primary adenoid cystic carcinoma of the lung. Ann Thorac Cardiovasc Surg, 2002, 8(2): 74-77.
10. Zhu F, Liu Z, Hou Y, et al. Primary salivary gland-type lung cancer: clinicopathological analysis of 88 cases from China. J Thorac Oncol, 2013, 8(12): 1578-1584.
11. Chopra A, Shim C, Sharma N, et al. Primary salivary type lung tumor: Mucoepidermoid carcinoma. Respir Med Case Rep, 2013, 9(4): 18-20.
12. Chin CH, Huang CC, Lin MC, et al. Prognostic factors of tracheobronchial mucoepidermoid carcinoma--15 years experience. Respirology, 2008, 13(2): 275-280.
13. Rivera MP. Lung cancer in women:differences in epidemiology,biology,histology,and treatment outcomes.Semin Respir Crit Care Med, 1994, 34(6): 51-52.
14. Teo YK. Bronchial mucoepidermoid carcinoma: an unusual cause of complex cystic lung mass in a young man. J Bronchology Interv Pulmonol, 2010, 17(1): 73-75.
15. Monaco SE, Khalbuss WE, Ustinova E, et al. The cytomorphologic spectrum of salivary gland type tumors in the lung and mediastinum: a report of 16 patients. Diagn Cytopathol, 2012, 40(12): 1062-1070.
16. Brassesco MS, Valera ET, Lira RC, et al. Mucoepidermoid carcinoma of the lung arising at the primary site of a bronchogenic cyst: clinical, cytogenetic, and molecular findings. Pediatr Blood Cancer, 2011, 56(2): 311-313.

West China Medical Journal

Clinical characteristics of 41 cases of primary salivary glandtype lung cancer

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