Research on the relationship between a body shape index and abnormal inflammation_West China Medical Journal

Authors：

HE Sen ¹ , LI Chunhui ² , ZHENG Yi ¹ , CUI Kaijun ¹ ,  CHEN Xiaoping ¹

1. Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Cardiology, General Hospital of Panzhihua Iron and Steel Group, Panzhihua, Sichuan 617023, P. R. China;

Corresponding author：

CHEN Xiaoping, Email: chenxp13@aliyun.com

Keywords：

A body shape index; Body mass index; Waist circumstance; Abnormal inflammation

DOI：

10.7507/1002-0179.201703032

Video：

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Objective To investigate the relationship between a body shape index (ABSI) and abnormal inflammation. Methods In May 2007, a cross-sectional study was conducted among 651 individuals by random sampling method in an urban community located in Chenghua district of Chengdu. We mainly assessed the relationship between ABSI and abnormal inflammation, which was defined as high sensitive C-reactive protein equal to 3 mg/L or higher. Results Logistic regression analysis showed that body mass index (BMI), waist circumference (WC) and ABSI were independently associated with abnormal inflammation. For identifying abnormal inflammation, WC had the best discriminatory power with the area under the receiver operating characteristic curve (AROC) was 0.627 [95% CI (0.564, 0.689)], followed by BMI (AROC: 0.609) and ABSI (AROC: 0.608). In addition, combination with ABSI could improve the discriminatory power of BMI for abnormal inflammation, and AROC increased from 0.609 to 0.646. Combination with ABSI could also improve the discriminatory power of WC for abnormal inflammation, and AROC only increased from 0.627 to 0.631. Conclusions In the general Chinese population, ABSI is independently associated with abnormal inflammation, but the discriminatory power is poor, no better than BMI and WC. Furthermore, combination with ABSI can improve the discriminatory power of BMI and WC for abnormal inflammation, especially for BMI. Further studies about ethnic specificities of ABSI are needed.

Citation： HE Sen, LI Chunhui, ZHENG Yi, CUI Kaijun, CHEN Xiaoping. Research on the relationship between a body shape index and abnormal inflammation. West China Medical Journal, 2017, 32(4): 515-519. doi: 10.7507/1002-0179.201703032 Copy

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18.	Sowmya S, Thomas T, Bharathi AV,et al. A body shape index and heart rate variability in healthy indians with low body mass index. J Nutr Metab, 2014, 2014: 865313.
19.	Cheung YB. " A Body Shape Index” in middle-age and older Indonesian population: scaling exponents and association withincident hypertension. PLoS One, 2014, 9: e85421.
20.	Afsar B, Elsurer R, Kirkpantur A. Body shape index and mortality in hemodialysis patients. Nutrition, 2013, 29(10): 1214-1218.
21.	舒燕, 何森, 陈晓平, 等. 甘油三酯和高密度脂蛋白胆固醇与炎症的关系. 中华心血管病杂志, 2012, 40(2): 125-130.
22.	Ren J, Grundy SM, Liu J,et al. Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS). Atherosclerosis, 2010, 211(1): 327-332.
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24.	罗健, 张源明. 高血压: 一种慢性低级别炎症性疾病. 心血管病学进展, 2010, 31(4): 567-569.
25.	罗勇, 李小平, 吕湛, 等. 超重及肥胖者血清 TNF-α、IL-6、CRP 水平变化及意义的研究. 四川医学, 2008, 29(6): 658-660.
26.	Mohamed-Ali V, Goodrick S, Rawesh A,et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha,in vivo. J Clin Endocrinol Metab, 1997, 82(12): 4196-4200.
27.	Heilbronn LK, Noakes M, Clifton PM. Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women. Arterioscler Thromb Vasc Biol, 2001, 21(6): 968-970.
28.	Tchernof A, Nolan A, Sites CK,et al. Weight loss reduces C-reactive protein levels in obese postmenopausal women. Circulation, 2002, 105(5): 564-569.
29.	Lear SA, Humphries KH, Kohli S,et al. Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT) Am J Clin Nutr, 2007, 86(2): 353-359.
30.	Ross R, Berentzen T, Bradshaw AJ,et al. Does the relationship between waist circumference, morbidity and mortality depend on measurement protocol for waist circumference?. Obes Rev, 2008, 9(4): 312-325.

1. Pei J, You X, Fu Q. Inflammation in the pathogenesis of ischemic stroke. Front Biosci (Landmark Ed), 2015, 20: 772-783.
2. Rethorst CD, Bernstein I, Trivedi MH. Inflammation, obesity, and metabolic syndrome in depression: analysis of the 2009-2010 National Health and Nutrition Examination Survey (NHANES). J Clin Psychiatry, 2014, 75: e1428-e1432.
3. Nakamura H, Ito H, Egami Y,et al. Waist circumference is the main determinant of elevated C-reactive protein in metabolic syndrome. Diabetes Res Clin Pract, 2008, 79(2): 330-336.
4. Rana JS, Arsenault BJ, Després JP,et al. Inflammatory biomarkers, physical activity, waist circumference, and risk of future coronary heart disease in healthy men and women. Eur Heart J, 2011, 32(3): 336-344.
5. Bansal T, Pandey A, D D,et al. C-reactive protein (CRP) and its association with periodontal disease: a brief review. J Clin Diagn Res, 2014, 8: ZE21-ZE24.
6. Ghaffari MA, Askari Sede S, Rashtchizadeh N,et al. Association of CRP gene polymorphism with CRP levels and coronary artery disease in type 2 diabetes in Ahvaz, southwest of Iran. Bioimpacts, 2014, 4(3): 133-139.
7. Brandt C, Pedersen M, Rinnov A,et al. Obesity and low-grade inflammation increase plasma follistatin-like 3 in humans. Mediators Inflamm, 2014, 2014: 364209.
8. Mraz M, Haluzik M. The role of adipose tissue immune cells in obesity and low-grade inflammation. J Endocrinol, 2014, 222(3): R113-R127.
9. Ota T. Obesity-induced inflammation and insulin resistance. Front Endocrinol (Lausanne), 2014, 5: 204.
10. Krakauer NY, Krakauer JC. A new body shape index predicts mortality hazard independently of body mass index. PLoS One, 2012, 7: e39504.
11. Krakauer NY, Krakauer JC. Dynamic association of mortality hazard with body shape. PLoS One, 2014, 9: e88793.
12. Eom BW, Joo J, Yoon HM,et al. A body shape index has a good correlation with postoperative complications in gastric cancer surgery. Ann Surg Oncol, 2014, 21(4): 1115-1122.
13. Duncan MJ, Mota J, Vale S,et al. Associations between body mass index, waist circumference and body shape index with resting blood pressure in Portuguese adolescents. Ann Hum Biol, 2013, 40(2): 163-167.
14. He S, Chen X. Could the new body shape index predict the new onset of diabetes mellitus in the Chinese population?. PLoS One, 2013: e50573.
15. Haghighatdoost F, Sarrafzadegan N, Mohammadifard N,et al. Assessing body shape index as a risk predictor for cardiovascular diseases and metabolic syndrome among Iranian adults. Nutrition, 2014, 30(6): 636-644.
16. Maessen MF, Eijsvogels TM, Verheggen RJ,et al. Entering a new era of body indices: the feasibility of a body shape index and body roundness index to identifycardiovascular health status. PLoS One, 2014, 9: e107212.
17. Biolo G, Di Girolamo FG, Breglia A,et al. Inverse relationship between " a body shape index” (ABSI) and fat-free mass in women and men: insights into mechanisms of sarcopenic obesity. Clin Nutr, 2015, 34(2): 323-327.
18. Sowmya S, Thomas T, Bharathi AV,et al. A body shape index and heart rate variability in healthy indians with low body mass index. J Nutr Metab, 2014, 2014: 865313.
19. Cheung YB. " A Body Shape Index” in middle-age and older Indonesian population: scaling exponents and association withincident hypertension. PLoS One, 2014, 9: e85421.
20. Afsar B, Elsurer R, Kirkpantur A. Body shape index and mortality in hemodialysis patients. Nutrition, 2013, 29(10): 1214-1218.
21. 舒燕, 何森, 陈晓平, 等. 甘油三酯和高密度脂蛋白胆固醇与炎症的关系. 中华心血管病杂志, 2012, 40(2): 125-130.
22. Ren J, Grundy SM, Liu J,et al. Long-term coronary heart disease risk associated with very-low-density lipoprotein cholesterol in Chinese: the results of a 15-Year Chinese Multi-Provincial Cohort Study (CMCS). Atherosclerosis, 2010, 211(1): 327-332.
23. 中国高血压防治指南修订委员会. 中国高血压防治指南 (2005 年修订版). 高血压杂志, 2005, 134(增刊1): 2-41.
24. 罗健, 张源明. 高血压: 一种慢性低级别炎症性疾病. 心血管病学进展, 2010, 31(4): 567-569.
25. 罗勇, 李小平, 吕湛, 等. 超重及肥胖者血清 TNF-α、IL-6、CRP 水平变化及意义的研究. 四川医学, 2008, 29(6): 658-660.
26. Mohamed-Ali V, Goodrick S, Rawesh A,et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha,in vivo. J Clin Endocrinol Metab, 1997, 82(12): 4196-4200.
27. Heilbronn LK, Noakes M, Clifton PM. Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women. Arterioscler Thromb Vasc Biol, 2001, 21(6): 968-970.
28. Tchernof A, Nolan A, Sites CK,et al. Weight loss reduces C-reactive protein levels in obese postmenopausal women. Circulation, 2002, 105(5): 564-569.
29. Lear SA, Humphries KH, Kohli S,et al. Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT) Am J Clin Nutr, 2007, 86(2): 353-359.
30. Ross R, Berentzen T, Bradshaw AJ,et al. Does the relationship between waist circumference, morbidity and mortality depend on measurement protocol for waist circumference?. Obes Rev, 2008, 9(4): 312-325.

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Research on the relationship between a body shape index and abnormal inflammation

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