片仔癀联合多西他赛对舌鳞状细胞癌细胞生长及凋亡的影响_West China Medical Journal

Authors：

王丹 ¹ ,  张忠提 ² , 王振华 ¹

1. ;
2. ;

Corresponding author：

张忠提, Email: zhangzhongti@163.com

Keywords：

片仔癀; 多西他赛; 舌鳞状细胞癌; 细胞生长; 细胞凋亡

DOI：

10.7507/1002-0179.201704054

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的探讨片仔癀联合多西他赛对舌鳞状细胞癌（鳞癌）Tca8113 细胞生长、凋亡及细胞周期的影响。方法取对数生长期 Tca8113 细胞，设对照组、片仔癀单药组（450 μg/mL）、多西他赛单药组（0.01 μg/L）及联合用药组，培养 48 h 后，应用碘化丙啶（propidium iodide，PI）染色检测药物对 Tca8113 细胞周期的影响，应用流式细胞仪检测细胞的凋亡情况。结果 PI 染色结果显示片仔癀与多西他赛联合用药可阻滞细胞于 G₀/G₁ 期和 G₂/M 期，且与对照组及各单药组相比 S 期细胞的下降比例显著降低（P<0.01）。AnnexinV/PI 双染试验结果显示联合用药组与对照组及各单药组相比，细胞凋亡比例显著升高（P<0.01）。结论片仔癀与多西他赛联合应用可抑制舌鳞癌细胞生长并促进细胞凋亡。

Citation： 王丹, 张忠提, 王振华. 片仔癀联合多西他赛对舌鳞状细胞癌细胞生长及凋亡的影响. West China Medical Journal, 2017, 32(6): 880-882. doi: 10.7507/1002-0179.201704054 Copy

1.	张陈平. 关于舌癌治疗的几点建议. 中国实用口腔科杂志, 2010, 3(7): 385-387.
2.	Takácsi-Nagy Z, Hitre E, Remenár É, et al. Docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by chemoradiotherapy or chemoradiotherapy alone in stage Ⅲ-Ⅳ unresectable head and neck cancer: Results of a randomized phase Ⅱ study. Strahlenther Onkol, 2015, 191(8): 635-641.
3.	Van Der Veldt AA, Lubberink M, Mathijssen RH, et al. Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [¹¹C] docetaxel and positron emission tomography. Clin Cancer Res, 2013, 19(15): 4163-4173.
4.	王兴远, 江波, 李程, 等. 多西他赛联合拓扑替康治疗晚期胃癌的临床观察. 华西医学, 2009, 24(9): 2336-2337.
5.	Lü L, Wai MS, Yew DT, et al. Pien Tze huang, a composite Chinese traditional herbal extract, affects survival of neuroblastoma cells. Int J Neurosci, 2009, 119(2): 255-262.
6.	Zhuang Q, Hong F, Shen A, et al. Pien Tze huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. Int J Oncol, 2012, 40(5): 1569-1574.
7.	Fu Y, Zhang L, Hong Z, et al. Methanolic extract of Pien Tze huang induces apoptosis signaling in human osteosarcoma MG63 cells via multiple pathways. Molecules, 2016, 21(3): 283.
8.	Lin J, Feng J, Jin Y, et al. Pien Tze huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer. Oncol Rep, 2016, 36(6): 3568-3576.
9.	He F, Wu HN, Cai MY, et al. Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway. Oncol Lett, 2014, 7(6): 2047-2052.
10.	Shen A, Chen Y, Hong F, et al. Pien Tze huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. Oncol Rep, 2012, 28(6): 2125-2130.
11.	Motonaga M, Yamamoto N, Makino Y, et al. Phase Ⅰ dose-finding and pharmacokinetic study of docetaxel and gefitinib in patients with advanced or metastatic non-small-cell lung cancer: evaluation of drug-drug interaction. Cancer Chemother Pharmacol, 2015, 76(4): 713-721.

1. 张陈平. 关于舌癌治疗的几点建议. 中国实用口腔科杂志, 2010, 3(7): 385-387.
2. Takácsi-Nagy Z, Hitre E, Remenár É, et al. Docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by chemoradiotherapy or chemoradiotherapy alone in stage Ⅲ-Ⅳ unresectable head and neck cancer: Results of a randomized phase Ⅱ study. Strahlenther Onkol, 2015, 191(8): 635-641.
3. Van Der Veldt AA, Lubberink M, Mathijssen RH, et al. Toward prediction of efficacy of chemotherapy: a proof of concept study in lung cancer patients using [¹¹C] docetaxel and positron emission tomography. Clin Cancer Res, 2013, 19(15): 4163-4173.
4. 王兴远, 江波, 李程, 等. 多西他赛联合拓扑替康治疗晚期胃癌的临床观察. 华西医学, 2009, 24(9): 2336-2337.
5. Lü L, Wai MS, Yew DT, et al. Pien Tze huang, a composite Chinese traditional herbal extract, affects survival of neuroblastoma cells. Int J Neurosci, 2009, 119(2): 255-262.
6. Zhuang Q, Hong F, Shen A, et al. Pien Tze huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model. Int J Oncol, 2012, 40(5): 1569-1574.
7. Fu Y, Zhang L, Hong Z, et al. Methanolic extract of Pien Tze huang induces apoptosis signaling in human osteosarcoma MG63 cells via multiple pathways. Molecules, 2016, 21(3): 283.
8. Lin J, Feng J, Jin Y, et al. Pien Tze huang suppresses VEGF-C-mediated lymphangiogenesis in colorectal cancer. Oncol Rep, 2016, 36(6): 3568-3576.
9. He F, Wu HN, Cai MY, et al. Inhibition of ovarian cancer cell proliferation by Pien Tze Huang via the AKT-mTOR pathway. Oncol Lett, 2014, 7(6): 2047-2052.
10. Shen A, Chen Y, Hong F, et al. Pien Tze huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3. Oncol Rep, 2012, 28(6): 2125-2130.
11. Motonaga M, Yamamoto N, Makino Y, et al. Phase Ⅰ dose-finding and pharmacokinetic study of docetaxel and gefitinib in patients with advanced or metastatic non-small-cell lung cancer: evaluation of drug-drug interaction. Cancer Chemother Pharmacol, 2015, 76(4): 713-721.

Previous Article
Investigation on the awareness of diabetes complications in outpatients with diabetes
Next Article
合并 2 型糖尿病对晚期结直肠癌患者疾病无进展生存时间的影响

West China Medical Journal

片仔癀联合多西他赛对舌鳞状细胞癌细胞生长及凋亡的影响

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content