Diagnostic value of vascular endothelial growth factor-D for the diagnosis of lymphangioleiomyoatosis: a Meta-analysis_West China Medical Journal

Authors：

LI Min , WAN Chu , SUN Shibo , WANG Rongchun , SHI Shaoqing ,  LUO Zhuang

Department of Respiratory Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032. P. R. China;

Corresponding author：

LUO Zhuang, Email: skyny4511@126.com

Keywords：

Vascular endothelial growth factor-D; Lymphangioleiomyomatosis; Diagnostic test; Meta-analysis

DOI：

10.7507/1002-0179.201710031

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To evaluate the diagnostic value of vascular endothelial growth factor (VEGF)-D detection for the diagnosis of lymphangioleiomyomatosis (LAM) by Meta-analysis. Methods Literatures published before August 2017 were retrieved from PubMed, Embase, China Biology Medicine database, China National Knowledge Internet, Wangfang, and VIP database to retrieve the study about VEGF-D detection for LAM. The studies were screened according to the inclusive and exclusive criteria, the data were extracted, the quality was assessed and the Meta-analysis was performed with related statistical software. Results Six primary studies were included and 521 patients met the inclusion criterion. The Meta-analysis showed the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and diagnostic odds ratio of 0.75 [95% confidence interval (CI) (0.70, 0.79)], 0.95 [95%CI (0.91, 0.98)], 16.20 [95%CI (8.70, 30.19)], 0.20 [95%CI (0.10, 0.40)] and 89.49 [95%CI (38.46, 208.22)], respectively. The area under the curve was 0.953 9. Conclusions VEGF-D detection showes a good diagnostic value for LAM. A positive result is more clinical meaningful compared with a negative result, helping for the confirmation of the disease.

Citation： LI Min, WAN Chu, SUN Shibo, WANG Rongchun, SHI Shaoqing, LUO Zhuang. Diagnostic value of vascular endothelial growth factor-D for the diagnosis of lymphangioleiomyoatosis: a Meta-analysis. West China Medical Journal, 2018, 33(1): 53-59. doi: 10.7507/1002-0179.201710031 Copy

1.	Meraj R, Wikenheiser-Brokamp KA, Young LR. Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment. Semin Respir Crit Care Med, 2012, 33(5): 486-497.
2.	Johnson SR, Cordier JF, Lazor R, et al. European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis. Eur Respir J, 2010, 35(1): 14-26.
3.	Hagaman JT, Schauer DP, McCormack FX, et al. Screening for lymphangioleiomyomatosis by high-resolution computed tomography in young, nonsmoking women presenting with spontaneous pneumothorax is cost-effective. Am J Respir Crit Care Med, 2010, 181(12): 1376-1382.
4.	Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun, 1989, 161(2): 851-858.
5.	Achen MG, Jeltsch M, Kukk E, et al. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinasesVEGF receptor 2(Flk1) and VEGF receptor 3(Flt4). Proc Natl Acad Sci USA, 1998, 95(2): 548-553.
6.	Kumasaka T, Seyama K, Mitani K, et al. Lymphangiogenesis in lymphangioleiomyomatosis: its implication in the progression of lymphangioleiomyomatosis. Am J Surg Pathol, 2004, 28(8): 1007-1016.
7.	Kumasaka T, Seyama K, Mitani K, et al. Lymphangiogenesis-mediated shedding of LAM cell clusters as a mechanism for dissemination in lymphangioleiomyomatosis. Am J Surg Pathol, 2005, 29(10): 1356-1366.
8.	Seyama K, Kumasaka T, Souma S, et al. Vascular endothelial growth factor-D is increased in serum of patients with lymphangioleiomyomatosis. Lymphat Res Biol, 2006, 4(3): 143-152.
9.	Glasgow CG, Avila NA, Lin JP, et al. Serum vascular endothelial growth factor-D levels in patients with lymphangioleiomyomatosis reflect lymphatic involvement. Chest, 2009, 135(5): 1293-1300.
10.	Young LR, Inoue Y, McCormack FX. Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis. N Engl J Med, 2008, 358(2): 199-200.
11.	Young LR, Vandyke R, Gulleman PM, et al. Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest, 2010, 138(3): 674-681.
12.	Chang WY, Cane JL, Blakey JD, et al. Clinical utility of diagnostic guidelines and putative biomarkers in lymphangioleiomyomatosis. Respir Res, 2012, 13: 34.
13.	Radzikowska E, Jaguś P, Skoczylas A, et al. Role of serum vascular endothelial growth factor D in discrimination of patients with polycystic lung diseases. Pol Arch Med Wewn, 2013, 123(10): 533-538.
14.	Xu KF, Zhang P, Tian X, et al. The role of vascular endothelial growth factor-D in diagnosis of lymphangioleiomyomatosis (LAM) . Respir Med, 2013, 107(2): 263-268.
15.	Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuary studies. Ann Intern Med, 2011, 155(8): 529-536.
16.	Irwig L, Tosteson AN, Gatsonis C, et al. Guidelines for meta-analyses evaluating diagnostic tests. Ann Intern Med, 1994, 120(8): 667-676.
17.	Vamvakas EC. Meta-analyses of studies of the diagnostic accuracy of laboratory tests: a review of the concepts and methods. Arch Pathol Lab Med, 1998, 122(8): 675-686.
18.	Deeks JJ, Macaskill P, Irwig L. The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol, 2005, 58(9): 882-893.
19.	刘关键, 吴泰相. 诊断性试验的Meta分析——SROC曲线法介绍. 中国循证医学杂志, 2003, 3(1): 41-44.
20.	Xu KF, Lo BH. Lymphangioleiomyomatosis: differential diagnosis and optimal management. Ther Clin Risk Manag, 2014, 10: 691-700.
21.	Hyman MH, Whittemore VH. National institutes of health consensus conference: tuberous sclerosis complex. Arch Neurol, 2000, 57(5): 662-665.
22.	McCormack FX, Gupta N, Finlay GR, et al. Official American Thoracic Society/Japanses Respiratory Society clinical practice guidelines: lymphangioleiomymatosis diagnosis and management. Am J Respir Crit Care Med, 2016, 194(6): 748-761.

1. Meraj R, Wikenheiser-Brokamp KA, Young LR. Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment. Semin Respir Crit Care Med, 2012, 33(5): 486-497.
2. Johnson SR, Cordier JF, Lazor R, et al. European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis. Eur Respir J, 2010, 35(1): 14-26.
3. Hagaman JT, Schauer DP, McCormack FX, et al. Screening for lymphangioleiomyomatosis by high-resolution computed tomography in young, nonsmoking women presenting with spontaneous pneumothorax is cost-effective. Am J Respir Crit Care Med, 2010, 181(12): 1376-1382.
4. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun, 1989, 161(2): 851-858.
5. Achen MG, Jeltsch M, Kukk E, et al. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinasesVEGF receptor 2(Flk1) and VEGF receptor 3(Flt4). Proc Natl Acad Sci USA, 1998, 95(2): 548-553.
6. Kumasaka T, Seyama K, Mitani K, et al. Lymphangiogenesis in lymphangioleiomyomatosis: its implication in the progression of lymphangioleiomyomatosis. Am J Surg Pathol, 2004, 28(8): 1007-1016.
7. Kumasaka T, Seyama K, Mitani K, et al. Lymphangiogenesis-mediated shedding of LAM cell clusters as a mechanism for dissemination in lymphangioleiomyomatosis. Am J Surg Pathol, 2005, 29(10): 1356-1366.
8. Seyama K, Kumasaka T, Souma S, et al. Vascular endothelial growth factor-D is increased in serum of patients with lymphangioleiomyomatosis. Lymphat Res Biol, 2006, 4(3): 143-152.
9. Glasgow CG, Avila NA, Lin JP, et al. Serum vascular endothelial growth factor-D levels in patients with lymphangioleiomyomatosis reflect lymphatic involvement. Chest, 2009, 135(5): 1293-1300.
10. Young LR, Inoue Y, McCormack FX. Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis. N Engl J Med, 2008, 358(2): 199-200.
11. Young LR, Vandyke R, Gulleman PM, et al. Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest, 2010, 138(3): 674-681.
12. Chang WY, Cane JL, Blakey JD, et al. Clinical utility of diagnostic guidelines and putative biomarkers in lymphangioleiomyomatosis. Respir Res, 2012, 13: 34.
13. Radzikowska E, Jaguś P, Skoczylas A, et al. Role of serum vascular endothelial growth factor D in discrimination of patients with polycystic lung diseases. Pol Arch Med Wewn, 2013, 123(10): 533-538.
14. Xu KF, Zhang P, Tian X, et al. The role of vascular endothelial growth factor-D in diagnosis of lymphangioleiomyomatosis (LAM) . Respir Med, 2013, 107(2): 263-268.
15. Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuary studies. Ann Intern Med, 2011, 155(8): 529-536.
16. Irwig L, Tosteson AN, Gatsonis C, et al. Guidelines for meta-analyses evaluating diagnostic tests. Ann Intern Med, 1994, 120(8): 667-676.
17. Vamvakas EC. Meta-analyses of studies of the diagnostic accuracy of laboratory tests: a review of the concepts and methods. Arch Pathol Lab Med, 1998, 122(8): 675-686.
18. Deeks JJ, Macaskill P, Irwig L. The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol, 2005, 58(9): 882-893.
19. 刘关键, 吴泰相. 诊断性试验的Meta分析——SROC曲线法介绍. 中国循证医学杂志, 2003, 3(1): 41-44.
20. Xu KF, Lo BH. Lymphangioleiomyomatosis: differential diagnosis and optimal management. Ther Clin Risk Manag, 2014, 10: 691-700.
21. Hyman MH, Whittemore VH. National institutes of health consensus conference: tuberous sclerosis complex. Arch Neurol, 2000, 57(5): 662-665.
22. McCormack FX, Gupta N, Finlay GR, et al. Official American Thoracic Society/Japanses Respiratory Society clinical practice guidelines: lymphangioleiomymatosis diagnosis and management. Am J Respir Crit Care Med, 2016, 194(6): 748-761.

West China Medical Journal

Diagnostic value of vascular endothelial growth factor-D for the diagnosis of lymphangioleiomyoatosis: a Meta-analysis

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