左下肺片团影_West China Medical Journal

Authors：

 杨小东 , 王茂筠 , 陈旭萍 , 王业

四川大学华西医院呼吸与危重症医学科（成都 610041）;

Corresponding author：

杨小东, Email: yang-xiaodong@163.com

Keywords：

肺部片团影; 肺动静脉瘘; 遗传性出血性毛细血管扩张症

DOI：

10.7507/1002-0179.201710032

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

讨论病案为胸部 CT 平扫显示的肺部片团影像，是呼吸系统常见的影像学改变，临床多考虑感染性疾病、肿瘤或非感染非肿瘤性病变。初诊医师根据临床特征、影像学细微的差异，对患者进行胸部增强 CT 易于发现此病灶为血管结构，并非常见的感染或肿瘤病变。有条件的单位可进行肺血管重建、心室声学造影以及肺动脉造影，就能确诊肺动静脉瘘。临床医师以此为最终诊断是非常普遍的，但专科医师应结合患者受凉感冒后易发生鼻衄且有家族史，全面考虑并深入探究其可能的病因如先天性或遗传性因素的可能，应当熟悉各种罕见病的临床特征，如遗传性出血性毛细血管扩张症。通过家系资料收集、连锁分析，目标基因全外显子测序，最终证实该例患者是遗传性出血性毛细血管扩张症，临床表现出动静脉瘘并有其他部位出血。

Citation： 杨小东, 王茂筠, 陈旭萍, 王业. 左下肺片团影. West China Medical Journal, 2018, 33(1): 108-114. doi: 10.7507/1002-0179.201710032 Copy

1.	Sutton HG. Epistaxis as an indication of impaired nutrition, and of degeneration of the vascular system. Med Mirror, 1864, 1: 769-781.
2.	Pau H, Caney AS, Murty G, et al. Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): otorhinolaryngological manifestations. Clin Otolaryngol, 2001, 26(2): 93-98.
3.	Hanes FM. Multiple hereditary telangiectasia causing hemorrhage (hereditary hemorrhagic telangiectasia). Bull Johns Hopkins Hisp, 1909, 20: 63-75.
4.	Mcdonald MT, Papenberg KA, Ghosh S, et al. A disease locus for hereditary haemorrhagic telangiectasia maps to chromosome 9q33-34. Nat Genet, 1994, 6(2): 197-204.
5.	Vincent P, Plauchu H, Hazan J, et al. A third locus for hereditary hemorrhagic telangiectasia maps to chromosome 12q. Hum Mol Genet, 1995, 4(5): 945-949.
6.	Cole SG, Begbie ME, Wallace GM, et al. A new locus for hereditary haemorrhagic telangiectasia (HHT3) maps to chromosome 5. J Med Genet, 2005, 42(7): 577-582.
7.	Richards-Yutz J, Grant K, Chao EC, et al. Update on molecular diagnosis of hereditary hemorrhagic telangiectasia. Hum Genet, 2010, 128(1): 61-77.
8.	Shovlin CL, Letarte M. Hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms. Thorax, 1999, 54(8): 714-729.
9.	李为民, 刘伦旭. 呼吸系统疾病基础与临床. 北京: 人民卫生出版社, 2017: 1120-1126.
10.	Faughnan ME, Palda VA, Garcia-Tsao G, et al. International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia. J Med Genet, 2011, 48(2): 73-87.
11.	Shovlin CL, Guttmacher AE, Buscarini E, et al. Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). Am J Med Genet, 2000, 91(1): 66-67.

1. Sutton HG. Epistaxis as an indication of impaired nutrition, and of degeneration of the vascular system. Med Mirror, 1864, 1: 769-781.
2. Pau H, Caney AS, Murty G, et al. Hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome): otorhinolaryngological manifestations. Clin Otolaryngol, 2001, 26(2): 93-98.
3. Hanes FM. Multiple hereditary telangiectasia causing hemorrhage (hereditary hemorrhagic telangiectasia). Bull Johns Hopkins Hisp, 1909, 20: 63-75.
4. Mcdonald MT, Papenberg KA, Ghosh S, et al. A disease locus for hereditary haemorrhagic telangiectasia maps to chromosome 9q33-34. Nat Genet, 1994, 6(2): 197-204.
5. Vincent P, Plauchu H, Hazan J, et al. A third locus for hereditary hemorrhagic telangiectasia maps to chromosome 12q. Hum Mol Genet, 1995, 4(5): 945-949.
6. Cole SG, Begbie ME, Wallace GM, et al. A new locus for hereditary haemorrhagic telangiectasia (HHT3) maps to chromosome 5. J Med Genet, 2005, 42(7): 577-582.
7. Richards-Yutz J, Grant K, Chao EC, et al. Update on molecular diagnosis of hereditary hemorrhagic telangiectasia. Hum Genet, 2010, 128(1): 61-77.
8. Shovlin CL, Letarte M. Hereditary hemorrhagic telangiectasia and pulmonary arteriovenous malformations: issues in clinical management and review of pathogenic mechanisms. Thorax, 1999, 54(8): 714-729.
9. 李为民, 刘伦旭. 呼吸系统疾病基础与临床. 北京: 人民卫生出版社, 2017: 1120-1126.
10. Faughnan ME, Palda VA, Garcia-Tsao G, et al. International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia. J Med Genet, 2011, 48(2): 73-87.
11. Shovlin CL, Guttmacher AE, Buscarini E, et al. Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome). Am J Med Genet, 2000, 91(1): 66-67.

Previous Article
The clinical value of lung rehabilitation in the perioperative period of enhanced recovery after surgery
Next Article
误诊为重症哮喘的呼吸窘迫一例

West China Medical Journal

左下肺片团影

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content