The disinfection effect of peracetic acid <b><i>versus</i></b> glutaraldehyde in disinfection of flexible endoscope: a Meta-analysis _West China Medical Journal

Authors：

 XIE Jing ¹ , CHEN Min ² , LUO Xuefeng ²

1. Operation Management Department, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

XIE Jing, Email: 1207328440@qq.com

Keywords：

Peracetic acid; Glutaraldehyde; Endoscope; Disinfection; Meta-analysis

DOI：

10.7507/1002-0179.201710179

Video：

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ObjectiveTo compare the disinfection effect of peracetic acid versus glutaraldehyde in disinfection of flexible endoscope, and provide suggestions for choosing endoscopic disinfectant.MethodsWe searched literatures in PubMed, Embase, Cochrane Central Library, China National Knowledge Infrastructure, Wanfang database and VIP database, with the retrieval time from the establishment of each database to July 2017, screening and comparing the disinfection qualification rate of peroxyacetic acid versus glutaraldehyde in immersion disinfection of flexible endoscope. The number of flexible endoscopies after disinfection was the main effect index, and a fixed effect model analysis was performed.ResultsSix comparative studies were enrolled in this Meta-analysis, with a total of 786 flexible endoscopes. The result of Meta-analysis showed that the qualification rate of disinfection of peracetic acid was higher than that of glutaraldehyde with the same disinfection time [relative risk=1.09, 95% confidence interval (1.06, 1.13), P<0.000 01].ConclusionThe disinfection effect of peroxyacetic acid immersion method is better than that of glutaraldehyde.

Citation： XIE Jing, CHEN Min, LUO Xuefeng. The disinfection effect of peracetic acid versus glutaraldehyde in disinfection of flexible endoscope: a Meta-analysis . West China Medical Journal, 2018, 33(3): 302-306. doi: 10.7507/1002-0179.201710179 Copy

1.	Park S, Jang JY, Koo JS, et al. A review of current disinfectants for gastrointestinal endoscopic reprocessing. Clin Endosc, 2013, 46(4): 337-341.
2.	Beilenhoff U, Neumann CS, Rey JF, et al. European society of gastrointestinal endoscopy; European society of gastroenterology and endoscopy nurses and associates. ESGE-ESGENA guideline: cleaning and disinfection in gastrointestinal endoscopy. Endoscopy, 2008, 40(11): 939.
3.	Vizcaino-Alcaide MJ. Herruzo-Cabrera R, Fernandez-Aceñero M J.comparison of the disinfectant efficacy of perasafe and 2% glutaraldehyde in in vitro tests. J Hosp Infect, 2003, 53(2): 124-128.
4.	Petersen BT, Chennat J, Cohen J, et al. Multisociety guideline on reprocessing flexible gastrointestinal endoscopes: 2011. Gastrointest Endosc, 2011, 73(6): 1075-1084.
5.	马春丽, 李武平, 宋向阳, 等. 三种消毒剂对消化内镜消毒效果比较观察. 中国消毒学杂志, 2013, 30(5): 414-415, 419.
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7.	刘倩雯, 李练, 叶婉华, 等. 新型过氧乙酸对软式内镜消毒效果的评价. 中国药物经济学, 2016, 11(8): 69-72.
8.	吴仁培, 方爱乔, 刘建强, 等. 新型过氧乙酸溶液消毒消化内镜的效果评价. 中华消化内镜杂志, 2012, 29(3): 159-162.
9.	于泳, 崔静, 刘霞, 等. 新型过氧乙酸溶液消毒消化内镜的效果评价. 中国伤残医学, 2014(18): 24-25.
10.	王泽琼. 过氧乙酸型内镜消毒机对纤维支气管镜消毒的应用观察. 当代护士: 专科版, 2012(11): 9-10.
11.	钟昱文, 翁涛华, 黄美卿, 等. 四种全自动内镜消毒机对内镜消毒效果的比对观察. 中国消毒学杂志, 2008, 25(4): 359-362.
12.	徐勇. 内镜消毒剂的选择. 中国内镜杂志, 2002, 8(7): 28-30.
13.	张艳红. 消化内镜消毒剂选择. 中华医院感染学杂志, 2006, 16(9): 1078-1080.
14.	刘运喜, 邢玉斌, 巩玉秀. 软式内镜清洗消毒技术规范 WS 507－2016. 中国感染控制杂志, 2017, 16(6): 587-592.
15.	Chenjiao W, Hongyan Z, Qing G, et al. In-use evaluation of peracetic acid for high-level disinfection of endoscopes. Gastroenterol Nurs, 2016, 39(2): 116-120.
16.	Herruzo R, Vizcaino MJ, Herruzo I. Efficacy of a new peracetic acid-based disinfectant agent (" Adaspor ready to use”). J Hosp Infect, 2010, 74(2): 192-193.
17.	吴忱姣, 张弘炎, 顾青, 等. 过氧乙酸消毒剂对胃镜污染枯草杆菌黑色变种芽孢的消毒研究. 护理与康复, 2015, 14(10): 903-904, 908.
18.	陆烨, 胡国庆, 陆龙喜, 等. 新型消毒剂对内镜消毒效果的研究. 中华医院感染学杂志, 2012, 22(12): 2598-2600.
19.	周晓, 李鹏, 韦键, 等. 两种消毒剂对消化内镜现场消毒效果的比较研究. 中国消毒学杂志, 2013, 30(2): 114-115.
20.	周晓, 李鹏, 韦键, 等. 过氧乙酸对消化内镜消毒效果研究. 中国消毒学杂志, 2013, 30(1): 11-12.

1. Park S, Jang JY, Koo JS, et al. A review of current disinfectants for gastrointestinal endoscopic reprocessing. Clin Endosc, 2013, 46(4): 337-341.
2. Beilenhoff U, Neumann CS, Rey JF, et al. European society of gastrointestinal endoscopy; European society of gastroenterology and endoscopy nurses and associates. ESGE-ESGENA guideline: cleaning and disinfection in gastrointestinal endoscopy. Endoscopy, 2008, 40(11): 939.
3. Vizcaino-Alcaide MJ. Herruzo-Cabrera R, Fernandez-Aceñero M J.comparison of the disinfectant efficacy of perasafe and 2% glutaraldehyde in in vitro tests. J Hosp Infect, 2003, 53(2): 124-128.
4. Petersen BT, Chennat J, Cohen J, et al. Multisociety guideline on reprocessing flexible gastrointestinal endoscopes: 2011. Gastrointest Endosc, 2011, 73(6): 1075-1084.
5. 马春丽, 李武平, 宋向阳, 等. 三种消毒剂对消化内镜消毒效果比较观察. 中国消毒学杂志, 2013, 30(5): 414-415, 419.
6. 罗淑君. 新型过氧乙酸溶液应用于消化内镜消毒 50 例. 吉林医学, 2013, 34(30): 6332-6333.
7. 刘倩雯, 李练, 叶婉华, 等. 新型过氧乙酸对软式内镜消毒效果的评价. 中国药物经济学, 2016, 11(8): 69-72.
8. 吴仁培, 方爱乔, 刘建强, 等. 新型过氧乙酸溶液消毒消化内镜的效果评价. 中华消化内镜杂志, 2012, 29(3): 159-162.
9. 于泳, 崔静, 刘霞, 等. 新型过氧乙酸溶液消毒消化内镜的效果评价. 中国伤残医学, 2014(18): 24-25.
10. 王泽琼. 过氧乙酸型内镜消毒机对纤维支气管镜消毒的应用观察. 当代护士: 专科版, 2012(11): 9-10.
11. 钟昱文, 翁涛华, 黄美卿, 等. 四种全自动内镜消毒机对内镜消毒效果的比对观察. 中国消毒学杂志, 2008, 25(4): 359-362.
12. 徐勇. 内镜消毒剂的选择. 中国内镜杂志, 2002, 8(7): 28-30.
13. 张艳红. 消化内镜消毒剂选择. 中华医院感染学杂志, 2006, 16(9): 1078-1080.
14. 刘运喜, 邢玉斌, 巩玉秀. 软式内镜清洗消毒技术规范 WS 507－2016. 中国感染控制杂志, 2017, 16(6): 587-592.
15. Chenjiao W, Hongyan Z, Qing G, et al. In-use evaluation of peracetic acid for high-level disinfection of endoscopes. Gastroenterol Nurs, 2016, 39(2): 116-120.
16. Herruzo R, Vizcaino MJ, Herruzo I. Efficacy of a new peracetic acid-based disinfectant agent (" Adaspor ready to use”). J Hosp Infect, 2010, 74(2): 192-193.
17. 吴忱姣, 张弘炎, 顾青, 等. 过氧乙酸消毒剂对胃镜污染枯草杆菌黑色变种芽孢的消毒研究. 护理与康复, 2015, 14(10): 903-904, 908.
18. 陆烨, 胡国庆, 陆龙喜, 等. 新型消毒剂对内镜消毒效果的研究. 中华医院感染学杂志, 2012, 22(12): 2598-2600.
19. 周晓, 李鹏, 韦键, 等. 两种消毒剂对消化内镜现场消毒效果的比较研究. 中国消毒学杂志, 2013, 30(2): 114-115.
20. 周晓, 李鹏, 韦键, 等. 过氧乙酸对消化内镜消毒效果研究. 中国消毒学杂志, 2013, 30(1): 11-12.

West China Medical Journal

The disinfection effect of peracetic acid versus glutaraldehyde in disinfection of flexible endoscope: a Meta-analysis

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