Echocardiographic characteristics of aortic valve disease in different ethnic groups in Xinjiang_West China Medical Journal

Authors：

ALIMU Palisha , MA Xiang ,  MA Yitong

Department of Cardiology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P. R. China;

Corresponding author：

MA Yitong, Email: myt-xj@163.com

Keywords：

Aortic valve disease; Echocardiography; Nationality; Characteristics

DOI：

10.7507/1002-0179.201711136

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo explore the echocardiography characteristics of aortic valve disease (AVD) among different ethnic groups in Xinjiang.MethodsThe data of a large sample (n=130 358) of different ethnic groups in Xinjiang based on the results of echocardiography were analyzed between January 2011 and December 2016, and the echocardiography characteristics of AVD among the Han nationality and different ethnic minorities in Xinjiang were summarized.ResultsThe study recruited 130 358 patients, involving Han nationality (58.49%) and 33 ethnic minorities. The ethnic minorities included the Uygur (27.42%), Kazak (7.47%), Hui nationality (3.48%) and other minorities (3.13%). Apart from Uygur, Kazak and Hui nationality, no description was given due to the small sample sizes of other minorities (3.13%). In the total study population, the prevalence of aortic valve stenosis (AS) was 0.44%, and the prevalence of severe AS was 0.10%; the prevalence of aortic valve regurgitation (AR) was 0.37%, and the prevalence of severe AR was 0.02%; the prevalence of aortic valve calcification (AVC) was 6.51%, and the highest AVC prevalence existed in ≥75 years old age group (24.45%); the prevalence of bicuspid aortic valve (BAV) was 0.54%, and the highest BAV prevalence existed in 18-44 years old age group (0.86%). Among different ethnic groups, the Uygur had the highest prevalence in terms of AS (0.60%), AR (0.63%) and BAV (0.88%), while the Han had the lowest prevalence in terms of AS (0.37%) and AR (0.24%), but the highest AVC prevalence existed in the Han nationality (7.83%). The etiology of AVD showed that the degenerative valve changes was the main cause of AS with the largest proportion of 61.97%. While the aorta root diseases (35.97%) and BAV (22.87%) were the main etiology of AR.ConclusionsIn Xinjiang the overall prevalence of AVD is low. In the elderly population, the Uygur, Kazak and Hui nationality have the higher AS prevalence than the Han nationality does. Different ethnic groups have different AVD characteristics based on the echocardiography. In the Uygur group, AVD presents the younger age of onset; the prevalence of BAV is the highest in the Uygur population, while the lowest in the Hui nationality.

Citation： ALIMU Palisha, MA Xiang, MA Yitong. Echocardiographic characteristics of aortic valve disease in different ethnic groups in Xinjiang. West China Medical Journal, 2018, 33(2): 188-194. doi: 10.7507/1002-0179.201711136 Copy

1.	Osnabrugge RL, Mylotte D, Head SJ, et al. Aortic stenosis in the elderly disease prevalence and number of candidates for transcatheter aortic valve replacement: a Meta-Analysis and modeling study. J Am Coll Cardiol, 2013, 62(11): 1002-1012.
2.	Exadactylos N, Sugrue DD, Oakley CM. Prevalence of coronary artery disease in patients with isolated aortic valve stenosis. Br Heart J, 1984, 51(2): 121-124.
3.	Peter M, Hoffmann A, Parker C, et al. Progression of aortic stenosis. Role of age and concomitant coronary artery disease. Chest, 1993, 103(6): 1715-1719.
4.	Brosius FC 3rd, Hostetter TH, Kelepouris E, et al. Detection of chronic kidney disease in patients with or at increased risk of cardiovascular disease: a science advisory from the American Heart Association Kidney And Cardiovascular Disease Council; the Councils on High Blood Pressure Research, Cardiovascular Disease in the Young, and Epidemiology and Prevention; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: developed in collaboration with the National Kidney Foundation. Circulation, 2006, 114(10):1083-1087.
5.	Nkomo VT, Gardin JM, Skelton TN, et al. Burden of valvular heart diseases: a population-based study. Lancet, 2006, 368(9540): 1005-1011.
6.	Pan W, Zhou D, Cheng L, et al. Aortic regurgitation is more prevalent than aortic stenosis in Chinese elderly population: implications for transcatheter aortic valve replacement. Int J Cardiol, 2015, 201: 547-548.
7.	Pan WZ, Zhou DX, Cheng L, et al. Candidates for transcatheter aortic valve implantation may be fewer in China. Int J Cardiol, 2013, 168(5): E133-E134.
8.	Zoghbi WA, Enriquez-Sarano M, Foster E, et al. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr, 2003, 16(7): 777-802.
9.	Quiñones MA, Otto CM, Stoddard M, et al. Recommendations for quantification of Doppler echocardiography: a report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr, 2002, 15(2): 167-184.
10.	Erbel R, Aboyans V, Boileau C, et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The task force for the diagnosis and treatment of aortic diseases of the European Society of Cardiology (ESC). Eur Heart J, 2014, 35(41):2873-2926.
11.	安勇. 新疆地区不同民族心脏瓣膜病流行病学研究. 乌鲁木齐: 新疆医科大学, 2012.
12.	Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol, 1997, 29(3): 630-634.
13.	Otto CM, Lind BK, Kitzman DW, et al. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med, 1999, 341(3): 142-147.
14.	Lindroos M, Kupari M, Heikkilä J, et al. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol, 1993, 21(5): 1220-1225.
15.	Iung B, Baron G, Butchart EG, et al. A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on Valvular Heart Disease. Eur Heart J, 2003, 24(13): 1231-1243.
16.	Iung B, Vahanian A. Epidemiology of valvular heart disease in the adult. Nat Rev Cardiol, 2011, 8(3): 162-172.
17.	Lebowitz NE, Bella JN, Roman MJ, et al. Prevalence and correlates of aortic regurgitation in American Indians: the Strong Heart Study. J Am Coll Cardiol, 2000, 36(2): 461-467.
18.	Fenoglio JJ Jr, McAllister HA Jr, DeCastro CM, et al. Congenital bicuspid aortic valve after age 20. Am J Cardiol, 1977, 39(2): 164-169.
19.	Warnes CA, Williams RG, Bashore TM, et al. ACC/AHA 2008 guidelines for the management of adults with congenital heart disease. J Am Coll Cardiol, 2008, 52(23): E1-E121.

1. Osnabrugge RL, Mylotte D, Head SJ, et al. Aortic stenosis in the elderly disease prevalence and number of candidates for transcatheter aortic valve replacement: a Meta-Analysis and modeling study. J Am Coll Cardiol, 2013, 62(11): 1002-1012.
2. Exadactylos N, Sugrue DD, Oakley CM. Prevalence of coronary artery disease in patients with isolated aortic valve stenosis. Br Heart J, 1984, 51(2): 121-124.
3. Peter M, Hoffmann A, Parker C, et al. Progression of aortic stenosis. Role of age and concomitant coronary artery disease. Chest, 1993, 103(6): 1715-1719.
4. Brosius FC 3rd, Hostetter TH, Kelepouris E, et al. Detection of chronic kidney disease in patients with or at increased risk of cardiovascular disease: a science advisory from the American Heart Association Kidney And Cardiovascular Disease Council; the Councils on High Blood Pressure Research, Cardiovascular Disease in the Young, and Epidemiology and Prevention; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: developed in collaboration with the National Kidney Foundation. Circulation, 2006, 114(10):1083-1087.
5. Nkomo VT, Gardin JM, Skelton TN, et al. Burden of valvular heart diseases: a population-based study. Lancet, 2006, 368(9540): 1005-1011.
6. Pan W, Zhou D, Cheng L, et al. Aortic regurgitation is more prevalent than aortic stenosis in Chinese elderly population: implications for transcatheter aortic valve replacement. Int J Cardiol, 2015, 201: 547-548.
7. Pan WZ, Zhou DX, Cheng L, et al. Candidates for transcatheter aortic valve implantation may be fewer in China. Int J Cardiol, 2013, 168(5): E133-E134.
8. Zoghbi WA, Enriquez-Sarano M, Foster E, et al. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr, 2003, 16(7): 777-802.
9. Quiñones MA, Otto CM, Stoddard M, et al. Recommendations for quantification of Doppler echocardiography: a report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr, 2002, 15(2): 167-184.
10. Erbel R, Aboyans V, Boileau C, et al. 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The task force for the diagnosis and treatment of aortic diseases of the European Society of Cardiology (ESC). Eur Heart J, 2014, 35(41):2873-2926.
11. 安勇. 新疆地区不同民族心脏瓣膜病流行病学研究. 乌鲁木齐: 新疆医科大学, 2012.
12. Stewart BF, Siscovick D, Lind BK, et al. Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study. J Am Coll Cardiol, 1997, 29(3): 630-634.
13. Otto CM, Lind BK, Kitzman DW, et al. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med, 1999, 341(3): 142-147.
14. Lindroos M, Kupari M, Heikkilä J, et al. Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample. J Am Coll Cardiol, 1993, 21(5): 1220-1225.
15. Iung B, Baron G, Butchart EG, et al. A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on Valvular Heart Disease. Eur Heart J, 2003, 24(13): 1231-1243.
16. Iung B, Vahanian A. Epidemiology of valvular heart disease in the adult. Nat Rev Cardiol, 2011, 8(3): 162-172.
17. Lebowitz NE, Bella JN, Roman MJ, et al. Prevalence and correlates of aortic regurgitation in American Indians: the Strong Heart Study. J Am Coll Cardiol, 2000, 36(2): 461-467.
18. Fenoglio JJ Jr, McAllister HA Jr, DeCastro CM, et al. Congenital bicuspid aortic valve after age 20. Am J Cardiol, 1977, 39(2): 164-169.
19. Warnes CA, Williams RG, Bashore TM, et al. ACC/AHA 2008 guidelines for the management of adults with congenital heart disease. J Am Coll Cardiol, 2008, 52(23): E1-E121.

West China Medical Journal

Echocardiographic characteristics of aortic valve disease in different ethnic groups in Xinjiang

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content