Establishment of normal reference value range of specific thyroid function in pregnant women with Beckman reagent in Chengdu area_West China Medical Journal

Authors：

LIANG Xinying ,  LI Yao , LI Ting , QIU Ping , MEI Xi

Department of Endocrinology and Metabolic Disease, the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, P. R. China;

Corresponding author：

LI Yao, Email: 240877508@qq.com

Keywords：

Beckman reagent; Pregnancy; Thyroid function index; Normal reference value

DOI：

10.7507/1002-0179.201804042

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo establish a normal reference value range of specific thyroid function in pregnant women corresponding to Beckman reagent in Chengdu.MethodsWe randomly selected 120 non-pregnant women and 445 pregnant women who underwent routine examinations at the First Affiliated Hospital of Chengdu Medical College from November 2016 to June 2017; tested for free triiodothyronine (FT₃), free thyroxine (FT₄), and thyroid stimulating hormone (TSH) in serum; used SPSS 24.0 to calculate the bilateral limit of each index (Section 2.5, 97. 5 Quot); established the normal range of Beckman reagent.ResultsThe reference ranges of FT₃, FT₄, and TSH in the first, second, and third trimester of pregnancy were 4.41–6.33, 4.17–6.12, and 3.86–6.39 pmol/L; 7.64–14.63, 6.62–13.69, and 6.62–12.51 pmol/L; 0.21–3.62, 0.16–4.35, and 0.89–4.88 mU/L; respectively. There was no significant difference in serum TSH between the first and second trimester (P>0.05), and neither between the first and second trimesters and the controls in serum FT₃ (P>0.05). The differences in serum FT₃, FT₄, and TSH among the rest of trimesters, and between each trimester and the normal control group were statistically significant (P<0.05). There was a significant correlation between TSH and FT₄ in the early and middle stages of pregnancy (r=–0.277, –0.392, P<0.01).ConclusionThe reference value of FT₃, FT₄, and TSH in pregnant women with Beckman reagent was significantly different from that in non-pregnant women.

Citation： LIANG Xinying, LI Yao, LI Ting, QIU Ping, MEI Xi. Establishment of normal reference value range of specific thyroid function in pregnant women with Beckman reagent in Chengdu area. West China Medical Journal, 2018, 33(5): 527-531. doi: 10.7507/1002-0179.201804042 Copy

1.	Shan ZY, Chen YY, Teng WP, et al. A study for maternal thyroid hormone deficiency during the first half of pregnancy in China. Eur J Clin Invest, 2009, 39(1): 37-42.
2.	关海霞, 李晨阳, 李玉姝, 等. 妊娠晚期妇女甲状腺疾病特点及甲状腺自身抗体变化的研究. 中华妇产科杂志, 2006, 41(8): 529-532.
3.	史娜娜, 马莉, 黄亚娟, 等. 建立特异性甲状腺功能参考值在评价妊娠晚期甲状腺功能减退中的意义. 中国妇幼保健, 2015(29): 4964-4967.
4.	中华医学会内分泌学分会, 中华医学会围产医学分会. 妊娠和产后甲状腺疾病诊治指南. 中华内分泌代谢杂志, 2012, 28(5): 354-371.
5.	Alexander EK, Pearce EN, Brent GA, et al. 2017 guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid, 2017, 27(3): 315-389.
6.	张春艳. 成都地区妊娠妇女甲状腺激素正常参考值范围的建立及甲状腺疾病的筛查. 南充: 川北医学院, 2014.
7.	杨建波, 甘西伦, 王明霜, 等. 川南地区各孕期甲状腺激素变化及参考范围. 标记免疫分析与临床, 2016, 23(5): 498-500.
8.	陈玉敏, 曾菁, 严悦溶, 等. 成都地区妊娠妇女甲状腺激素正常参考值建立及甲状腺自身抗体对孕妇甲状腺功能的影响. 四川大学学报: 医学版, 2017, 48(3): 450-454.
9.	Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev, 1997, 18(3): 404-433.
10.	Soldin OP, Tractenberg RE, Hollowell JG, et al. Treimester-specific changes in maternal throid hormorne, thyrotropin, and thyroglobulin concentrations during gestation: trends and associations across trimesters in iodine sufficiency. Thyroid, 2004, 14: 1084-1090.
11.	Haddow JE, Palomaki GE, Allan WC, et al. Maternal thvroid deficiency during pregnancy and subsequent neuropsyehological development of the child. N Engl Med, 1999, 341(8): 549-555.
12.	Li Y, Shan Z, Teng W, et al. Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25–30 months. Clin Endocrinol (Oxf), 2010, 72(6): 825-829.
13.	李佳, 滕卫平, 单忠艳, 等. 中国汉族碘适量地区月份特异性TSH和T4的正常参考范围. 中华内分泌代谢杂志, 2008, 12(24): 605-608.
14.	Korevaar TIM, Medici M, Visser TJ, et al. Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nat Rev Endocrinol, 2017, 13(10): 610-622.
15.	Knight BA, Shields BM, Hattersley AT, et al. Maternal hypothyroxinaemia in pregnancy is associated with obesity and adverse maternal metabolic parameters. J Endocrinol, 2016, 174(1): 51-57.
16.	舒小雨, 漆洪波, 蒋利华, 等. BECKMAN试剂检测妊娠各期特异性甲状腺功能指标正常值范围研究. 中国实用内科杂志, 2013(11): 881-884.
17.	陈巧巧, 王志成. 宁波市妊娠期妇女甲状腺功能指标参考区间的建立. 中华全科医学, 2016, 14(6): 1013-1016.
18.	陈乔彬, 李维, 皇甫英, 等. 妊娠妇女促甲状腺素和游离甲状腺素参考区间初步建立. 临床检验杂志, 2013, 31(12): 948-950.
19.	王瑜. 兰州地区妊娠期甲状腺激素参考值范围探讨. 兰州: 兰州大学, 2017.
20.	韩锐, 鲁颖, 吴琳, 等. 抚顺地区妇女妊娠期特异性甲状腺功能参考区间的建立与评价. 大连医科大学学报, 2016, 38(2): 168-171.
21.	黄璐, 罗丹, 王利民, 等. 成都地区妊娠期特异性甲状腺激素水平参考值范围的探讨及临床分析. 现代妇产科进展, 2016, 25(4): 269-272.
22.	马瑞婷, 黄慧, 严悦溶, 等. 正常成人甲状腺激素水平影响因素探讨. 四川大学学报: 医学版, 2015, 46(4): 611-614.

1. Shan ZY, Chen YY, Teng WP, et al. A study for maternal thyroid hormone deficiency during the first half of pregnancy in China. Eur J Clin Invest, 2009, 39(1): 37-42.
2. 关海霞, 李晨阳, 李玉姝, 等. 妊娠晚期妇女甲状腺疾病特点及甲状腺自身抗体变化的研究. 中华妇产科杂志, 2006, 41(8): 529-532.
3. 史娜娜, 马莉, 黄亚娟, 等. 建立特异性甲状腺功能参考值在评价妊娠晚期甲状腺功能减退中的意义. 中国妇幼保健, 2015(29): 4964-4967.
4. 中华医学会内分泌学分会, 中华医学会围产医学分会. 妊娠和产后甲状腺疾病诊治指南. 中华内分泌代谢杂志, 2012, 28(5): 354-371.
5. Alexander EK, Pearce EN, Brent GA, et al. 2017 guidelines of the American thyroid association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid, 2017, 27(3): 315-389.
6. 张春艳. 成都地区妊娠妇女甲状腺激素正常参考值范围的建立及甲状腺疾病的筛查. 南充: 川北医学院, 2014.
7. 杨建波, 甘西伦, 王明霜, 等. 川南地区各孕期甲状腺激素变化及参考范围. 标记免疫分析与临床, 2016, 23(5): 498-500.
8. 陈玉敏, 曾菁, 严悦溶, 等. 成都地区妊娠妇女甲状腺激素正常参考值建立及甲状腺自身抗体对孕妇甲状腺功能的影响. 四川大学学报: 医学版, 2017, 48(3): 450-454.
9. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev, 1997, 18(3): 404-433.
10. Soldin OP, Tractenberg RE, Hollowell JG, et al. Treimester-specific changes in maternal throid hormorne, thyrotropin, and thyroglobulin concentrations during gestation: trends and associations across trimesters in iodine sufficiency. Thyroid, 2004, 14: 1084-1090.
11. Haddow JE, Palomaki GE, Allan WC, et al. Maternal thvroid deficiency during pregnancy and subsequent neuropsyehological development of the child. N Engl Med, 1999, 341(8): 549-555.
12. Li Y, Shan Z, Teng W, et al. Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25–30 months. Clin Endocrinol (Oxf), 2010, 72(6): 825-829.
13. 李佳, 滕卫平, 单忠艳, 等. 中国汉族碘适量地区月份特异性TSH和T4的正常参考范围. 中华内分泌代谢杂志, 2008, 12(24): 605-608.
14. Korevaar TIM, Medici M, Visser TJ, et al. Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nat Rev Endocrinol, 2017, 13(10): 610-622.
15. Knight BA, Shields BM, Hattersley AT, et al. Maternal hypothyroxinaemia in pregnancy is associated with obesity and adverse maternal metabolic parameters. J Endocrinol, 2016, 174(1): 51-57.
16. 舒小雨, 漆洪波, 蒋利华, 等. BECKMAN试剂检测妊娠各期特异性甲状腺功能指标正常值范围研究. 中国实用内科杂志, 2013(11): 881-884.
17. 陈巧巧, 王志成. 宁波市妊娠期妇女甲状腺功能指标参考区间的建立. 中华全科医学, 2016, 14(6): 1013-1016.
18. 陈乔彬, 李维, 皇甫英, 等. 妊娠妇女促甲状腺素和游离甲状腺素参考区间初步建立. 临床检验杂志, 2013, 31(12): 948-950.
19. 王瑜. 兰州地区妊娠期甲状腺激素参考值范围探讨. 兰州: 兰州大学, 2017.
20. 韩锐, 鲁颖, 吴琳, 等. 抚顺地区妇女妊娠期特异性甲状腺功能参考区间的建立与评价. 大连医科大学学报, 2016, 38(2): 168-171.
21. 黄璐, 罗丹, 王利民, 等. 成都地区妊娠期特异性甲状腺激素水平参考值范围的探讨及临床分析. 现代妇产科进展, 2016, 25(4): 269-272.
22. 马瑞婷, 黄慧, 严悦溶, 等. 正常成人甲状腺激素水平影响因素探讨. 四川大学学报: 医学版, 2015, 46(4): 611-614.

West China Medical Journal

Establishment of normal reference value range of specific thyroid function in pregnant women with Beckman reagent in Chengdu area

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content