Clinical assessment of depression for adult epilepsy patients_West China Medical Journal

Authors：

LUO Rong ¹ ,  WU Bo ² , WANG Minghua ¹ , YANG Xiao ¹ , LIANG Jingjing ¹

1. Department of Neurology, Emeishan People’s Hospital, Emeishan, Sichuan 614200, P. R. China;
2. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WU Bo, Email: dr.bowu@hotmail.com

Keywords：

Epilepsy; Adult; Depression

DOI：

10.7507/1002-0179.201909108

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the clinical characteristics of epilepsy and depression patients, and provide guidance for clinical intervention of epilepsy and depression patients.Methods Patients with epilepsy (epilepsy group) were prospectively enrolled in Emeishan People’s Hospital from 2015 to 2017, and healthy controls (control group) were enrolled in the same period. Clinical assessment of depression was conducted and compared between the two groups. In the epilepsy group, the severity and incidence of depression were analyzed and compared among different subgroups according to the epileptic seizure type, frequency and course.Results A total of 120 patients and 70 healthy controls were enrolled. The Hamilton Depression Scale score of epilepsy group was higher than that of the control group (t=7.430, P<0.001), and the depression degree of epilepsy group was significantly higher than that of the control group (Z=−4.371, P< 0.001). There was no significant difference in depression rating between convulsive epilepsy patients and partial epilepsy patients (Z=−1.591, P=0.112); there was no significant difference in depression rating among patients with different epilepsy course (χ²=1.943, P=0.584); there was significant difference in depression rating among patients with different seizure frequency (χ²=27.575, P<0.001). Patients with high frequency of seizures were more likely to suffer from depression and severe depression, with the lowest proportion of normal neuropsychological state. Conversely, patients with low frequency of epileptic seizures had a lower proportion of depression and severe depression.Conclusions The incidence of depression in epilepsy patients is higher than that in normal people. Timely detection and treatment of depression in clinical work have a positive impact on the prognosis of patients.

Citation： LUO Rong, WU Bo, WANG Minghua, YANG Xiao, LIANG Jingjing. Clinical assessment of depression for adult epilepsy patients. West China Medical Journal, 2019, 34(10): 1134-1137. doi: 10.7507/1002-0179.201909108 Copy

1.	Wang WZ, Wu JZ, Wang DS, et al. The prevalence and treatment gap in epilepsy in China: an ILAE/IBE/WHO study. Neurology, 2003, 60(9): 1544-1545.
2.	Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2197-2223.
3.	World Health Organization. World Health Statistics 2008. (2008-05-20)[2019-09-03]. https://www.who.int/whosis/whostat/2008/en/.
4.	Thome-Souza S, Kuczynski E, Assumpção F Jr, et al. Which factors may play a pivotal role on determining the type of psychiatric disorder in children and adolescents with epilepsy?. Epilepsy Behav, 2004, 5(6): 988-994.
5.	Austin JK, Harezlak J, Dunn DW, et al. Behavior problems in children before first recognized seizures. Pediatrics, 2001, 107(1): 115-122.
6.	Fiest KM, Dykeman J, Patten SB, et al. Depression in epilepsy: a systematic review and meta-analysis. Neurology, 2013, 80(6): 590-599.
7.	Josephson CB, Lowerison M, Vallerand I, et al. Association of depression and treated depression with epilepsy and seizure outcomes: a multicohort analysis. JAMA Neurol, 2017, 74(5): 533-539.
8.	Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE commission for classification and terminology. Epilepsia, 2017, 58(4): 522-530.
9.	Zack MM, Kobau R. National and state estimates of the numbers of adults and children with active epilepsy-United States, 2015. MMWR Morb Mortal Wkly Rep, 2017, 66(31): 821-825.
10.	Plioplys S. Depression in children and adolescents with epilepsy. Epilepsy Behav, 2003, 4(Suppl 3): S39-S45.
11.	Williams J, Steel C, Sharp GB, et al. Anxiety in children with epilepsy. Epilepsy Behav, 2003, 4(6): 729-732.
12.	Kanner AM. Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment. Biol Psychiatry, 2003, 54: 388-398.
13.	Kanner AM. Depression and epilepsy: a bidirectional relation?. Epilepsia, 2011, 52(Suppl 1): 21-27.
14.	Stefanello S, Marín-Léon L, Fernandes PT, et al. Depression and anxiety in a community sample with epilepsy in Brazil. Arq Neuropsiquiatr, 2011, 69(2B): 342-348.
15.	Bromfield EB, Altshuler L, Leiderman DB, et al. Cerebral metabolism and depression in patients with complex partial seizures. Arch Neurol, 1992, 49(6): 617-623.
16.	Dias R, Bateman LM, Farias ST, et al. Depression in epilepsy is associated with lack of seizure control. Epilepsy Behav, 2010, 19(3): 445-447.

1. Wang WZ, Wu JZ, Wang DS, et al. The prevalence and treatment gap in epilepsy in China: an ILAE/IBE/WHO study. Neurology, 2003, 60(9): 1544-1545.
2. Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2197-2223.
3. World Health Organization. World Health Statistics 2008. (2008-05-20)[2019-09-03]. https://www.who.int/whosis/whostat/2008/en/.
4. Thome-Souza S, Kuczynski E, Assumpção F Jr, et al. Which factors may play a pivotal role on determining the type of psychiatric disorder in children and adolescents with epilepsy?. Epilepsy Behav, 2004, 5(6): 988-994.
5. Austin JK, Harezlak J, Dunn DW, et al. Behavior problems in children before first recognized seizures. Pediatrics, 2001, 107(1): 115-122.
6. Fiest KM, Dykeman J, Patten SB, et al. Depression in epilepsy: a systematic review and meta-analysis. Neurology, 2013, 80(6): 590-599.
7. Josephson CB, Lowerison M, Vallerand I, et al. Association of depression and treated depression with epilepsy and seizure outcomes: a multicohort analysis. JAMA Neurol, 2017, 74(5): 533-539.
8. Fisher RS, Cross JH, French JA, et al. Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE commission for classification and terminology. Epilepsia, 2017, 58(4): 522-530.
9. Zack MM, Kobau R. National and state estimates of the numbers of adults and children with active epilepsy-United States, 2015. MMWR Morb Mortal Wkly Rep, 2017, 66(31): 821-825.
10. Plioplys S. Depression in children and adolescents with epilepsy. Epilepsy Behav, 2003, 4(Suppl 3): S39-S45.
11. Williams J, Steel C, Sharp GB, et al. Anxiety in children with epilepsy. Epilepsy Behav, 2003, 4(6): 729-732.
12. Kanner AM. Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment. Biol Psychiatry, 2003, 54: 388-398.
13. Kanner AM. Depression and epilepsy: a bidirectional relation?. Epilepsia, 2011, 52(Suppl 1): 21-27.
14. Stefanello S, Marín-Léon L, Fernandes PT, et al. Depression and anxiety in a community sample with epilepsy in Brazil. Arq Neuropsiquiatr, 2011, 69(2B): 342-348.
15. Bromfield EB, Altshuler L, Leiderman DB, et al. Cerebral metabolism and depression in patients with complex partial seizures. Arch Neurol, 1992, 49(6): 617-623.
16. Dias R, Bateman LM, Farias ST, et al. Depression in epilepsy is associated with lack of seizure control. Epilepsy Behav, 2010, 19(3): 445-447.

West China Medical Journal

Clinical assessment of depression for adult epilepsy patients

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content