• 1. Emergency Department, Bazhong Central Hospital, Bazhong, Sichuan 636000, P. R. China;
  • 2. Department of Respiratory Medicine, Bazhong Central Hospital, Bazhong, Sichuan 636000, P. R. China;
ZHU Yu, Email: taoguox@163.com
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Objective To explore the correlation of serum neutrophil gelatinase-associated lipocalin (sNGAL) with inflammatory response in patients with community-acquired pneumonia (CAP) and assess the diagnostic value of sNGAL for severe CAP (SCAP).Methods From January 2018 to June 2019, a total of 85 patients with CAP were enrolled in this study. Age, length of hospital stay, the levels of serum creatinine, blood urea nitrogen, white blood cell count,C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin, and CURB-65 score were compared between patients with SCAP (n=34) and patients without SCAP (n=51). The correlations of sNGAL with serum creatinine, blood urea nitrogen, white blood cell count, CRP, IL-6, procalcitonin, and CURB-65 score were assessed with Spearman’s correlation analysis. The area under the receiver operating characteristic (ROC) curve for sNGAL diagnosing SCAP was examined. Results Compared with patients without SCAP, SCAP patients demonstrated older age, longer hospital stay, higher serum CRP and IL-6 concentritions, and higher CURB-65 score (P<0.05). The Spearman’s correlation test showed that sNGAL was positively correlated with serum CRP, IL-6, PCT and CURB-65 score (rs=0.472, 0.504, 0.388, and 0.405, respectively; P<0.01). According to ROC analysis, the area under curve of sNGAL for diagnosing SCAP were 0.816, with a sensitivity of 76.56% and a specificity of 74.4% when the cut-off value was 171.0 ng/mL.Conclusions sNGAL concentration is positively correlated with the serverity of CAP. It can be regarded as a reliable indicator for diagnosis of SCAP in patients with CAP.

Citation: KANG Guoping, ZHU Yu, YANG Huan, ZHANG Ji, CHENG Hairong, TANG Ziwen, LIU Weixian. Correlation of serum neutrophil gelatinase-associated lipocalin with inflammatory response and its diagnostic value for severe community-acquired pneumonia. West China Medical Journal, 2020, 35(1): 17-21. doi: 10.7507/1002-0179.201910025 Copy

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