Research progress of microRNA-215 gene_West China Medical Journal

Authors：

YAN Qiong ,  XU Anshu

Surgery of North City, Qujing Hospital, Kunming Medical University, Qujing, Yunnan 655000, P. R. China;

Corresponding author：

XU Anshu, Email: 315000722@qq.com

Keywords：

MicroRNA-215 gene; oncogene; tumor suppressor gene

DOI：

10.7507/1002-0179.202002138

Video：

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At present, there are relatively many clinical gene studies. microRNA -215 (miR-215) is a miRNA induced by p53. It exists in animals and humans. miR-215 can exist not only in tumor tissues, but also in blood, urine and feces. miR-215 is abnormally expressed in a variety of tumors and plays a role in promoting and inhibiting cancer. Therefore, miR-215 may provide a new research direction for tumor diagnosis, treatment and prognosis. This paper reviews the expression of miR-215 as a oncogene and tumor suppressor gene in tumors and in non tumors.

Citation： YAN Qiong, XU Anshu. Research progress of microRNA-215 gene. West China Medical Journal, 2022, 37(1): 151-155. doi: 10.7507/1002-0179.202002138 Copy

1.	Boni V, Bitarte N, Cristobal I, et al. miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation. Mol Cancer Ther, 2010, 9(8): 2265-2275.
2.	娄杰, 刘华, 毛涛, 等. 结直肠肿瘤组织 miR-215 表达及临床意义. 齐鲁医学杂志, 2015, 30(6): 631-634.
3.	To KK, Tong CW, Wu M, et al. MicroRNAs in the prognosis and therapy of colorectal cancer: from bench to bedside. World J Gastroenterol, 2018, 24(27): 2949-2973.
4.	晏玥, 王乙安, 陈芳, 等. 尿外泌体 microRNA 与肾脏疾病相关性的研究进展. 实用医学杂志, 2019, 35(4): 673-676.
5.	余绮荷, 张文. MicroRNA 与结直肠癌化疗关系的研究进展. 中国癌症杂志, 2014, 24(1): 62-68.
6.	Vychytilova-Faltejskova P, Merhautova J, Machackova T, et al. MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9. Oncogenesis, 2017, 6(11): 399.
7.	吴旭波, 曹奕鸥, 浦文兰, 等. miR-215 在进展期结肠直肠癌中的表达及其临床意义. 外科理论与实践, 2013, 18(3): 247-251.
8.	宋敏, 宋志超, 王镇, 等. miR-215-3p 通过调控 CXCR4 逆转结肠癌 HCT8 细胞 5-FU 耐药的实验研究. 临床肿瘤学杂志, 2019, 24(6): 513-517.
9.	张永锋, 郭长军, 谭永港, 等. 溃疡性结肠炎相关性结肠癌差异表达的 miRNA 的筛选研究. 中国中西医结合消化杂志, 2014, 22(2): 65-68.
10.	Tan YG, Zhang YF, Guo CJ, et al. Screening of differentially expressed microRNA in ulcerative colitis related colorectal cancer. Asian Pac J Trop Med, 2013, 6(12): 972-976.
11.	李勇, 徐丽瑶, 付碧琪, 等. miR-192、miR-215 及 ERCC3 在 NSCLC 细胞系 A549 放疗后的表达变化及意义. 实用临床医学, 2011, 12(12): 1-3.
12.	Cai X, Peng D, Wei H, et al. miR-215 suppresses proliferation and migration of non-small cell lung cancer cells. Oncol lett, 2017, 13(4): 2349-2353.
13.	刘锐, 董文刚, 王飞, 等. miR-215 抑制骨肉瘤细胞生长及其分子机制. 现代肿瘤医学, 2019, 27(9): 1472-1476.
14.	Han J, Zhang M, Nie C, et al. miR-215 suppresses papillary thyroid cancer proliferation, migration, and invasion through the AKT/GSK-3β/Snail signaling by targeting ARFGEF1. Cell Death Dis, 2019, 10(3): 195.
15.	Li M, Zou X, Xia T, et al. A five-miRNA panel in plasma was identified for breast cancer diagnosis. Cancer Med, 2019, 8(16): 7006-7017.
16.	Gao JB, Zhu MN, Zhu XL. miRNA-215-5p suppresses the aggressiveness of breast cancer cells by targeting Sox9. FEBS Open Bio, 2019, 9(11): 1957-1967.
17.	庞琦, 牟娇, 郭艳红, 等. microRNA-215 在糖尿病肾病小鼠肾组织中的表达及意义. 中华肾脏病杂志, 2012, 28(4): 305-311.
18.	崔胜金, 陈泽衍, 郭伟权, 等. microRNA 在肥胖相关肾病发生的临床应用. 数理医药学杂志, 2018, 31(8): 1118-1120.
19.	杨梦戈, 张晓洁, 肇玉明. MicroRNA 对缺血性脑卒中自噬调控作用的研究进展. 生命的化学, 2019, 39(2): 338-352.
20.	侯静芳, 杨华, 赵世民, 等. 慢病毒介导 miR-215 过表达对克罗恩病的影响及作用机制. 国际消化病杂志, 2019, 39(5): 347-351.
21.	林振吕, 张琳, 郑建涛. miR-215 对胃癌细胞侵袭转移能力的影响及机制. 中国老年学杂志, 2015, 35(21): 6064-6067.
22.	刁卓, 刘晓超, 唐玉虎, 等. 胃癌组织 miR-215 表达变化及其与患者预后的关系. 山东医药, 2017, 57(8): 80-82.
23.	张军, 陈兆峰, 刘晓光, 等. 微小 RNA-215 在胃癌中的表达及其临床意义. 兰州大学学报(医学版), 2013, 39(4): 13-16,20.
24.	李良平, 龙思泽, 高采平. 胃癌患者血清 microRNA-192 和 microRNA-215 的表达及临床意义. 中华临床医师杂志(电子版), 2013, 7(12): 5223-5227.
25.	Deng Y, Huang Z, Xu Y, et al. MiR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Lett, 2014, 342(1): 27-35.
26.	杨林声, 王理论, 杜青卫. microRNA-215 对人视网膜母细胞瘤细胞生长及抑癌基因 Rb1 表达的调控作用. 海南医学, 2015, 26(24): 3592-3597.
27.	符小林, 李谟汉, 符密. MiR-215 和 RUNX1 在视网膜母细胞瘤中的表达水平及临床意义. 中国医师杂志, 2018, 20(9): 1310-1315.
28.	Agostini A, Brunetti M, Davidson B, et al. The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas. Sci Rep, 2018, 8(1): 11069.
29.	裴颖皓, 钟勇, 王俊, 等. 稳定型心绞痛患者血清 microRNA 的表达差异. 临床心血管病杂志, 2014, 30(1): 18-23.
30.	杜伟, 郭丽娜, 庞席宁. 下调 miR-215-5p 对 TGF-β诱导的人肺成纤维细胞 IMR-90 增殖抑制作用观察. 山东医药, 2018, 58(40): 15-19.
31.	Tian H, He Z. miR-215 enhances HCV replication by targeting TRIM22 and inactivating NF-κB signaling. Yonsei Med J, 2018, 59(4): 511-518.
32.	Liang H, Li Y, Luo RY, et al. MicroRNA-215 is a potential prognostic marker for cervical cancer. J Huazhong Univ Sci Technology Med Sci, 2014, 34(2): 207-212.
33.	Liu CQ, Chen Y, Xie BF, et al. MicroRNA-215-3p suppresses the growth and metastasis of cervical cancer cell via targeting SOX9. Eur Rev Med Pharmacol Sci, 2019, 23(13): 5628-5639.
34.	杨庆辉, 李伟伟, 王瑾, 等. 肝内胆管癌上皮组织 miR-215 表达与病理特征的相关性. 现代消化及介入诊疗, 2019, 24(5): 529-532.
35.	孙嘉玲, 文彬, 孙海涛, 等. 不同转移潜能肝癌细胞株 miRNAs 表达谱的差异性研究. 中国药理学通报, 2018, 34(5): 656-663.
36.	周原世, 李响, 姜兴明, 等. 前列腺癌相关转录因子 1 在恶性肿瘤中的研究进展. 中国临床医学, 2019, 26(1): 126-131.
37.	Ali LH, Higazi AM, Moness HM, et al. Clinical significances and diagnostic utilities of both miR-215 and squamous cell carcinoma antigen-IgM versus alpha-fetoprotein in Egyptian patients with hepatitis C virus-induced hepatocellular carcinoma. Clin Exp Gastroenterol, 2019, 12: 51-66.
38.	Mamdouh S, Khorshed F, Aboushousha T, et al. Evaluation of mir-224, mir-215 and mir-143 as serum biomarkers for HCV associated hepatocellular carcinoma. Asian Pac J Cancer Prev, 2017, 18(11): 3167-3171.
39.	Ren Y, Shang J, Li J, et al. The long noncoding RNA PCAT-1 links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma. J Boil Chem, 2017, 292(43): 17939-17949.

1. Boni V, Bitarte N, Cristobal I, et al. miR-192/miR-215 influence 5-fluorouracil resistance through cell cycle-mediated mechanisms complementary to its post-transcriptional thymidilate synthase regulation. Mol Cancer Ther, 2010, 9(8): 2265-2275.
2. 娄杰, 刘华, 毛涛, 等. 结直肠肿瘤组织 miR-215 表达及临床意义. 齐鲁医学杂志, 2015, 30(6): 631-634.
3. To KK, Tong CW, Wu M, et al. MicroRNAs in the prognosis and therapy of colorectal cancer: from bench to bedside. World J Gastroenterol, 2018, 24(27): 2949-2973.
4. 晏玥, 王乙安, 陈芳, 等. 尿外泌体 microRNA 与肾脏疾病相关性的研究进展. 实用医学杂志, 2019, 35(4): 673-676.
5. 余绮荷, 张文. MicroRNA 与结直肠癌化疗关系的研究进展. 中国癌症杂志, 2014, 24(1): 62-68.
6. Vychytilova-Faltejskova P, Merhautova J, Machackova T, et al. MiR-215-5p is a tumor suppressor in colorectal cancer targeting EGFR ligand epiregulin and its transcriptional inducer HOXB9. Oncogenesis, 2017, 6(11): 399.
7. 吴旭波, 曹奕鸥, 浦文兰, 等. miR-215 在进展期结肠直肠癌中的表达及其临床意义. 外科理论与实践, 2013, 18(3): 247-251.
8. 宋敏, 宋志超, 王镇, 等. miR-215-3p 通过调控 CXCR4 逆转结肠癌 HCT8 细胞 5-FU 耐药的实验研究. 临床肿瘤学杂志, 2019, 24(6): 513-517.
9. 张永锋, 郭长军, 谭永港, 等. 溃疡性结肠炎相关性结肠癌差异表达的 miRNA 的筛选研究. 中国中西医结合消化杂志, 2014, 22(2): 65-68.
10. Tan YG, Zhang YF, Guo CJ, et al. Screening of differentially expressed microRNA in ulcerative colitis related colorectal cancer. Asian Pac J Trop Med, 2013, 6(12): 972-976.
11. 李勇, 徐丽瑶, 付碧琪, 等. miR-192、miR-215 及 ERCC3 在 NSCLC 细胞系 A549 放疗后的表达变化及意义. 实用临床医学, 2011, 12(12): 1-3.
12. Cai X, Peng D, Wei H, et al. miR-215 suppresses proliferation and migration of non-small cell lung cancer cells. Oncol lett, 2017, 13(4): 2349-2353.
13. 刘锐, 董文刚, 王飞, 等. miR-215 抑制骨肉瘤细胞生长及其分子机制. 现代肿瘤医学, 2019, 27(9): 1472-1476.
14. Han J, Zhang M, Nie C, et al. miR-215 suppresses papillary thyroid cancer proliferation, migration, and invasion through the AKT/GSK-3β/Snail signaling by targeting ARFGEF1. Cell Death Dis, 2019, 10(3): 195.
15. Li M, Zou X, Xia T, et al. A five-miRNA panel in plasma was identified for breast cancer diagnosis. Cancer Med, 2019, 8(16): 7006-7017.
16. Gao JB, Zhu MN, Zhu XL. miRNA-215-5p suppresses the aggressiveness of breast cancer cells by targeting Sox9. FEBS Open Bio, 2019, 9(11): 1957-1967.
17. 庞琦, 牟娇, 郭艳红, 等. microRNA-215 在糖尿病肾病小鼠肾组织中的表达及意义. 中华肾脏病杂志, 2012, 28(4): 305-311.
18. 崔胜金, 陈泽衍, 郭伟权, 等. microRNA 在肥胖相关肾病发生的临床应用. 数理医药学杂志, 2018, 31(8): 1118-1120.
19. 杨梦戈, 张晓洁, 肇玉明. MicroRNA 对缺血性脑卒中自噬调控作用的研究进展. 生命的化学, 2019, 39(2): 338-352.
20. 侯静芳, 杨华, 赵世民, 等. 慢病毒介导 miR-215 过表达对克罗恩病的影响及作用机制. 国际消化病杂志, 2019, 39(5): 347-351.
21. 林振吕, 张琳, 郑建涛. miR-215 对胃癌细胞侵袭转移能力的影响及机制. 中国老年学杂志, 2015, 35(21): 6064-6067.
22. 刁卓, 刘晓超, 唐玉虎, 等. 胃癌组织 miR-215 表达变化及其与患者预后的关系. 山东医药, 2017, 57(8): 80-82.
23. 张军, 陈兆峰, 刘晓光, 等. 微小 RNA-215 在胃癌中的表达及其临床意义. 兰州大学学报(医学版), 2013, 39(4): 13-16,20.
24. 李良平, 龙思泽, 高采平. 胃癌患者血清 microRNA-192 和 microRNA-215 的表达及临床意义. 中华临床医师杂志(电子版), 2013, 7(12): 5223-5227.
25. Deng Y, Huang Z, Xu Y, et al. MiR-215 modulates gastric cancer cell proliferation by targeting RB1. Cancer Lett, 2014, 342(1): 27-35.
26. 杨林声, 王理论, 杜青卫. microRNA-215 对人视网膜母细胞瘤细胞生长及抑癌基因 Rb1 表达的调控作用. 海南医学, 2015, 26(24): 3592-3597.
27. 符小林, 李谟汉, 符密. MiR-215 和 RUNX1 在视网膜母细胞瘤中的表达水平及临床意义. 中国医师杂志, 2018, 20(9): 1310-1315.
28. Agostini A, Brunetti M, Davidson B, et al. The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas. Sci Rep, 2018, 8(1): 11069.
29. 裴颖皓, 钟勇, 王俊, 等. 稳定型心绞痛患者血清 microRNA 的表达差异. 临床心血管病杂志, 2014, 30(1): 18-23.
30. 杜伟, 郭丽娜, 庞席宁. 下调 miR-215-5p 对 TGF-β诱导的人肺成纤维细胞 IMR-90 增殖抑制作用观察. 山东医药, 2018, 58(40): 15-19.
31. Tian H, He Z. miR-215 enhances HCV replication by targeting TRIM22 and inactivating NF-κB signaling. Yonsei Med J, 2018, 59(4): 511-518.
32. Liang H, Li Y, Luo RY, et al. MicroRNA-215 is a potential prognostic marker for cervical cancer. J Huazhong Univ Sci Technology Med Sci, 2014, 34(2): 207-212.
33. Liu CQ, Chen Y, Xie BF, et al. MicroRNA-215-3p suppresses the growth and metastasis of cervical cancer cell via targeting SOX9. Eur Rev Med Pharmacol Sci, 2019, 23(13): 5628-5639.
34. 杨庆辉, 李伟伟, 王瑾, 等. 肝内胆管癌上皮组织 miR-215 表达与病理特征的相关性. 现代消化及介入诊疗, 2019, 24(5): 529-532.
35. 孙嘉玲, 文彬, 孙海涛, 等. 不同转移潜能肝癌细胞株 miRNAs 表达谱的差异性研究. 中国药理学通报, 2018, 34(5): 656-663.
36. 周原世, 李响, 姜兴明, 等. 前列腺癌相关转录因子 1 在恶性肿瘤中的研究进展. 中国临床医学, 2019, 26(1): 126-131.
37. Ali LH, Higazi AM, Moness HM, et al. Clinical significances and diagnostic utilities of both miR-215 and squamous cell carcinoma antigen-IgM versus alpha-fetoprotein in Egyptian patients with hepatitis C virus-induced hepatocellular carcinoma. Clin Exp Gastroenterol, 2019, 12: 51-66.
38. Mamdouh S, Khorshed F, Aboushousha T, et al. Evaluation of mir-224, mir-215 and mir-143 as serum biomarkers for HCV associated hepatocellular carcinoma. Asian Pac J Cancer Prev, 2017, 18(11): 3167-3171.
39. Ren Y, Shang J, Li J, et al. The long noncoding RNA PCAT-1 links the microRNA miR-215 to oncogene CRKL-mediated signaling in hepatocellular carcinoma. J Boil Chem, 2017, 292(43): 17939-17949.

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