Early intervention to prevent and block “sepsis”_West China Medical Journal

Authors：

 WANG Zhong ^1,2

1. Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing 102218, P. R. China;
2. School of Clinical Medicine, Tsinghua University, Beijing 100084, P. R. China;

Corresponding author：

WANG Zhong, Email: wangzhong523@vip.163.com

Keywords：

Sepsis; Infection; Prevention

DOI：

10.7507/1002-0179.202010245

Video：

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Sepsis, a serious clinical syndrome known as organs dysfunction caused by an unbalanced host inflammatory response to infection, is of great concern in emergency medicine. Over the past two decades, the definition of sepsis has changed from systemic inflammatory response syndrome lead by infection to organs damage caused by infection. Under the new diagnostic criterion, septic patients are too serious to be treated in Emergency Department, and need intensive treatment of Intensive Care Unit. In this paper, by analyzing the development process from infection to sepsis and expounding the role of cytokines in the development of sepsis, we think that measures should be taken at the early stage of infection in order to prevent and block the occurrence of sepsis.

Citation： WANG Zhong. Early intervention to prevent and block “sepsis”. West China Medical Journal, 2020, 35(11): 1299-1302. doi: 10.7507/1002-0179.202010245 Copy

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10.	中国医疗保健国际交流促进会急诊医学分会, 中华医学会急诊医学分会, 中国医师协会急诊医师分会, 等. 中国“脓毒症早期预防与阻断”急诊专家共识. 中华危重病急救医学, 2020, 32(5): 518-530.

1. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 2016, 315(8): 801-810.
2. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest, 1992, 101(6): 1644-1655.
3. Slade E, Tamber PS, Vincent JL. The Surviving Sepsis Campaign: raising awareness to reduce mortality. Crit Care, 2003, 7(1): 1-2.
4. Ashbaugh DG, Bigelow DB, Petty TL, et al. Acute respiratory distress in adults. Lancet, 1967, 2(7511): 319-323.
5. Petty TL, Ashbaugh DG. The adult respiratory distress syndrome. Clinical features, factors influencing prognosis and principles of management. Chest, 1971, 60(3): 233-239.
6. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med, 1994, 149(3 Pt 1): 818-824.
7. Shoemaker WC. Editorial: Multiple injuries and multiple organ failure. Crit Care Med, 1973, 1(3): 157.
8. Chousterman BG, Swirski FK, Weber GF. Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol, 2017, 39(5): 517-528.
9. van der Poll T, Meijers JC. Systemic inflammatory response syndrome and compensatory anti-inflammatory response syndrome in sepsis. J Innate Immun, 2010, 2(5): 379-380.
10. 中国医疗保健国际交流促进会急诊医学分会, 中华医学会急诊医学分会, 中国医师协会急诊医师分会, 等. 中国“脓毒症早期预防与阻断”急诊专家共识. 中华危重病急救医学, 2020, 32(5): 518-530.

West China Medical Journal

Early intervention to prevent and block “sepsis”

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