Characteristics and challenges of diabetic foot infection_West China Medical Journal

Authors：

 XU Jun

NHC Key Laboratory of Hormones and Development (Tianjin Medical University); Tianjin Key Laboratory of Metabolic Diseases; Department of Diabetic Foot, Tianjin Medical University Chu Hsien-I Memorial Hospital (Metabolic Diseases Hospital) & Tianjin Institute of Endocrinology; Tianjin 300134, P. R. China;

Corresponding author：

XU Jun, Email: xujun0602@163.com

Keywords：

Diabetic foot infection; Multidrug-resistant bacteria; Biofilm; Diabetic foot osteomyelitis; Multidisciplinary cooperation

DOI：

10.7507/1002-0179.202103015

Video：

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Abstract Full text Figures/Tables Video References Cited by

Diabetic foot infection (DFI) is one of the main causes of hospitalized patients with diabetic foot. DFI should be diagnosed according to the clinical manifestations, and the severity of infection should be graded in time. Diabetic foot wounds are mostly chronic wounds, and there are many kinds of bacterial infections. The bacteria and antibiotics resistance will change with the progress of the disease. Bacterial biofilm is also one of the important causes of antibiotic resistance. Reasonable and timely surgical treatment combined with effective antibiotic treatment is an effective measure to deal with the challenge of DFI. On this basis, multidisciplinary cooperation will achieve the best clinical outcome.

Citation： XU Jun. Characteristics and challenges of diabetic foot infection. West China Medical Journal, 2021, 36(4): 436-439. doi: 10.7507/1002-0179.202103015 Copy

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6.	Wukich DK, Hobizal KB, Brooks MM. Severity of diabetic foot infection and rate of limb salvage. Foot Ankle Int, 2013, 34(3): 351-358.
7.	Pickwell K, Siersma V, Kars M, et al. Predictors of lower-extremity amputation in patients with an infected diabetic foot ulcer. Diabetes Care, 2015, 38(5): 852-857.
8.	Seth A, Attri AK, Kataria H, et al. Clinical profile and outcome in patients of diabetic foot infection. Int J Appl Basic Med Res, 2019, 9(1): 14-19.
9.	Zou M, Cai Y, Hu P, et al. Analysis of the composition and functions of the microbiome in diabetic foot osteomyelitis based on 16S rRNA and metagenome sequencing technology. Diabetes, 2020, 69(11): 2423-2439.
10.	Hurlow JJ, Humphreys GJ, Bowling FL, et al. Diabetic foot infection: acritical complication. Int Wound J, 2018, 15(5): 814-821.
11.	Mottola C, Matias CS, Mendes JJ, et al. Susceptibility patterns of Staphylococcus aureus biofilms in diabetic foot infections. BMC Microbiol, 2016, 16(1): 119.
12.	Høiby N, Bjarnsholt T, Moser C, et al. ESCMID guideline for the diagnosis and treatment of biofilm infections 2014. Clin Microbiol Infect, 2015, 21(Suppl 1): S1-S25.
13.	Vatan A, Saltoglu N, Yemisen M, et al. Association between biofilm and multi/extensive drug resistance in diabetic foot infection. Int J Clin Pract, 2018, 72(3): e13060.
14.	徐俊, 霍爱梅, 王素, 等. 糖尿病足创面铜绿假单胞菌三型分泌系统和生物膜特点及与抗生素耐药性的关系. 中华内分泌代谢杂志, 2021, 37(2): 135-142.
15.	Boulton AJM, Armstrong DG, Hardman MJ, et al. Diagnosis and management of diabetic foot infections. Arlington, VA: American Diabetes Association, 2020.

1. Saltoglu N, Yemisen M, Ergonul O, et al. Predictors for limb loss among patient with diabetic foot infections: an observational retrospective multicentric study in Turkey. Clin Microbiol Infect, 2015, 21(7): 659-664.
2. 中华医学会糖尿病分会, 中华医学会感染病学分会, 中华医学会组织修复与再生分会. 中国糖尿病足防治指南(2019 版)(Ⅲ). 中华糖尿病杂志, 2019, 11(4): 238-247.
3. Monteiro-Soares M, Russell D, Boyko EJ, et al. Guidelines on the classification of diabetic foot ulcers (IWGDF 2019). Diabetes Metab Res Rev, 2020, 36(Suppl 1): e3273.
4. 徐俊, 许樟荣. 国际糖尿病足工作组《糖尿病足感染诊断与治疗指南(2019版)》解读. 国际内分泌代谢杂志, 2020, 40(6): 425-429.
5. Prompers L, Huijberts M, Apelqvist J, et al. High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study. Diabetologia, 2007, 50(1): 18-25.
6. Wukich DK, Hobizal KB, Brooks MM. Severity of diabetic foot infection and rate of limb salvage. Foot Ankle Int, 2013, 34(3): 351-358.
7. Pickwell K, Siersma V, Kars M, et al. Predictors of lower-extremity amputation in patients with an infected diabetic foot ulcer. Diabetes Care, 2015, 38(5): 852-857.
8. Seth A, Attri AK, Kataria H, et al. Clinical profile and outcome in patients of diabetic foot infection. Int J Appl Basic Med Res, 2019, 9(1): 14-19.
9. Zou M, Cai Y, Hu P, et al. Analysis of the composition and functions of the microbiome in diabetic foot osteomyelitis based on 16S rRNA and metagenome sequencing technology. Diabetes, 2020, 69(11): 2423-2439.
10. Hurlow JJ, Humphreys GJ, Bowling FL, et al. Diabetic foot infection: acritical complication. Int Wound J, 2018, 15(5): 814-821.
11. Mottola C, Matias CS, Mendes JJ, et al. Susceptibility patterns of Staphylococcus aureus biofilms in diabetic foot infections. BMC Microbiol, 2016, 16(1): 119.
12. Høiby N, Bjarnsholt T, Moser C, et al. ESCMID guideline for the diagnosis and treatment of biofilm infections 2014. Clin Microbiol Infect, 2015, 21(Suppl 1): S1-S25.
13. Vatan A, Saltoglu N, Yemisen M, et al. Association between biofilm and multi/extensive drug resistance in diabetic foot infection. Int J Clin Pract, 2018, 72(3): e13060.
14. 徐俊, 霍爱梅, 王素, 等. 糖尿病足创面铜绿假单胞菌三型分泌系统和生物膜特点及与抗生素耐药性的关系. 中华内分泌代谢杂志, 2021, 37(2): 135-142.
15. Boulton AJM, Armstrong DG, Hardman MJ, et al. Diagnosis and management of diabetic foot infections. Arlington, VA: American Diabetes Association, 2020.

West China Medical Journal

Characteristics and challenges of diabetic foot infection

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