Association between pretreatment prognostic nutritional index and prognosis of small cell lung cancer patients: a meta-analysis_West China Medical Journal

Authors：

ZHANG Liming ^1,2 , SONG Wenpeng ¹ , WANG Yan ¹ ,  CHE Guowei ¹

1. Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R China;
2. Department of Thoracic Surgery, Sichuan Science City Hospital, Mianyang, Sichuan 621000, P. R China;

Corresponding author：

CHE Guowei, Email: cheguowei_hx@aliyun.com

Keywords：

Prognostic nutritional index; small cell lung cancer; prognosis; meta-analysis

DOI：

10.7507/1002-0179.202105195

Video：

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Objective To explore the association of pretreatment prognostic nutritional index (PNI) with the prognosis of small cell lung cancer (SCLC) patients. Methods The PubMed, Web of Science, Embase, China National Knowledge Infrastructure, WanFang and VIP databases were searched for relevant literature which identified the prognostic role of PNI in SCLC up to March 9th, 2022. The primary endpoint was overall survival (OS) and the secondary endpoint was progression-free survival (PFS). The hazard ratio (HR) and 95% confidence interval (CI) were combined by Stata 12.0 software. Results A total of 19 retrospective cohort studies were included, involving 5999 participates. The pooled results indicated that low pretreatment PNI predicted poorer OS [HR=1.58, 95%CI (1.37, 1.83), P<0.001] and PFS [HR=1.51, 95%CI (1.03, 2.22), P=0.037]. Conclusion Low pretreatment PNI may be a risk factor for poor prognosis of SCLC patients and could be applied for the evaluation of prognosis and formulation of therapy strategy.

Citation： ZHANG Liming, SONG Wenpeng, WANG Yan, CHE Guowei. Association between pretreatment prognostic nutritional index and prognosis of small cell lung cancer patients: a meta-analysis. West China Medical Journal, 2022, 37(3): 424-430. doi: 10.7507/1002-0179.202105195 Copy

1.	Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin, 2020, 70(1): 7-30.
2.	Lee H, Park SD, Kim T, et al. Algorithm using neuron-specific enolase and pro-gastrin-releasing peptide to increase the diagnostic accuracy for small cell lung cancer. Ann Lab Med, 2021, 41(3): 339-341.
3.	Li J, Wang Y, Li J, et al. Prognostic value of pretreatment d-dimer level in small-cell lung cancer: a meta-analysis. Technol Cancer Res Treat, 2021, 20: 1533033821989822.
4.	Wang Y, Wu Y, Li J, et al. Clinicopathological and prognostic significance of thyroid transcription factor-1 expression in small cell lung cancer: a systemic review and meta-analysis. Pathol Res Pract, 2019, 215(12): 152706.
5.	Li J, Cheng Y, Liu G, et al. The association of pretreatment serum albumin with outcomes in bladder cancer: a meta-analysis. Onco Targets Ther, 2018, 11: 3449-3459.
6.	Ge LN, Wang F. Prognostic significance of preoperative serum albumin in epithelial ovarian cancer patients: a systematic review and dose-response meta-analysis of observational studies. Cancer Manag Res, 2018, 10: 815-825.
7.	Wang Y, Hu X, Huang Y, et al. Prognostic value of the C-reactive protein to albumin ratio in esophageal cancer: a systematic review and meta-analysis. Kaohsiung J Med Sci, 2020, 36(1): 54-61.
8.	王彦, 王彦文, 郑智尧, 等. 治疗前系统免疫炎症指数与食管癌患者预后关系的 meta 分析. 华西医学, 2019, 34(3): 315-321.
9.	王彦, 徐文颖, 蒲俊栏, 等. 治疗前淋巴细胞/单核细胞比值与中国食管鳞癌患者预后关系的 Meta 分析. 医学研究杂志, 2020, 49(1): 128-132, 117.
10.	Jin J, Yang L, Liu D, et al. Prognostic value of pretreatment lymphocyte-to-monocyte ratio in lung cancer: a systematic review and meta-analysis. Technol Cancer Res Treat, 2021, 20: 1533033820983085.
11.	Mjaess G, Chebel R, Karam A, et al. Prognostic role of neutrophil-to-lymphocyte ratio (NLR) in urological tumors: an umbrella review of evidence from systematic reviews and meta-analyses. Acta Oncol, 2021, 60(6): 704-713.
12.	Tang M, Gao X, Sun H, et al. Neutrophil-lymphocyte ratio as a prognostic parameter in nsclc patients receiving EGFR-TKIs: a systematic review and meta-analysis. J Oncol, 2021, 2021: 6688346.
13.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
14.	王彦, 李佳龙, 吴砚铭, 等. 术前 D-二聚体水平与中国食管癌患者预后关系的系统评价与 Meta 分析. 中国胸心血管外科临床杂志, 2020, 27(6): 689-692.
15.	王彦, 吴砚铭, 王彦文, 等. C 反应蛋白/白蛋白比值与肺癌患者预后关系的 meta 分析. 华西医学, 2019, 34(1): 50-57.
16.	Hong X, Cui B, Wang M, et al. Systemic immune-inflammation index, based on platelet counts and neutrophil-lymphocyte ratio, is useful for predicting prognosis in small cell lung cancer. Tohoku J Exp Med, 2015, 236(4): 297-304.
17.	Hong S, Zhou T, Fang W, et al. The prognostic nutritional index (PNI) predicts overall survival of small-cell lung cancer patients. Tumor Biol, 2015, 36(5): 3389-3397.
18.	崔贤杰. 预后营养指数在小细胞肺癌患者预后判断中的应用. 肿瘤学杂志, 2015, 21(7): 551-554.
19.	Minami S, Ogata Y, Ihara S, et al. Pretreatment Glasgow prognostic score and prognostic nutritional index predict overall survival of patients with advanced small cell lung cancer. Lung Cancer (Auckl), 2017, 8: 249-257.
20.	Jin S, Cao S, Xu S, et al. Clinical impact of pretreatment prognostic nutritional index (PNI) in small cell lung cancer patients treated with platinum-based chemotherapy. Clin Respir J, 2018, 12(9): 2433-2440.
21.	Go SI, Jeon H, Park S W, et al. Low pre-treatment nutritional index is significantly related to poor outcomes in small cell lung cancer. Thorac Cancer, 2018, 9(11): 1483-1491.
22.	张佳奇, 王优优, 许昆鹏, 等. 营养指标对局限期小细胞肺癌患者预后的影响. 中华肿瘤杂志, 2019, 41(12): 937-942.
23.	刘倩倩, 杨卫华. 系统免疫-炎性反应指数与小细胞肺癌脑转移患者预后的关系. 肿瘤, 2019, 39(8): 649-657.
24.	薛晶雯, 王又君, 郭静, 等预后营养指数评估小细胞肺癌患者预后的临床价值. 承德医学院学报, 2019, 36(5): 393-397.
25.	Zhou T, Zhao Y, Zhao S, et al. Comparison of the prognostic value of systemic inflammation response markers in small cell lung cancer patients. J Cancer, 2019, 10(7): 1685-1692.
26.	许文娟, 马莹, 王译民, 等. 预后营养指数预测小细胞肺癌预后的临床应用研究. 四川大学学报(医学版), 2020, 51(4): 573-577.
27.	Gul B, Metintas S, Ak G, et al. The relationship between nutritional status and prognosis in patients with locally advanced and advanced stage lung cancer. Support Care Cancer, 2021, 29(6): 3357-3365.
28.	Liu J, Li S, Zhang S, et al. Pretreatment prognostic nutritional index is a prognostic marker for extensive-stage small cell lung cancer patients treated with anlotinib. J Thorac Dis, 2020, 12(10): 5765-5773.
29.	Yenibertiz D, Ozyurek BA, Erdogan Y. Is Onodera’s prognostic nutritional index (OPNI) a prognostic factor in small cell lung cancer (SCLC)?. Clin Respir J, 2020, 14: 689-694.
30.	Yılmaz A, Tekin SB, Bilici M, et al. The Significance of Controlling Nutritional Status (CONUT) Score as a novel prognostic parameter in small cell lung cancer. Lung, 2020, 198(4): 695-704.
31.	Wang C, Jin S, Xu S, et al. The combination of pretreatment prognostic nutritional index and neuron-specific enolase enhances prognosis predicting value of small cell lung cancer. Clin Respir J, 2021, 15(3): 264-271.
32.	Li L, Wang Y, Yang P, et al. Correlation of the controlling nutritional status score and the prognostic nutritional index with the prognosis of patients treated with radiotherapy for small-cell lung cancer. Ann Palliat Med, 2021, 10(11): 11635-11642.
33.	Qi WX, Xiang Y, Zhao S, et al. Assessment of systematic inflammatory and nutritional indexes in extensive-stage small-cell lung cancer treated with first-line chemotherapy and atezolizumab. Cancer Immunol Immunother, 2021, 70(11): 3199-3206.
34.	张瑞锋. 小细胞肺癌脑转移颅内放疗患者预后因素分析. 长春: 吉林大学, 2021.
35.	Tang M, Jia Z, Zhang J. The prognostic role of prognostic nutritional index in nasopharyngeal carcinoma: a systematic review and meta-analysis. Int J Clin Oncol, 2021, 26(1): 66-77.
36.	Dai Y, Liu M, Lei L, et al. Prognostic significance of preoperative prognostic nutritional index in ovarian cancer: a systematic review and meta-analysis. Medicine (Baltimore), 2020, 99(38): e21840.
37.	Hao J, Chen C, Wan F, et al. Prognostic value of pre-treatment prognostic nutritional index in esophageal cancer: a systematic review and meta-analysis. Front Oncol, 2020, 10: 797.
38.	Salati M, Filippi R, Vivaldi C, et al. The prognostic nutritional index predicts survival and response to first-line chemotherapy in advanced biliary cancer. Liver Int, 2020, 40(3): 704-711.

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin, 2020, 70(1): 7-30.
2. Lee H, Park SD, Kim T, et al. Algorithm using neuron-specific enolase and pro-gastrin-releasing peptide to increase the diagnostic accuracy for small cell lung cancer. Ann Lab Med, 2021, 41(3): 339-341.
3. Li J, Wang Y, Li J, et al. Prognostic value of pretreatment d-dimer level in small-cell lung cancer: a meta-analysis. Technol Cancer Res Treat, 2021, 20: 1533033821989822.
4. Wang Y, Wu Y, Li J, et al. Clinicopathological and prognostic significance of thyroid transcription factor-1 expression in small cell lung cancer: a systemic review and meta-analysis. Pathol Res Pract, 2019, 215(12): 152706.
5. Li J, Cheng Y, Liu G, et al. The association of pretreatment serum albumin with outcomes in bladder cancer: a meta-analysis. Onco Targets Ther, 2018, 11: 3449-3459.
6. Ge LN, Wang F. Prognostic significance of preoperative serum albumin in epithelial ovarian cancer patients: a systematic review and dose-response meta-analysis of observational studies. Cancer Manag Res, 2018, 10: 815-825.
7. Wang Y, Hu X, Huang Y, et al. Prognostic value of the C-reactive protein to albumin ratio in esophageal cancer: a systematic review and meta-analysis. Kaohsiung J Med Sci, 2020, 36(1): 54-61.
8. 王彦, 王彦文, 郑智尧, 等. 治疗前系统免疫炎症指数与食管癌患者预后关系的 meta 分析. 华西医学, 2019, 34(3): 315-321.
9. 王彦, 徐文颖, 蒲俊栏, 等. 治疗前淋巴细胞/单核细胞比值与中国食管鳞癌患者预后关系的 Meta 分析. 医学研究杂志, 2020, 49(1): 128-132, 117.
10. Jin J, Yang L, Liu D, et al. Prognostic value of pretreatment lymphocyte-to-monocyte ratio in lung cancer: a systematic review and meta-analysis. Technol Cancer Res Treat, 2021, 20: 1533033820983085.
11. Mjaess G, Chebel R, Karam A, et al. Prognostic role of neutrophil-to-lymphocyte ratio (NLR) in urological tumors: an umbrella review of evidence from systematic reviews and meta-analyses. Acta Oncol, 2021, 60(6): 704-713.
12. Tang M, Gao X, Sun H, et al. Neutrophil-lymphocyte ratio as a prognostic parameter in nsclc patients receiving EGFR-TKIs: a systematic review and meta-analysis. J Oncol, 2021, 2021: 6688346.
13. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
14. 王彦, 李佳龙, 吴砚铭, 等. 术前 D-二聚体水平与中国食管癌患者预后关系的系统评价与 Meta 分析. 中国胸心血管外科临床杂志, 2020, 27(6): 689-692.
15. 王彦, 吴砚铭, 王彦文, 等. C 反应蛋白/白蛋白比值与肺癌患者预后关系的 meta 分析. 华西医学, 2019, 34(1): 50-57.
16. Hong X, Cui B, Wang M, et al. Systemic immune-inflammation index, based on platelet counts and neutrophil-lymphocyte ratio, is useful for predicting prognosis in small cell lung cancer. Tohoku J Exp Med, 2015, 236(4): 297-304.
17. Hong S, Zhou T, Fang W, et al. The prognostic nutritional index (PNI) predicts overall survival of small-cell lung cancer patients. Tumor Biol, 2015, 36(5): 3389-3397.
18. 崔贤杰. 预后营养指数在小细胞肺癌患者预后判断中的应用. 肿瘤学杂志, 2015, 21(7): 551-554.
19. Minami S, Ogata Y, Ihara S, et al. Pretreatment Glasgow prognostic score and prognostic nutritional index predict overall survival of patients with advanced small cell lung cancer. Lung Cancer (Auckl), 2017, 8: 249-257.
20. Jin S, Cao S, Xu S, et al. Clinical impact of pretreatment prognostic nutritional index (PNI) in small cell lung cancer patients treated with platinum-based chemotherapy. Clin Respir J, 2018, 12(9): 2433-2440.
21. Go SI, Jeon H, Park S W, et al. Low pre-treatment nutritional index is significantly related to poor outcomes in small cell lung cancer. Thorac Cancer, 2018, 9(11): 1483-1491.
22. 张佳奇, 王优优, 许昆鹏, 等. 营养指标对局限期小细胞肺癌患者预后的影响. 中华肿瘤杂志, 2019, 41(12): 937-942.
23. 刘倩倩, 杨卫华. 系统免疫-炎性反应指数与小细胞肺癌脑转移患者预后的关系. 肿瘤, 2019, 39(8): 649-657.
24. 薛晶雯, 王又君, 郭静, 等预后营养指数评估小细胞肺癌患者预后的临床价值. 承德医学院学报, 2019, 36(5): 393-397.
25. Zhou T, Zhao Y, Zhao S, et al. Comparison of the prognostic value of systemic inflammation response markers in small cell lung cancer patients. J Cancer, 2019, 10(7): 1685-1692.
26. 许文娟, 马莹, 王译民, 等. 预后营养指数预测小细胞肺癌预后的临床应用研究. 四川大学学报(医学版), 2020, 51(4): 573-577.
27. Gul B, Metintas S, Ak G, et al. The relationship between nutritional status and prognosis in patients with locally advanced and advanced stage lung cancer. Support Care Cancer, 2021, 29(6): 3357-3365.
28. Liu J, Li S, Zhang S, et al. Pretreatment prognostic nutritional index is a prognostic marker for extensive-stage small cell lung cancer patients treated with anlotinib. J Thorac Dis, 2020, 12(10): 5765-5773.
29. Yenibertiz D, Ozyurek BA, Erdogan Y. Is Onodera’s prognostic nutritional index (OPNI) a prognostic factor in small cell lung cancer (SCLC)?. Clin Respir J, 2020, 14: 689-694.
30. Yılmaz A, Tekin SB, Bilici M, et al. The Significance of Controlling Nutritional Status (CONUT) Score as a novel prognostic parameter in small cell lung cancer. Lung, 2020, 198(4): 695-704.
31. Wang C, Jin S, Xu S, et al. The combination of pretreatment prognostic nutritional index and neuron-specific enolase enhances prognosis predicting value of small cell lung cancer. Clin Respir J, 2021, 15(3): 264-271.
32. Li L, Wang Y, Yang P, et al. Correlation of the controlling nutritional status score and the prognostic nutritional index with the prognosis of patients treated with radiotherapy for small-cell lung cancer. Ann Palliat Med, 2021, 10(11): 11635-11642.
33. Qi WX, Xiang Y, Zhao S, et al. Assessment of systematic inflammatory and nutritional indexes in extensive-stage small-cell lung cancer treated with first-line chemotherapy and atezolizumab. Cancer Immunol Immunother, 2021, 70(11): 3199-3206.
34. 张瑞锋. 小细胞肺癌脑转移颅内放疗患者预后因素分析. 长春: 吉林大学, 2021.
35. Tang M, Jia Z, Zhang J. The prognostic role of prognostic nutritional index in nasopharyngeal carcinoma: a systematic review and meta-analysis. Int J Clin Oncol, 2021, 26(1): 66-77.
36. Dai Y, Liu M, Lei L, et al. Prognostic significance of preoperative prognostic nutritional index in ovarian cancer: a systematic review and meta-analysis. Medicine (Baltimore), 2020, 99(38): e21840.
37. Hao J, Chen C, Wan F, et al. Prognostic value of pre-treatment prognostic nutritional index in esophageal cancer: a systematic review and meta-analysis. Front Oncol, 2020, 10: 797.
38. Salati M, Filippi R, Vivaldi C, et al. The prognostic nutritional index predicts survival and response to first-line chemotherapy in advanced biliary cancer. Liver Int, 2020, 40(3): 704-711.

West China Medical Journal

Association between pretreatment prognostic nutritional index and prognosis of small cell lung cancer patients: a meta-analysis

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