Application of rehabilitation training in lung cancer patients during chemotherapy_West China Medical Journal

Authors：

CONG Qirui ¹ ,  NI Jun ²

1. Department of Rehabilitation Medicine, Danyang People’s Hospital, Danyang, Jiangsu 212300, P. R. China;
2. Department of Rehabilitation Medicine, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P. R. China;

Corresponding author：

NI Jun, Email: nijun1000@126.com

Keywords：

Lung cancer; chemotherapy; rehabilitation

DOI：

10.7507/1002-0179.202106137

Video：

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Abstract Full text Figures/Tables Video References Cited by

The global incidence of lung cancer ranks second among cancers, which has caused a serious burden on patients’ family and society. Chemotherapy is a common treatment for lung cancer, which often leads to a decrease in patients’ physical function and quality of life. Pulmonary rehabilitation during perioperative period of lung cancer has received extensive attention, but pulmonary rehabilitation during chemotherapy of lung cancer has not been paid much attention. This article reviews the role of rehabilitation during chemotherapy for lung cancer, and focuses on the role of rehabilitation during chemotherapy for lung cancer patients with different treatment programs. The purpose is to promote the research and promotion of rehabilitation training in lung cancer patients receiving chemotherapy, so as to further improve patients’ function and quality of life.

Citation： CONG Qirui, NI Jun. Application of rehabilitation training in lung cancer patients during chemotherapy. West China Medical Journal, 2022, 37(1): 12-16. doi: 10.7507/1002-0179.202106137 Copy

1.	Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021, 71(3): 209-249.
2.	郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析. 中华肿瘤杂志, 2019, 41(1): 19-28.
3.	Molina JR, Yang P, Cassivi SD, et al. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc, 2008, 83(5): 584-594.
4.	Lakoski SG, Eves ND, Douglas PS, et al. Exercise rehabilitation in patients with cancer. Nat Rev Clin Oncol, 2012, 9(5): 288-296.
5.	Spruit MA, Janssen PP, Willemsen SC, et al. Exercise capacity before and after an 8-week multidisciplinary inpatient rehabilitation program in lung cancer patients: a pilot study. Lung Cancer, 2006, 52(2): 257-260.
6.	Hanna N, Neubauer M, Yiannoutsos C, et al. Phase Ⅲ study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage Ⅲ non-small-cell lung cancer: the Hoosier Oncology Group and U. S. Oncology. J Clin Oncol, 2008, 26(35): 5755-5760.
7.	Giese-Davis J, Collie K, Rancourt KM, et al. Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis. J Clin Oncol, 2011, 29(4): 413-420.
8.	Clouston SAP, Rubin MS, Chae DH, et al. Fundamental causes of accelerated declines in colorectal cancer mortality: modeling multiple ways that disadvantage influences mortality risk. Soc Sci Med, 2017, 187: 1-10.
9.	臧瑜, 于虹, 李妍, 等. 肺癌患者症状群的调查研究. 中华护理杂志, 2016, 51(3): 316-320.
10.	Lee J. Physiologic and psychologic adaptation to exercise interventions in lung cancer patients undergoing chemotherapy: a systematic review and meta-analysis of randomized controlled trials. Support Care Cancer, 2021, 29(6): 2863-2873.
11.	Chasen MR, Dippenaar AP. Cancer nutrition and rehabilitation-its time has come!. Curr Oncol, 2008, 15(3): 117-122.
12.	Campbell KL, Winters-Stone KM, Wiskemann J, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc, 2019, 51(11): 2375-2390.
13.	Schmitz KH, Courneya KS, Matthews C, et al. American college of sports medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc, 2010, 42(7): 1409-1426.
14.	Knols R, Aaronson NK, Uebelhart D, et al. Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol, 2005, 23(16): 3830-3842.
15.	Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med, 2013, 188(8): e13-e64.
16.	Edbrooke L, Aranda S, Granger CL, et al. Benefits of home-based multidisciplinary exercise and supportive care in inoperable non-small cell lung cancer - protocol for a phase Ⅱ randomised controlled trial. BMC Cancer, 2017, 17(1): 663.
17.	Hoffman AJ, Brintnall RA, von Eye A, et al. Home-based exercise: promising rehabilitation for symptom relief, improved functional status and quality of life for post-surgical lung cancer patients. J Thorac Dis, 2014, 6(6): 632-640.
18.	Rock CL, Doyle C, Demark-Wahnefried W, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin, 2012, 62(4): 243-274.
19.	董倩, 林洪生. 从国外癌症康复现状论中医药在癌症康复中的应用与挑战. 世界中医药, 2014, 9(7): 857-863.
20.	Wesa K, Gubili J, Cassileth B. Integrative oncology: complementary therapies for cancer survivors. Hematol Oncol Clin North Am, 2008, 22(2): 343-353, viii.
21.	韩睿, 林洪生. 健身气功八段锦对非小细胞肺癌术后患者肺功能及生存质量干预疗效的临床研究. 天津中医药, 2016, 33(12): 715-718.
22.	刘秀英, 潘孟侠, 夏立伟. 应用中医音乐疗法治疗肺癌患者术后不良情绪的效果及护理. 时珍国医国药, 2013, 24(1): 216-217.
23.	杨术兰, 何燕, 王丹. 肺癌术后化疗患者的中医饮食护理研究. 时珍国医国药, 2018, 29(2): 386-387.
24.	彭博, 黄雨滟, 黄厚强, 等. 术后肺康复训练对肺癌患者影响的系统评价及meta分析. 现代医药卫生, 2021, 37(22): 3836-3841, 3880.
25.	陈瑞英, 刘雅, 孙婷, 等. 肺康复运动训练对肺癌患者呼吸运动功能、生活质量及总生存期的影响. 中华物理医学与康复杂志, 2019(1): 31-36.
26.	赵磊, 周媛媛. 术前呼吸功能锻炼联合术后强化式呼吸道在老年肺癌胸腔镜术后康复中的效果. 新疆医学, 2021, 51(11): 1280-1283.
27.	Shi JF, Wang L, Wu N, et al. Clinical characteristics and medical service utilization of lung cancer in China, 2005-2014: overall design and results from a multicenter retrospective epidemiologic survey. Lung Cancer, 2019, 128: 91-100.
28.	Granger CL. Physiotherapy management of lung cancer. J Physiother, 2016, 62(2): 60-67.
29.	Jastrzębski D, Maksymiak M, Kostorz S, et al. Pulmonary rehabilitation in advanced lung cancer patients during chemotherapy. Adv Exp Med Biol, 2015, 861: 57-64.
30.	Quist M, Adamsen L, Rørth M, et al. The impact of a multidimensional exercise intervention on physical and functional capacity, anxiety, and depression in patients with advanced-stage lung cancer undergoing chemotherapy. Integr Cancer Ther, 2015, 14(4): 341-349.
31.	Rutkowska A, Jastrzebski D, Rutkowski S, et al. Exercise training in patients with non-small cell lung cancer during in-hospital chemotherapy treatment: a randomized controlled trial. J Cardiopulm Rehabil Prev, 2019, 39(2): 127-133.
32.	朱烨, 徐敏. 肺康复运动训练对非手术肺癌患者呼吸运动功能、中长期生活质量、生存状况及并发症的影响分析. 实用心脑肺血管病杂志, 2021, 29(增刊 2): 67-69.
33.	Tao X, Yuan C, Zheng D, et al. Outcomes comparison between neoadjuvant chemotherapy and adjuvant chemotherapy in stage ⅢA non-small cell lung cancer patients. J Thorac Dis, 2019, 11(4): 1443-1455.
34.	Margaritora S, Cesario A, Cusumano G, et al. Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery. J Thorac Cardiovasc Surg, 2010, 139(6): 1457-1463.
35.	Venuta F, Anile M, Diso D, et al. Operative complications and early mortality after induction therapy for lung cancer. Eur J Cardiothorac Surg, 2007, 31(4): 714-717.
36.	Tarumi S, Yokomise H, Gotoh M, et al. Pulmonary rehabilitation during induction chemoradiotherapy for lung cancer improves pulmonary function. J Thorac Cardiovasc Surg, 2015, 149(2): 569-573.
37.	朱文军. 中医非药物疗法对非小细胞肺癌术后康复患者生活质量的影响. 南京: 南京中医药大学, 2019: 1-62.
38.	Bezjak A, Lee CW, Ding K, et al. Quality-of-life outcomes for adjuvant chemotherapy in early-stage non-small-cell lung cancer: results from a randomized trial, JBR. 10. J Clin Oncol, 2008, 26(31): 5052-5059.
39.	Hickok JT, Roscoe JA, Morrow GR, et al. Frequency, severity, clinical course, and correlates of fatigue in 372 patients during 5 weeks of radiotherapy for cancer. Cancer, 2005, 104(8): 1772-1778.
40.	Phillips SM, McAuley E. Physical activity and fatigue in breast cancer survivors: a panel model examining the role of self-efficacy and depression. Cancer Epidemiol Biomarkers Prev, 2013, 22(5): 773-781.
41.	Mitchell SA, Hoffman AJ, Clark JC, et al. Putting evidence into practice: an update of evidence-based interventions for cancer-related fatigue during and following treatment. Clin J Oncol Nurs, 2014(Suppl 18): 38-58.
42.	Hoffman AJ, Brintnall RA, Brown JK, et al. Virtual reality bringing a new reality to postthoracotomy lung cancer patients via a home-based exercise intervention targeting fatigue while undergoing adjuvant treatment. Cancer Nurs, 2014, 37(1): 23-33.
43.	Hoffman AJ, Brintnall RA, Given BA, et al. Using perceived self-efficacy to improve fatigue and fatigability in postsurgical lung cancer patients: a pilot randomized controlled trial. Cancer Nurs, 2017, 40(1): 1-12.
44.	Hilfiker R, Meichtry A, Eicher M, et al. Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: a systematic review incorporating an indirect-comparisons meta-analysis. Br J Sports Med, 2018, 52(10): 651-658.
45.	Scott JM, Thomas SM, Herndon JE 2nd, et al. Effects and tolerability of exercise therapy modality on cardiorespiratory fitness in lung cancer: a randomized controlled trial. J Cachexia Sarcopenia Muscle, 2021, 12(6): 1456-1465.
46.	Brunelli A, Kim AW, Berger KI, et al. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 2013, 143(Suppl 5): e166S-e190S.
47.	Brunelli A, Belardinelli R, Refai M, et al. Peak oxygen consumption during cardiopulmonary exercise test improves risk stratification in candidates to major lung resection. Chest, 2009, 135(5): 1260-1267.
48.	Cavalheri V, Burtin C, Formico VR, et al. Exercise training undertaken by people within 12 months of lung resection for non-small cell lung cancer. Cochrane Database Syst Rev, 2019, 6(6): CD009955.
49.	陈玉芬, 杨春茂, 李燕舞. 肺康复训练对肺癌化疗病人肺功能、癌因性疲乏及生活质量的影响. 蚌埠医学院学报, 2019, 44(8): 1123-1126.
50.	张婷, 权美丽. 肺康复训练对肺癌患者术后化疗肺功能及生活质量的影响. 中国煤炭工业医学杂志, 2016, 19(9): 1371-1374.
51.	叶静, 谢国省. 家庭肺康复训练对肺癌肺叶切除术后化疗患者肺功能、癌因性疲乏和焦虑抑郁情绪的影响. 中国煤炭工业医学杂志, 2019, 22(2): 220-224.
52.	张慧明. 肺康复训练对肺癌术后化疗患者生活质量的影响. 天津: 天津医科大学, 2014: 1-54.
53.	孔轻轻. 肺康复训练对肺癌术后化疗患者生活质量及癌因性疲乏的影响. 天津: 天津医科大学, 2014: 1-74.

1. Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021, 71(3): 209-249.
2. 郑荣寿, 孙可欣, 张思维, 等. 2015年中国恶性肿瘤流行情况分析. 中华肿瘤杂志, 2019, 41(1): 19-28.
3. Molina JR, Yang P, Cassivi SD, et al. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc, 2008, 83(5): 584-594.
4. Lakoski SG, Eves ND, Douglas PS, et al. Exercise rehabilitation in patients with cancer. Nat Rev Clin Oncol, 2012, 9(5): 288-296.
5. Spruit MA, Janssen PP, Willemsen SC, et al. Exercise capacity before and after an 8-week multidisciplinary inpatient rehabilitation program in lung cancer patients: a pilot study. Lung Cancer, 2006, 52(2): 257-260.
6. Hanna N, Neubauer M, Yiannoutsos C, et al. Phase Ⅲ study of cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel in patients with inoperable stage Ⅲ non-small-cell lung cancer: the Hoosier Oncology Group and U. S. Oncology. J Clin Oncol, 2008, 26(35): 5755-5760.
7. Giese-Davis J, Collie K, Rancourt KM, et al. Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis. J Clin Oncol, 2011, 29(4): 413-420.
8. Clouston SAP, Rubin MS, Chae DH, et al. Fundamental causes of accelerated declines in colorectal cancer mortality: modeling multiple ways that disadvantage influences mortality risk. Soc Sci Med, 2017, 187: 1-10.
9. 臧瑜, 于虹, 李妍, 等. 肺癌患者症状群的调查研究. 中华护理杂志, 2016, 51(3): 316-320.
10. Lee J. Physiologic and psychologic adaptation to exercise interventions in lung cancer patients undergoing chemotherapy: a systematic review and meta-analysis of randomized controlled trials. Support Care Cancer, 2021, 29(6): 2863-2873.
11. Chasen MR, Dippenaar AP. Cancer nutrition and rehabilitation-its time has come!. Curr Oncol, 2008, 15(3): 117-122.
12. Campbell KL, Winters-Stone KM, Wiskemann J, et al. Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Med Sci Sports Exerc, 2019, 51(11): 2375-2390.
13. Schmitz KH, Courneya KS, Matthews C, et al. American college of sports medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc, 2010, 42(7): 1409-1426.
14. Knols R, Aaronson NK, Uebelhart D, et al. Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol, 2005, 23(16): 3830-3842.
15. Spruit MA, Singh SJ, Garvey C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med, 2013, 188(8): e13-e64.
16. Edbrooke L, Aranda S, Granger CL, et al. Benefits of home-based multidisciplinary exercise and supportive care in inoperable non-small cell lung cancer - protocol for a phase Ⅱ randomised controlled trial. BMC Cancer, 2017, 17(1): 663.
17. Hoffman AJ, Brintnall RA, von Eye A, et al. Home-based exercise: promising rehabilitation for symptom relief, improved functional status and quality of life for post-surgical lung cancer patients. J Thorac Dis, 2014, 6(6): 632-640.
18. Rock CL, Doyle C, Demark-Wahnefried W, et al. Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin, 2012, 62(4): 243-274.
19. 董倩, 林洪生. 从国外癌症康复现状论中医药在癌症康复中的应用与挑战. 世界中医药, 2014, 9(7): 857-863.
20. Wesa K, Gubili J, Cassileth B. Integrative oncology: complementary therapies for cancer survivors. Hematol Oncol Clin North Am, 2008, 22(2): 343-353, viii.
21. 韩睿, 林洪生. 健身气功八段锦对非小细胞肺癌术后患者肺功能及生存质量干预疗效的临床研究. 天津中医药, 2016, 33(12): 715-718.
22. 刘秀英, 潘孟侠, 夏立伟. 应用中医音乐疗法治疗肺癌患者术后不良情绪的效果及护理. 时珍国医国药, 2013, 24(1): 216-217.
23. 杨术兰, 何燕, 王丹. 肺癌术后化疗患者的中医饮食护理研究. 时珍国医国药, 2018, 29(2): 386-387.
24. 彭博, 黄雨滟, 黄厚强, 等. 术后肺康复训练对肺癌患者影响的系统评价及meta分析. 现代医药卫生, 2021, 37(22): 3836-3841, 3880.
25. 陈瑞英, 刘雅, 孙婷, 等. 肺康复运动训练对肺癌患者呼吸运动功能、生活质量及总生存期的影响. 中华物理医学与康复杂志, 2019(1): 31-36.
26. 赵磊, 周媛媛. 术前呼吸功能锻炼联合术后强化式呼吸道在老年肺癌胸腔镜术后康复中的效果. 新疆医学, 2021, 51(11): 1280-1283.
27. Shi JF, Wang L, Wu N, et al. Clinical characteristics and medical service utilization of lung cancer in China, 2005-2014: overall design and results from a multicenter retrospective epidemiologic survey. Lung Cancer, 2019, 128: 91-100.
28. Granger CL. Physiotherapy management of lung cancer. J Physiother, 2016, 62(2): 60-67.
29. Jastrzębski D, Maksymiak M, Kostorz S, et al. Pulmonary rehabilitation in advanced lung cancer patients during chemotherapy. Adv Exp Med Biol, 2015, 861: 57-64.
30. Quist M, Adamsen L, Rørth M, et al. The impact of a multidimensional exercise intervention on physical and functional capacity, anxiety, and depression in patients with advanced-stage lung cancer undergoing chemotherapy. Integr Cancer Ther, 2015, 14(4): 341-349.
31. Rutkowska A, Jastrzebski D, Rutkowski S, et al. Exercise training in patients with non-small cell lung cancer during in-hospital chemotherapy treatment: a randomized controlled trial. J Cardiopulm Rehabil Prev, 2019, 39(2): 127-133.
32. 朱烨, 徐敏. 肺康复运动训练对非手术肺癌患者呼吸运动功能、中长期生活质量、生存状况及并发症的影响分析. 实用心脑肺血管病杂志, 2021, 29(增刊 2): 67-69.
33. Tao X, Yuan C, Zheng D, et al. Outcomes comparison between neoadjuvant chemotherapy and adjuvant chemotherapy in stage ⅢA non-small cell lung cancer patients. J Thorac Dis, 2019, 11(4): 1443-1455.
34. Margaritora S, Cesario A, Cusumano G, et al. Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery. J Thorac Cardiovasc Surg, 2010, 139(6): 1457-1463.
35. Venuta F, Anile M, Diso D, et al. Operative complications and early mortality after induction therapy for lung cancer. Eur J Cardiothorac Surg, 2007, 31(4): 714-717.
36. Tarumi S, Yokomise H, Gotoh M, et al. Pulmonary rehabilitation during induction chemoradiotherapy for lung cancer improves pulmonary function. J Thorac Cardiovasc Surg, 2015, 149(2): 569-573.
37. 朱文军. 中医非药物疗法对非小细胞肺癌术后康复患者生活质量的影响. 南京: 南京中医药大学, 2019: 1-62.
38. Bezjak A, Lee CW, Ding K, et al. Quality-of-life outcomes for adjuvant chemotherapy in early-stage non-small-cell lung cancer: results from a randomized trial, JBR. 10. J Clin Oncol, 2008, 26(31): 5052-5059.
39. Hickok JT, Roscoe JA, Morrow GR, et al. Frequency, severity, clinical course, and correlates of fatigue in 372 patients during 5 weeks of radiotherapy for cancer. Cancer, 2005, 104(8): 1772-1778.
40. Phillips SM, McAuley E. Physical activity and fatigue in breast cancer survivors: a panel model examining the role of self-efficacy and depression. Cancer Epidemiol Biomarkers Prev, 2013, 22(5): 773-781.
41. Mitchell SA, Hoffman AJ, Clark JC, et al. Putting evidence into practice: an update of evidence-based interventions for cancer-related fatigue during and following treatment. Clin J Oncol Nurs, 2014(Suppl 18): 38-58.
42. Hoffman AJ, Brintnall RA, Brown JK, et al. Virtual reality bringing a new reality to postthoracotomy lung cancer patients via a home-based exercise intervention targeting fatigue while undergoing adjuvant treatment. Cancer Nurs, 2014, 37(1): 23-33.
43. Hoffman AJ, Brintnall RA, Given BA, et al. Using perceived self-efficacy to improve fatigue and fatigability in postsurgical lung cancer patients: a pilot randomized controlled trial. Cancer Nurs, 2017, 40(1): 1-12.
44. Hilfiker R, Meichtry A, Eicher M, et al. Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: a systematic review incorporating an indirect-comparisons meta-analysis. Br J Sports Med, 2018, 52(10): 651-658.
45. Scott JM, Thomas SM, Herndon JE 2nd, et al. Effects and tolerability of exercise therapy modality on cardiorespiratory fitness in lung cancer: a randomized controlled trial. J Cachexia Sarcopenia Muscle, 2021, 12(6): 1456-1465.
46. Brunelli A, Kim AW, Berger KI, et al. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest, 2013, 143(Suppl 5): e166S-e190S.
47. Brunelli A, Belardinelli R, Refai M, et al. Peak oxygen consumption during cardiopulmonary exercise test improves risk stratification in candidates to major lung resection. Chest, 2009, 135(5): 1260-1267.
48. Cavalheri V, Burtin C, Formico VR, et al. Exercise training undertaken by people within 12 months of lung resection for non-small cell lung cancer. Cochrane Database Syst Rev, 2019, 6(6): CD009955.
49. 陈玉芬, 杨春茂, 李燕舞. 肺康复训练对肺癌化疗病人肺功能、癌因性疲乏及生活质量的影响. 蚌埠医学院学报, 2019, 44(8): 1123-1126.
50. 张婷, 权美丽. 肺康复训练对肺癌患者术后化疗肺功能及生活质量的影响. 中国煤炭工业医学杂志, 2016, 19(9): 1371-1374.
51. 叶静, 谢国省. 家庭肺康复训练对肺癌肺叶切除术后化疗患者肺功能、癌因性疲乏和焦虑抑郁情绪的影响. 中国煤炭工业医学杂志, 2019, 22(2): 220-224.
52. 张慧明. 肺康复训练对肺癌术后化疗患者生活质量的影响. 天津: 天津医科大学, 2014: 1-54.
53. 孔轻轻. 肺康复训练对肺癌术后化疗患者生活质量及癌因性疲乏的影响. 天津: 天津医科大学, 2014: 1-74.

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