Research progress of cystic neutrophilic granulomatous mastitis_West China Medical Journal

Authors：

ZHANG Yuna , TAN Qiuwen , WANG Xiaodong , LÜ Qing ,  YANG Xiaoqin

Department of Breast Surgery, West China Hospital, Scihuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

YANG Xiaoqin, Email: laurayang1977@hotmail.com

Keywords：

Mastitis; Corynebacterium; granulomatous mastitis

DOI：

10.7507/1002-0179.202111171

Video：

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Granulomatous lobular mastitis (GLM) is a rare mastitis disease, which mainly occurs in childbearing period. The etiology, diagnosis and treatment of GLM are still disputed. In recent years, the role of Corynebacterium infection in the pathogenesis of GLM has attracted more and more attention. Cystic neutrophilic granulomatous mastitis (CNGM) has been proposed, and more and more studies have targeted CNGM as a unique subtype of GLM. This article summarizes the published literature on CNGM so far to discuss the research progress in clinicopathological features, microbiological findings, clinical diagnosis and treatment of CNGM.

Citation： ZHANG Yuna, TAN Qiuwen, WANG Xiaodong, LÜ Qing, YANG Xiaoqin. Research progress of cystic neutrophilic granulomatous mastitis. West China Medical Journal, 2022, 37(12): 1899-1903. doi: 10.7507/1002-0179.202111171 Copy

1.	Paviour S, Musaad S, Roberts S, et al. Corynebacterium species isolated from patients with mastitis. Clin Infect Dis. 2002, 35(11): 1434-1440.
2.	Renshaw AA, Derhagopian RP, Gould EW. Cystic neutrophilic granulomatous mastitis: an underappreciated pattern strongly associated with gram-positive bacilli. Am J Clin Pathol, 2011, 136(3): 424-427.
3.	Taylor GB, Paviour SD, Musaad S, et al. A clinicopathological review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. Pathology, 2003, 35(2): 109-119.
4.	D’Alfonso TM, Moo TA, Arleo EK, et al. Cystic neutrophilic granulomatous mastitis: further characterization of a distinctive histopathologic entity not always demonstrably attributable to Corynebacterium infection. Am J Surg Pathol, 2015, 39(10): 1440-1447.
5.	Troxell ML, Gordon NT, Doggett JS, et al. Cystic neutrophilic granulomatous mastitis: association with gram-positive bacilli and Corynebacterium . Am J Clin Pathol, 2016, 145(5): 635-645.
6.	Johnstone KJ, Robson J, Cherian SG, et al. Cystic neutrophilic granulomatous mastitis associated with Corynebacterium including Corynebacterium kroppenstedtii. Pathology, 2017, 49(4): 405-412.
7.	Gautham I, Radford DM, Kovacs CS, et al. Cystic neutrophilic granulomatous mastitis: the cleveland clinic experience with diagnosis and management. Breast J, 2019, 25(1): 80-85.
8.	Shoyele O, Vidhun R, Dodge J, et al. Cystic neutrophilic granulomatous mastitis: a clinicopathologic study of a distinct entity with supporting evidence of a role for Corynebacterium -targeted therapy. Ann Diagn Pathol, 2018, 37: 51-56.
9.	Wang Y, LeGolvan M, Chapin K, et al. Cystic neutrophilic granulomatous mastitis with Corynebacterium and staphylococcus mimicking breast carcinoma. Clin Case Rep, 2018, 6(11): 2208-2210.
10.	Crum-Cianflone NF, Ballon-Landa G, Zorn G. Photo quiz. Recurrent breast abscess in a 33-year-old woman. Clin Infect Dis, 2014, 59(3): 410,454-455.
11.	Sangoi AR. “Thick section” gram stain yields improved detection of organisms in tissue sections of cystic neutrophilic granulomatous mastitis. Am J Clin Pathol, 2020, 153(5): 593-597.
12.	Naik MA, Korlimarla A, Shetty ST, et al. Cystic neutrophilic granulomatous mastitis: a clinicopathological study with 16s rRNA sequencing for the detection of corynebacteria in formalin-fixed paraffin-embedded tissue. Int J Surg Pathol, 2020, 28(4): 371-381.
13.	Oddó D, Stefanelli A, Villarroel A, et al. Coryneform bacteria in granulomatous lobular mastitis: morphological diagnosis in breast biopsies. Int J Surg Pathol, 2019, 27(4): 380-386.
14.	Wu JM, Turashvili G. Cystic neutrophilic granulomatous mastitis: an update. J Clin Pathol, 2020, 73(8): 445-453.
15.	Tan C, Lu FI, Aftanas P, et al. Whole genome sequence of Corynebacterium kroppenstedtii isolated from a case of recurrent granulomatous mastitis. IDCases, 2020, 23: e01034.
16.	Alibi S, Ferjani A, Gaillot O, et al. Identification of clinically relevant Corynebacterium strains by Api Coryne, MALDI-TOF-mass spectrometry and molecular approaches. Pathol Biol (Paris), 2015, 63(4/5): 153-157.
17.	Bao R, Gao X, Hu B, et al. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for identification of Corynebacterium species. J Thorac Dis, 2017, 9(9): 3239-3245.
18.	Zasada AA, Mosiej E. Contemporary microbiology and identification of corynebacteria spp. causing infections in human. Lett Appl Microbiol, 2018, 66(6): 472-483.
19.	Oberman HA. Invasive carcinoma of the breast with granulomatous response. Am J Clin Pathol, 1987, 88(6): 718-721.
20.	Coyne JD. Necrobiotic palisading granulomas associated with breast carcinoma. J Clin Pathol, 2005, 58(12): 1290-1293.
21.	Ming J, Meng G, Yuan Q, et al. Clinical characteristics and surgical modality of plasma cell mastitis: analysis of 91 cases. Am Surg, 2013, 79(1): 54-60.
22.	Liu Y, Zhang J, Zhou YH, et al. IL-6/STAT3 signaling pathway is activated in plasma cell mastitis. Int J Clin Exp Pathol, 2015, 8(10): 12541-12548.
23.	Dong Y, Yu JJ, Shibahara Y, et al. Intercellular adhesion molecule 1/2 and E-selectin in plasma cell mastitis: immunohistochemical study of 35 cases. Hum Pathol, 2014, 45(3): 606-610.
24.	Erivwo P, Turashvili G. Pathology of IgG4-related sclerosing mastitis. J Clin Pathol, 2021, 74(8): 475-482.
25.	Zen Y, Kasahara Y, Horita K, et al. Inflammatory pseudotumor of the breast in a patient with a high serum IgG4 level: histologic similarity to sclerosing pancreatitis. Am J Surg Pathol, 2005, 29(2): 275-278.
26.	Allen SG, Soliman AS, Toy K, et al. Chronic mastitis in Egypt and morocco: differentiating between idiopathic granulomatous mastitis and IgG4-related disease. Breast J, 2016, 22(5): 501-509.
27.	Deng JQ, Yu L, Yang Y, et al. Steroids administered after vacuum-assisted biopsy in the management of idiopathic granulomatous mastitis. J Clin Pathol, 2017, 70(10): 827-831.
28.	Kong C, Zhang C, Wu Y, et al. The expression and meaning of CD68, CD163, CD57, and IgG4 in granulomatous lobular mastitis. Gland Surg, 2020, 9(4): 936-949.
29.	Kilic MO, Sağlam C, Ağca FD, et al. Clinical, diagnostic and therapeutic management of patients with breast tuberculosis: analysis of 46 Cases. Kaohsiung J Med Sci, 2016, 32(1): 27-31.
30.	刘启梁, 雷美. 31 例肉芽肿性小叶性乳腺炎的临床病理特征. 临床与病理杂志, 2019, 39(9): 1891-1895.
31.	Dobinson HC, Anderson TP, Chambers ST, et al. Antimicrobial treatment options for granulomatous mastitis caused by Corynebacterium species. J Clin Microbiol, 2015, 53(9): 2895-2899.
32.	Tauch A, Fernández-Natal I, Soriano F. A microbiological and clinical review on Corynebacterium kroppenstedtii. Int J Infect Dis, 2016, 48: 33-39.
33.	Saraiya N, Corpuz M. Corynebacterium kroppenstedtii: a challenging culprit in breast abscesses and granulomatous mastitis. Curr Opin Obstet Gynecol, 2019, 31(5): 325-332.
34.	Kutsuna S, Mezaki K, Nagamatsu M, et al. Two cases of granulomatous mastitis caused by Corynebacterium kroppenstedtii infection in nulliparous young women with hyperprolactinemia. Intern Med, 2015, 54(14): 1815-1818.
35.	Bercot B, Kannengiesser C, Oudin C, et al. First description of NOD2 variant associated with defective neutrophil responses in a woman with granulomatous mastitis related to corynebacteria. J Clin Microbiol, 2009, 47(9): 3034-3037.

1. Paviour S, Musaad S, Roberts S, et al. Corynebacterium species isolated from patients with mastitis. Clin Infect Dis. 2002, 35(11): 1434-1440.
2. Renshaw AA, Derhagopian RP, Gould EW. Cystic neutrophilic granulomatous mastitis: an underappreciated pattern strongly associated with gram-positive bacilli. Am J Clin Pathol, 2011, 136(3): 424-427.
3. Taylor GB, Paviour SD, Musaad S, et al. A clinicopathological review of 34 cases of inflammatory breast disease showing an association between corynebacteria infection and granulomatous mastitis. Pathology, 2003, 35(2): 109-119.
4. D’Alfonso TM, Moo TA, Arleo EK, et al. Cystic neutrophilic granulomatous mastitis: further characterization of a distinctive histopathologic entity not always demonstrably attributable to Corynebacterium infection. Am J Surg Pathol, 2015, 39(10): 1440-1447.
5. Troxell ML, Gordon NT, Doggett JS, et al. Cystic neutrophilic granulomatous mastitis: association with gram-positive bacilli and Corynebacterium . Am J Clin Pathol, 2016, 145(5): 635-645.
6. Johnstone KJ, Robson J, Cherian SG, et al. Cystic neutrophilic granulomatous mastitis associated with Corynebacterium including Corynebacterium kroppenstedtii. Pathology, 2017, 49(4): 405-412.
7. Gautham I, Radford DM, Kovacs CS, et al. Cystic neutrophilic granulomatous mastitis: the cleveland clinic experience with diagnosis and management. Breast J, 2019, 25(1): 80-85.
8. Shoyele O, Vidhun R, Dodge J, et al. Cystic neutrophilic granulomatous mastitis: a clinicopathologic study of a distinct entity with supporting evidence of a role for Corynebacterium -targeted therapy. Ann Diagn Pathol, 2018, 37: 51-56.
9. Wang Y, LeGolvan M, Chapin K, et al. Cystic neutrophilic granulomatous mastitis with Corynebacterium and staphylococcus mimicking breast carcinoma. Clin Case Rep, 2018, 6(11): 2208-2210.
10. Crum-Cianflone NF, Ballon-Landa G, Zorn G. Photo quiz. Recurrent breast abscess in a 33-year-old woman. Clin Infect Dis, 2014, 59(3): 410,454-455.
11. Sangoi AR. “Thick section” gram stain yields improved detection of organisms in tissue sections of cystic neutrophilic granulomatous mastitis. Am J Clin Pathol, 2020, 153(5): 593-597.
12. Naik MA, Korlimarla A, Shetty ST, et al. Cystic neutrophilic granulomatous mastitis: a clinicopathological study with 16s rRNA sequencing for the detection of corynebacteria in formalin-fixed paraffin-embedded tissue. Int J Surg Pathol, 2020, 28(4): 371-381.
13. Oddó D, Stefanelli A, Villarroel A, et al. Coryneform bacteria in granulomatous lobular mastitis: morphological diagnosis in breast biopsies. Int J Surg Pathol, 2019, 27(4): 380-386.
14. Wu JM, Turashvili G. Cystic neutrophilic granulomatous mastitis: an update. J Clin Pathol, 2020, 73(8): 445-453.
15. Tan C, Lu FI, Aftanas P, et al. Whole genome sequence of Corynebacterium kroppenstedtii isolated from a case of recurrent granulomatous mastitis. IDCases, 2020, 23: e01034.
16. Alibi S, Ferjani A, Gaillot O, et al. Identification of clinically relevant Corynebacterium strains by Api Coryne, MALDI-TOF-mass spectrometry and molecular approaches. Pathol Biol (Paris), 2015, 63(4/5): 153-157.
17. Bao R, Gao X, Hu B, et al. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for identification of Corynebacterium species. J Thorac Dis, 2017, 9(9): 3239-3245.
18. Zasada AA, Mosiej E. Contemporary microbiology and identification of corynebacteria spp. causing infections in human. Lett Appl Microbiol, 2018, 66(6): 472-483.
19. Oberman HA. Invasive carcinoma of the breast with granulomatous response. Am J Clin Pathol, 1987, 88(6): 718-721.
20. Coyne JD. Necrobiotic palisading granulomas associated with breast carcinoma. J Clin Pathol, 2005, 58(12): 1290-1293.
21. Ming J, Meng G, Yuan Q, et al. Clinical characteristics and surgical modality of plasma cell mastitis: analysis of 91 cases. Am Surg, 2013, 79(1): 54-60.
22. Liu Y, Zhang J, Zhou YH, et al. IL-6/STAT3 signaling pathway is activated in plasma cell mastitis. Int J Clin Exp Pathol, 2015, 8(10): 12541-12548.
23. Dong Y, Yu JJ, Shibahara Y, et al. Intercellular adhesion molecule 1/2 and E-selectin in plasma cell mastitis: immunohistochemical study of 35 cases. Hum Pathol, 2014, 45(3): 606-610.
24. Erivwo P, Turashvili G. Pathology of IgG4-related sclerosing mastitis. J Clin Pathol, 2021, 74(8): 475-482.
25. Zen Y, Kasahara Y, Horita K, et al. Inflammatory pseudotumor of the breast in a patient with a high serum IgG4 level: histologic similarity to sclerosing pancreatitis. Am J Surg Pathol, 2005, 29(2): 275-278.
26. Allen SG, Soliman AS, Toy K, et al. Chronic mastitis in Egypt and morocco: differentiating between idiopathic granulomatous mastitis and IgG4-related disease. Breast J, 2016, 22(5): 501-509.
27. Deng JQ, Yu L, Yang Y, et al. Steroids administered after vacuum-assisted biopsy in the management of idiopathic granulomatous mastitis. J Clin Pathol, 2017, 70(10): 827-831.
28. Kong C, Zhang C, Wu Y, et al. The expression and meaning of CD68, CD163, CD57, and IgG4 in granulomatous lobular mastitis. Gland Surg, 2020, 9(4): 936-949.
29. Kilic MO, Sağlam C, Ağca FD, et al. Clinical, diagnostic and therapeutic management of patients with breast tuberculosis: analysis of 46 Cases. Kaohsiung J Med Sci, 2016, 32(1): 27-31.
30. 刘启梁, 雷美. 31 例肉芽肿性小叶性乳腺炎的临床病理特征. 临床与病理杂志, 2019, 39(9): 1891-1895.
31. Dobinson HC, Anderson TP, Chambers ST, et al. Antimicrobial treatment options for granulomatous mastitis caused by Corynebacterium species. J Clin Microbiol, 2015, 53(9): 2895-2899.
32. Tauch A, Fernández-Natal I, Soriano F. A microbiological and clinical review on Corynebacterium kroppenstedtii. Int J Infect Dis, 2016, 48: 33-39.
33. Saraiya N, Corpuz M. Corynebacterium kroppenstedtii: a challenging culprit in breast abscesses and granulomatous mastitis. Curr Opin Obstet Gynecol, 2019, 31(5): 325-332.
34. Kutsuna S, Mezaki K, Nagamatsu M, et al. Two cases of granulomatous mastitis caused by Corynebacterium kroppenstedtii infection in nulliparous young women with hyperprolactinemia. Intern Med, 2015, 54(14): 1815-1818.
35. Bercot B, Kannengiesser C, Oudin C, et al. First description of NOD2 variant associated with defective neutrophil responses in a woman with granulomatous mastitis related to corynebacteria. J Clin Microbiol, 2009, 47(9): 3034-3037.

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Research progress of cystic neutrophilic granulomatous mastitis

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